Biodiversity and noncanonical notch signaling

Current Topics in Developmental Biology

Volumn 92, Issue C, 2010, Pages 457-481

  Heitzler, Pascal ^a  

^a INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

NOTCH RECEPTOR;

ANIMAL; BIODIVERSITY; BOOK; HUMAN; METABOLISM; SIGNAL TRANSDUCTION;

ANIMALS; BIODIVERSITY; HUMANS; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION;

EID: 77956328365     PISSN: 00702153     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0070-2153(10)92014-0     Document Type: Book

References (116)

1. Aifantis I., Vilimas T., Buonamici S. Notch, NF-kBs and the making of T cell leukemia. Cell Cycle 2007, 6:403-406.
2. Albig A.R., Becenti D.J., Roy T.G., Schiemann W.P. Microfibril-associate glycoprotein-2 (MAGP-2) promotes angiogenic cell sprouting by blocking Notch signaling in endothelial cells. Microvasc. Res. 2008, 76:7-17.
3. Allenspach E.J., Maillard I., Aster J.C., Pear W.S. Notch signaling in cancer. Cancer Biol. Therapy 2002, 1:466-476.
4. Ambros V. Cell cycle-dependent sequencing of cell fate decisions in Caenorhabditis elegans vulva precursor cells. Development 1999, 126:1947-1956.
5. Artavanis-Tsakonas S., Rand M.D., Lake R.J. Notch signaling: cell fate control and signal integration in development. Science 1999, 284:770-776.
6. Aster J.C., Pear W.S., Blacklow S.C. Notch signaling in leukemia. Annu. Rev. Pathol. 2008, 3:587-613.
7. Axelrod J.D., Matsuno K., Artavanis-Tsakonas S., Perrimon N. Interaction between Wingless and Notch signaling pathways mediated by dishevelled. Science 1996, 271:1826-1832.
8. Ayyar S., Pistillo D., Calleja M., Brookfield A., Gittins K., Goldstone C., Simpson P. NF-kB/Rel-mediated regulation of the neural fate in Drosophila. PloS ONE 2007, 11:e1178.
9. Bedogni B., Warneke J.A., Nickoloff B.J., Giaccia A.J., Broome Powell M. Notch1 is an effector of Akt and hypoxia in melanoma development. J. Clin. Invest. 2008, 118:3660-3670.
10. Beres T.M., Masui T., Swift G.H., Shi L., Henke R.M., MacDonald R.J. PTF1 is an organ-specific and Notch-independent basic helix-loop-helix complex containing the mammalian Suppressor of Hairless (RBP-J) or its paralogue, RBP-L. Mol. Cell. Biol. 2006, 26:117-130.
11. Blokzijl A., Dahlqvist C., Reissmann E., Falk A., Moliner A., Lendhal U., Ibanez C.F. Cross-talk between the Notch and the TGF-Β signaling pathways mediated by interaction of the Notch intracellular domain with Smad3. J. Cell Biol. 2003, 163:723-728.
12. Bray S.J. Notch signalling: a simple pathway becomes complex. Nat. Rev. Mol. Cell Biol. 2006, 7:678-689.
13. Chen Y., De Marco M.A., Graziani I., Gazdar A.F., Strack P.R., Miele L., Bocchetta M. Oxygen concentration determines the biological effects of Notch-1 signaling in adenocarcinoma of the lung. Cancer Res. 2007, 67:7954-7959.
14. Chen N., Greenwald I. The lateral signal for LIN-12/Notch in C. elegans vulval development comprises redundant secreted and transmembrane DSL proteins. Dev. Cell 2004, 6:183-192.
15. Chiang M.Y., Xu M.L., Histen G., Shestova O., Roy M., Nam Y., Blacklow S.C., Sacks D.B., Pear W.S., Aster J.C. Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1. Mol. Cell. Biol. 2006, 26:6261-6271.
16. Coleman M.L., McDonough M.A., Hewitson K.S., Coles C., Mecinovic J., Edelmann M., Cook K.M., Cockman M.E., Lancaster D.E., Kessler B.M., et al. Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor. J. Biol. Chem. 2007, 282:24027-24038.
