메뉴 건너뛰기




Volumn 139, Issue 1, 2013, Pages 41-50

Epigenetics: A novel therapeutic approach for the treatment of Alzheimer's disease

Author keywords

Alzheimer's disease; DNA methylation; Epigenetics; Histone modification; Memory; Therapy

Indexed keywords

4 PHENYLBUTYRIC ACID; ACETYLCYSTEINE; AMYLOID BETA PROTEIN; ANTIDEPRESSANT AGENT; BETAINE; BUTYRIC ACID; CILOSTAZOL; CREBINOSTAT; CURCUMIN; DNA; DONEPEZIL; E1A ASSOCIATED P300 PROTEIN; ERYTHROMYCIN; EVP 0334; HISTONE; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE INHIBITOR; NICOTINAMIDE; PAROXETINE; PLACEBO; RESVERATROL; ROMIDEPSIN; S ADENOSYLMETHIONINE; SIRTUIN; SRT 2104; SRT 2379; TOLFENAMIC ACID; UNCLASSIFIED DRUG; UNTRANSLATED RNA; VALPROIC ACID; VORINOSTAT;

EID: 84877927154     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2013.03.010     Document Type: Review
Times cited : (93)

References (210)
  • 1
    • 33745226490 scopus 로고    scopus 로고
    • Tolfenamic acid and pancreatic cancer growth, angiogenesis, and Sp protein degradation
    • M. Abdelrahim, C.H. Baker, J.L. Abbruzzese, and S. Safe Tolfenamic acid and pancreatic cancer growth, angiogenesis, and Sp protein degradation J Natl Cancer Inst 98 2006 855 868
    • (2006) J Natl Cancer Inst , vol.98 , pp. 855-868
    • Abdelrahim, M.1    Baker, C.H.2    Abbruzzese, J.L.3    Safe, S.4
  • 2
    • 38649124003 scopus 로고    scopus 로고
    • Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders
    • T. Abel, and R.S. Zukin Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders Curr Opin Pharmacol 8 2008 57 64
    • (2008) Curr Opin Pharmacol , vol.8 , pp. 57-64
    • Abel, T.1    Zukin, R.S.2
  • 3
    • 79959334031 scopus 로고    scopus 로고
    • Tolfenamic acid interrupts the de novo synthesis of the beta-amyloid precursor protein and lowers amyloid beta via a transcriptional pathway
    • L.I. Adwan, R. Basha, M. Abdelrahim, G.M. Subaiea, and N.H. Zawia Tolfenamic acid interrupts the de novo synthesis of the beta-amyloid precursor protein and lowers amyloid beta via a transcriptional pathway Curr Alzheimer Res 8 2011 385 392
    • (2011) Curr Alzheimer Res , vol.8 , pp. 385-392
    • Adwan, L.I.1    Basha, R.2    Abdelrahim, M.3    Subaiea, G.M.4    Zawia, N.H.5
  • 4
    • 84871713547 scopus 로고    scopus 로고
    • Integration of genome-wide expression and methylation data: Relevance to aging and Alzheimer's disease
    • H. Alashwal, R. Dosunmu, and N.H. Zawia Integration of genome-wide expression and methylation data: Relevance to aging and Alzheimer's disease Neurotoxicology 33 2012 1450 1453
    • (2012) Neurotoxicology , vol.33 , pp. 1450-1453
    • Alashwal, H.1    Dosunmu, R.2    Zawia, N.H.3
  • 5
    • 75149192820 scopus 로고    scopus 로고
    • Sirtuins as novel targets for Alzheimer's disease and other neurodegenerative disorders: Experimental and genetic evidence
    • D. Albani, L. Polito, and G. Forloni Sirtuins as novel targets for Alzheimer's disease and other neurodegenerative disorders: Experimental and genetic evidence J Alzheimers Dis 19 2010 11 26
    • (2010) J Alzheimers Dis , vol.19 , pp. 11-26
    • Albani, D.1    Polito, L.2    Forloni, G.3
  • 6
    • 0031012497 scopus 로고    scopus 로고
    • Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: Sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau
    • A.D. Alonso, I. Grundke-Iqbal, H.S. Barra, and K. Iqbal Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: Sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau Proc Natl Acad Sci U S A 94 1997 298 303
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 298-303
    • Alonso, A.D.1    Grundke-Iqbal, I.2    Barra, H.S.3    Iqbal, K.4
  • 7
    • 84858225391 scopus 로고    scopus 로고
    • 2012 Alzheimer's disease facts and figures
    • Alzheimer's Association
    • Alzheimer's Association 2012 Alzheimer's disease facts and figures Alzheimers Dement 8 2012 131 168
    • (2012) Alzheimers Dement , vol.8 , pp. 131-168
  • 8
    • 84875354777 scopus 로고    scopus 로고
    • 2013 Alzheimer's disease facts and figures
    • Alzheimer's Association
    • Alzheimer's Association 2013 Alzheimer's disease facts and figures Alzheimers Dement 9 2013 208 245
    • (2013) Alzheimers Dement , vol.9 , pp. 208-245
  • 9
    • 0032830639 scopus 로고    scopus 로고
    • Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2
    • R.E. Amir, I.B. Van den Veyver, M. Wan, C.Q. Tran, U. Francke, and H.Y. Zoghbi Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2 Nat Genet 23 1999 185 188
    • (1999) Nat Genet , vol.23 , pp. 185-188
    • Amir, R.E.1    Van Den Veyver, I.B.2    Wan, M.3    Tran, C.Q.4    Francke, U.5    Zoghbi, H.Y.6
  • 11
    • 84859412462 scopus 로고    scopus 로고
    • Genome-wide DNA methylation differences between late-onset Alzheimer's disease and cognitively normal controls in human frontal cortex
    • K.M. Bakulski, D.C. Dolinoy, M.A. Sartor, H.L. Paulson, J.R. Konen, and A.P. Lieberman Genome-wide DNA methylation differences between late-onset Alzheimer's disease and cognitively normal controls in human frontal cortex J Alzheimers Dis 29 2012 571 588
    • (2012) J Alzheimers Dis , vol.29 , pp. 571-588
    • Bakulski, K.M.1    Dolinoy, D.C.2    Sartor, M.A.3    Paulson, H.L.4    Konen, J.R.5    Lieberman, A.P.6
  • 12
    • 10944243759 scopus 로고    scopus 로고
    • Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription
    • K. Balasubramanyam, R.A. Varier, M. Altaf, V. Swaminathan, N.B. Siddappa, and U. Ranga Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription J Biol Chem 279 2004 51163 51171
    • (2004) J Biol Chem , vol.279 , pp. 51163-51171
    • Balasubramanyam, K.1    Varier, R.A.2    Altaf, M.3    Swaminathan, V.4    Siddappa, N.B.5    Ranga, U.6
  • 13
    • 84869880178 scopus 로고    scopus 로고
    • Histone deacetylases and cancer
    • B. Barneda-Zahonero, and M. Parra Histone deacetylases and cancer Mol Oncol 6 2012 579 589
    • (2012) Mol Oncol , vol.6 , pp. 579-589
    • Barneda-Zahonero, B.1    Parra, M.2
  • 14
    • 80051669619 scopus 로고    scopus 로고
    • The projected effect of risk factor reduction on Alzheimer's disease prevalence
    • D.E. Barnes, and K. Yaffe The projected effect of risk factor reduction on Alzheimer's disease prevalence Lancet Neurol 10 2011 819 828
    • (2011) Lancet Neurol , vol.10 , pp. 819-828
    • Barnes, D.E.1    Yaffe, K.2
  • 15
    • 69449086451 scopus 로고    scopus 로고
    • DNA methylation of Alzheimer disease and tauopathy-related genes in postmortem brain
    • M. Barrachina, and I. Ferrer DNA methylation of Alzheimer disease and tauopathy-related genes in postmortem brain J Neuropathol Exp Neurol 68 2009 880 891
    • (2009) J Neuropathol Exp Neurol , vol.68 , pp. 880-891
    • Barrachina, M.1    Ferrer, I.2
  • 16
    • 45749089694 scopus 로고    scopus 로고
    • Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer's disease
    • A.N. Begum, M.R. Jones, G.P. Lim, T. Morihara, P. Kim, and D.D. Heath Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer's disease J Pharmacol Exp Ther 326 2008 196 208
    • (2008) J Pharmacol Exp Ther , vol.326 , pp. 196-208
    • Begum, A.N.1    Jones, M.R.2    Lim, G.P.3    Morihara, T.4    Kim, P.5    Heath, D.D.6
  • 17
    • 84897527775 scopus 로고    scopus 로고
    • Infantile exposure to lead (Pb) and late age cognitive decline: Relevance to AD
    • in press
    • S.W. Bihaqi, A. Bahmani, G.M. Subaiea, and N.H. Zawia Infantile exposure to lead (Pb) and late age cognitive decline: relevance to AD Alzheimers Dement 2013 (in press)
    • (2013) Alzheimers Dement
    • Bihaqi, S.W.1    Bahmani, A.2    Subaiea, G.M.3    Zawia, N.H.4
  • 18
