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Volumn 15, Issue 6, 2012, Pages

Simultaneous environmental manipulations in semi-perfusion cultures of CHO cells producing rh-tPA

Author keywords

CHO cells; Galactose; Glutamate; Low temperature; Perfusion culture; Rh tPA

Indexed keywords

CHO CELL; GALACTOSE; GLUTAMATE; LOW TEMPERATURES; PERFUSION CULTURES; RH-TPA;

EID: 84870021614     PISSN: None     EISSN: 07173458     Source Type: Journal    
DOI: 10.2225/vol15-issue6-fulltext-2     Document Type: Article
Times cited : (6)

References (32)
  • 1
    • 33646066296 scopus 로고    scopus 로고
    • The cold-shock response in cultured mammalian cells: Harnessing the response for the improvement of recombinant protein production
    • CrossRef
    • AL-FAGEEH, M.; MARCHANT, R.; CARDEN, M. and SMALES, C. (2006). The cold-shock response in cultured mammalian cells: Harnessing the response for the improvement of recombinant protein production. Biotechnology and Bioengineering, vol. 93, no. 5, p. 829-835. [CrossRef]
    • (2006) Biotechnology and Bioengineering , vol.93 , Issue.5 , pp. 829-835
    • Al-Fageeh, M.1    Marchant, R.2    Carden, M.3    Smales, C.4
  • 2
    • 0033952514 scopus 로고    scopus 로고
    • Improvement of CHO cell culture medium formulation: Simultaneous substitution of glucose and glutamine
    • CrossRef
    • ALTAMIRANO, C.; PAREDES, C.; CAIRÓ, J. and GÒDIA, F. (2000). Improvement of CHO cell culture medium formulation: Simultaneous substitution of glucose and glutamine. Biotechnology Progress, vol. 16, no. 1, p. 69-75. [CrossRef]
    • (2000) Biotechnology Progress , vol.16 , Issue.1 , pp. 69-75
    • Altamirano, C.1    Paredes, C.2    Cairó, J.3    Gòdia, F.4
  • 3
    • 0035829827 scopus 로고    scopus 로고
    • Decoupling cell growth and product formation in Chinese hamster ovary cells through metabolic control
    • CrossRef
    • ALTAMIRANO, C.; CAIRÓ, J. and GÒDIA, F. (2001). Decoupling cell growth and product formation in Chinese hamster ovary cells through metabolic control. Biotechnology and Bioengineering, vol. 76, no. 4, p. 351-360. [CrossRef]
    • (2001) Biotechnology and Bioengineering , vol.76 , Issue.4 , pp. 351-360
    • Altamirano, C.1    Cairó, J.2    Gòdia, F.3
  • 4
    • 32044464074 scopus 로고    scopus 로고
    • Specific nutrient supplementation of defined serum-free medium for the improvement of CHO cells growth and t-PA production
    • CrossRef
    • ALTAMIRANO, C.; ILLANES, A.; CANESSA, R. and BECERRA, S. (2006). Specific nutrient supplementation of defined serum-free medium for the improvement of CHO cells growth and t-PA production. Electronic Journal of Biotechnology, vol. 9, no. 1, p. 61-67. [CrossRef]
    • (2006) Electronic Journal of Biotechnology , vol.9 , Issue.1 , pp. 61-67
    • Altamirano, C.1    Illanes, A.2    Canessa, R.3    Becerra, S.4
  • 5
    • 33645573249 scopus 로고    scopus 로고
    • Initial transcriptome and proteome analyses of low culture temperature-induced expression in CHO cells producing erythropoietin
    • CrossRef
    • BAIK, J.K.; LEE, M.S.; AN, S.R.; YOON, S.K.; JOO, E.J.; KIM, Y.H.; PARK, H.W. and LEE, G.M. (2006). Initial transcriptome and proteome analyses of low culture temperature-induced expression in CHO cells producing erythropoietin. Biotechnology and Bioengineering, vol. 93, no. 2, p. 361-371. [CrossRef]
    • (2006) Biotechnology and Bioengineering , vol.93 , Issue.2 , pp. 361-371
