-
1
-
-
0000674913
-
The theory of the gene
-
Morgan, T. H. The theory of the gene. Am. Nat. 51, 513-544 (1917).
-
(1917)
Am. Nat.
, vol.51
, pp. 513-544
-
-
Morgan, T.H.1
-
2
-
-
33747623018
-
Notch signalling: A simple pathway becomes complex
-
Bray, S. J. Notch signalling: a simple pathway becomes complex. Nature Rev. Mol. Cell Biol. 7, 678-689 (2006).
-
(2006)
Nature Rev. Mol. Cell Biol.
, vol.7
, pp. 678-689
-
-
Bray, S.J.1
-
3
-
-
64249172203
-
The canonical Notch signaling pathway: Unfolding the activation mechanism
-
Kopan, R. & Ilagan, M. X. G. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell 137, 216-233 (2009).
-
(2009)
Cell
, vol.137
, pp. 216-233
-
-
Kopan, R.1
Ilagan, M.X.G.2
-
4
-
-
56049092014
-
Modulating Notch signaling by pathway-intrinsic and pathway-extrinsic mechanisms
-
Poellinger, L. & Lendahl, U. Modulating Notch signaling by pathway-intrinsic and pathway-extrinsic mechanisms. Curr. Opin. Genet. Dev. 18, 449-454 (2008).
-
(2008)
Curr. Opin. Genet. Dev.
, vol.18
, pp. 449-454
-
-
Poellinger, L.1
Lendahl, U.2
-
5
-
-
52649179291
-
Notch1 and TGFβ1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells
-
Samon, J. B. et al. Notch1 and TGFβ1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells. Blood 112, 1813-1821 (2008).
-
(2008)
Blood
, vol.112
, pp. 1813-1821
-
-
Samon, J.B.1
-
6
-
-
77956328365
-
Biodiversity and noncanonical Notch signaling
-
Heitzler, P. Biodiversity and noncanonical Notch signaling. Curr. Top. Dev. Biol. 92, 457-481 (2010).
-
(2010)
Curr. Top. Dev. Biol.
, vol.92
, pp. 457-481
-
-
Heitzler, P.1
-
7
-
-
33845306813
-
NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth
-
Palomero, T. et al. NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth. Proc. Natl Acad. Sci. USA 103, 18261-18266 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 18261-18266
-
-
Palomero, T.1
-
8
-
-
33746546368
-
C-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma
-
Weng, A. P. et al. c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. Genes Dev. 20, 2096-2109 (2006).
-
(2006)
Genes Dev.
, vol.20
, pp. 2096-2109
-
-
Weng, A.P.1
-
9
-
-
0037363922
-
HES and HERP families: Multiple effectors of the Notch signaling pathway
-
Iso, T., Kedes, L. & Hamamori, Y. HES and HERP families: multiple effectors of the Notch signaling pathway. J. Cell. Physiol. 194, 237-255 (2003).
-
(2003)
J. Cell. Physiol.
, vol.194
, pp. 237-255
-
-
Iso, T.1
Kedes, L.2
Hamamori, Y.3
-
10
-
-
0033136717
-
Deficient T cell fate specification in mice with an induced inactivation of Notch1
-
Radtke, F. et al. Deficient T cell fate specification in mice with an induced inactivation of Notch1. Immunity 10, 547-558 (1999).
-
(1999)
Immunity
, vol.10
, pp. 547-558
-
-
Radtke, F.1
-
11
-
-
0035988246
-
Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision
-
Han, H. et al. Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision. Int. Immunol. 14, 637-645 (2002).
-
(2002)
Int. Immunol.
, vol.14
, pp. 637-645
-
-
Han, H.1
-
12
-
-
20244389684
-
Notch1 expression in early lymphopoiesis influences B versus T lineage determination
-
Pui, J. C. et al. Notch1 expression in early lymphopoiesis influences B versus T lineage determination. Immunity 11, 299-308 (1999).
-
(1999)
Immunity
, vol.11
, pp. 299-308
-
-
Pui, J.C.1
-
13
-
-
0034869258
-
Subversion of the T/B lineage decision in the thymus by lunatic fringe-mediated inhibition of Notch-1
-
Koch, U. et al. Subversion of the T/B lineage decision in the thymus by lunatic fringe-mediated inhibition of Notch-1. Immunity 15, 225-236 (2001).
-
(2001)
Immunity
, vol.15
, pp. 225-236
-
-
Koch, U.1
-
14
-
-
18344388633
-
Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1
-
Izon, D. J. et al. Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1. Immunity 16, 231-243 (2002).
-
(2002)
Immunity
, vol.16
, pp. 231-243
-
-
Izon, D.J.1
-
15
-
-
0037606092
-
Notch-regulated ankyrin-repeat protein inhibits Notch1 signaling: Multiple Notch1 signaling pathways involved in T cell development
-
Yun, T. J. & Bevan, M. J. Notch-regulated ankyrin-repeat protein inhibits Notch1 signaling: multiple Notch1 signaling pathways involved in T cell development. J. Immunol. 170, 5834-5841 (2003).