17. Couso J.P., Martinez-Arias A. Notch is required for Wingless signaling in the epidermis of Drosophila. Cell 1994, 79:259-272.
18. Cras-Méneur C., Li L., Kopan R., Permutt M.A. Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window. Genes Dev. 2009, 23:2088-2101.
19. Dahlqvist C., Blokzijl A., Chapman G., Falk A., Dannaeus K., Ibanez C.F., Lendhal U. Functional Notch signaling is required for BMP4-induced inhibition of myogenic differentiation. Development 2003, 130:6089-6099.
20. Demarest R.M., Ratti F., Capobianco A.J. It's T-ALL about Notch. Oncogene 2008, 27:5082-5091.
21. Demehri S., Liu Z., Lee J., Lin M.H., Crosby S.D., Roberts C.J., Grigsby P.W., Miner J.H., Farr A.G., Kopan R. Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity. PLoS Biol. 2008, 6:e123.
22. Diederich R.J., Matsuno K., Hing H., Artavanis-Tsakonas S. Cytosolic interaction between deltex and Notch ankyrin repeats implicated deltex in the Notch signalling pathway. Development 1994, 120:473-481.
23. Diez H., Fischer A., Winkler A., Hu C.J., Hatzopoulos A.K., Breier G., Gessler M. Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate. Exp. Cell Res. 2007, 313:1-9.
24. D'Souza B., Miyamoto A., Weinmaster G. The many facets of Notch ligands. Oncogene 2008, 27:5148-5167.
25. Eliasz S., Liang S., Chen Y., De Marco M.A., Machek O., Skucha S., Miele L., Bocchetta M. Notch1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway. Oncogene 2010, 29:2488-2498.
26. Espinosa L., Ingles-Esteve J., Aguilera C., Bigas A. Phosphorylation by glycogen synthase kinase-3Β down-regulates Notch activity, a link for Notch and Wnt pathways. J. Biol. Chem. 2003, 278:32227-32235.
27. Feldman B.J., Hampton T., Clearly M.L. A carboxy-terminal deletion mutant of Notch1 accelerates lymphoid oncogenesis in E2A-PBX1 transgenic mice. Blood 2000, 96:1906-1913.
28. Fiuza U.M., Klein T., Martinez-Arias A., Hayward P. Mechanisms of ligand-mediated inhibition in Notch signaling activity in Drosophila. Dev. Dyn. 2010, 239:798-805.
29. Fryer C.J., Lamar E., Turbachova I., Kintner C., Jones K.A. Mastermind mediates chromatin-specific transcription and turnover enhancer complex. Genes Dev. 2002, 16:1397-1411.
30. Fryer C.J., White J.B., Jones K.A. Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. Mol. Cell 2004, 16:509-520.
31. Giniger E. A role for Abl in Notch signaling. Neuron 1998, 20:667-681.
32. Giraldez A.J., Cohen S.M. Wingless and Notch signaling provide cell survival cues and control cell proliferation during wing development. Development 2003, 130:6533-6543.
33. Goldbeter A., Pourquie O. Modeling the segmentation clock as a network of coupled oscillations in the Notch, Wnt and FGF signaling pathways. J. Theor. Biol. 2008, 252:574-585.
34. Grabher C., von Boehmer H., Look A.T. Notch1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia. Nat. Rev. Cancer 2006, 6:347-359.
35. Greenwald I. LIN-12/Notch signaling: lessons from worms and flies. Development 1998, 125:3101-3109.
36. Greenwald I., Seydoux G. Analysis of gain-of-function mutations in lin-12 gene of Caenorhabditis elegans. Nature 1990, 346:197-199.
37. Guo X., Wang X.F. Signaling cross-talk between TGF-Β/BMP and other pathways. Cell Res. 2009, 19:71-88.
38. Guo D., Ye J., Dai J., Li L., Chen F., Ma D., Ji C. Notch1 regulates Akt signaling pathway and the expression of cell cycle regulatory proteins cyclin D1, CDK2 and p21 in T-ALL cell lines. Leuk. Res. 2009, 33:678-685.
39. Gupta R., Hong D., Iborra F., Sarno S., Enver T. NOV (CCN3) functions as a regulator of human hematopoietic stem or progenitor cells. Science 2007, 316:590-593.