    • Baik, J.K.1    Lee, M.S.2    An, S.R.3    Yoon, S.K.4    Joo, E.J.5    Kim, Y.H.6    Park, H.W.7    Lee, G.M.8
  • 6
    • 33746772688 scopus 로고    scopus 로고
    • Mammalian cell factories for efficient and stable protein expression
    • CrossRef
    • BARNES, L. and DICKSON, A. (2006). Mammalian cell factories for efficient and stable protein expression. Current Opinion in Biotechnology, vol. 17, no. 4, p. 381-386. [CrossRef]
    • (2006) Current Opinion In Biotechnology , vol.17 , Issue.4 , pp. 381-386
    • Barnes, L.1    Dickson, A.2
  • 7
    • 83555176235 scopus 로고    scopus 로고
    • Exploring the effect of mild hypothermia on CHO cell productivity
    • CrossRef
    • BECERRA, S.; BERRIOS, J.; OSSES, N. and ALTAMIRANO, C. (2012). Exploring the effect of mild hypothermia on CHO cell productivity. Biochemical Engineering Journal, vol. 60, p. 1-8. [CrossRef]
    • (2012) Biochemical Engineering Journal , vol.60 , pp. 1-8
    • Becerra, S.1    Berrios, J.2    Osses, N.3    Altamirano, C.4
  • 8
    • 70350103519 scopus 로고    scopus 로고
    • Relationship between tissue plasminogen activator production and specific growth rate in Chinese hamster ovary cells cultured in mannose at low temperature
    • CrossRef
    • BERRIOS, J.; DÍAZ-BARRERA, A.; BAZÁN, C. and ALTAMIRANO, C. (2009). Relationship between tissue plasminogen activator production and specific growth rate in Chinese hamster ovary cells cultured in mannose at low temperature. Biotechnology Letters, vol. 31, no. 10, p. 1493-1497. [CrossRef]
    • (2009) Biotechnology Letters , vol.31 , Issue.10 , pp. 1493-1497
    • Berrios, J.1    Díaz-Barrera, A.2    Bazán, C.3    Altamirano, C.4
  • 9
    • 79953705943 scopus 로고    scopus 로고
    • Continuous CHO cell cultures with improved recombinant protein productivity by using mannose as carbon source: Metabolic analysis and scale-up simulation
    • CrossRef
    • BERRIOS, J.; ALTAMIRANO C.; OSSES, N. and GONZALEZ, R. (2011). Continuous CHO cell cultures with improved recombinant protein productivity by using mannose as carbon source: Metabolic analysis and scale-up simulation. Chemical Engineering Science, vol. 66, no. 11, p. 2431-2439. [CrossRef]
    • (2011) Chemical Engineering Science , vol.66 , Issue.11 , pp. 2431-2439
    • Berrios, J.1    Altamirano, C.2    Osses, N.3    Gonzalez, R.4
  • 10
    • 1542410260 scopus 로고    scopus 로고
    • Uncoupling of cell growth and proliferation results in enhancement of productivity in p21Cip1-arrested CHO cells
    • CrossRef
    • BI, J.; SHUTTLEWORTH, J. and AL-RUBEAI, M. (2004). Uncoupling of cell growth and proliferation results in enhancement of productivity in p21Cip1-arrested CHO cells. Biotechnology and Bioengineering, vol. 85, no. 7, p. 741-749. [CrossRef]
    • (2004) Biotechnology and Bioengineering , vol.85 , Issue.7 , pp. 741-749
    • Bi, J.1    Shuttleworth, J.2    Al-Rubeai, M.3
  • 11
    • 1842425836 scopus 로고    scopus 로고
    • Impact of temperature reduction and expression of yeast pyruvate carboxylase on hGM-CSF producing CHO cells
    • CrossRef
    • BOLLATI-FOGOLÍN, M.; WAGNER, R.; ETCHEVERRIGARAY, M. and KRATJE, R. (2004). Impact of temperature reduction and expression of yeast pyruvate carboxylase on hGM-CSF producing CHO cells. Journal of Biotechnology, vol. 109, no. 1-2, p. 179-191. [CrossRef]
    • (2004) Journal of Biotechnology , vol.109 , Issue.1-2 , pp. 179-191
    • Bollati-Fogolín, M.1    Wagner, R.2    Etcheverrigaray, M.3    Kratje, R.4