    • 84455193330 scopus 로고    scopus 로고
    • Infant exposure to lead (Pb) and epigenetic modifications in the aging primate brain: Implications for Alzheimer's disease
    • S.W. Bihaqi, H. Huang, J. Wu, and N.H. Zawia Infant exposure to lead (Pb) and epigenetic modifications in the aging primate brain: Implications for Alzheimer's disease J Alzheimers Dis 27 2011 819 833
    • (2011) J Alzheimers Dis , vol.27 , pp. 819-833
    • Bihaqi, S.W.1    Huang, H.2    Wu, J.3    Zawia, N.H.4
  • 19
    • 84861174335 scopus 로고    scopus 로고
    • Alzheimer's disease biomarkers and epigenetic intermediates following exposure to Pb in vitro
    • S.W. Bihaqi, and N.H. Zawia Alzheimer's disease biomarkers and epigenetic intermediates following exposure to Pb in vitro Curr Alzheimer Res 9 2012 555 562
    • (2012) Curr Alzheimer Res , vol.9 , pp. 555-562
    • Bihaqi, S.W.1    Zawia, N.H.2
  • 20
    • 0022540321 scopus 로고
    • CpG-rich islands and the function of DNA methylation
    • A. Bird CpG-rich islands and the function of DNA methylation Nature 321 1986 209 213
    • (1986) Nature , vol.321 , pp. 209-213
    • Bird, A.1
  • 21
    • 34249337761 scopus 로고    scopus 로고
    • Perceptions of epigenetics
    • A. Bird Perceptions of epigenetics Nature 447 2007 396 398
    • (2007) Nature , vol.447 , pp. 396-398
    • Bird, A.1
  • 22
    • 0030463470 scopus 로고    scopus 로고
    • CREB phosphorylation and dephosphorylation: A Ca(2+)- and stimulus duration-dependent switch for hippocampal gene expression
    • H. Bito, K. Deisseroth, and R.W. Tsien CREB phosphorylation and dephosphorylation: A Ca(2+)- and stimulus duration-dependent switch for hippocampal gene expression Cell 87 1996 1203 1214
    • (1996) Cell , vol.87 , pp. 1203-1214
    • Bito, H.1    Deisseroth, K.2    Tsien, R.W.3
  • 23
    • 0025606597 scopus 로고
    • Cerebrospinal fluid S-adenosylmethionine in depression and dementia: Effects of treatment with parenteral and oral S-adenosylmethionine
    • T. Bottiglieri, P. Godfrey, T. Flynn, M.W. Carney, B.K. Toone, and E.H. Reynolds Cerebrospinal fluid S-adenosylmethionine in depression and dementia: Effects of treatment with parenteral and oral S-adenosylmethionine J Neurol Neurosurg Psychiatry 53 1990 1096 1098
    • (1990) J Neurol Neurosurg Psychiatry , vol.53 , pp. 1096-1098
    • Bottiglieri, T.1    Godfrey, P.2    Flynn, T.3    Carney, M.W.4    Toone, B.K.5    Reynolds, E.H.6
  • 24
    • 0028102526 scopus 로고
    • The clinical potential of ademetionine (S-adenosylmethionine) in neurological disorders
    • T. Bottiglieri, K. Hyland, and E.H. Reynolds The clinical potential of ademetionine (S-adenosylmethionine) in neurological disorders Drugs 48 1994 137 152
    • (1994) Drugs , vol.48 , pp. 137-152
    • Bottiglieri, T.1    Hyland, K.2    Reynolds, E.H.3
  • 25
    • 78651072485 scopus 로고    scopus 로고
    • CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease
    • A. Caccamo, M.A. Maldonado, A.F. Bokov, S. Majumder, and S. Oddo CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease Proc Natl Acad Sci U S A 107 2010 22687 22692
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 22687-22692
    • Caccamo, A.1    Maldonado, M.A.2    Bokov, A.F.3    Majumder, S.4    Oddo, S.5
  • 26
    • 84875066630 scopus 로고    scopus 로고
    • Epigenetic drugs for Alzheimer's Disease: Hopes and challenges
    • F. Caraci, G.M. Leggio, F. Drago, and S. Salomone Epigenetic drugs for Alzheimer's Disease: Hopes and challenges Br J Clin Pharmacol 75 2012 1154 1155
    • (2012) Br J Clin Pharmacol , vol.75 , pp. 1154-1155
    • Caraci, F.1    Leggio, G.M.2    Drago, F.3    Salomone, S.4
  • 27
    • 84862263248 scopus 로고    scopus 로고
    • The NIH roadmap epigenomics program data resource
    • L.H. Chadwick The NIH roadmap epigenomics program data resource Epigenomics 4 2012 317 324
    • (2012) Epigenomics , vol.4 , pp. 317-324
    • Chadwick, L.H.1
  • 28
    • 45849105557 scopus 로고    scopus 로고
    • MeCP2, a key contributor to neurological disease, activates and represses transcription
    • M. Chahrour, S.Y. Jung, C. Shaw, X. Zhou, S.T. Wong, and J. Qin MeCP2, a key contributor to neurological disease, activates and represses transcription Science 320 2008 1224 1229
    • (2008) Science , vol.320 , pp. 1224-1229
    • Chahrour, M.1    Jung, S.Y.2    Shaw, C.3    Zhou, X.4    Wong, S.T.5    Qin, J.6
  • 29
    • 0042132027 scopus 로고    scopus 로고
    • Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b
    • T. Chen, Y. Ueda, J.E. Dodge, Z. Wang, and E. Li Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b Mol Cell Biol 23 2003 5594 5605
    • (2003) Mol Cell Biol , vol.23 , pp. 5594-5605
    • Chen, T.1    Ueda, Y.2    Dodge, J.E.3    Wang, Z.4    Li, E.5
  • 31
    • 84861138595 scopus 로고    scopus 로고
    • Age-related increase in levels of 5-hydroxymethylcytosine in mouse hippocampus is prevented by caloric restriction
    • L. Chouliaras, D.L. van den Hove, G. Kenis, S. Keitel, P.R. Hof, and J. van Os Age-related increase in levels of 5-hydroxymethylcytosine in mouse hippocampus is prevented by caloric restriction Curr Alzheimer Res 9 2012 536 544
    • (2012) Curr Alzheimer Res , vol.9 , pp. 536-544
    • Chouliaras, L.1    Van Den Hove, D.L.2    Kenis, G.3    Keitel, S.4    Hof, P.R.5    Van Os, J.6
  • 32
    • 84861894813 scopus 로고    scopus 로고
    • Prevention of age-related changes in hippocampal levels of 5-methylcytidine by caloric restriction
    • L. Chouliaras, D.L. van den Hove, G. Kenis, S. Keitel, P.R. Hof, and J. van Os Prevention of age-related changes in hippocampal levels of 5-methylcytidine by caloric restriction Neurobiol Aging 33 2012 1672 1681
    • (2012) Neurobiol Aging , vol.33 , pp. 1672-1681
    • Chouliaras, L.1    Van Den Hove, D.L.2    Kenis, G.3    Keitel, S.4    Hof, P.R.5    Van Os, J.6
  • 33
    • 33744793463 scopus 로고    scopus 로고
    • ERK/MAPK regulates hippocampal histone phosphorylation following contextual fear conditioning
    • W.B. Chwang, K.J. O'Riordan, J.M. Levenson, and J.D. Sweatt ERK/MAPK regulates hippocampal histone phosphorylation following contextual fear conditioning Learn Mem 13 2006 322 328
    • (2006) Learn Mem , vol.13 , pp. 322-328
    • Chwang, W.B.1    O'Riordan, K.J.2    Levenson, J.M.3    Sweatt, J.D.4
  • 34
    • 0028924248 scopus 로고
    • Generation of amyloid beta protein from its precursor is sequence specific
    • M. Citron, D.B. Teplow, and D.J. Selkoe Generation of amyloid beta protein from its precursor is sequence specific Neuron 14 1995 661 670
    • (1995) Neuron , vol.14 , pp. 661-670
    • Citron, M.1    Teplow, D.B.2    Selkoe, D.J.3
  • 39
    • 47849124269 scopus 로고    scopus 로고
    • Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways
    • J.P. Cogswell, J. Ward, I.A. Taylor, M. Waters, Y. Shi, and B. Cannon Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways J Alzheimers Dis 14 2008 27 41
    • (2008) J Alzheimers Dis , vol.14 , pp. 27-41
    • Cogswell, J.P.1    Ward, J.2    Taylor, I.A.3    Waters, M.4    Shi, Y.5    Cannon, B.6
  • 41
    • 40649111338 scopus 로고    scopus 로고
    • Non-coding RNAs, epigenetics and complexity
    • F.F. Costa Non-coding RNAs, epigenetics and complexity Gene 410 2008 9 17
    • (2008) Gene , vol.410 , pp. 9-17
    • Costa, F.F.1
  • 43
    • 4544358286 scopus 로고    scopus 로고
    • Betaine in human nutrition
    • S.A. Craig Betaine in human nutrition Am J Clin Nutr 80 2004 539 549
    • (2004) Am J Clin Nutr , vol.80 , pp. 539-549
    • Craig, S.A.1
  • 44
    • 70349751583 scopus 로고    scopus 로고
    • Epigenetic side-effects of common pharmaceuticals: A potential new field in medicine and pharmacology
