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Volumn 66, Issue 4, 1999, Pages 238-246

Improvement of the primary metabolism of cell cultures by introducing a new cytoplasmic pyruvate carboxylase reaction

Author keywords

Energy metabolism; Mammalian cell lines; Metabolic engineering; Pyruvate carboxylase

Indexed keywords

ADENOSINETRIPHOSPHATE; BIODEGRADATION; BIOMEDICAL ENGINEERING; CARBOXYLIC ACIDS; DRUG PRODUCTS; GLUCOSE; METABOLISM; OXIDATION;

EID: 0033385223     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0290(1999)66:4<238::AID-BIT5>3.0.CO;2-6     Document Type: Article
Times cited : (98)

References (48)
  • 1
    • 0018304375 scopus 로고
    • Pyruvate carboxylase and phosphoenolpyruvate carboxykinase activity in leukocytes and fibroblasts from a patient with pyruvate carboxylase deficiency
    • Atkin BM, Ulter MF, Weinberg MB. 1979. Pyruvate carboxylase and phosphoenolpyruvate carboxykinase activity in leukocytes and fibroblasts from a patient with pyruvate carboxylase deficiency. Pediatr Res 13:38-43.
    • (1979) Pediatr Res , vol.13 , pp. 38-43
    • Atkin, B.M.1    Ulter, M.F.2    Weinberg, M.B.3
  • 4
    • 0028888674 scopus 로고
    • In situ removal of ammonium and lactate through electrical means for hybridoma cultures
    • Chang Y-HD, Grodzinsky AJ, Wang DIC. 1995a. In situ removal of ammonium and lactate through electrical means for hybridoma cultures. Biotechnol Bioeng 47:308-318.
    • (1995) Biotechnol Bioeng , vol.47 , pp. 308-318
    • Chang, Y.-H.D.1    Grodzinsky, A.J.2    Wang, D.I.C.3
  • 5
    • 0028989413 scopus 로고
    • Nutrient enrichment and in situ waste removal through electrical means for hybridoma cultures
    • Chang Y-HD, Grodzinsky AJ, Wang DIC. 1995b. Nutrient enrichment and in situ waste removal through electrical means for hybridoma cultures. Biotechnol Bioeng 47:319-326.
    • (1995) Biotechnol Bioeng , vol.47 , pp. 319-326
    • Chang, Y.-H.D.1    Grodzinsky, A.J.2    Wang, D.I.C.3
  • 6
    • 0027234775 scopus 로고
    • Oxidation of pyruvate, malate, citrate and cytosolic reducing equivalents by AS-30D hepatoma mitochondria
    • Dietzen DJ, Davis EJ. 1993. Oxidation of pyruvate, malate, citrate and cytosolic reducing equivalents by AS-30D hepatoma mitochondria. Arch Biochem Biophys 305:91-102.
    • (1993) Arch Biochem Biophys , vol.305 , pp. 91-102
    • Dietzen, D.J.1    Davis, E.J.2
  • 7
    • 0024307104 scopus 로고
    • Metabolic control of glucose degradation in yeast and tumor cells
    • Fiechter A, editor. Berlin: Springer
    • Fiechter A, Gmünder FK. 1989. Metabolic control of glucose degradation in yeast and tumor cells. In: Fiechter A, editor. Advances in biochemical engineering/biotechnology, vol 39. Berlin: Springer. p 1-28.
    • (1989) Advances in Biochemical Engineering/Biotechnology , vol.39 , pp. 1-28
    • Fiechter, A.1    Gmünder, F.K.2
  • 8
    • 0027692808 scopus 로고
    • Glucose and glutamine metabolism of a murine B-lymphocyte hybridoma grown in batch culture
    • Fitzpatrick L, Jenkins HA, Butler M. 1993. Glucose and glutamine metabolism of a murine B-lymphocyte hybridoma grown in batch culture. Appl Biochem Biotechnol 43:93-116.
    • (1993) Appl Biochem Biotechnol , vol.43 , pp. 93-116
    • Fitzpatrick, L.1    Jenkins, H.A.2    Butler, M.3
  • 9
    • 0032485239 scopus 로고    scopus 로고
    • Ammonium ion and glucosamine dependent increases of oligosaccharide complexity in recombinant glycoproteins secreted from cultivated BHK-21 cells
    • Gawlitzek M, Valley U, Wagner R. 1998. Ammonium ion and glucosamine dependent increases of oligosaccharide complexity in recombinant glycoproteins secreted from cultivated BHK-21 cells. Biotechnol Bioeng 57:518-528.