  • 12
    • 13544251527 scopus 로고    scopus 로고
    • Temperature reduction in cultures of hGM-CSF-expressing CHO cells: Effect on productivity and product quality
    • CrossRef
    • BOLLATI-FOGOLÍN, M.; FORNO, G.; NIMTZ, M.; CONRADT, H.S.; ETCHEVERRIGARAY, M. and KRATJE, R. (2005). Temperature reduction in cultures of hGM-CSF-expressing CHO cells: Effect on productivity and product quality. Biotechnology Progress, vol. 21, no. 1, p. 17-21. [CrossRef]
    • (2005) Biotechnology Progress , vol.21 , Issue.1 , pp. 17-21
    • Bollati-Fogolín, M.1    Forno, G.2    Nimtz, M.3    Conradt, H.S.4    Etcheverrigaray, M.5    Kratje, R.6
  • 13
    • 0942265268 scopus 로고    scopus 로고
    • Maximizing interferon-γ production by Chinese hamster ovary cells through temperature shift optimization: Experimental and modeling
    • CrossRef
    • FOX, S.; PATEL, U.; YAP, M. and WANG, D. (2004). Maximizing interferon-γ production by Chinese hamster ovary cells through temperature shift optimization: Experimental and modeling. Biotechnology and Bioengineering, vol. 85, no. 2, p. 177-184. [CrossRef]
    • (2004) Biotechnology and Bioengineering , vol.85 , Issue.2 , pp. 177-184
    • Fox, S.1    Patel, U.2    Yap, M.3    Wang, D.4
  • 15
    • 70350141643 scopus 로고    scopus 로고
    • Enhanced interferon-β production by CHO cells through elevated osmolality and reduced culture temperature
    • CrossRef
    • HAN, Y.; KOO, T. and LEE, G. (2009). Enhanced interferon-β production by CHO cells through elevated osmolality and reduced culture temperature. Biotechnology Progress, vol. 25, no. 5, p. 1440-1447. [CrossRef]
    • (2009) Biotechnology Progress , vol.25 , Issue.5 , pp. 1440-1447
    • Han, Y.1    Koo, T.2    Lee, G.3
  • 16
    • 0035922885 scopus 로고    scopus 로고
    • Metabolic control of recombinant monoclonal antibody N-glycosylation in GS-NS0 cells
    • CrossRef
    • HILLS, A.; PATEL, A.; BOYD, P. and JAMES, D. (2001). Metabolic control of recombinant monoclonal antibody N-glycosylation in GS-NS0 cells. Biotechnology and Bioengineering, vol. 75, no. 2, p. 239-251. [CrossRef]
    • (2001) Biotechnology and Bioengineering , vol.75 , Issue.2 , pp. 239-251
    • Hills, A.1    Patel, A.2    Boyd, P.3    James, D.4
  • 17
    • 0020526007 scopus 로고
    • Effect of temperature on kinetics of hexose uptake by human placental plasma membrane vesicles
    • CrossRef
    • INGERMANN, R. and BISSONNETTE, J. (1983). Effect of temperature on kinetics of hexose uptake by human placental plasma membrane vesicles. Biochimica et Biophysica Acta (BBA)-Biomembranes, vol. 734, no. 2, p. 329-335. [CrossRef]
    • (1983) Biochimica Et Biophysica Acta (BBA)-Biomembranes , vol.734 , Issue.2 , pp. 329-335
    • Ingermann, R.1    Bissonnette, J.2
  • 18
    • 34250628439 scopus 로고    scopus 로고
    • Proliferation control strategies to improve productivity and survival during CHO based production culture. A summary of recent methods employed and the effects of proliferation control in product secreting CHO cell lines
    • CrossRef
    • KUMAR, N.; GAMMELL, P. and CLYNES, M. (2007). Proliferation control strategies to improve productivity and survival during CHO based production culture. A summary of recent methods employed and the effects of proliferation control in product secreting CHO cell lines. Cytotechnology, vol. 53, no. 1-3, p. 33-46. [CrossRef]
    • (2007) Cytotechnology , vol.53 , Issue.1-3 , pp. 33-46