    • A.B. Csoka, and M. Szyf Epigenetic side-effects of common pharmaceuticals: A potential new field in medicine and pharmacology Med Hypotheses 73 2009 770 780
    • (2009) Med Hypotheses , vol.73 , pp. 770-780
    • Csoka, A.B.1    Szyf, M.2
  • 45
    • 0033990169 scopus 로고    scopus 로고
    • Presenilins and Alzheimer's disease: Biological functions and pathogenic mechanisms
    • C. Czech, G. Tremp, and L. Pradier Presenilins and Alzheimer's disease: Biological functions and pathogenic mechanisms Prog Neurobiol 60 2000 363 384
    • (2000) Prog Neurobiol , vol.60 , pp. 363-384
    • Czech, C.1    Tremp, G.2    Pradier, L.3
  • 46
    • 0033257094 scopus 로고    scopus 로고
    • Control of histone modifications
    • J.R. Davie, and V.A. Spencer Control of histone modifications J Cell Biochem Suppl 32-33 1999 141 148
    • (1999) J Cell Biochem Suppl , vol.32-33 , pp. 141-148
    • Davie, J.R.1    Spencer, V.A.2
  • 47
    • 77958580776 scopus 로고    scopus 로고
    • DNA methylation and memory formation
    • J.J. Day, and J.D. Sweatt DNA methylation and memory formation Nat Neurosci 13 2010 1319 1323
    • (2010) Nat Neurosci , vol.13 , pp. 1319-1323
    • Day, J.J.1    Sweatt, J.D.2
  • 50
    • 49549083278 scopus 로고    scopus 로고
    • Histone deacetylase 6 interacts with the microtubule-associated protein tau
    • H. Ding, P.J. Dolan, and G.V. Johnson Histone deacetylase 6 interacts with the microtubule-associated protein tau J Neurochem 106 2008 2119 2130
    • (2008) J Neurochem , vol.106 , pp. 2119-2130
    • Ding, H.1    Dolan, P.J.2    Johnson, G.V.3
  • 51
    • 7444257309 scopus 로고    scopus 로고
    • Sp1 and Smad transcription factors co-operate to mediate TGF-beta-dependent activation of amyloid-beta precursor protein gene transcription
    • F. Docagne, C. Gabriel, N. Lebeurrier, S. Lesne, Y. Hommet, and L. Plawinski Sp1 and Smad transcription factors co-operate to mediate TGF-beta-dependent activation of amyloid-beta precursor protein gene transcription Biochem J 383 2004 393 399
    • (2004) Biochem J , vol.383 , pp. 393-399
    • Docagne, F.1    Gabriel, C.2    Lebeurrier, N.3    Lesne, S.4    Hommet, Y.5    Plawinski, L.6
  • 52
    • 77955046461 scopus 로고    scopus 로고
    • SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10
    • G. Donmez, D. Wang, D.E. Cohen, and L. Guarente SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10 Cell 142 2010 320 332
    • (2010) Cell , vol.142 , pp. 320-332
    • Donmez, G.1    Wang, D.2    Cohen, D.E.3    Guarente, L.4
  • 53
    • 84863102171 scopus 로고    scopus 로고
    • Genome-wide expression and methylation profiling in the aged rodent brain due to early-life Pb exposure and its relevance to aging
    • R. Dosunmu, H. Alashwal, and N.H. Zawia Genome-wide expression and methylation profiling in the aged rodent brain due to early-life Pb exposure and its relevance to aging Mech Ageing Dev 133 2012 435 443
    • (2012) Mech Ageing Dev , vol.133 , pp. 435-443
    • Dosunmu, R.1    Alashwal, H.2    Zawia, N.H.3
  • 54
    • 46749083733 scopus 로고    scopus 로고
    • Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase
    • M.A. Faghihi, F. Modarresi, A.M. Khalil, D.E. Wood, B.G. Sahagan, and T.E. Morgan Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase Nat Med 14 2008 723 730
    • (2008) Nat Med , vol.14 , pp. 723-730
    • Faghihi, M.A.1    Modarresi, F.2    Khalil, A.M.3    Wood, D.E.4    Sahagan, B.G.5    Morgan, T.E.6
  • 55
    • 0025806596 scopus 로고
    • Association of decreased paternal age and late-onset Alzheimer's disease. An example of genetic imprinting?
    • L.A. Farrer, L.A. Cupples, L. Connor, P.A. Wolf, and J.H. Growdon Association of decreased paternal age and late-onset Alzheimer's disease. An example of genetic imprinting? Arch Neurol 48 1991 599 604
    • (1991) Arch Neurol , vol.48 , pp. 599-604
    • Farrer, L.A.1    Cupples, L.A.2    Connor, L.3    Wolf, P.A.4    Growdon, J.H.5
  • 56
    • 84866387948 scopus 로고    scopus 로고
    • Crebinostat: A novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity
    • D.M. Fass, S.A. Reis, B. Ghosh, K.M. Hennig, N.F. Joseph, and W.N. Zhao Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity Neuropharmacology 64 2013 81 96
    • (2013) Neuropharmacology , vol.64 , pp. 81-96
    • Fass, D.M.1    Reis, S.A.2    Ghosh, B.3    Hennig, K.M.4    Joseph, N.F.5    Zhao, W.N.6
  • 57
    • 40949093544 scopus 로고    scopus 로고
    • Epigenetics at the epicenter of modern medicine
    • A.P. Feinberg Epigenetics at the epicenter of modern medicine JAMA 299 2008 1345 1350
    • (2008) JAMA , vol.299 , pp. 1345-1350
    • Feinberg, A.P.1
  • 58
    • 34247469843 scopus 로고    scopus 로고
    • Epigenetic regulation of neural gene expression and neuronal function
    • J. Feng, S. Fouse, and G. Fan Epigenetic regulation of neural gene expression and neuronal function Pediatr Res 61 2007 58R 63R
    • (2007) Pediatr Res , vol.61
    • Feng, J.1    Fouse, S.2    Fan, G.3
  • 59
    • 77950187447 scopus 로고    scopus 로고
    • Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons
    • J. Feng, Y. Zhou, S.L. Campbell, T. Le, E. Li, and J.D. Sweatt Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons Nat Neurosci 13 2010 423 430
    • (2010) Nat Neurosci , vol.13 , pp. 423-430
    • Feng, J.1    Zhou, Y.2    Campbell, S.L.3    Le, T.4    Li, E.5    Sweatt, J.D.6
  • 60
    • 34248523169 scopus 로고    scopus 로고
    • Recovery of learning and memory is associated with chromatin remodelling
    • A. Fischer, F. Sananbenesi, X. Wang, M. Dobbin, and L.H. Tsai Recovery of learning and memory is associated with chromatin remodelling Nature 447 2007 178 182
    • (2007) Nature , vol.447 , pp. 178-182
    • Fischer, A.1    Sananbenesi, F.2    Wang, X.3    Dobbin, M.4    Tsai, L.H.5
  • 62
    • 10644237168 scopus 로고    scopus 로고
    • S-adenosylmethionine/homocysteine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-amyloid production
    • A. Fuso, L. Seminara, R.A. Cavallaro, F. D'Anselmi, and S. Scarpa S-adenosylmethionine/homocysteine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-amyloid production Mol Cell Neurosci 28 2005 195 204
    • (2005) Mol Cell Neurosci , vol.28 , pp. 195-204
    • Fuso, A.1    Seminara, L.2    Cavallaro, R.A.3    D'Anselmi, F.4    Scarpa, S.5
  • 63
    • 77950627166 scopus 로고    scopus 로고
    • Histone modifications, DNA methylation, and schizophrenia
    • D.P. Gavin, and R.P. Sharma Histone modifications, DNA methylation, and schizophrenia Neurosci Biobehav Rev 34 2010 882 888
    • (2010) Neurosci Biobehav Rev , vol.34 , pp. 882-888
    • Gavin, D.P.1    Sharma, R.P.2
  • 64
    • 78650826181 scopus 로고    scopus 로고
    • Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates
    • D. Globisch, M. Munzel, M. Muller, S. Michalakis, M. Wagner, and S. Koch Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates PLoS One 5 2010 e15367
    • (2010) PLoS One , vol.5 , pp. 15367
    • Globisch, D.1    Munzel, M.2    Muller, M.3    Michalakis, S.4    Wagner, M.5    Koch, S.6
  • 65
    • 0026088977 scopus 로고
    • Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
    • A. Goate, M.C. Chartier-Harlin, M. Mullan, J. Brown, F. Crawford, and L. Fidani Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease Nature 349 1991 704 706
    • (1991) Nature , vol.349 , pp. 704-706
    • Goate, A.1    Chartier-Harlin, M.C.2    Mullan, M.3    Brown, J.4    Crawford, F.5    Fidani, L.6
  • 66
    • 18244383806 scopus 로고    scopus 로고
    • Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