    • (1998) Biotechnol Bioeng , vol.57 , pp. 518-528
    • Gawlitzek, M.1    Valley, U.2    Wagner, R.3
  • 10
    • 0023763120 scopus 로고
    • Catabolic control of mammalian cell culture
    • Glacken MW. 1988. Catabolic control of mammalian cell culture. Bio/Technology 6:1041-1050.
    • (1988) Bio/Technology , vol.6 , pp. 1041-1050
    • Glacken, M.W.1
  • 11
    • 0343976797 scopus 로고
    • Influence of lactate and ammonia on death rate of lactate and ammonia
    • Spier RE, Griffiths JB, Berthold W, editors. Oxford: Butterworth-Heinemann
    • Goergen JL, Marc A, Engasser JM. 1994. Influence of lactate and ammonia on death rate of lactate and ammonia. In: Spier RE, Griffiths JB, Berthold W, editors. Animal cell technology: products of today, prospects for tomorrow. Oxford: Butterworth-Heinemann. p 161-166.
    • (1994) Animal Cell Technology: Products of Today, Prospects for Tomorrow , pp. 161-166
    • Goergen, J.L.1    Marc, A.2    Engasser, J.M.3
  • 12
    • 0025840338 scopus 로고
    • The oligosaccharides of glycoproteins: Bioprocess factors affecting oligosaccharide structure and their effect on glycoprotein properties
    • Goochee CF, Gramer MJ, Andersen DC, Bahr JB, Rasmussen JR. 1991. The oligosaccharides of glycoproteins: bioprocess factors affecting oligosaccharide structure and their effect on glycoprotein properties, Bio/Technology 9:1347-1355.
    • (1991) Bio/Technology , vol.9 , pp. 1347-1355
    • Goochee, C.F.1    Gramer, M.J.2    Andersen, D.C.3    Bahr, J.B.4    Rasmussen, J.R.5
  • 13
    • 0032078486 scopus 로고    scopus 로고
    • Intracellular UDP-N-acetyl-hexosamine pool affects W-glycan complexity: Mechanism of ammonium action on protein glycosylation
    • Grammatikos SI, Valley U, Nimtz M, Conradt HS, Wagner R., 1998. Intracellular UDP-N-acetyl-hexosamine pool affects W-glycan complexity: mechanism of ammonium action on protein glycosylation. Biotechnol Prog 14:410-419.
    • (1998) Biotechnol Prog , vol.14 , pp. 410-419
    • Grammatikos, S.I.1    Valley, U.2    Nimtz, M.3    Conradt, H.S.4    Wagner, R.5
  • 14
    • 0026196692 scopus 로고
    • Growth inhibition in animal cell culture. The effect of lactate and ammonia
    • Hassell T, Gleave S, Butler M. 1991. Growth inhibition in animal cell culture. The effect of lactate and ammonia. Appl Biochem Biotechnol 30:29-41.
    • (1991) Appl Biochem Biotechnol , vol.30 , pp. 29-41
    • Hassell, T.1    Gleave, S.2    Butler, M.3
  • 15
    • 0025745222 scopus 로고
    • The ATP requirement for initiation of eukaryotic translation varies according to the mRNA species
    • Jackson RJ. 1991. The ATP requirement for initiation of eukaryotic translation varies according to the mRNA species. Eur J Biochem 200: 285-294.
    • (1991) Eur J Biochem , vol.200 , pp. 285-294
    • Jackson, R.J.1
  • 16
    • 0029994368 scopus 로고    scopus 로고
    • Retroviral infection of Syrian hamster cells depends on age and susceptibility towards sialidase
    • Karreman C, Karreman S, Hauser H. 1996. Retroviral infection of Syrian hamster cells depends on age and susceptibility towards sialidase. Virology 220:46-50.
    • (1996) Virology , vol.220 , pp. 46-50
    • Karreman, C.1    Karreman, S.2    Hauser, H.3
  • 18
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli UK. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 19
    • 0023880944 scopus 로고
    • End products of glucose and glutamine metabolism by cultured cell lines
    • Lanks KW, Li PW. 1988. End products of glucose and glutamine metabolism by cultured cell lines. J Cell Physiol 135:151-155.
