Notch3 inhibition in myelin-reactive T cells down-regulates protein kinase Cθ and attenuates experimental autoimmune encephalomyelitis

Journal of Immunology

Volumn 180, Issue 4, 2008, Pages 2634-2640

  Jurynczyk, Maciej ^a   Jurewicz, Anna ^a   Raine, Cedric S ^b   Selmaj, Krzysztof ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA SECRETASE INHIBITOR; MYELIN; NOTCH1 RECEPTOR; NOTCH3 RECEPTOR; PROTEIN KINASE C THETA; BLOCKING ANTIBODY; ISOENZYME; MESSENGER RNA; NOTCH RECEPTOR; NOTCH1 PROTEIN, MOUSE; NOTCH3 PROTEIN, MOUSE; PRKCQ PROTEIN, MOUSE; PROTEIN KINASE C; SECRETASE; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; CD4+ T LYMPHOCYTE; CELL MEMBRANE POTENTIAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; FEMALE; IMMUNOSTIMULATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; RECEPTOR BLOCKING; SIGNAL TRANSDUCTION; TH1 CELL; TH17 CELL; ANIMAL; BIOSYNTHESIS; CELL CULTURE; COMPARATIVE STUDY; DRUG ANTAGONISM; ENZYMOLOGY; GENETICS; IMMUNOLOGY; METABOLISM; MYELIN SHEATH; REGULATORY T LYMPHOCYTE; UPREGULATION;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANTIBODIES, BLOCKING; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; DOWN-REGULATION; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; ISOENZYMES; MICE; MYELIN SHEATH; PROTEIN KINASE C; RECEPTOR, NOTCH1; RECEPTORS, NOTCH; RNA, MESSENGER; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, REGULATORY; TH1 CELLS; UP-REGULATION;

EID: 42149177242     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.180.4.2634     Document Type: Article

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