    • M. Gottlicher, S. Minucci, P. Zhu, O.H. Kramer, A. Schimpf, and S. Giavara Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells EMBO J 20 2001 6969 6978
    • (2001) EMBO J , vol.20 , pp. 6969-6978
    • Gottlicher, M.1    Minucci, S.2    Zhu, P.3    Kramer, O.H.4    Schimpf, A.5    Giavara, S.6
  • 67
    • 84862777943 scopus 로고    scopus 로고
    • An epigenetic blockade of cognitive functions in the neurodegenerating brain
    • J. Graff, D. Rei, J.S. Guan, W.Y. Wang, J. Seo, and K.M. Hennig An epigenetic blockade of cognitive functions in the neurodegenerating brain Nature 483 2012 222 226
    • (2012) Nature , vol.483 , pp. 222-226
    • Graff, J.1    Rei, D.2    Guan, J.S.3    Wang, W.Y.4    Seo, J.5    Hennig, K.M.6
  • 68
    • 0035862199 scopus 로고    scopus 로고
    • The human histone deacetylase family
    • S.G. Gray, and T.J. Ekstrom The human histone deacetylase family Exp Cell Res 262 2001 75 83
    • (2001) Exp Cell Res , vol.262 , pp. 75-83
    • Gray, S.G.1    Ekstrom, T.J.2
  • 69
    • 58149267462 scopus 로고    scopus 로고
    • Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau
    • K.N. Green, J.S. Steffan, H. Martinez-Coria, X. Sun, S.S. Schreiber, and L.M. Thompson Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau J Neurosci 28 2008 11500 11510
    • (2008) J Neurosci , vol.28 , pp. 11500-11510
    • Green, K.N.1    Steffan, J.S.2    Martinez-Coria, H.3    Sun, X.4    Schreiber, S.S.5    Thompson, L.M.6
  • 72
    • 77956402632 scopus 로고    scopus 로고
    • REVIEW: Curcumin and Alzheimer's disease
    • T. Hamaguchi, K. Ono, and M. Yamada REVIEW: curcumin and Alzheimer's disease CNS Neurosci Ther 16 2010 285 297
    • (2010) CNS Neurosci Ther , vol.16 , pp. 285-297
    • Hamaguchi, T.1    Ono, K.2    Yamada, M.3
  • 73
    • 0026597063 scopus 로고
    • Alzheimer's disease: The amyloid cascade hypothesis
    • J. Hardy, and G.A. Higgins Alzheimer's disease: The amyloid cascade hypothesis Science 256 1992 184 185
    • (1992) Science , vol.256 , pp. 184-185
    • Hardy, J.1    Higgins, G.A.2
  • 74
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • J. Hardy, and D.J. Selkoe The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics Science 297 2002 353 356
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 75
    • 44049108170 scopus 로고    scopus 로고
    • Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression
    • S.S. Hebert, K. Horre, L. Nicolai, A.S. Papadopoulou, W. Mandemakers, and A.N. Silahtaroglu Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression Proc Natl Acad Sci U S A 105 2008 6415 6420
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 6415-6420
    • Hebert, S.S.1    Horre, K.2    Nicolai, L.3    Papadopoulou, A.S.4    Mandemakers, W.5    Silahtaroglu, A.N.6
  • 76
    • 84856181467 scopus 로고    scopus 로고
    • Current research trends in early life stress and depression: Review of human studies on sensitive periods, gene-environment interactions, and epigenetics
    • C. Heim, and E.B. Binder Current research trends in early life stress and depression: Review of human studies on sensitive periods, gene-environment interactions, and epigenetics Exp Neurol 233 2012 102 111
    • (2012) Exp Neurol , vol.233 , pp. 102-111
    • Heim, C.1    Binder, E.B.2
  • 77
    • 0031201685 scopus 로고    scopus 로고
    • Exploring and explaining epigenetic effects
    • S. Henikoff, and M.A. Matzke Exploring and explaining epigenetic effects Trends Genet 13 1997 293 295
    • (1997) Trends Genet , vol.13 , pp. 293-295
    • Henikoff, S.1    Matzke, M.A.2
  • 78
    • 78649406219 scopus 로고    scopus 로고
    • Cilostazol prevents amyloid beta peptide(25-35)-induced memory impairment and oxidative stress in mice
    • M. Hiramatsu, O. Takiguchi, A. Nishiyama, and H. Mori Cilostazol prevents amyloid beta peptide(25-35)-induced memory impairment and oxidative stress in mice Br J Pharmacol 161 2010 1899 1912
    • (2010) Br J Pharmacol , vol.161 , pp. 1899-1912
    • Hiramatsu, M.1    Takiguchi, O.2    Nishiyama, A.3    Mori, H.4
  • 79
    • 0029063726 scopus 로고
    • DNA binding and regulatory effects of transcription factors SP1 and USF at the rat amyloid precursor protein gene promoter
    • P.W. Hoffman, and J.M. Chernak DNA binding and regulatory effects of transcription factors SP1 and USF at the rat amyloid precursor protein gene promoter Nucleic Acids Res 23 1995 2229 2235
    • (1995) Nucleic Acids Res , vol.23 , pp. 2229-2235
    • Hoffman, P.W.1    Chernak, J.M.2
  • 80
    • 84871118476 scopus 로고    scopus 로고
    • Pharmacokinetics and tolerability of SRT2104, a first-in-class small molecule activator of SIRT1, after single and repeated oral administration in man
    • E. Hoffmann, J. Wald, S. Lavu, J. Roberts, C. Beaumont, and J. Haddad Pharmacokinetics and tolerability of SRT2104, a first-in-class small molecule activator of SIRT1, after single and repeated oral administration in man Br J Clin Pharmacol 75 2013 186 196
    • (2013) Br J Clin Pharmacol , vol.75 , pp. 186-196
    • Hoffmann, E.1    Wald, J.2    Lavu, S.3    Roberts, J.4    Beaumont, C.5    Haddad, J.6
  • 81
    • 0024083068 scopus 로고
    • Sp1 transcription factor binds DNA and activates transcription even when the binding site is CpG methylated
    • M. Holler, G. Westin, J. Jiricny, and W. Schaffner Sp1 transcription factor binds DNA and activates transcription even when the binding site is CpG methylated Genes Dev 2 1988 1127 1135
    • (1988) Genes Dev , vol.2 , pp. 1127-1135
    • Holler, M.1    Westin, G.2    Jiricny, J.3    Schaffner, W.4
  • 82
    • 29344463643 scopus 로고    scopus 로고
    • Depressive symptoms in Alzheimer's disease: Natural course and temporal relation to function and cognitive status
    • R. Holtzer, N. Scarmeas, D.J. Wegesin, M. Albert, J. Brandt, and B. Dubois Depressive symptoms in Alzheimer's disease: Natural course and temporal relation to function and cognitive status J Am Geriatr Soc 53 2005 2083 2089
    • (2005) J Am Geriatr Soc , vol.53 , pp. 2083-2089
    • Holtzer, R.1    Scarmeas, N.2    Wegesin, D.J.3    Albert, M.4    Brandt, J.5    Dubois, B.6
  • 84
    • 0033499867 scopus 로고    scopus 로고
    • In vivo activity of murine de novo methyltransferases, Dnmt3a and Dnmt3b
    • C.L. Hsieh In vivo activity of murine de novo methyltransferases, Dnmt3a and Dnmt3b Mol Cell Biol 19 1999 8211 8218
    • (1999) Mol Cell Biol , vol.19 , pp. 8211-8218
    • Hsieh, C.L.1
  • 85
    • 84863337843 scopus 로고    scopus 로고
    • Alzheimer mechanisms and therapeutic strategies
    • Y. Huang, and L. Mucke Alzheimer mechanisms and therapeutic strategies Cell 148 2012 1204 1222
    • (2012) Cell , vol.148 , pp. 1204-1222
    • Huang, Y.1    Mucke, L.2
  • 86
    • 79958265915 scopus 로고    scopus 로고
    • After the grape rush: Sirtuins as epigenetic drug targets in neurodegenerative disorders
    • K. Huber, and G. Superti-Furga After the grape rush: Sirtuins as epigenetic drug targets in neurodegenerative disorders Bioorg Med Chem 19 2011 3616 3624
    • (2011) Bioorg Med Chem , vol.19 , pp. 3616-3624
    • Huber, K.1    Superti-Furga, G.2
  • 87
    • 0032543684 scopus 로고    scopus 로고
    • Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17
    • M. Hutton, C.L. Lendon, P. Rizzu, M. Baker, S. Froelich, and H. Houlden Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17 Nature 393 1998 702 705
    • (1998) Nature , vol.393 , pp. 702-705
    • Hutton, M.1    Lendon, C.L.2    Rizzu, P.3    Baker, M.4    Froelich, S.5    Houlden, H.6
  • 90
    • 0037372003 scopus 로고    scopus 로고
    • Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals
    • (Suppl.)
