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Volumn 150, Issue 4, 2010, Pages 497-508

A detailed metabolic flux analysis of an underdetermined network of CHO cells

Author keywords

Convex analysis; Mammalian cells; Metabolic flux analysis; Metabolic networks; Underdetermined systems

Indexed keywords

CONVEX ANALYSIS; MAMMALIAN CELLS; METABOLIC FLUX ANALYSIS; METABOLIC NETWORK; UNDERDETERMINED SYSTEMS;

EID: 78649447462     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2010.09.944     Document Type: Article
Times cited : (52)

References (37)
  • 1
  • 2
    • 33745155105 scopus 로고    scopus 로고
    • Determination of confidence intervals of metabolic fluxes estimated from stable isotope measurements
    • Antoniewicz M.R., Kelleher J.K., Stephanopoulos G. Determination of confidence intervals of metabolic fluxes estimated from stable isotope measurements. Metabolic Engineering 2006, 8:324-337.
    • (2006) Metabolic Engineering , vol.8 , pp. 324-337
    • Antoniewicz, M.R.1    Kelleher, J.K.2    Stephanopoulos, G.3
  • 3
    • 76749097100 scopus 로고    scopus 로고
    • Metabolic flux analysis and pharmaceutical production. Metabolic Engineering. doi:10.1016/j.ymben.2009.10.004
    • Boghigian, B. A., Seth, G., Kiss, R., Pfeifer, B. A., 2009. Metabolic flux analysis and pharmaceutical production. Metabolic Engineering. doi:10.1016/j.ymben.2009.10.004.
    • (2009)
    • Boghigian, B.A.1    Seth, G.2    Kiss, R.3    Pfeifer, B.A.4
  • 6
    • 0034026656 scopus 로고    scopus 로고
    • Metabolic flux analysis of hybridoma cells under oxidative and reductive stress using mas balances
    • Bonarius H.P.J., Houtman J.H., Schmid G., de Gooijer C.D., Tramper J. Metabolic flux analysis of hybridoma cells under oxidative and reductive stress using mas balances. Cytotechnology 2000, 32:97-107.
    • (2000) Cytotechnology , vol.32 , pp. 97-107
    • Bonarius, H.P.J.1    Houtman, J.H.2    Schmid, G.3    de Gooijer, C.D.4    Tramper, J.5
  • 7
    • 0030804853 scopus 로고    scopus 로고
    • Flux analysis of underdetermined metabolic networks: the quest for the missing constraints
    • August
    • Bonarius H.P.J., Schmid G., Tramper J. Flux analysis of underdetermined metabolic networks: the quest for the missing constraints. TIBTECH 1997, 15:308-314. August.
    • (1997) TIBTECH , vol.15 , pp. 308-314
    • Bonarius, H.P.J.1    Schmid, G.2    Tramper, J.3
  • 8
    • 29044432251 scopus 로고    scopus 로고
    • Metabolic flux analysis of HEK-293 cells in perfusion cultures for the production of adenoviral vectors
    • Henry O., Perrier M., Kamen A. Metabolic flux analysis of HEK-293 cells in perfusion cultures for the production of adenoviral vectors. Metabolic Engineering 2005, 7:467-476.
    • (2005) Metabolic Engineering , vol.7 , pp. 467-476
    • Henry, O.1    Perrier, M.2    Kamen, A.3
  • 9
    • 78649448177 scopus 로고    scopus 로고
    • Cell Biology for Process Engineering. Tech. Rep., Cellular Bioprocess Technology, University of Minnesota.
    • Hu, W.-S., 2004. Cell Biology for Process Engineering. Tech. Rep., Cellular Bioprocess Technology, University of Minnesota.
    • (2004)
    • Hu, W.-S.1
  • 10
    • 0014064216 scopus 로고
    • Genetics of somatic mammalian cells. IV. Properties of Chinese hamster cell mutants with respect to the requirement for proline
    • Kao F.-T., Puck T.T. Genetics of somatic mammalian cells. IV. Properties of Chinese hamster cell mutants with respect to the requirement for proline. Genetics 1967, 55:513-524.
    • (1967) Genetics , vol.55 , pp. 513-524
    • Kao, F.-T.1    Puck, T.T.2
  • 11
    • 78649444021 scopus 로고    scopus 로고
    • KEGG, Kyoto Encyclopedia of Genes and Genomes. Online.
