Advances in improving mammalian cells metabolism for recombinant protein production

Electronic Journal of Biotechnology

Volumn 16, Issue 3, 2013, Pages

  Altamirano, Claudia ^a,b   Berrios, Julio ^a   Vergara, Mauricio ^a   Becerra, Silvana ^b  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO   (Chile)

^b Centro Regional de Estudios en Alimentos Saludables Valparaiso   (Chile)

Author keywords

Aerobic glycolysis; Cell engineering; CHO cells; Glutaminolysis; Metabolism

Indexed keywords

AEROBIC GLYCOLYSIS; ALTERNATIVE SUBSTRATES; BIOTECHNOLOGY INDUSTRY; CHO CELL; GENETIC MODIFICATIONS; GLUTAMINOLYSIS; RECOMBINANT PROTEIN PRODUCTIONS; TECHNOLOGICAL LIMITATIONS;

AMINO ACIDS; CELL CULTURE; CELL ENGINEERING; CELL PROLIFERATION; CELLS; NUTRIENTS; PHYSIOLOGY; RECOMBINANT PROTEINS;

METABOLISM;

6 PHOSPHOFRUCTOKINASE; ALANINE AMINOTRANSFERASE; ALANYLGLUTAMINE; ALPHA ENOLASE; AMMONIA; ASPARTATE AMINOTRANSFERASE; FRUCTOSE; GALACTOSE; GLUCOSE; GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 3; GLUCOSE TRANSPORTER 5; GLUTAMATE DEHYDROGENASE; GLUTAMINE; GLYCYLGLUTAMINE; HEXOKINASE; HEXOKINASE ISOENZYME; HYPOXIA INDUCIBLE FACTOR 1; LACTIC ACID; MALATE DEHYDROGENASE (DECARBOXYLATING); MANNOSE; PROTEIN EM II; PYRUVATE CARBOXYLASE; PYRUVATE DEHYDROGENASE; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

AMMONIA FORMATION; ANAEROBIC GLYCOLYSIS; APOPTOSIS; BIOACCUMULATION; CATABOLISM; CELL ENGINEERING; CELL GROWTH; CELL METABOLISM; CELL PROLIFERATION; CHO CELL; CONCENTRATION (PARAMETERS); ENERGY METABOLISM; GLUCOSE INTAKE; GLUTAMINOLYSIS; HUMAN; HYBRIDOMA CELL CULTURE; MAMMAL CELL; MOLECULAR DYNAMICS; NONHUMAN; PROTEIN EXPRESSION; PROTEIN QUALITY; PROTEIN SYNTHESIS; REVIEW;

EID: 84878101105     PISSN: None     EISSN: 07173458     Source Type: Journal    
DOI: 10.2225/vol16-issue3-fulltext-2     Document Type: Review

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