    • (1988) J Cell Physiol , vol.135 , pp. 151-155
    • Lanks, K.W.1    Li, P.W.2
  • 20
    • 0002508214 scopus 로고
    • A method for quantitative amino acid analysis using precolumn O-phthaldialdehyde derivatization and high performance liquid chromatography
    • Larsen BR, West FG. 1981. A method for quantitative amino acid analysis using precolumn O-phthaldialdehyde derivatization and high performance liquid chromatography. J Chromatogr Sci 19:259-265.
    • (1981) J Chromatogr Sci , vol.19 , pp. 259-265
    • Larsen, B.R.1    West, F.G.2
  • 21
    • 0024321508 scopus 로고
    • Alteration of terminal glycosylation sequences on N-linked oligosaccharides of Chinese hamster ovary cells by expression of β-galactoside a2,6-sialyltransferase
    • Lee EU, Roth J, Paulson JC. 1989. Alteration of terminal glycosylation sequences on N-linked oligosaccharides of Chinese hamster ovary cells by expression of β-galactoside a2,6-sialyltransferase. J Biol Chem 264:13848-13855.
    • (1989) J Biol Chem , vol.264 , pp. 13848-13855
    • Lee, E.U.1    Roth, J.2    Paulson, J.C.3
  • 22
    • 0017687586 scopus 로고
    • Biochemical transformation of mouse cells by fragments of herpes simplex virus DNA
    • Maitland NJ, McDougall JK. 1977. Biochemical transformation of mouse cells by fragments of herpes simplex virus DNA. Cell 11:233-241
    • (1977) Cell , vol.11 , pp. 233-241
    • Maitland, N.J.1    McDougall, J.K.2
  • 23
    • 0019898583 scopus 로고
    • Glycolysis, glutaminolysis and cell proliferation
    • McKeehan WL. 1982. Glycolysis, glutaminolysis and cell proliferation. Cell Biol Int Rep 6:635-650.
    • (1982) Cell Biol Int Rep , vol.6 , pp. 635-650
    • McKeehan, W.L.1
  • 24
    • 0343540974 scopus 로고
    • Metabolic management of a hybridoma cell line
    • Spier RE, Griffiths JB, MacDonald C, editors. Oxford: Butterworth-Heinemann
    • Murray K, Dickson AJ, Gull K. 1992. Metabolic management of a hybridoma cell line. In: Spier RE, Griffiths JB, MacDonald C, editors. Animal technology: developments, processes and products. Oxford: Butterworth-Heinemann. p 261-263.
    • (1992) Animal Technology: Developments, Processes and Products , pp. 261-263
    • Murray, K.1    Dickson, A.J.2    Gull, K.3
  • 25
    • 0030049769 scopus 로고    scopus 로고
    • Comparative analysis of glucose and glutamine metabolism in transformed mammalian cell lines, insect and primary liver cells
    • Neermann J, Wagner R. 1996. Comparative analysis of glucose and glutamine metabolism in transformed mammalian cell lines, insect and primary liver cells. J Cell Physiol 166:152-169.
    • (1996) J Cell Physiol , vol.166 , pp. 152-169
    • Neermann, J.1    Wagner, R.2
  • 26
    • 0025425146 scopus 로고
    • Hybridoma growth limitations: The roles of energy metabolism and ammonia production
    • Newland M, Greenfield PF, Reid S. 1990. Hybridoma growth limitations: the roles of energy metabolism and ammonia production. Cytotechnology 3:215-229.
    • (1990) Cytotechnology , vol.3 , pp. 215-229
    • Newland, M.1    Greenfield, P.F.2    Reid, S.3
  • 27
    • 0022982448 scopus 로고
    • Pyruvate carboxylase defect: Metabolic studies on cultured skin fibroblasts
    • Oizumi J, Ng WG, Donnell GN. 1986. Pyruvate carboxylase defect: metabolic studies on cultured skin fibroblasts. J Inher Metab Dis 9: 120-128.
    • (1986) J Inher Metab Dis , vol.9 , pp. 120-128
    • Oizumi, J.1    Ng, W.G.2    Donnell, G.N.3
  • 28
    • 0026254349 scopus 로고
    • Growth, metabolic and antibody production kinetics of hybridoma cell culture: 2. Effects of serum concentration, dissolved oxygen concentration, and medium pH in a batch reactor
    • Ozturk SS, Palsson BO. 1991. Growth, metabolic and antibody production kinetics of hybridoma cell culture: 2. Effects of serum concentration, dissolved oxygen concentration, and medium pH in a batch reactor. Biotechnol Prog 7:481-494.