40. Gustafsson M.V., Zheng X., Pereira T., Gradin K., Jin S., Lundkvist J., Ruas J.L., Poellinger L., Lendhal U., Bondesson M. Hypoxia requires Notch signaling to maintain the undifferentiated cell state. Dev. Cell 2005, 9:617-628.
41. Hayward P., Kalmar T., Martinez-Arias A. Wnt/Notch signalling and information processing during development. Development 2008, 135:411-424.
42. Heitzler P., Simpson P. The choice of cell fate in the epidermis of Drosophila. Cell 1991, 64:1083-1092.
43. Heitzler P., Simpson P. Altered epidermal growth factor-like sequences provide evidence for a role of Notch as a receptor in cell fate decisions. Development 1993, 117:1113-1123.
44. Henderson S.T., Gao D., Lambie E.J., Kimble J. lag-2 may encode a signaling ligand for the GLP-1 and LIN-12 receptors in C. elegans. Development 1994, 120:2913-2924.
45. Herranz H., Milan M. Notch and the affinity boudaries in Drosophila. BioEssays 2006, 28:113-116.
46. Hoemann C.D., Beaulieu N., Girard L., Rebai N., Jolicoeur P. Two distinct Notch1 mutant alleles are involved in the induction of T-cell leukemia in c-myc transgenic mice. Mol. Cell. Biol. 2000, 20:3831-3842.
47. Hori K., Cholewa-Waclaw J., Nakada Y., Glasgow S.M., Masui T., Henke R.M., Wildner H., Martarelli B., Beres T.M., Epstein J.A. A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling. Genes Dev. 2008, 22:166-178.
48. Hori K., Fostier M., Ito M., Fuwa T.J., Go M.J., Okano H., Baron M., Matsuno K. Drosophila Deltex mediates Suppressor of Hairless-independent and late-endosomal activation of Notch signaling. Development 2004, 131:5527-5537.
49. Hsieh J.J.D., Hayward S.D. Masking of the CBF1/RBPJk transcriptional repression domain by Epstein-Barr virus EBNA2. Science 1995, 268:560-563.
50. Hu Q.D., Ang B.T., Karsak M., Hu W.P., Cui X.Y., Duka T., Takeda Y., Chia W., Sankar N., Ng Y.K., Ling E.A., Maciag T., et al. F3/Contactin acts as a functional ligand for Notch during oligodendrocyte maturation. Cell 2003, 115:163-175.
51. Hudson C., Lotito S., Yasuo H. Sequential and combinatorial imputs from Nodal, Delta2/Notch and FGF/MEK/ERK signalling pathways establish a grid-like organisation of distinct cell identities in the ascidian neural plate. Development 2007, 134:3527-3537.
52. Irvine K.D., Rauskolb C. Boundaries in development formation and function. Annu. Rev. Cell Dev. Biol. 2001, 17:189-214.
53. Ishitani T., Hirao T., Suzuki M., Isoda M., Ishitani S., Harigaya K., Kitagawa M., Matsumoto K., Itoh M. Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex. Nat. Cell Biol. 2010, 12:278-285.
54. Itoh F., Itoh S., Goumans M.J., Valdimarsdottir G., Iso T., Dotto G.P., Hamamori Y., Kedes L., Kato M., ten Dijke Pt.P. Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells. EMBO J. 2004, 23:541-551.
55. Jorgensen M.C., Ahnfelt-Ronne J., Hald J., Madsen O.D., Serup P., Hecksher-Sorensen J. An illustrated review of early pancreas development in the mouse. Endocr. Rev. 2007, 28:685-705.
56. Joutel A., Corpechot C., Ducros A., Vahedi K., Chabriat H., Mouton P., et al. Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia. Nature 1996, 383:707-710.
57. Kankel M.W., et al. Investigating the genetic circuitry of mastermind in Drosophila, a Notch signal effector. Genetics 2007, 177:2493-2505.
58. Klüppel M., Wrana J.L. Turning it up a Notch: cross-talk between TGFΒ and Notch signaling. BioEssays 2005, 27:115-117.