-
(2003)
J. Immunol.
, vol.170
, pp. 5834-5841
-
-
Yun, T.J.1
Bevan, M.J.2
-
16
-
-
4444328365
-
Mastermind critically regulates Notch-mediated lymphoid cell fate decisions
-
Maillard, I. et al. Mastermind critically regulates Notch-mediated lymphoid cell fate decisions. Blood 104, 1696-1702 (2004).
-
(2004)
Blood
, vol.104
, pp. 1696-1702
-
-
Maillard, I.1
-
17
-
-
0035477668
-
Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus
-
Wilson, A., MacDonald, H. R. & Radtke, F. Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus. J. Exp. Med. 194, 1003-1012 (2001).
-
(2001)
J. Exp. Med.
, vol.194
, pp. 1003-1012
-
-
Wilson, A.1
MacDonald, H.R.2
Radtke, F.3
-
18
-
-
42049087865
-
The earliest thymic progenitors for T cells possess myeloid lineage potential
-
Bell, J. J. & Bhandoola, A. The earliest thymic progenitors for T cells possess myeloid lineage potential. Nature 452, 764-767 (2008).
-
(2008)
Nature
, vol.452
, pp. 764-767
-
-
Bell, J.J.1
Bhandoola, A.2
-
19
-
-
42049089318
-
Adult T-cell progenitors retain myeloid potential
-
Wada, H. et al. Adult T-cell progenitors retain myeloid potential. Nature 452, 768-772 (2008).
-
(2008)
Nature
, vol.452
, pp. 768-772
-
-
Wada, H.1
-
20
-
-
58149251919
-
Deletion of Notch1 converts pro-T cells to dendritic cells and promotes thymic B cells by cell-extrinsic and cell-intrinsic mechanisms
-
Feyerabend, T. B. et al. Deletion of Notch1 converts pro-T cells to dendritic cells and promotes thymic B cells by cell-extrinsic and cell-intrinsic mechanisms. Immunity 30, 67-79 (2009).
-
(2009)
Immunity
, vol.30
, pp. 67-79
-
-
Feyerabend, T.B.1
-
21
-
-
78649363017
-
Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation
-
Wendorff, A. A. et al. Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation. Immunity 33, 671-684 (2010).
-
(2010)
Immunity
, vol.33
, pp. 671-684
-
-
Wendorff, A.A.1
-
22
-
-
0035476891
-
Differential effects of Notch ligands 5-1 and Jagged-1 in human lymphoid differentiation
-
Jaleco, A. C. et al. Differential effects of Notch ligands 5-1 and Jagged-1 in human lymphoid differentiation. J. Exp. Med. 194, 991-1002 (2001).
-
(2001)
J. Exp. Med.
, vol.194
, pp. 991-1002
-
-
Jaleco, A.C.1
-
23
-
-
0036916440
-
Induction of T cell development from hematopoietic progenitor cells by δ-like-1 in vitro
-
Schmitt, T. M. & Zuniga-Pflucker, J. C. Induction of T cell development from hematopoietic progenitor cells by δ-like-1 in vitro. Immunity 17, 749-756 (2002).
-
(2002)
Immunity
, vol.17
, pp. 749-756
-
-
Schmitt, T.M.1
Zuniga-Pflucker, J.C.2
-
24
-
-
58149154746
-
δ-like 4 is indispensable in thymic environment specific for T cell development
-
Hozumi, K. et al. δ-like 4 is indispensable in thymic environment specific for T cell development. J. Exp. Med. 205, 2507-2513 (2008).
-
(2008)
J. Exp. Med.
, vol.205
, pp. 2507-2513
-
-
Hozumi, K.1
-
25
-
-
58149151302
-
δ-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment
-
Koch, U. et al. δ-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment. J. Exp. Med. 205, 2515-2523 (2008).
-
(2008)
J. Exp. Med.
, vol.205
, pp. 2515-2523
-
-
Koch, U.1
-
26
-
-
77955496968
-
Direct comparison of Dll1-and Dll4-mediated Notch activation levels shows differential lymphomyeloid lineage commitment outcomes
-
Mohtashami, M. et al. Direct comparison of Dll1-and Dll4-mediated Notch activation levels shows differential lymphomyeloid lineage commitment outcomes. J. Immunol. 185, 867-876 (2010).
-
(2010)
J. Immunol.
, vol.185
, pp. 867-876
-
-
Mohtashami, M.1
-
27
-
-
30444454357
-
Developmental and molecular characterization of emerging β-and yô-selected pre-T cells in the adult mouse thymus
-
Taghon, T., Yui, M. A., Pant, R., Diamond, R. A. & Rothenberg, E. V. Developmental and molecular characterization of emerging β-and yô-selected pre-T cells in the adult mouse thymus. Immunity 24, 53-64 (2006).
-
(2006)
Immunity
, vol.24
, pp. 53-64
-
-
Taghon, T.1
Yui, M.A.2
Pant, R.3
Diamond, R.A.4
Rothenberg, E.V.5
-
28
-
-
63849086285
-
An early decrease in Notch activation is required for human TCR-aβ lineage differentiation at the expense of TCR-yδ T cells
-
Van de Walle, I. et al. An early decrease in Notch activation is required for human TCR-aβ lineage differentiation at the expense of TCR-yδ T cells. Blood 113, 2988-2998 (2009).