    • (1991) Biotechnol Prog , vol.7 , pp. 481-494
    • Ozturk, S.S.1    Palsson, B.O.2
  • 29
    • 0026816686 scopus 로고
    • Effects of ammonia and lactate on hybridoma growth, metabolism, and antibody production
    • Ozturk SS, Riley MR, Palsson BO. 1992. Effects of ammonia and lactate on hybridoma growth, metabolism, and antibody production. Biotechnol Bioeng 39:418-431.
    • (1992) Biotechnol Bioeng , vol.39 , pp. 418-431
    • Ozturk, S.S.1    Riley, M.R.2    Palsson, B.O.3
  • 30
    • 0028171092 scopus 로고
    • Effect of Vitreoscilla hemoglobin expression on growth and specific tissue plasminogen activator productivity in recombinant Chinese hamster ovary cells
    • Pendse GJ, Bailey JE. 1994. Effect of Vitreoscilla hemoglobin expression on growth and specific tissue plasminogen activator productivity in recombinant Chinese hamster ovary cells. Biotechnol Bioeng 44: 1367-1370.
    • (1994) Biotechnol Bioeng , vol.44 , pp. 1367-1370
    • Pendse, G.J.1    Bailey, J.E.2
  • 31
    • 0028077867 scopus 로고
    • Profile of energy metabolism in a murine hybridoma: Glucose and glutamine utilization
    • Petch D, Butler M. 1994. Profile of energy metabolism in a murine hybridoma: glucose and glutamine utilization. J Cell Physiol 161:71-76.
    • (1994) J Cell Physiol , vol.161 , pp. 71-76
    • Petch, D.1    Butler, M.2
  • 32
    • 0001856373 scopus 로고
    • Regulation of the mitochondrial branched chain 2-oxoacid dehydrogenase complex of animal tissue by reversible phosphorylation
    • Cohen P, editor. Amsterdam: Elsevier
    • Randle PJ, Fatania HR, Lau KS. 1984. Regulation of the mitochondrial branched chain 2-oxoacid dehydrogenase complex of animal tissue by reversible phosphorylation. In: Cohen P, editor. Molecular aspects of cellular regulation, vol 3. Amsterdam: Elsevier. p 1.
    • (1984) Molecular Aspects of Cellular Regulation , vol.3 , pp. 1
    • Randle, P.J.1    Fatania, H.R.2    Lau, K.S.3
  • 33
    • 0029120812 scopus 로고
    • The biosynthesis of threonine by mammalian cells: Expression of a complete bacterial biosynthethic pathway in an animal cell
    • Rees DW, Hay SM. 1995. The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthethic pathway in an animal cell. Biochem J 309:999-1007.
    • (1995) Biochem J , vol.309 , pp. 999-1007
    • Rees, D.W.1    Hay, S.M.2
  • 34
    • 0018386209 scopus 로고
    • Evidence that glutamine, not sugar, is the major source for cultured HeLa cells
    • Reitzer LJ, Wice BM, Kennell D. 1979. Evidence that glutamine, not sugar, is the major source for cultured HeLa cells. J Biol Chem 254: 2669-2676.
    • (1979) J Biol Chem , vol.254 , pp. 2669-2676
    • Reitzer, L.J.1    Wice, B.M.2    Kennell, D.3
  • 35
    • 0029347496 scopus 로고
    • Recombinant cyclin E expression activates proliferation and obviates surface attachment of Chinese hamster ovary (CHO) cells in protein-free medium
    • Renner WA, Lee KH, Hatzimanikatis V, Bailey JE, Eppenberger HM. 1995. Recombinant cyclin E expression activates proliferation and obviates surface attachment of Chinese hamster ovary (CHO) cells in protein-free medium. Biotechnol Bioeng 47:476-482.
    • (1995) Biotechnol Bioeng , vol.47 , pp. 476-482
    • Renner, W.A.1    Lee, K.H.2    Hatzimanikatis, V.3    Bailey, J.E.4    Eppenberger, H.M.5
  • 36
    • 0024488710 scopus 로고
    • Lacticacidemia. Biochemical, clinical, and genetic considerations
    • Robinson BH. 1989. Lacticacidemia. Biochemical, clinical, and genetic considerations. Adv Hum Genet 18:151-179.