59. Koelzer S., Klein T. Regulation of expression of Vg and establishment of the dorsoventral compartment boundary in the wing imaginal disc by Suppressor of Hairless. Dev. Biol. 2006, 289:77-90.
60. Komatsu, H., Chao, M. Y., Larkins-Ford, J., Corkins, M. E., Somers, G. A., Tucey, T., Dionne, H. M., White, J. Q., Wani, K., Boxem, M., and Hart, A. C. (2008). OSM-11 facilitates LIN-12 Notch signaling during Caenorhabditis elegans vulval development. PLoS Biol. 6, e196.
61. Kopan R., Ilagan M.X.G. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell 2009, 137:216-233.
62. Kraman M., McCright B. Functional conservation of Notch1 and Notch2 intracellular domains. FASEB J. 2005, 19:1311-1313.
63. Lai E.C. Notch signaling: control of cell communication and cell fate. Development 2004, 131:965-973.
64. Langdon T., Hayward P., Brennan K., Wirtz-Peitz F., Sanders P., Zecchini V., Friday A., Balayo T., Martinez Arias A. Notch receptor encodes two structurally separable functions in Drosophila: a genetic analysis. Dev. Dyn. 2006, 235:998-1013.
65. Le Gall M., De Mattei C., Giniger E. Molecular separation of two signaling pathways for the receptor. Notch. Dev. Biol. 2008, 313:556-567.
66. Louvi A., Arboleda-Velasquez J.F., Artavanis-Tsakonas S. CADASIL: a critical look at a Notch disease. Dev. Neurosci. 2006, 28:5-12.
67. Martinez Arias A., Zecchini V., Brennan K. CSL-independent Notch signalling: a checkpoint in cell fate decisions during development?. Curr. Opin. Genet. Dev. 2002, 12:524-533.
68. Masui T., Long Q., Beres T.M., Magnuson M.A., Macdonald R.J. Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex. Genes Dev. 2007, 21:2629-2643.
69. Matsuno K., Diederich R.J., Go M.J., Blaumueller C.M., Artavanis-Tsakonas S. Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats. Development 1995, 121:2633-2644.
70. Matsuno K., Eastman D., Mitsiades T., Quinn A.M., Carcanciu M.L., Ordentlich P. Human deltex is a conserved regulator of Notch signaling. Nat. Genet. 1998, 19:74-78.
71. McElhinny A.S., Li J.L., Wu L. Mastermind-like transcriptional co-activators: emerging roles in regulating cross talk among multiple signaling pathways. Oncogene 2008, 27:5138-5147.
72. Meurette O., Stylianou S., Rock R., Collu G.M., Gilmore A.P., Brennan K. Notch activation induces Akt signaling via an autocrine loop to prevent apoptosis in breast epithelial cells. Cancer Res. 2009, 69:5015-5022.
73. Micchelli C.A., Rulifson E.J., Blair S.S. The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate. Development 1997, 124:1485-1495.
74. Milan M., Cohen S.M. Temporal regulation of Apterous activity during the development of the Drosophila wing. Development 2000, 127:3069-3078.
75. Milan M., Cohen S.M. A re-evaluation of the contributions of Apterous and Notch to the dorsoventral lineage restriction boundary in the Drosophila wing. Development 2003, 130:553-562.
76. Minamizato T., Sakamoto K., Liu T., Kokubo H., Katsube K., Perbal B., et al. CCN3/NOV inhibits BMP-2-induced osteoblast differentiation by interacting with BMP and Notch signaling pathways. Biochem. Biophys. Res. Commun. 2007, 354:567-573.
77. Miyamoto A., Lau R., Hein P.W., Shipley J.M., Weinmaster G. Microfibrillar proteins MAGP-1 and MAGP-2 induce Notch1 extracellular domain dissociation and receptor activation. J. Biol. Chem. 2006, 281:10089-10097.
78. Moellering R.E., Cornejo M., Davis T.N., Del Bianco C., Aster J.C., Blacklow S.C., Kung A.L., Gilliland D.G., Verdine G.L., Bradner J.E. Direct inhibition of the Notch transcription factor complex. Nature 2009, 462:182-188.