-
(2009)
Blood
, vol.113
, pp. 2988-2998
-
-
Van De Walle, I.1
-
29
-
-
65349103035
-
Notch signaling is required for proliferation but not for differentiation at a well-defined β-selection checkpoint during human T-cell development
-
Taghon, T. et al. Notch signaling is required for proliferation but not for differentiation at a well-defined β-selection checkpoint during human T-cell development. Blood 113, 3254-3263 (2009).
-
(2009)
Blood
, vol.113
, pp. 3254-3263
-
-
Taghon, T.1
-
30
-
-
67650588402
-
Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A
-
Yashiro-Ohtani, Y. et al. Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A. Genes Dev. 23, 1665-1676 (2009).
-
(2009)
Genes Dev.
, vol.23
, pp. 1665-1676
-
-
Yashiro-Ohtani, Y.1
-
31
-
-
70350515662
-
The follicular versus marginal zone B lymphocyte cell fate decision
-
Pillai, S. & Cariappa, A. The follicular versus marginal zone B lymphocyte cell fate decision. Nature Rev. Immunol. 9, 767-777 (2009).
-
(2009)
Nature Rev. Immunol.
, vol.9
, pp. 767-777
-
-
Pillai, S.1
Cariappa, A.2
-
32
-
-
0036754302
-
Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses
-
Balazs, M., Martin, F., Zhou, T. & Kearney, J. Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses. Immunity 17, 341-352 (2002).
-
(2002)
Immunity
, vol.17
, pp. 341-352
-
-
Balazs, M.1
Martin, F.2
Zhou, T.3
Kearney, J.4
-
33
-
-
2942659675
-
δ-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo
-
Hozumi, K. et al. δ-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo. Nature Immunol. 5, 638-644 (2004).
-
(2004)
Nature Immunol.
, vol.5
, pp. 638-644
-
-
Hozumi, K.1
-
34
-
-
0038742790
-
Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development
-
Saito, T. et al. Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development. Immunity 18, 675-685 (2003).
-
(2003)
Immunity
, vol.18
, pp. 675-685
-
-
Saito, T.1
-
35
-
-
0036094254
-
Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells
-
Tanigaki, K. et al. Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells. Nature Immunol. 3, 443-450 (2002).
-
(2002)
Nature Immunol.
, vol.3
, pp. 443-450
-
-
Tanigaki, K.1
-
36
-
-
34547447032
-
Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo
-
Oyama, T. et al. Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo. Proc. Natl Acad. Sci. USA 104, 9764-9769 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 9764-9769
-
-
Oyama, T.1
-
37
-
-
36348966669
-
The transcriptional coactivator Maml1 is required for Notch2-mediated marginal zone B-cell development
-
Wu, L., Maillard, I., Nakamura, M., Pear, W. S. & Griffin, J. D. The transcriptional coactivator Maml1 is required for Notch2-mediated marginal zone B-cell development. Blood 110, 3618-3623 (2007).
-
(2007)
Blood
, vol.110
, pp. 3618-3623
-
-
Wu, L.1
Maillard, I.2
Nakamura, M.3
Pear, W.S.4
Griffin, J.D.5
-
38
-
-
58149143044
-
Mind bomb 1 in the lymphopoietic niches is essential for T and marginal zone B cell development
-
Song, R. et al. Mind bomb 1 in the lymphopoietic niches is essential for T and marginal zone B cell development. J. Exp. Med. 205, 2525-2536 (2008).
-
(2008)
J. Exp. Med.
, vol.205
, pp. 2525-2536
-
-
Song, R.1
-
39
-
-
77949528417
-
ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo
-
Gibb, D. R. et al. ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo. J. Exp. Med. 207, 623-635 (2010).
-
(2010)
J. Exp. Med.
, vol.207
, pp. 623-635
-
-
Gibb, D.R.1
-
40
-
-
0037332254
-
Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway
-
Kuroda, K. et al. Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway. Immunity 18, 301-312 (2003).
-
(2003)
Immunity
, vol.18
, pp. 301-312
-
-
Kuroda, K.1
-
41
-
-
60149102638
-
Lunatic and manic fringe cooperatively enhance marginal zone B cell precursor competition for δ-like 1 in splenic endothelial niches
-
Tan, J. et al. Lunatic and manic fringe cooperatively enhance marginal zone B cell precursor competition for δ-like 1 in splenic endothelial niches. Immunity 30, 254-263 (2009).
-
(2009)
Immunity
, vol.30
, pp. 254-263
-
-
Tan, J.1
-
42
-
-
34447275920
-
Notch-RBP-J signaling controls the homeostasis of CD8-dendritic cells in the spleen
-
Caton, M. L., Smith-Raska, M. R. & Reizis, B. Notch-RBP-J signaling controls the homeostasis of CD8-dendritic cells in the spleen. J. Exp. Med. 204, 1653-1664 (2007).
-
(2007)
J. Exp. Med.
, vol.204
, pp. 1653-1664
-
-
Caton, M.L.1
Smith-Raska, M.R.2
Reizis, B.3
-
43
-
-
81955164775
-
Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine
-
Lewis, K. L. et al. Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine. Immunity 35, 780-791 (2011).