    • KEGG, 2008. Kyoto Encyclopedia of Genes and Genomes. Online. http://www.genome.ad.jp/kegg/pathway/map/map01100.html.
    • (2008)
  • 12
    • 0036040830 scopus 로고    scopus 로고
    • Calculating as many fluxes as possible in underdetermined metabolic networks
    • Klamt S., Schuster S. Calculating as many fluxes as possible in underdetermined metabolic networks. Molecular Biology Reports 2002, 29:243-248.
    • (2002) Molecular Biology Reports , vol.29 , pp. 243-248
    • Klamt, S.1    Schuster, S.2
  • 13
    • 0037197159 scopus 로고    scopus 로고
    • Calculability analysis in underdetermined metabolic networks illustrated by a model of the central metabolism in purple nonsulfur bacteria
    • Klamt S., Schuster S., Gilles E.D. Calculability analysis in underdetermined metabolic networks illustrated by a model of the central metabolism in purple nonsulfur bacteria. Biotechnology and Bioengineering 2002, 77(7):734-751.
    • (2002) Biotechnology and Bioengineering , vol.77 , Issue.7 , pp. 734-751
    • Klamt, S.1    Schuster, S.2    Gilles, E.D.3
  • 14
    • 34247094270 scopus 로고    scopus 로고
    • An interval approach for dealing with flux distributions and elementary modes activity patterns
    • Llaneras F., Picó J. An interval approach for dealing with flux distributions and elementary modes activity patterns. Journal of Theoretical Biology 2007, 246:290-308.
    • (2007) Journal of Theoretical Biology , vol.246 , pp. 290-308
    • Llaneras, F.1    Picó, J.2
  • 15
    • 0028066753 scopus 로고
    • Use of on-line gas analysis to monitor recombinant
    • Lovrecz G., Gray P. Use of on-line gas analysis to monitor recombinant. Mammalian Cell cultures 1994, 167-175.
    • (1994) Mammalian Cell cultures , pp. 167-175
    • Lovrecz, G.1    Gray, P.2
  • 16
    • 0034511786 scopus 로고    scopus 로고
    • Human 293 cell metabolism in low glutamine-supplied culture: interpretation of metabolic changes through metabolic flux analysis
    • Nadeau I., Sabatié J., Koehl M., Perrier M., Kamen A. Human 293 cell metabolism in low glutamine-supplied culture: interpretation of metabolic changes through metabolic flux analysis. Metabolic Engineering 2000, 2:277-292.
    • (2000) Metabolic Engineering , vol.2 , pp. 277-292
    • Nadeau, I.1    Sabatié, J.2    Koehl, M.3    Perrier, M.4    Kamen, A.5
  • 17
    • 78649446394 scopus 로고    scopus 로고
    • Lehninger, Principles of Biochemistry, fourth edition.
    • Nelson, D., Cox, M., 2005. Lehninger, Principles of Biochemistry, fourth edition.
    • (2005)
    • Nelson, D.1    Cox, M.2
  • 19
    • 78649450128 scopus 로고    scopus 로고
    • Metabolic design of dynamic bioreaction models. Ph.D. Thesis, Université Catholique de Louvain.
    • Provost, A., 2006. Metabolic design of dynamic bioreaction models. Ph.D. Thesis, Université Catholique de Louvain.
    • (2006)
    • Provost, A.1
  • 21
    • 2342452470 scopus 로고    scopus 로고
    • Dynamic metabolic modelling under the balanced growth condition
    • Provost A., Bastin G. Dynamic metabolic modelling under the balanced growth condition. Journal of Process Control 2004, 14:717-728.
    • (2004) Journal of Process Control , vol.14 , pp. 717-728
    • Provost, A.1    Bastin, G.2
  • 23
    • 0026594358 scopus 로고
    • Optimal selection of metabolic fluxes for in vivo measurement. I. Development of mathematical methods
    • Savinell J.M., Palsson B.O. Optimal selection of metabolic fluxes for in vivo measurement. I. Development of mathematical methods. Journal of Theoretical Biology 1992, 155:201-214.
    • (1992) Journal of Theoretical Biology , vol.155 , pp. 201-214
    • Savinell, J.M.1    Palsson, B.O.2
  • 24
    • 0026566666 scopus 로고