79. Monet-Lepetre M., Bardot B., Lemaire B., Domenga V., Godin O., Dichgans M., Tournier-Lasserve E., Cohen-Tannoudji M., Chabriat H., Joutel A. Distinct phenotypic and functional features of CADASIL mutations in the Notch3 ligand binding domain. Brain 2009, 132:1601-1612.
80. Mummery-Widmer J.L., Yamazaki M., Stoeger T., Novatchkova M., Bhalerao S., Chen D., Dietzl G., Dickson B.J., Knoblich J.A. Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. Nature 2009, 458:987-992.
81. Mungamuri S.K., Yang X., Thor A.D., Somasundaram K. Survival signaling by Notch1: mammalian target of rapamycin (mTOR)-dependent p53. Cancer Res. 2006, 66:4715-4724.
82. Murtaugh L.C. The what, where, when and how Wnt/Β-catenin signaling in pancreas development. Organogenesis 2008, 4:81-86.
83. Nam Y., Sliz P., Pear W.S., Aster J.C., Blacklow S.C. Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:2103-2108.
84. Nam Y., Sliz P., Song L., Aster J.C., Blacklow S.C. Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell 2006, 124:973-983.
85. Nicolas M., Wolfer A., Raj K., Kummer J.A., Mill P., van Noort M., Hui C.C., Clevers H., Dotto G.P., Radtke F. Notch1 functions as a tumor suppressor in mouse skin. Nat. Genet. 2003, 33:416-421.
86. Niimi H., Pardali K., Vanlandewijck M., Heldin C.H., Moustakas A. Notch signaling is necessary for epithelial growth arrest by TGF-Β. J. Cell Biol. 2007, 176:695-707.
87. O'Neil J., Grim J., Strack P., Rao S., Tibbitts D., Winter C., Hardwick J., Welcker M., Meijerink J.P., Pieters R., et al. FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors. J. Exp. Med. 2007, 204:1813-1824.
88. Ordentlich P., Lin A., Shen C.P., Blaumueller C., Matsuno K., Artavanis-Tsakonas S. Notch inhibition of E47 supports the existence of a novel signaling pathway. Mol. Cell. Biol. 1998, 18:2230-2239.
89. Palomero T., Sulis M.L., Cortina M., Real P.J., Barnes K., Ciofani M., Caparros E., Buteau J., Brown K., Perkins S.L., Bhagat G., Agarwal A.M., et al. Mutational loss of PTEN induces resistance to Notch1 inhibition in T-cell leukemia. Nat. Med. 2007, 13:1203-1210.
90. Pan Y., Lin M.H., Tian X., Cheng H.T., Gridley T., et al. γ-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis. Dev. Cell 2004, 7:731-743.
91. Patel N.S., Li J.L., Generali D., Poulsom R., Cranston D.W., Harris A.L. Up-regulation of Delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function. Cancer Res. 2005, 65:8690-8697.
92. Perumalsamy L.R., Nagala M., Banerjee P., Sarin A. A hierarchical cascade activated by non-canonical Notch signaling and the mTOR-Rictor complex regulates neglect-induced death in mammalian cells. Cell Death Diff. 2009, 16:879-889.
93. Perumalsamy L.R., Nagala M., Sarin A. Notch-activated signaling cascade interacts with mitochondrial remodeling proteins to regulate cell survival. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:6882-6887.
94. Poellinger L., Lendahl U. Modulating Notch signaling by pathway-intrinsic and pathway-extrinsic mechanisms. Curr. Opin. Genet. Dev. 2008, 18:449-454.
95. Powell P.A., Wesley C., Spencer S., Cagan R.L. Scabrous complexes with Notch to mediate boundary formation. Nature 2001, 409:626-630.
96. Ramain P., Khechumian K., Seugnet L., Arbogast N., Ackermann C., Heitzler P. Novel Notch alleles reveal a Deltex-dependent pathway repressing neural fate. Curr. Biol. 2001, 11:1729-1738.
97. Rebay I., Fehon R.G., Artavanis-Tsakonas S. Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor. Cell 1993, 74:319-329.
98. Rusconi J.C., Corbin V. Evidence for a novel Notch pathway required for muscle precursor selection in Drosophila. Mech. Dev. 1998, 79:39-50.