-
(2011)
Immunity
, vol.35
, pp. 780-791
-
-
Lewis, K.L.1
-
44
-
-
0034599854
-
Notch1 deficiency dissociates the intrathymic development of dendritic cells and T cells
-
Radtke, F. et al. Notch1 deficiency dissociates the intrathymic development of dendritic cells and T cells. J. Exp. Med. 191, 1085-1094 (2000).
-
(2000)
J. Exp. Med.
, vol.191
, pp. 1085-1094
-
-
Radtke, F.1
-
45
-
-
0037108556
-
+ plasmacytoid dendritic cells develop independently of the T-cell lineage
-
+ plasmacytoid dendritic cells develop independently of the T-cell lineage. Blood 100, 2852-2857 (2002).
-
(2002)
Blood
, vol.100
, pp. 2852-2857
-
-
Ferrero, I.1
-
46
-
-
84859384082
-
Innate lymphoid cells: Emerging insights in development, lineage relationships, and function
-
Spits, H. & Cupedo, T. Innate lymphoid cells: emerging insights in development, lineage relationships, and function. Annu. Rev. Immunol. 30, 647-675 (2012).
-
(2012)
Annu. Rev. Immunol.
, vol.30
, pp. 647-675
-
-
Spits, H.1
Cupedo, T.2
-
47
-
-
84872977452
-
Innate lymphoid cells-a proposal for uniform nomenclature
-
Spits, H. et al. Innate lymphoid cells-a proposal for uniform nomenclature. Nature Rev. Immunol. 13, 145-149 (2013).
-
(2013)
Nature Rev. Immunol.
, vol.13
, pp. 145-149
-
-
Spits, H.1
-
48
-
-
78650310810
-
The expanding family of innate lymphoid cells: Regulators and effectors of immunity and tissue remodeling
-
Spits, H. & Di Santo, J. P. The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling. Nature Immunol. 12, 21-27 (2011).
-
(2011)
Nature Immunol.
, vol.12
, pp. 21-27
-
-
Spits, H.1
Di Santo, J.P.2
-
49
-
-
84861722864
-
Id2, and RORγt sequentially orchestrate the fetal development of lymphoid tissue inducer cells
-
Cherrier, M., Sawa, S. & Eberl, G. Notch, Id2, and RORγt sequentially orchestrate the fetal development of lymphoid tissue inducer cells. J. Exp. Med. 209, 729-740 (2012).
-
(2012)
J. Exp. Med.
, vol.209
, pp. 729-740
-
-
Cherrier, M.1
Sawa, S.2
Notch, E.G.3
-
50
-
-
57449118239
-
+ cells that provide innate mucosal immune defense
-
+ cells that provide innate mucosal immune defense. Immunity 29, 958-970 (2008).
-
(2008)
Immunity
, vol.29
, pp. 958-970
-
-
Satoh-Takayama, N.1
-
51
-
-
40049083827
-
Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens
-
Zheng, Y. et al. Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nature Med. 14, 282-289 (2008).
-
(2008)
Nature Med.
, vol.14
, pp. 282-289
-
-
Zheng, Y.1
-
52
-
-
83855160821
-
Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles
-
Kiss, E. A. et al. Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles. Science 334, 1561-1565 (2011).
-
(2011)
Science
, vol.334
, pp. 1561-1565
-
-
Kiss, E.A.1
-
53
-
-
80155164160
-
Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation
-
Li, Y. et al. Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation. Cell 147, 629-640 (2011).
-
(2011)
Cell
, vol.147
, pp. 629-640
-
-
Li, Y.1
-
54
-
-
84855917402
-
AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch
-
Lee, J. S. et al. AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch. Nature Immunol. 13, 144-151 (2012).
-
(2012)
Nature Immunol.
, vol.13
, pp. 144-151
-
-
Lee, J.S.1
-
55
-
-
77951878587
-
Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology
-
Buonocore, S. et al. Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology Nature 464, 1371-1375 (2010).
-
(2010)
Nature
, vol.464
, pp. 1371-1375
-
-
Buonocore, S.1
-
56
-
-
77951817855
-
Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
-
Neill, D. R. et al. Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature 464, 1367-1370 (2010).
-
(2010)
Nature
, vol.464
, pp. 1367-1370
-
-
Neill, D.R.1
-
57
-
-
77954926597
-
Systemically dispersed innate IL-13-expressing cells in type 2 immunity
-
Price, A. E. et al. Systemically dispersed innate IL-13-expressing cells in type 2 immunity. Proc. Natl Acad. Sci. USA 107, 11489-11494 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 11489-11494
-
-
Price, A.E.1
-
58
-
-
84863393407
-
Transcription factor RORa is critical for nuocyte development
-
Wong, S. H. et al. Transcription factor RORa is critical for nuocyte development. Nature Immunol. 13, 229-236 (2012).
-
(2012)
Nature Immunol.
, vol.13
, pp. 229-236
-
-
Wong, S.H.1
-
59
-
-
0022640843
-
Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
-
Mosmann, T. R., Cherwinski, H., Bond, M. W., Giedlin, M. A. & Coffman, R. L. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136, 2348-2357 (1986).
-
(1986)
J. Immunol.
, vol.136
, pp. 2348-2357
-
-
Mosmann, T.R.1
Cherwinski, H.2
Bond, M.W.3
Giedlin, M.A.4
Coffman, R.L.5
-
60
-
-
27544490377
-
+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
-
+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nature Immunol. 6, 1123-1132 (2005).