    • R. Jaenisch, and A. Bird Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals Nat Genet 33 2003 245 254 (Suppl.)
    • (2003) Nat Genet , vol.33 , pp. 245-254
    • Jaenisch, R.1    Bird, A.2
  • 91
    • 0036527775 scopus 로고    scopus 로고
    • Histone-deacetylase inhibitors: Novel drugs for the treatment of cancer
    • R.W. Johnstone Histone-deacetylase inhibitors: Novel drugs for the treatment of cancer Nat Rev Drug Discov 1 2002 287 299
    • (2002) Nat Rev Drug Discov , vol.1 , pp. 287-299
    • Johnstone, R.W.1
  • 94
    • 84877921767 scopus 로고    scopus 로고
    • Potential of chromatin modifying compounds for the treatment of Alzheimer's disease
    • T.C. Karagiannis, and K. Ververis Potential of chromatin modifying compounds for the treatment of Alzheimer's disease Pathobiol Aging Age Relat Dis 2 2012
    • (2012) Pathobiol Aging Age Relat Dis , vol.2
    • Karagiannis, T.C.1    Ververis, K.2
  • 96
    • 76749091005 scopus 로고    scopus 로고
    • Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease
    • M. Kilgore, C.A. Miller, D.M. Fass, K.M. Hennig, S.J. Haggarty, and J.D. Sweatt Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease Neuropsychopharmacology 35 2010 870 880
    • (2010) Neuropsychopharmacology , vol.35 , pp. 870-880
    • Kilgore, M.1    Miller, C.A.2    Fass, D.M.3    Hennig, K.M.4    Haggarty, S.J.5    Sweatt, J.D.6
  • 97
    • 34447308268 scopus 로고    scopus 로고
    • SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis
    • D. Kim, M.D. Nguyen, M.M. Dobbin, A. Fischer, F. Sananbenesi, and J.T. Rodgers SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis EMBO J 26 2007 3169 3179
    • (2007) EMBO J , vol.26 , pp. 3169-3179
    • Kim, D.1    Nguyen, M.D.2    Dobbin, M.M.3    Fischer, A.4    Sananbenesi, F.5    Rodgers, J.T.6
  • 98
    • 84867836211 scopus 로고    scopus 로고
    • Romidepsin: A histone deacetylase inhibitor for refractory cutaneous T-cell lymphoma
    • M. Kim, L.A. Thompson, S.D. Wenger, and C.L. O'Bryant Romidepsin: a histone deacetylase inhibitor for refractory cutaneous T-cell lymphoma Ann Pharmacother 46 2012 1340 1348
    • (2012) Ann Pharmacother , vol.46 , pp. 1340-1348
    • Kim, M.1    Thompson, L.A.2    Wenger, S.D.3    O'Bryant, C.L.4
  • 99
    • 0036318310 scopus 로고    scopus 로고
    • Regulation of transcription of the Dnmt1 gene by Sp1 and Sp3 zinc finger proteins
    • S. Kishikawa, T. Murata, H. Kimura, K. Shiota, and K.K. Yokoyama Regulation of transcription of the Dnmt1 gene by Sp1 and Sp3 zinc finger proteins Eur J Biochem 269 2002 2961 2970
    • (2002) Eur J Biochem , vol.269 , pp. 2961-2970
    • Kishikawa, S.1    Murata, T.2    Kimura, H.3    Shiota, K.4    Yokoyama, K.K.5
  • 100
    • 32344450824 scopus 로고    scopus 로고
    • Genomic DNA methylation: The mark and its mediators
    • R.J. Klose, and A.P. Bird Genomic DNA methylation: The mark and its mediators Trends Biochem Sci 31 2006 89 97
    • (2006) Trends Biochem Sci , vol.31 , pp. 89-97
    • Klose, R.J.1    Bird, A.P.2
  • 101
    • 0034861499 scopus 로고    scopus 로고
    • An open-label, 24-week pilot study of the methyl donor betaine in Alzheimer disease patients
    • D. Knopman, and M. Patterson An open-label, 24-week pilot study of the methyl donor betaine in Alzheimer disease patients Alzheimer Dis Assoc Disord 15 2001 162 165
    • (2001) Alzheimer Dis Assoc Disord , vol.15 , pp. 162-165
    • Knopman, D.1    Patterson, M.2
  • 102
    • 77950202526 scopus 로고    scopus 로고
    • Manipulating the brain with epigenetics
    • E. Korzus Manipulating the brain with epigenetics Nat Neurosci 13 2010 405 406
    • (2010) Nat Neurosci , vol.13 , pp. 405-406
    • Korzus, E.1
  • 103
    • 2942731425 scopus 로고    scopus 로고
    • CBP histone acetyltransferase activity is a critical component of memory consolidation
    • E. Korzus, M.G. Rosenfeld, and M. Mayford CBP histone acetyltransferase activity is a critical component of memory consolidation Neuron 42 2004 961 972
    • (2004) Neuron , vol.42 , pp. 961-972
    • Korzus, E.1    Rosenfeld, M.G.2    Mayford, M.3
  • 104
    • 84867263831 scopus 로고    scopus 로고
    • Exposure to enriched environments during adolescence prevents abnormal behaviours associated with histone deacetylation in phencyclidine-treated mice
    • T. Koseki, A. Mouri, T. Mamiya, Y. Aoyama, K. Toriumi, and S. Suzuki Exposure to enriched environments during adolescence prevents abnormal behaviours associated with histone deacetylation in phencyclidine-treated mice Int J Neuropsychopharmacol 15 2012 1489 1501
    • (2012) Int J Neuropsychopharmacol , vol.15 , pp. 1489-1501
    • Koseki, T.1    Mouri, A.2    Mamiya, T.3    Aoyama, Y.4    Toriumi, K.5    Suzuki, S.6
  • 105
    • 33847076849 scopus 로고    scopus 로고
    • Chromatin modifications and their function
    • T. Kouzarides Chromatin modifications and their function Cell 128 2007 693 705
    • (2007) Cell , vol.128 , pp. 693-705
    • Kouzarides, T.1
  • 106
    • 0037925520 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2
    • O.H. Kramer, P. Zhu, H.P. Ostendorff, M. Golebiewski, J. Tiefenbach, and M.A. Peters The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2 EMBO J 22 2003 3411 3420
    • (2003) EMBO J , vol.22 , pp. 3411-3420
    • Kramer, O.H.1    Zhu, P.2    Ostendorff, H.P.3    Golebiewski, M.4    Tiefenbach, J.5    Peters, M.A.6
  • 108
    • 70350432817 scopus 로고    scopus 로고
    • The LEARn model: An epigenetic explanation for idiopathic neurobiological diseases
    • D.K. Lahiri, B. Maloney, and N.H. Zawia The LEARn model: An epigenetic explanation for idiopathic neurobiological diseases Mol Psychiatry 14 2009 992 1003
    • (2009) Mol Psychiatry , vol.14 , pp. 992-1003
    • Lahiri, D.K.1    Maloney, B.2    Zawia, N.H.3
  • 109
    • 56049100240 scopus 로고    scopus 로고
    • Early-life events may trigger biochemical pathways for Alzheimer's disease: The "lEARn" model
    • D.K. Lahiri, N.H. Zawia, N.H. Greig, K. Sambamurti, and B. Maloney Early-life events may trigger biochemical pathways for Alzheimer's disease: the "LEARn" model Biogerontology 9 2008 375 379
    • (2008) Biogerontology , vol.9 , pp. 375-379
    • Lahiri, D.K.1    Zawia, N.H.2    Greig, N.H.3    Sambamurti, K.4    Maloney, B.5
  • 112
    • 33744920106 scopus 로고    scopus 로고
    • Evidence that DNA (cytosine-5) methyltransferase regulates synaptic plasticity in the hippocampus
    • J.M. Levenson, T.L. Roth, F.D. Lubin, C.A. Miller, I.C. Huang, and P. Desai Evidence that DNA (cytosine-5) methyltransferase regulates synaptic plasticity in the hippocampus J Biol Chem 281 2006 15763 15773
    • (2006) J Biol Chem , vol.281 , pp. 15763-15773
    • Levenson, J.M.1    Roth, T.L.2    Lubin, F.D.3    Miller, C.A.4    Huang, I.C.5    Desai, P.6
  • 113
    • 84857368903 scopus 로고    scopus 로고
    • Effects of S-adenosylmethionine augmentation of serotonin-reuptake inhibitor antidepressants on cognitive symptoms of major depressive disorder
    • Y. Levkovitz, J.E. Alpert, C.E. Brintz, D. Mischoulon, and G.I. Papakostas Effects of S-adenosylmethionine augmentation of serotonin-reuptake inhibitor antidepressants on cognitive symptoms of major depressive disorder J Affect Disord 136 2012 1174 1178
    • (2012) J Affect Disord , vol.136 , pp. 1174-1178