99. Sakamoto K., Yamaguchi S., Ando R., Miyawaki A., Kabasawa Y., Takagi M., et al. The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway. J. Biol. Chem. 2002, 277:29399-29405.
100. Sanders P.G., Munoz-Descalzo S., Balayo T., Wirtz-Peitz F., Hayward P., Martinez-Arias A. Ligand-independent traffic of Notch buffers activated Armadillo in Drosophila. PLoS Biol. 2009, 7:e1000169.
101. Shawber C., Nofziger D., Hsieh J.J.D., Lindsell C., Bogler O., Hayward D. Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway. Development 1996, 122:3765-3773.
102. Shin H.M., Minter L.M., Cho O.H., Gottipati S., Fauq A.H., Golde T.E., Sonenshein G.E., Osborne B.A. Notch1 augments NF-κB activity by facilitating its nuclear retention. EMBO J. 2006, 25:129-138.
103. Simpson P. Notch signalling in development: on equivalence groups and asymmetric developmental potential. Curr. Opin. Genet. Dev. 1997, 7:537-542.
104. Thompson B.J., Buonamici S., Sulis M.L., Palomero T., Vilimas T., Basso G., Ferrando A., Aifantis I. The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia. J. Exp. Med. 2007, 204:1825-1835.
105. Tsunematsu R., Nakayama K., Oike Y., Nishiyama M., Ishida N., Hatakeyama S., Bessho Y., Kageyama R., Suda T., Nakayama K.I. Mouse Fw7/Sel10/Cdc4 is required for Notch degradation during vascular development. J. Biol. Chem. 2004, 279:9417-9423.
106. Verheyen E.M., Purcell K.J., Fortini M.E., Artavanis-Tsakonas S. Analysis of dominant and suppressors of activated Notch in Drosophila. Genetics 1996, 144:1127-1141.
107. Vied C., Kalderon D. Hedgehog-stimulated stem cells depend on non-canonical activity of the Notch co-activator Mastermind. Development 2009, 136:2177-2186.
108. Vilimas T., Mascarenhas J., Palomero T., Mandal M., Buonamici S., Meng F., Thompson B., Spaulding C., Macaroun S., Alegre M.L., Kee B.L., Ferrando A., et al. Targeting the NF-kB signaling pathway in Notch1-induced T-cell leukemia. Nat. Med. 2007, 13:70-77.
109. Walsh D.W., Roxburgh S.A., McGettigan P., et al. Co-regulation of Gremlin and Notch signalling in diabetic nephropathy. Biochim. Biophys. Acta 2008, 1782:10-21.
110. Wang J., Shelly L., Miele L., Boykins R., Norcross M.A., Guan E. Human Notch-1 inhibits NF-kB activity in the nucleus through a direct interaction involving a novel domain. J. Immunol. 2001, 167:289-295.
111. Weng A.P., Ferrando A.A., Lee W., Morris J.P., Silverman L.B., Sanchez-Irizarry C., Blacklow S.C., Look A.T., Aster J.C. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 2004, 306:269-271.
112. Wesley C. Notch and Wingless regulate expression of cuticule patterning genes. Mol. Cell. Biol. 1999, 19:5743-5758.
113. Wilkin M.B., Carbery A.M., Gensch N., Clemence S., Motoki M., Yamada K., Hori K., Taniguchi-Kanai M., Franklin E., Matsuno K., Baron M. Drosophila HOPS and AP-3 complex genes are required for a Deltex-regulated activation of Notch in the endosomal trafficking pathway. Dev. Cell 2008, 15:762-772.
114. Wilkin M., Tongngok P., Fostier M., Aslam H., Mazaleyrat S.L., Higgs J., Myat A., Evans D.A.P., Cornell M., Baron M. Regulation of Notch endosomal sorting and signaling by Drosophila Nedd4 family proteins. Curr. Biol. 2004, 14:2237-2244.
115. Zavadil J., Cermak L., Soto-Nieves N., Bottinger E.P. Integration of TGF-Β/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition. EMBO J. 2004, 23:1155-1165.
116. Zheng X., Linke S., Dias J.M., Zheng X., Gradin K., Wallis T.P., Hamilton B.R., Gustafsson M., Ruas J.L., Wilkins S., et al. Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:3368-3373.