-
(2005)
Nature Immunol.
, vol.6
, pp. 1123-1132
-
-
Harrington, L.E.1
-
61
-
-
32244442562
-
TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
-
Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M. & Stockinger, B. TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24, 179-189 (2006).
-
(2006)
Immunity
, vol.24
, pp. 179-189
-
-
Veldhoen, M.1
Hocking, R.J.2
Atkins, C.J.3
Locksley, R.M.4
Stockinger, B.5
-
62
-
-
0348223787
-
+ regulatory T cells by TGF-β induction of transcription factor Foxp3
-
+ regulatory T cells by TGF-β induction of transcription factor Foxp3. J. Exp. Med. 198, 1875-1886 (2003).
-
(2003)
J. Exp. Med.
, vol.198
, pp. 1875-1886
-
-
Chen, W.1
-
63
-
-
56349154943
-
Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset
-
Veldhoen, M. et al. Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nature Immunol. 9, 1341-1346 (2008).
-
(2008)
Nature Immunol.
, vol.9
, pp. 1341-1346
-
-
Veldhoen, M.1
-
64
-
-
56349093347
-
+ Foxp3-effector T cells
-
+ Foxp3-effector T cells. Nature Immunol. 9, 1347-1355 (2008).
-
(2008)
Nature Immunol.
, vol.9
, pp. 1347-1355
-
-
Dardalhon, V.1
-
65
-
-
69249109601
-
Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation
-
Johnston, R. J. et al. Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science 325, 1006-1010 (2009).
-
(2009)
Science
, vol.325
, pp. 1006-1010
-
-
Johnston, R.J.1
-
66
-
-
69249101229
-
Bcl6 mediates the development of T follicular helper cells
-
Nurieva, R. I. et al. Bcl6 mediates the development of T follicular helper cells. Science 325, 1001-1005 (2009).
-
(2009)
Science
, vol.325
, pp. 1001-1005
-
-
Nurieva, R.I.1
-
70
-
-
74549176827
-
Notch signaling in the immune system
-
Radtke, F., Fasnacht, N. & Macdonald, H. R. Notch signaling in the immune system. Immunity 32, 14-27 (2010).
-
(2010)
Immunity
, vol.32
, pp. 14-27
-
-
Radtke, F.1
Fasnacht, N.2
MacDonald, H.R.3
-
72
-
-
2342496710
-
Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells
-
Amsen, D. et al. Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells. Cell 117, 515-526 (2004).
-
(2004)
Cell
, vol.117
, pp. 515-526
-
-
Amsen, D.1
-
73
-
-
58849099058
-
The different faces of Notch in T-helper-cell differentiation
-
Amsen, D., Antov, A. & Flavell, R. A. The different faces of Notch in T-helper-cell differentiation. Nature Rev. Immunol. 9, 116-124 (2009).
-
(2009)
Nature Rev. Immunol.
, vol.9
, pp. 116-124
-
-
Amsen, D.1
Antov, A.2
Flavell, R.A.3
-
74
-
-
22144492615
-
Inhibitors of y-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21
-
Minter, L. M. et al. Inhibitors of y-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21. Nature Immunol. 6, 680-688 (2005).
-
(2005)
Nature Immunol.
, vol.6
, pp. 680-688
-
-
Minter, L.M.1
-
75
-
-
42149177242
-
Notch3 inhibition in myelin-reactive T cells down-regulates protein kinase C theta and attenuates experimental autoimmune encephalomyelitis
-
Jurynczyk, M., Jurewicz, A., Raine, C. S. & Selmaj, K. Notch3 inhibition in myelin-reactive T cells down-regulates protein kinase C theta and attenuates experimental autoimmune encephalomyelitis. J. Immunol. 180, 2634-2640 (2008).
-
(2008)
J. Immunol.
, vol.180
, pp. 2634-2640
-
-
Jurynczyk, M.1
Jurewicz, A.2
Raine, C.S.3
Selmaj, K.4
-
76
-
-
34447642439
-
Notch directly regulates Gata3 expression during T helper 2 cell differentiation
-
Fang, T. C. et al. Notch directly regulates Gata3 expression during T helper 2 cell differentiation. Immunity 27, 100-110 (2007).
-
(2007)
Immunity
, vol.27
, pp. 100-110
-
-
Fang, T.C.1
-
77
-
-
26844538164
-
Notch signaling is an important regulator of type 2 immunity
-
Tu, L. et al. Notch signaling is an important regulator of type 2 immunity. J. Exp. Med. 202, 1037-1042 (2005).
-
(2005)
J. Exp. Med.
, vol.202
, pp. 1037-1042
-
-
Tu, L.1
-
78
-
-
84863598267
-
Redundant Notch1 and Notch2 signaling is necessary for IFNy secretion by T helper 1 cells during infection with Leishmania major
-
Auderset, F et al. Redundant Notch1 and Notch2 signaling is necessary for IFNy secretion by T helper 1 cells during infection with Leishmania major. PLoS Pathog. 8, e1002560 (2012).
-
(2012)
PLoS Pathog.