    • (1989) Adv Hum Genet , vol.18 , pp. 151-179
    • Robinson, B.H.1
  • 37
    • 0025449571 scopus 로고
    • Production of recombinant interleukin 2 with BHK cells in a hollow fibre and a stirred tank reactor with protein-free medium
    • Ryll T, Lucki-Lange M, Jäger V, Wagner R. 1990. Production of recombinant interleukin 2 with BHK cells in a hollow fibre and a stirred tank reactor with protein-free medium. J Biotechnol 14:377-392.
    • (1990) J Biotechnol , vol.14 , pp. 377-392
    • Ryll, T.1    Lucki-Lange, M.2    Jäger, V.3    Wagner, R.4
  • 38
    • 0025868196 scopus 로고
    • An improved ion-pair HPLC method for the quantization of a wide variety of nucleoside and sugar-nucleoside in animal cells
    • Ryll T, Wagner R. 1992. An improved ion-pair HPLC method for the quantization of a wide variety of nucleoside and sugar-nucleoside in animal cells. J Chromatogr 570:77-88.
    • (1992) J Chromatogr , vol.570 , pp. 77-88
    • Ryll, T.1    Wagner, R.2
  • 40
    • 0025866296 scopus 로고
    • Network rigidity and metabolic engineering in metabolite overproduction
    • Stephanopoulos G, Vallino JJ. 1991. Network rigidity and metabolic engineering in metabolite overproduction. Science 252:1675-1681.
    • (1991) Science , vol.252 , pp. 1675-1681
    • Stephanopoulos, G.1    Vallino, J.J.2
  • 41
    • 0026015230 scopus 로고
    • DNA sequences in chromosomes II and VII code for pyruvate carboxylase isoenzymes in Saccharomyces cerevisiae: Analysis of pyruvate carboxylase-deficient strains
    • Stucka R, Dequin S, Salmon JM, Gancedo C. 1991. DNA sequences in chromosomes II and VII code for pyruvate carboxylase isoenzymes in Saccharomyces cerevisiae: analysis of pyruvate carboxylase-deficient strains. Mol Gen Genet 229:307-315.
    • (1991) Mol Gen Genet , vol.229 , pp. 307-315
    • Stucka, R.1    Dequin, S.2    Salmon, J.M.3    Gancedo, C.4
  • 44
    • 0024017530 scopus 로고
    • The growth and productivity of recombinant animal cells in a bubble-free aeration system
    • Wagner R, Lehmann J. 1988. The growth and productivity of recombinant animal cells in a bubble-free aeration system. Trends Biotechnol 6: 101-104.
    • (1988) Trends Biotechnol , vol.6 , pp. 101-104
    • Wagner, R.1    Lehmann, J.2
  • 45
    • 0028436847 scopus 로고
    • Fed-batch cultivation of animal cells using different design concepts and feeding strategies
    • Xie L, Wang DIC. 1994a. Fed-batch cultivation of animal cells using different design concepts and feeding strategies. Biotechnol Bioeng 43:1175-1189.
    • (1994) Biotechnol Bioeng , vol.43 , pp. 1175-1189
    • Xie, L.1    Wang, D.I.C.2
  • 46
    • 0028436953 scopus 로고
    • Stoichiometric analysis of animal cell growth and its application in medium design
    • Xie L, Wang DIC. 1994b. Stoichiometric analysis of animal cell growth and its application in medium design. Biotechnol Bioeng 43: 1164-1174.
    • (1994) Biotechnol Bioeng , vol.43 , pp. 1164-1174
    • Xie, L.1    Wang, D.I.C.2
  • 47
    • 0029636793 scopus 로고
    • Mathematical modeling and analysis of glucose and glutamine utilization and regulation in cultures of continuous mammalian cells
    • Zeng A-P, Deckwer W-D. 1995. Mathematical modeling and analysis of glucose and glutamine utilization and regulation in cultures of continuous mammalian cells. Biotechnol Bioeng 47:334-346.
    • (1995) Biotechnol Bioeng , vol.47 , pp. 334-346
    • Zeng, A.-P.1    Deckwer, W.-D.2
  • 48
    • 0021366190 scopus 로고
    • Glutamine: A major energy source for cultured mammalian cells
    • Zielke HR, Zielke CL, Ozand PT. 1984. Glutamine: a major energy source for cultured mammalian cells. Fed Proc 43:121-125.
    • (1984) Fed Proc , vol.43 , pp. 121-125
    • Zielke, H.R.1    Zielke, C.L.2    Ozand, P.T.3


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