    • Levkovitz, Y.1    Alpert, J.E.2    Brintz, C.E.3    Mischoulon, D.4    Papakostas, G.I.5
  • 114
    • 0035503597 scopus 로고    scopus 로고
    • The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse
    • G.P. Lim, T. Chu, F. Yang, W. Beech, S.A. Frautschy, and G.M. Cole The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse J Neurosci 21 2001 8370 8377
    • (2001) J Neurosci , vol.21 , pp. 8370-8377
    • Lim, G.P.1    Chu, T.2    Yang, F.3    Beech, W.4    Frautschy, S.A.5    Cole, G.M.6
  • 115
    • 44449134663 scopus 로고    scopus 로고
    • Gene-environment interactions and epigenetic basis of human diseases
    • L. Liu, Y. Li, and T.O. Tollefsbol Gene-environment interactions and epigenetic basis of human diseases Curr Issues Mol Biol 10 2008 25 36
    • (2008) Curr Issues Mol Biol , vol.10 , pp. 25-36
    • Liu, L.1    Li, Y.2    Tollefsbol, T.O.3
  • 116
  • 117
    • 0036931742 scopus 로고    scopus 로고
    • Neuroprotective properties of valproate: Potential benefit for AD and tauopathies
    • R. Loy, and P.N. Tariot Neuroprotective properties of valproate: potential benefit for AD and tauopathies J Mol Neurosci 19 2002 303 307
    • (2002) J Mol Neurosci , vol.19 , pp. 303-307
    • Loy, R.1    Tariot, P.N.2
  • 118
    • 78650012970 scopus 로고    scopus 로고
    • To selectivity and beyond
    • G.S. Mack To selectivity and beyond Nat Biotechnol 28 2010 1259 1266
    • (2010) Nat Biotechnol , vol.28 , pp. 1259-1266
    • MacK, G.S.1
  • 119
    • 36148950997 scopus 로고    scopus 로고
    • FDA approval summary: Vorinostat for treatment of advanced primary cutaneous T-cell lymphoma
    • B.S. Mann, J.R. Johnson, M.H. Cohen, R. Justice, and R. Pazdur FDA approval summary: vorinostat for treatment of advanced primary cutaneous T-cell lymphoma Oncologist 12 2007 1247 1252
    • (2007) Oncologist , vol.12 , pp. 1247-1252
    • Mann, B.S.1    Johnson, J.R.2    Cohen, M.H.3    Justice, R.4    Pazdur, R.5
  • 121
    • 84860791082 scopus 로고    scopus 로고
    • Why schizophrenia genetics needs epigenetics: A review
    • N.P. Maric, and D.M. Svrakic Why schizophrenia genetics needs epigenetics: a review Psychiatr Danub 24 2012 2 18
    • (2012) Psychiatr Danub , vol.24 , pp. 2-18
    • Maric, N.P.1    Svrakic, D.M.2
  • 122
    • 2942748204 scopus 로고    scopus 로고
    • To learn better, keep the HAT on
    • K.C. Martin, and Y.E. Sun To learn better, keep the HAT on Neuron 42 2004 879 881
    • (2004) Neuron , vol.42 , pp. 879-881
    • Martin, K.C.1    Sun, Y.E.2
  • 125
    • 68949096744 scopus 로고    scopus 로고
    • Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease
    • D. Mastroeni, A. McKee, A. Grover, J. Rogers, and P.D. Coleman Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease PLoS One 4 2009 e6617
    • (2009) PLoS One , vol.4 , pp. 6617
    • Mastroeni, D.1    McKee, A.2    Grover, A.3    Rogers, J.4    Coleman, P.D.5
  • 126
    • 0026570528 scopus 로고
    • Beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
    • M.P. Mattson, B. Cheng, D. Davis, K. Bryant, I. Lieberburg, and R.E. Rydel beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity J Neurosci 12 1992 376 389
    • (1992) J Neurosci , vol.12 , pp. 376-389
    • Mattson, M.P.1    Cheng, B.2    Davis, D.3    Bryant, K.4    Lieberburg, I.5    Rydel, R.E.6
  • 127
    • 79251487813 scopus 로고    scopus 로고
    • The epigenetic landscape of addiction
    • I. Maze, and E.J. Nestler The epigenetic landscape of addiction Ann N Y Acad Sci 1216 2011 99 113
    • (2011) Ann N y Acad Sci , vol.1216 , pp. 99-113
    • Maze, I.1    Nestler, E.J.2
  • 129
    • 79958766982 scopus 로고    scopus 로고
    • Toward an integrated genetic and epigenetic approach to Alzheimer's disease
    • J. Mill Toward an integrated genetic and epigenetic approach to Alzheimer's disease Neurobiol Aging 32 2011 1188 1191
    • (2011) Neurobiol Aging , vol.32 , pp. 1188-1191
    • Mill, J.1
  • 130
    • 41649096261 scopus 로고    scopus 로고
    • DNA methylation and histone acetylation work in concert to regulate memory formation and synaptic plasticity
    • C.A. Miller, S.L. Campbell, and J.D. Sweatt DNA methylation and histone acetylation work in concert to regulate memory formation and synaptic plasticity Neurobiol Learn Mem 89 2008 599 603
    • (2008) Neurobiol Learn Mem , vol.89 , pp. 599-603
    • Miller, C.A.1    Campbell, S.L.2    Sweatt, J.D.3
  • 131
    • 33847614418 scopus 로고    scopus 로고
    • Covalent modification of DNA regulates memory formation
    • C.A. Miller, and J.D. Sweatt Covalent modification of DNA regulates memory formation Neuron 53 2007 857 869
    • (2007) Neuron , vol.53 , pp. 857-869
    • Miller, C.A.1    Sweatt, J.D.2
  • 132
    • 77957001697 scopus 로고    scopus 로고
    • Acetylation of tau inhibits its degradation and contributes to tauopathy
    • S.W. Min, S.H. Cho, Y. Zhou, S. Schroeder, V. Haroutunian, and W.W. Seeley Acetylation of tau inhibits its degradation and contributes to tauopathy Neuron 67 2010 953 966
    • (2010) Neuron , vol.67 , pp. 953-966
    • Min, S.W.1    Cho, S.H.2    Zhou, Y.3    Schroeder, S.4    Haroutunian, V.5    Seeley, W.W.6
  • 133
    • 80355125163 scopus 로고    scopus 로고
    • Effects of betaine on lipopolysaccharide-induced memory impairment in mice and the involvement of GABA transporter 2
    • M. Miwa, M. Tsuboi, Y. Noguchi, A. Enokishima, T. Nabeshima, and M. Hiramatsu Effects of betaine on lipopolysaccharide-induced memory impairment in mice and the involvement of GABA transporter 2 J Neuroinflammation 8 2011 153
    • (2011) J Neuroinflammation , vol.8 , pp. 153
    • Miwa, M.1    Tsuboi, M.2    Noguchi, Y.3    Enokishima, A.4    Nabeshima, T.5    Hiramatsu, M.6
  • 134
    • 84857094316 scopus 로고    scopus 로고
    • Advancing neuroscience through epigenetics: Molecular mechanisms of learning and memory
    • D.L. Molfese Advancing neuroscience through epigenetics: Molecular mechanisms of learning and memory Dev Neuropsychol 36 2011 810 827
    • (2011) Dev Neuropsychol , vol.36 , pp. 810-827
    • Molfese, D.L.1
  • 135
    • 33646683567 scopus 로고    scopus 로고
    • MeCP2 dysfunction in Rett syndrome and related disorders
    • P. Moretti, and H.Y. Zoghbi MeCP2 dysfunction in Rett syndrome and related disorders Curr Opin Genet Dev 16 2006 276 281
    • (2006) Curr Opin Genet Dev , vol.16 , pp. 276-281
    • Moretti, P.1    Zoghbi, H.Y.2
  • 136
    • 0029799427 scopus 로고    scopus 로고
    • Brain S-adenosylmethionine levels are severely decreased in Alzheimer's disease
    • L.D. Morrison, D.D. Smith, and S.J. Kish Brain S-adenosylmethionine levels are severely decreased in Alzheimer's disease J Neurochem 67 1996 1328 1331
    • (1996) J Neurochem , vol.67 , pp. 1328-1331
    • Morrison, L.D.1    Smith, D.D.2    Kish, S.J.3
  • 139
    • 0032574977 scopus 로고    scopus 로고
    • Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
    • X. Nan, H.H. Ng, C.A. Johnson, C.D. Laherty, B.M. Turner, and R.N. Eisenman Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex Nature 393 1998 386 389
    • (1998) Nature , vol.393 , pp. 386-389
    • Nan, X.1    Ng, H.H.2    Johnson, C.A.3    Laherty, C.D.4    Turner, B.M.5    Eisenman, R.N.6
  • 142
    • 84869869682 scopus 로고    scopus 로고
    • HDAC inhibitor-based therapies: Can we interpret the code?