, vol.8
-
-
Auderset, F.1
-
79
-
-
0041331708
-
TCR-mediated notch signaling regulates proliferation and IFN-y production in peripheral T cells
-
Palaga, T, Miele, L, Golde, T. E. & Osborne, B. A. TCR-mediated notch signaling regulates proliferation and IFN-y production in peripheral T cells. J. Immunol. 171, 3019-3024 (2003).
-
(2003)
J. Immunol.
, vol.171
, pp. 3019-3024
-
-
Palaga, T.1
Miele, L.2
Golde, T.E.3
Osborne, B.A.4
-
80
-
-
30444450802
-
Notch1 augments NF-KB activity by facilitating its nuclear retention
-
Shin, H. M. et al. Notch1 augments NF-KB activity by facilitating its nuclear retention. EMBO J. 25, 129-138 (2006).
-
(2006)
EMBO J.
, vol.25
, pp. 129-138
-
-
Shin, H.M.1
-
81
-
-
34447634411
-
Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch
-
Amsen, D. et al. Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity 27, 89-99 (2007).
-
(2007)
Immunity
, vol.27
, pp. 89-99
-
-
Amsen, D.1
-
82
-
-
33745081482
-
The interleukin-4 enhancer CNS-2 is regulated by Notch signals and controls initial expression in NKT cells and memory-type CD4 T cells
-
Tanaka, S. et al. The interleukin-4 enhancer CNS-2 is regulated by Notch signals and controls initial expression in NKT cells and memory-type CD4 T cells. Immunity 24, 689-701 (2006).
-
(2006)
Immunity
, vol.24
, pp. 689-701
-
-
Tanaka, S.1
-
83
-
-
0030810155
-
The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells
-
Zheng, W & Flavell, R. A. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89, 587-596 (1997).
-
(1997)
Cell
, vol.89
, pp. 587-596
-
-
Zheng, W.1
Flavell, R.A.2
-
84
-
-
84859997488
-
Notch receptors and Smad3 signaling cooperate in the induction of interleukin-9-producing T cells
-
Elyaman, W et al. Notch receptors and Smad3 signaling cooperate in the induction of interleukin-9-producing T cells. Immunity 36, 623-634 (2012).
-
(2012)
Immunity
, vol.36
, pp. 623-634
-
-
Elyaman, W.1
-
85
-
-
82955228112
-
H17 cytokines in autoimmune neuro-inflammation
-
H17 cytokines in autoimmune neuro-inflammation. Curr. Opin. Immunol. 23, 707-712 (2011).
-
(2011)
Curr. Opin. Immunol.
, vol.23
, pp. 707-712
-
-
Becher, B.1
Segal, B.M.2
-
87
-
-
10744222828
-
Expression of activated Notch3 in transgenic mice enhances generation of T regulatory cells and protects against experimental autoimmune diabetes
-
Anastasi, E. et al. Expression of activated Notch3 in transgenic mice enhances generation of T regulatory cells and protects against experimental autoimmune diabetes. J. Immunol. 171, 4504-4511 (2003).
-
(2003)
J. Immunol.
, vol.171
, pp. 4504-4511
-
-
Anastasi, E.1
-
88
-
-
66249108256
-
Notch3 and pTa/pre-TCR sustain the in vivo function of naturally occurring regulatory T cells
-
Campese, A. F et al. Notch3 and pTa/pre-TCR sustain the in vivo function of naturally occurring regulatory T cells. Int. Immunol. 21, 727-743 (2009).
-
(2009)
Int. Immunol.
, vol.21
, pp. 727-743
-
-
Campese, A.F.1
-
89
-
-
79958058411
-
Notch3 and canonical NF-KB signaling pathways cooperatively regulate Foxp3 transcription
-
Barbarulo, A. et al. Notch3 and canonical NF-KB signaling pathways cooperatively regulate Foxp3 transcription. J. Immunol. 186, 6199-6206 (2011).
-
(2011)
J. Immunol.
, vol.186
, pp. 6199-6206
-
-
Barbarulo, A.1
-
90
-
-
33846250032
-
Jagged2-expressing hematopoietic progenitors promote regulatory T cell expansion in the periphery through notch signaling
-
Kared, H. et al. Jagged2-expressing hematopoietic progenitors promote regulatory T cell expansion in the periphery through notch signaling. Immunity 25, 823-834 (2006).
-
(2006)
Immunity
, vol.25
, pp. 823-834
-
-
Kared, H.1
-
91
-
-
80052685578
-
Notch ligand δ-like 4 blockade alleviates experimental autoimmune encephalomyelitis by promoting regulatory T cell development
-
Bassil, R. et al. Notch ligand δ-like 4 blockade alleviates experimental autoimmune encephalomyelitis by promoting regulatory T cell development. J. Immunol. 187, 2322-2328 (2011).
-
(2011)
J. Immunol.
, vol.187
, pp. 2322-2328
-
-
Bassil, R.1
-
92
-
-
38449102218
-
JAGGED1 and δ1 differentially regulate the outcome of experimental autoimmune encephalomyelitis
-
Elyaman, W et al. JAGGED1 and δ1 differentially regulate the outcome of experimental autoimmune encephalomyelitis. J. Immunol. 179, 5990-5998 (2007).