    • Kumar, N.1    Gammell, P.2    Clynes, M.3
  • 19
    • 73949094323 scopus 로고    scopus 로고
    • Post-translational events of a model reporter protein proceed with higher fidelity and accuracy upon mild hypothermic culturing of Chinese hamster ovary cells
    • CrossRef
    • MASTERTON, R.; ROOBOL, A.; AL-FAGEEH, M.; CARDEN, M. and SMALES, C. (2009). Post-translational events of a model reporter protein proceed with higher fidelity and accuracy upon mild hypothermic culturing of Chinese hamster ovary cells. Biotechnology and Bioengineering, vol. 105, no. 1, p. 215-220. [CrossRef]
    • (2009) Biotechnology and Bioengineering , vol.105 , Issue.1 , pp. 215-220
    • Masterton, R.1    Roobol, A.2    Al-Fageeh, M.3    Carden, M.4    Smales, C.5
  • 20
    • 44949158950 scopus 로고    scopus 로고
    • Assessment of cell engineering strategies for improved therapeutic protein production in CHO cells
    • CrossRef
    • MOHAN, C.; KIM, Y.; KOO, J. and LEE, G. (2008). Assessment of cell engineering strategies for improved therapeutic protein production in CHO cells. Biotechnology Journal, vol. 3, no. 5, p. 624-630. [CrossRef]
    • (2008) Biotechnology Journal , vol.3 , Issue.5 , pp. 624-630
    • Mohan, C.1    Kim, Y.2    Koo, J.3    Lee, G.4
  • 21
    • 0023839257 scopus 로고
    • Evidence that monoclonal antibody production kinetics is related to the integral of viable cells curve in batch systems
    • CrossRef
    • RENARD, J.; SPAGNOLI, R.; MAIZER, C.; SALLES, M. and MANDINE, E. (1988). Evidence that monoclonal antibody production kinetics is related to the integral of viable cells curve in batch systems. Biotechnology Letters, vol. 10, no. 2, p. 91-96. [CrossRef]
    • (1988) Biotechnology Letters , vol.10 , Issue.2 , pp. 91-96
    • Renard, J.1    Spagnoli, R.2    Maizer, C.3    Salles, M.4    Mandine, E.5
  • 22
    • 0028452886 scopus 로고
    • Biochemistry of growth inhibition by ammonium ions in mammalian cells
    • CrossRef
    • RYLL, T.; VALLEY, U. and WAGNER, R. (1994). Biochemistry of growth inhibition by ammonium ions in mammalian cells. Biotechnology and Bioengineering, vol. 44, no. 2, p. 184-193. [CrossRef]
    • (1994) Biotechnology and Bioengineering , vol.44 , Issue.2 , pp. 184-193
    • Ryll, T.1    Valley, U.2    Wagner, R.3
  • 23
    • 4143145162 scopus 로고    scopus 로고
    • Effect of sodium butyrate on the production, heterogeneity and biological activity of human thrombopoietin by recombinant Chinese hamster ovary cells
    • CrossRef
    • SUNG, Y.; SONG, Y.; LIM, S.; CHUNG, J. and LEE, G. (2004). Effect of sodium butyrate on the production, heterogeneity and biological activity of human thrombopoietin by recombinant Chinese hamster ovary cells. Journal of Biotechnology, vol. 112, no. 3, p. 323-335. [CrossRef]
    • (2004) Journal of Biotechnology , vol.112 , Issue.3 , pp. 323-335
    • Sung, Y.1    Song, Y.2    Lim, S.3    Chung, J.4    Lee, G.5
  • 24
    • 77949566751 scopus 로고    scopus 로고
    • Strategies for the enhancement of recombinant protein production from mammalian cells by growth arrest
    • CrossRef
    • SUNLEY, K. and BUTLER, M. (2010). Strategies for the enhancement of recombinant protein production from mammalian cells by growth arrest. Biotechnology Advances, vol. 28, no. 3, p. 385-394. [CrossRef]
    • (2010) Biotechnology Advances , vol.28 , Issue.3 , pp. 385-394
    • Sunley, K.1    Butler, M.2
  • 25
  • 27
    • 58149214612 scopus 로고    scopus 로고