    • M. New, H. Olzscha, and N.B. La Thangue HDAC inhibitor-based therapies: Can we interpret the code? Mol Oncol 6 2012 637 656
    • (2012) Mol Oncol , vol.6 , pp. 637-656
    • New, M.1    Olzscha, H.2    La Thangue, N.B.3
  • 143
    • 77955803943 scopus 로고    scopus 로고
    • Global methylation profiling of lymphoblastoid cell lines reveals epigenetic contributions to autism spectrum disorders and a novel autism candidate gene, RORA, whose protein product is reduced in autistic brain
    • A. Nguyen, T.A. Rauch, G.P. Pfeifer, and V.W. Hu Global methylation profiling of lymphoblastoid cell lines reveals epigenetic contributions to autism spectrum disorders and a novel autism candidate gene, RORA, whose protein product is reduced in autistic brain FASEB J 24 2010 3036 3051
    • (2010) FASEB J , vol.24 , pp. 3036-3051
    • Nguyen, A.1    Rauch, T.A.2    Pfeifer, G.P.3    Hu, V.W.4
  • 144
    • 77953312769 scopus 로고    scopus 로고
    • Joint genome-wide profiling of miRNA and mRNA expression in Alzheimer's disease cortex reveals altered miRNA regulation
    • J. Nunez-Iglesias, C.C. Liu, T.E. Morgan, C.E. Finch, and X.J. Zhou Joint genome-wide profiling of miRNA and mRNA expression in Alzheimer's disease cortex reveals altered miRNA regulation PLoS One 5 2010 e8898
    • (2010) PLoS One , vol.5 , pp. 8898
    • Nunez-Iglesias, J.1    Liu, C.C.2    Morgan, T.E.3    Finch, C.E.4    Zhou, X.J.5
  • 145
    • 0033018277 scopus 로고    scopus 로고
    • Truncated CBP protein leads to classical Rubinstein-Taybi syndrome phenotypes in mice: Implications for a dominant-negative mechanism
    • Y. Oike, A. Hata, T. Mamiya, T. Kaname, Y. Noda, and M. Suzuki Truncated CBP protein leads to classical Rubinstein-Taybi syndrome phenotypes in mice: Implications for a dominant-negative mechanism Hum Mol Genet 8 1999 387 396
    • (1999) Hum Mol Genet , vol.8 , pp. 387-396
    • Oike, Y.1    Hata, A.2    Mamiya, T.3    Kaname, T.4    Noda, Y.5    Suzuki, M.6
  • 146
    • 0033615717 scopus 로고    scopus 로고
    • DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
    • M. Okano, D.W. Bell, D.A. Haber, and E. Li DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development Cell 99 1999 247 257
    • (1999) Cell , vol.99 , pp. 247-257
    • Okano, M.1    Bell, D.W.2    Haber, D.A.3    Li, E.4
  • 147
    • 84864461542 scopus 로고    scopus 로고
    • Rescue of aging-associated decline in Dnmt3a2 expression restores cognitive abilities
    • A.M. Oliveira, T.J. Hemstedt, and H. Bading Rescue of aging-associated decline in Dnmt3a2 expression restores cognitive abilities Nat Neurosci 15 2012 1111 1113
    • (2012) Nat Neurosci , vol.15 , pp. 1111-1113
    • Oliveira, A.M.1    Hemstedt, T.J.2    Bading, H.3
  • 148
    • 84864053192 scopus 로고    scopus 로고
    • Decreased 5-hydroxymethylcytosine is associated with neural progenitor phenotype in normal brain and shorter survival in malignant glioma
    • B.A. Orr, M.C. Haffner, W.G. Nelson, S. Yegnasubramanian, and C.G. Eberhart Decreased 5-hydroxymethylcytosine is associated with neural progenitor phenotype in normal brain and shorter survival in malignant glioma PLoS One 7 2012 e41036
    • (2012) PLoS One , vol.7 , pp. 41036
    • Orr, B.A.1    Haffner, M.C.2    Nelson, W.G.3    Yegnasubramanian, S.4    Eberhart, C.G.5
  • 149
    • 43749121572 scopus 로고    scopus 로고
    • Therapeutic role of sirtuins in neurodegenerative disease
    • T.F. Outeiro, O. Marques, and A. Kazantsev Therapeutic role of sirtuins in neurodegenerative disease Biochim Biophys Acta 1782 2008 363 369
    • (2008) Biochim Biophys Acta , vol.1782 , pp. 363-369
    • Outeiro, T.F.1    Marques, O.2    Kazantsev, A.3
  • 150
    • 6044256118 scopus 로고    scopus 로고
    • Histones and histone modifications
    • C.L. Peterson, and M.A. Laniel Histones and histone modifications Curr Biol 14 2004 R546 R551
    • (2004) Curr Biol , vol.14
    • Peterson, C.L.1    Laniel, M.A.2
  • 151
    • 0029022770 scopus 로고
    • Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP
    • F. Petrij, R.H. Giles, H.G. Dauwerse, J.J. Saris, R.C. Hennekam, and M. Masuno Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP Nature 376 1995 348 351
    • (1995) Nature , vol.376 , pp. 348-351
    • Petrij, F.1    Giles, R.H.2    Dauwerse, H.G.3    Saris, J.J.4    Hennekam, R.C.5    Masuno, M.6
  • 152
    • 0035965343 scopus 로고    scopus 로고
    • Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen
    • C.J. Phiel, F. Zhang, E.Y. Huang, M.G. Guenther, M.A. Lazar, and P.S. Klein Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen J Biol Chem 276 2001 36734 36741
    • (2001) J Biol Chem , vol.276 , pp. 36734-36741
    • Phiel, C.J.1    Zhang, F.2    Huang, E.Y.3    Guenther, M.G.4    Lazar, M.A.5    Klein, P.S.6
  • 153
    • 0026507460 scopus 로고
    • The expression of the amyloid precursor protein (APP) is regulated by two GC-elements in the promoter
    • P. Pollwein, C.L. Masters, and K. Beyreuther The expression of the amyloid precursor protein (APP) is regulated by two GC-elements in the promoter Nucleic Acids Res 20 1992 63 68
    • (1992) Nucleic Acids Res , vol.20 , pp. 63-68
    • Pollwein, P.1    Masters, C.L.2    Beyreuther, K.3
  • 154
    • 77952585703 scopus 로고    scopus 로고
    • MicroRNAs as a molecular basis for mental retardation, Alzheimer's and prion diseases
    • P. Provost MicroRNAs as a molecular basis for mental retardation, Alzheimer's and prion diseases Brain Res 1338 2010 58 66
    • (2010) Brain Res , vol.1338 , pp. 58-66
    • Provost, P.1
  • 155
    • 77952887283 scopus 로고    scopus 로고
    • Epigenetic mechanisms underlying human epileptic disorders and the process of epileptogenesis
    • I.A. Qureshi, and M.F. Mehler Epigenetic mechanisms underlying human epileptic disorders and the process of epileptogenesis Neurobiol Dis 39 2010 53 60
    • (2010) Neurobiol Dis , vol.39 , pp. 53-60
    • Qureshi, I.A.1    Mehler, M.F.2
  • 156
    • 82455212997 scopus 로고    scopus 로고
    • Sirtuins in neurodegenerative diseases: A biological-chemical perspective
    • A. Raghavan, and Z.A. Shah Sirtuins in neurodegenerative diseases: A biological-chemical perspective Neurodegener Dis 9 2012 1 10
    • (2012) Neurodegener Dis , vol.9 , pp. 1-10
    • Raghavan, A.1    Shah, Z.A.2
  • 158
    • 84867901639 scopus 로고    scopus 로고
    • Oral curcumin for Alzheimer's disease: Tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study
    • J.M. Ringman, S.A. Frautschy, E. Teng, A.N. Begum, J. Bardens, and M. Beigi Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study Alzheimers Res Ther 4 2012 43
    • (2012) Alzheimers Res Ther , vol.4 , pp. 43
    • Ringman, J.M.1    Frautschy, S.A.2    Teng, E.3    Begum, A.N.4    Bardens, J.5    Beigi, M.6
  • 159
    • 0028169984 scopus 로고
    • The upstream promoter of the beta-amyloid precursor protein gene (APP) shows differential patterns of methylation in human brain
    • E.I. Rogaev, W.J. Lukiw, O. Lavrushina, E.A. Rogaeva, and P.H. St George-Hyslop The upstream promoter of the beta-amyloid precursor protein gene (APP) shows differential patterns of methylation in human brain Genomics 22 1994 340 347
    • (1994) Genomics , vol.22 , pp. 340-347
    • Rogaev, E.I.1    Lukiw, W.J.2    Lavrushina, O.3    Rogaeva, E.A.4    St George-Hyslop, P.H.5
  • 160
    • 27744593088 scopus 로고    scopus 로고
    • Epidemiology of and risk factors for psychosis of Alzheimer's disease: A review of 55 studies published from 1990 to 2003
    • S.A. Ropacki, and D.V. Jeste Epidemiology of and risk factors for psychosis of Alzheimer's disease: A review of 55 studies published from 1990 to 2003 Am J Psychiatry 162 2005 2022 2030
    • (2005) Am J Psychiatry , vol.162 , pp. 2022-2030
    • Ropacki, S.A.1    Jeste, D.V.2
  • 161
    • 73649208151 scopus 로고
    • Broad thumbs and toes and facial abnormalities. A possible mental retardation syndrome
    • J.H. Rubinstein, and H. Taybi Broad thumbs and toes and facial abnormalities. A possible mental retardation syndrome Am J Dis Child 105 1963 588 608
    • (1963) Am J Dis Child , vol.105 , pp. 588-608
    • Rubinstein, J.H.1    Taybi, H.2
  • 162
    • 0037464488 scopus 로고    scopus 로고
    • Presenilin 1 gene silencing by S-adenosylmethionine: A treatment for Alzheimer disease?