-
(2007)
J. Immunol.
, vol.179
, pp. 5990-5998
-
-
Elyaman, W.1
-
93
-
-
84863794078
-
Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice
-
Billiard, F et al. Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice. J. Exp. Med. 209, 1011-1028 (2012).
-
(2012)
J. Exp. Med.
, vol.209
, pp. 1011-1028
-
-
Billiard, F.1
-
94
-
-
12444279957
-
Differentiation and expansion of T cells with regulatory function from human peripheral lymphocytes by stimulation in the presence of TGF-β
-
Rao, P. E., Petrone, A. L. & Ponath, P. D. Differentiation and expansion of T cells with regulatory function from human peripheral lymphocytes by stimulation in the presence of TGF-β. J. Immunol. 174, 1446-1455 (2005).
-
(2005)
J. Immunol.
, vol.174
, pp. 1446-1455
-
-
Rao, P.E.1
Petrone, A.L.2
Ponath, P.D.3
-
96
-
-
0141566334
-
Induction of antigen-specific regulatory T cells following overexpression of a Notch ligand by human B lymphocytes
-
Vigouroux, S. et al. Induction of antigen-specific regulatory T cells following overexpression of a Notch ligand by human B lymphocytes. J. Virol. 77, 10872-10880 (2003).
-
(2003)
J. Virol.
, vol.77
, pp. 10872-10880
-
-
Vigouroux, S.1
-
97
-
-
49149104488
-
Notch1 signaling and regulatory T cell function
-
Asano, N., Watanabe, T., Kitani, A., Fuss, I. J. & Strober, W Notch1 signaling and regulatory T cell function. J. Immunol. 180, 2796-2804 (2008).
-
(2008)
J. Immunol.
, vol.180
, pp. 2796-2804
-
-
Asano, N.1
Watanabe, T.2
Kitani, A.3
Fuss, I.J.4
Strober, W.5
-
98
-
-
84872498240
-
Notch1 modulates mesenchymal stem cells mediated regulatory T-cell induction
-
Del Papa, B. et al. Notch1 modulates mesenchymal stem cells mediated regulatory T-cell induction. Eur. J. Immunol. 43, 182-187 (2012).
-
(2012)
Eur. J. Immunol.
, vol.43
, pp. 182-187
-
-
Del Papa, B.1
-
99
-
-
84864125056
-
Programming of regulatory T cells from pluripotent stem cells and prevention of autoimmunity
-
Haque, R. et al. Programming of regulatory T cells from pluripotent stem cells and prevention of autoimmunity. J. Immunol. 189, 1228-1236 (2012).
-
(2012)
J. Immunol.
, vol.189
, pp. 1228-1236
-
-
Haque, R.1
-
100
-
-
0347951391
-
+ cell-dependent mechanism
-
+ cell-dependent mechanism. J. Clin. Invest. 112, 1741-1750 (2003).
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 1741-1750
-
-
Wong, K.1
-
101
-
-
52549130987
-
Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity
-
Maekawa, Y et al. Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity. Nature Immunol. 9, 1140-1147 (2008).
-
(2008)
Nature Immunol.
, vol.9
, pp. 1140-1147
-
-
Maekawa, Y.1
-
102
-
-
80555149831
-
Blockade of Notch ligand δ1 promotes allograft survival by inhibiting alloreactive Th1 cells and cytotoxic T cell generation
-
Riella, L. V et al. Blockade of Notch ligand δ1 promotes allograft survival by inhibiting alloreactive Th1 cells and cytotoxic T cell generation. J. Immunol. 187, 4629-4638 (2011).
-
(2011)
J. Immunol.
, vol.187
, pp. 4629-4638
-
-
Riella, L.V.1
-
103
-
-
77954507341
-
Notch2 signaling is required for potent antitumor immunity in vivo
-
Sugimoto, K. et al. Notch2 signaling is required for potent antitumor immunity in vivo. J. Immunol. 184, 4673-4678 (2010).
-
(2010)
J. Immunol.
, vol.184
, pp. 4673-4678
-
-
Sugimoto, K.1
-
104
-
-
65449183749
-
+ T cells
-
+ T cells. J. Immunol. 182, 3380-3389 (2009).
-
(2009)
J. Immunol.
, vol.182
, pp. 3380-3389
-
-
Cho, O.H.1
-
105
-
-
84878264534
-
+ T cells
-
+ T cells. Blood 121, 2638-2646 (2013).
-
(2013)
Blood
, vol.121
, pp. 2638-2646
-
-
Kuijk, L.M.1
-
106
-
-
34247867901
-
Immunobiology of allogeneic hematopoietic stem cell transplantation
-
Welniak, L. A., Blazar, B. R. & Murphy, W J. Immunobiology of allogeneic hematopoietic stem cell transplantation. Annu. Rev. Immunol. 25, 139-170 (2007).
-
(2007)
Annu. Rev. Immunol.
, vol.25
, pp. 139-170
-
-
Welniak, L.A.1
Blazar, B.R.2
Murphy, W.J.3
-
107
-
-
78650996522
-
+ T-cell responses mediating graft-versus-host disease
-
+ T-cell responses mediating graft-versus-host disease. Blood 117, 299-308 (2011).