    • Comparative transcriptome analysis to unveil genes affecting recombinant protein productivity in mammalian cells
    • CrossRef
    • YEE, J.C.; GERDTZEN, Z.P. and HU, W.H. (2009). Comparative transcriptome analysis to unveil genes affecting recombinant protein productivity in mammalian cells. Biotechnology and Bioengineering, vol. 102, no. 1, p. 246-263. [CrossRef]
    • (2009) Biotechnology and Bioengineering , vol.102 , Issue.1 , pp. 246-263
    • Yee, J.C.1    Gerdtzen, Z.P.2    Hu, W.H.3
  • 28
    • 0041476091 scopus 로고    scopus 로고
    • Effect of low culture temperature of specific productivity and transcription level of anti 4-1BB antibody in recombinant Chinese hamster ovary cells
    • CrossRef
    • YOON, S.; KIM, S. and LEE, G. (2003a). Effect of low culture temperature of specific productivity and transcription level of anti 4-1BB antibody in recombinant Chinese hamster ovary cells. Biotechnology Progress, vol. 19, no. 4, p. 1383-1386. [CrossRef]
    • (2003) Biotechnology Progress , vol.19 , Issue.4 , pp. 1383-1386
    • Yoon, S.1    Kim, S.2    Lee, G.3
  • 29
    • 0037420754 scopus 로고    scopus 로고
    • Effect of low culture temperature on specific productivity, transcription level, and heterogeneity of erythropoietin in Chinese hamster ovary cells
    • CrossRef
    • YOON, S.; SONG, J. and LEE, G. (2003b). Effect of low culture temperature on specific productivity, transcription level, and heterogeneity of erythropoietin in Chinese hamster ovary cells. Biotechnology and Bioengineering, vol. 82, no. 3, p. 289-298. [CrossRef]
    • (2003) Biotechnology and Bioengineering , vol.82 , Issue.3 , pp. 289-298
    • Yoon, S.1    Song, J.2    Lee, G.3
  • 30
    • 14244265076 scopus 로고    scopus 로고
    • Effect of culture pH on erythropoietin production by Chinese hamster ovary cells grown in suspension at 32.5 and 37°C
    • CrossRef
    • YOON, S.; CHOI, S.; SONG, J. and LEE, G. (2005). Effect of culture pH on erythropoietin production by Chinese hamster ovary cells grown in suspension at 32.5 and 37oC. Biotechnology and Bioengineering, vol. 89, no. 3, p. 345-356. [CrossRef]
    • (2005) Biotechnology and Bioengineering , vol.89 , Issue.3 , pp. 345-356
    • Yoon, S.1    Choi, S.2    Song, J.3    Lee, G.4
  • 31
    • 33646790863 scopus 로고    scopus 로고
    • Biphasic culture strategy for enhancing volumetric erythropoietin productivity of Chinese hamster ovary cells
    • CrossRef
    • YOON, S.; KIM, S.; SONG, J. and LEE, G. (2006). Biphasic culture strategy for enhancing volumetric erythropoietin productivity of Chinese hamster ovary cells. Enzyme and Microbial Technology, vol. 39, no. 3, p. 362-365. [CrossRef]
    • (2006) Enzyme and Microbial Technology , vol.39 , Issue.3 , pp. 362-365
    • Yoon, S.1    Kim, S.2    Song, J.3    Lee, G.4
  • 32
    • 34547583141 scopus 로고    scopus 로고
    • Effect of culture temperature on follicle-stimulating hormone production by Chinese hamster ovary cells in a perfusion bioreactor
    • CrossRef
    • YOON, S.; AHN, Y. and JEONG, M. (2007). Effect of culture temperature on follicle-stimulating hormone production by Chinese hamster ovary cells in a perfusion bioreactor. Applied Microbiology and Biotechnology, vol. 76, no. 1, p. 83-89. [CrossRef]
    • (2007) Applied Microbiology and Biotechnology , vol.76 , Issue.1 , pp. 83-89
    • Yoon, S.1    Ahn, Y.2    Jeong, M.3


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