    • Optimal selection of metabolic fluxes for in vivo measurement. II. Application to Escherichia coli and hybridoma cell metabolism
    • Savinell J.M., Palsson B.O. Optimal selection of metabolic fluxes for in vivo measurement. II. Application to Escherichia coli and hybridoma cell metabolism. Journal of Theoretical Biology 1992, 155:215-242.
    • (1992) Journal of Theoretical Biology , vol.155 , pp. 215-242
    • Savinell, J.M.1    Palsson, B.O.2
  • 26
    • 0033080396 scopus 로고    scopus 로고
    • Detection of elementary flux modes in biochemical networks: a promising tool for pathway analysis and metabolic engineering
    • Schuster S., Dandekar T., Fell D.A. Detection of elementary flux modes in biochemical networks: a promising tool for pathway analysis and metabolic engineering. TIBTECH 1999, 17:53-60.
    • (1999) TIBTECH , vol.17 , pp. 53-60
    • Schuster, S.1    Dandekar, T.2    Fell, D.A.3
  • 28
    • 42049113587 scopus 로고    scopus 로고
    • Comparison of metabolic flux distributions for MDCK cell growth in glutamine- and pyruvate-containing media
    • Sidorenko Y., Wahl A., Dauner M., Genzel Y., Reichl U. Comparison of metabolic flux distributions for MDCK cell growth in glutamine- and pyruvate-containing media. Biotechnology Progress 2008, 24:311-320.
    • (2008) Biotechnology Progress , vol.24 , pp. 311-320
    • Sidorenko, Y.1    Wahl, A.2    Dauner, M.3    Genzel, Y.4    Reichl, U.5
  • 29
  • 32
    • 0028764687 scopus 로고
    • Linear constraint relations in biochemical reaction systems. I. Classification of the calculability and the balanceability of conversion rates
    • van der Heijden R., Heijnen J., Hellinga C., Romein B., Luyben K. Linear constraint relations in biochemical reaction systems. I. Classification of the calculability and the balanceability of conversion rates. Biotechnology and Bioengineering 1994, 43:3-10.
    • (1994) Biotechnology and Bioengineering , vol.43 , pp. 3-10
    • van der Heijden, R.1    Heijnen, J.2    Hellinga, C.3    Romein, B.4    Luyben, K.5
  • 34
    • 0028693147 scopus 로고
    • Applications of improved stoichiometric model in medium design and fed-batch cultivation of animal cells in bioreactor
    • Xie L., Wang D.I. Applications of improved stoichiometric model in medium design and fed-batch cultivation of animal cells in bioreactor. Cytotechnology 1994, 15:17-29.
    • (1994) Cytotechnology , vol.15 , pp. 17-29
    • Xie, L.1    Wang, D.I.2
  • 35
    • 0030571589 scopus 로고    scopus 로고
    • Material balance studies on animal cell metabolism using stoichiometrically based reaction network
    • Xie L., Wang D.I. Material balance studies on animal cell metabolism using stoichiometrically based reaction network. Biotechnology and Bioengineering 1996, 52:579-590.
    • (1996) Biotechnology and Bioengineering , vol.52 , pp. 579-590
    • Xie, L.1    Wang, D.I.2
  • 36
    • 0030571616 scopus 로고    scopus 로고
    • Energy metabolism and ATP balance in animall cell cultivation using a stoichiometrically based reaction network
    • Xie L., Wang D.I. Energy metabolism and ATP balance in animall cell cultivation using a stoichiometrically based reaction network. Biotechnology and Bioengineering 1996, 52:591-601.
    • (1996) Biotechnology and Bioengineering , vol.52 , pp. 591-601
    • Xie, L.1    Wang, D.I.2
  • 37
    • 0029239589 scopus 로고
    • Intracellular flux analysis in hybridomas using mass balances and in vitro 13C NMR
    • Zupke C., Stephanopoulos G. Intracellular flux analysis in hybridomas using mass balances and in vitro 13C NMR. Biotechnology and Bioengineering 1995, 45:292-303.
    • (1995) Biotechnology and Bioengineering , vol.45 , pp. 292-303
    • Zupke, C.1    Stephanopoulos, G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.