-
(2011)
Blood
, vol.117
, pp. 299-308
-
-
Zhang, Y.1
-
108
-
-
84875837518
-
Blockade of individual Notch ligands and receptors controls graft-versus-host disease
-
Tran, I. T. et al. Blockade of individual Notch ligands and receptors controls graft-versus-host disease. J. Clin. Invest. 123, 1590-1604 (2013).
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 1590-1604
-
-
Tran, I.T.1
-
109
-
-
79960111924
-
Ikaros-Notch axis in host hematopoietic cells regulates experimental graft-versus-host disease
-
Toubai, T. et al. Ikaros-Notch axis in host hematopoietic cells regulates experimental graft-versus-host disease. Blood 118, 192-204 (2011).
-
(2011)
Blood
, vol.118
, pp. 192-204
-
-
Toubai, T.1
-
110
-
-
33645227683
-
Notch activation is an early and critical event during T-cell leukemogenesis in Ikaros-deficient mice
-
Dumortier, A. et al. Notch activation is an early and critical event during T-cell leukemogenesis in Ikaros-deficient mice. Mol. Cell. Biol. 26, 209-220 (2006).
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 209-220
-
-
Dumortier, A.1
-
111
-
-
78650213618
-
Alternative promoter usage at the Notch1 locus supports ligand-independent signaling in T cell development and leukemogenesis
-
Gomez-del Arco, P. et al. Alternative promoter usage at the Notch1 locus supports ligand-independent signaling in T cell development and leukemogenesis. Immunity 33, 685-698 (2010).
-
(2010)
Immunity
, vol.33
, pp. 685-698
-
-
Gomez-Del Arco, P.1
-
112
-
-
0035168209
-
Y-secretase inhibitors as molecular probes of presenilin function
-
Wolfe, M. S. y-secretase inhibitors as molecular probes of presenilin function. J. Mol. Neurosci. 17, 199-204 (2001).
-
(2001)
J. Mol. Neurosci.
, vol.17
, pp. 199-204
-
-
Wolfe, M.S.1
-
113
-
-
0037137482
-
Modulation of receptor signaling by glycosylation: Fringe is an O-fucose-β 1, 3-N-acetylglucosaminyltransferase
-
Haltiwanger, R. S. & Stanley, P. Modulation of receptor signaling by glycosylation: fringe is an O-fucose-β 1, 3-N- acetylglucosaminyltransferase. Biochim. Biophys. Acta 1573, 328-335 (2002).
-
(2002)
Biochim. Biophys. Acta
, vol.1573
, pp. 328-335
-
-
Haltiwanger, R.S.1
Stanley, P.2
-
114
-
-
0242593940
-
Glycosyltransferase activity of Fringe modulates Notch-0 interactions
-
Bruckner, K., Perez, L, Clausen, H. & Cohen, S. Glycosyltransferase activity of Fringe modulates Notch-0 interactions. Nature 406, 411-415 (2000).
-
(2000)
Nature
, vol.406
, pp. 411-415
-
-
Bruckner, K.1
Perez, L.2
Clausen, H.3
Cohen, S.4
-
115
-
-
12944255642
-
Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by 51 and Jagged1
-
Yang, L. T. et al. Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by 51 and Jagged1. Mol. Biol. Cell 16, 927-942 (2005).
-
(2005)
Mol. Biol. Cell
, vol.16
, pp. 927-942
-
-
Yang, L.T.1
-
116
-
-
33847103659
-
Hierarchy of Notch-0 interactions promoting T cell lineage commitment and maturation
-
Besseyrias, V et al. Hierarchy of Notch-0 interactions promoting T cell lineage commitment and maturation. J. Exp. Med. 204, 331-343 (2007).
-
(2007)
J. Exp. Med.
, vol.204
, pp. 331-343
-
-
Besseyrias, V.1
-
117
-
-
35549010987
-
The origin and application of experimental autoimmune encephalomyelitis
-
Baxter, A. G. The origin and application of experimental autoimmune encephalomyelitis. Nature Rev. Immunol. 7, 904-912 (2007).
-
(2007)
Nature Rev. Immunol.
, vol.7
, pp. 904-912
-
-
Baxter, A.G.1
-
118
-
-
77956107505
-
Ameliorating effects of anti-Dll4 mAb on Theiler's murine encephalomyelitis virus-induced demyelinating disease
-
Takeichi, N. et al. Ameliorating effects of anti-Dll4 mAb on Theiler's murine encephalomyelitis virus-induced demyelinating disease. Int. Immunol. 22, 729-738 (2010).
-
(2010)
Int. Immunol.
, vol.22
, pp. 729-738
-
-
Takeichi, N.1
-
119
-
-
80052655552
-
δ-like ligand 4 regulates central nervous system T cell accumulation during experimental autoimmune encephalomyelitis
-
Reynolds, N. D., Lukacs, N. W., Long, N. & Karpus, W J. δ-like ligand 4 regulates central nervous system T cell accumulation during experimental autoimmune encephalomyelitis. J. Immunol. 187, 2803-2813 (2011).
-
(2011)
J. Immunol.
, vol.187
, pp. 2803-2813
-
-
Reynolds, N.D.1
Lukacs, N.W.2
Long, N.3
Karpus, W.J.4
|