    • S. Scarpa, A. Fuso, F. D'Anselmi, and R.A. Cavallaro Presenilin 1 gene silencing by S-adenosylmethionine: A treatment for Alzheimer disease? FEBS Lett 541 2003 145 148
    • (2003) FEBS Lett , vol.541 , pp. 145-148
    • Scarpa, S.1    Fuso, A.2    D'Anselmi, F.3    Cavallaro, R.A.4
  • 163
    • 84867888439 scopus 로고    scopus 로고
    • Decoding the non-coding RNAs in Alzheimer's disease
    • N. Schonrock, and J. Gotz Decoding the non-coding RNAs in Alzheimer's disease Cell Mol Life Sci 69 2012 3543 3559
    • (2012) Cell Mol Life Sci , vol.69 , pp. 3543-3559
    • Schonrock, N.1    Gotz, J.2
  • 164
    • 34250161829 scopus 로고    scopus 로고
    • Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse
    • F.A. Schroeder, C.L. Lin, W.E. Crusio, and S. Akbarian Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse Biol Psychiatry 62 2007 55 64
    • (2007) Biol Psychiatry , vol.62 , pp. 55-64
    • Schroeder, F.A.1    Lin, C.L.2    Crusio, W.E.3    Akbarian, S.4
  • 165
    • 0027367764 scopus 로고
    • Physiological production of the beta-amyloid protein and the mechanism of Alzheimer's disease
    • D.J. Selkoe Physiological production of the beta-amyloid protein and the mechanism of Alzheimer's disease Trends Neurosci 16 1993 403 409
    • (1993) Trends Neurosci , vol.16 , pp. 403-409
    • Selkoe, D.J.1
  • 166
    • 84866456583 scopus 로고    scopus 로고
    • Preventing Alzheimer's disease
    • D.J. Selkoe Preventing Alzheimer's disease Science 337 2012 1488 1492
    • (2012) Science , vol.337 , pp. 1488-1492
    • Selkoe, D.J.1
  • 167
    • 78649891582 scopus 로고    scopus 로고
    • Tuning acetylation levels with HAT activators: Therapeutic strategy in neurodegenerative diseases
    • B.R. Selvi, J.C. Cassel, T.K. Kundu, and A.L. Boutillier Tuning acetylation levels with HAT activators: Therapeutic strategy in neurodegenerative diseases Biochim Biophys Acta 1799 2010 840 853
    • (2010) Biochim Biophys Acta , vol.1799 , pp. 840-853
    • Selvi, B.R.1    Cassel, J.C.2    Kundu, T.K.3    Boutillier, A.L.4
  • 168
    • 0032530145 scopus 로고    scopus 로고
    • Phosphorylation of tau at both Thr 231 and ser 262 is required for maximal inhibition of its binding to microtubules
    • A. Sengupta, J. Kabat, M. Novak, Q. Wu, I. Grundke-Iqbal, and K. Iqbal Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules Arch Biochem Biophys 357 1998 299 309
    • (1998) Arch Biochem Biophys , vol.357 , pp. 299-309
    • Sengupta, A.1    Kabat, J.2    Novak, M.3    Wu, Q.4    Grundke-Iqbal, I.5    Iqbal, K.6
  • 170
    • 0036917867 scopus 로고    scopus 로고
    • Rett syndrome and MeCP2: Linking epigenetics and neuronal function
    • M.D. Shahbazian, and H.Y. Zoghbi Rett syndrome and MeCP2: Linking epigenetics and neuronal function Am J Hum Genet 71 2002 1259 1272
    • (2002) Am J Hum Genet , vol.71 , pp. 1259-1272
    • Shahbazian, M.D.1    Zoghbi, H.Y.2
  • 171
    • 0029004341 scopus 로고
    • Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
    • R. Sherrington, E.I. Rogaev, Y. Liang, E.A. Rogaeva, G. Levesque, and M. Ikeda Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease Nature 375 1995 754 760
    • (1995) Nature , vol.375 , pp. 754-760
    • Sherrington, R.1    Rogaev, E.I.2    Liang, Y.3    Rogaeva, E.A.4    Levesque, G.5    Ikeda, M.6
  • 172
    • 33847169885 scopus 로고    scopus 로고
    • Decreased Abeta secretion by cells expressing familial Alzheimer's disease-linked mutant presenilin 1
    • M. Shimojo, N. Sahara, M. Murayama, H. Ichinose, and A. Takashima Decreased Abeta secretion by cells expressing familial Alzheimer's disease-linked mutant presenilin 1 Neurosci Res 57 2007 446 453
    • (2007) Neurosci Res , vol.57 , pp. 446-453
    • Shimojo, M.1    Sahara, N.2    Murayama, M.3    Ichinose, H.4    Takashima, A.5
  • 173
    • 0026760261 scopus 로고
    • Production of the Alzheimer amyloid beta protein by normal proteolytic processing
    • M. Shoji, T.E. Golde, J. Ghiso, T.T. Cheung, S. Estus, and L.M. Shaffer Production of the Alzheimer amyloid beta protein by normal proteolytic processing Science 258 1992 126 129
    • (1992) Science , vol.258 , pp. 126-129
    • Shoji, M.1    Golde, T.E.2    Ghiso, J.3    Cheung, T.T.4    Estus, S.5    Shaffer, L.M.6
  • 174
    • 41149090082 scopus 로고    scopus 로고
    • DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons
    • K.D. Siegmund, C.M. Connor, M. Campan, T.I. Long, D.J. Weisenberger, and D. Biniszkiewicz DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons PLoS One 2 2007 e895
    • (2007) PLoS One , vol.2 , pp. 895
    • Siegmund, K.D.1    Connor, C.M.2    Campan, M.3    Long, T.I.4    Weisenberger, D.J.5    Biniszkiewicz, D.6
  • 176
    • 79956098248 scopus 로고    scopus 로고
    • Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
    • R.A. Sperling, P.S. Aisen, L.A. Beckett, D.A. Bennett, S. Craft, and A.M. Fagan Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease Alzheimers Dement 7 2011 280 292
    • (2011) Alzheimers Dement , vol.7 , pp. 280-292
    • Sperling, R.A.1    Aisen, P.S.2    Beckett, L.A.3    Bennett, D.A.4    Craft, S.5    Fagan, A.M.6
  • 177
    • 84865987956 scopus 로고    scopus 로고
    • Inhibition of sirtuin 2 with sulfobenzoic acid derivative AK1 is non-toxic and potentially neuroprotective in a mouse model of frontotemporal dementia
    • T.L. Spires-Jones, L.M. Fox, A. Rozkalne, R. Pitstick, G.A. Carlson, and A.G. Kazantsev Inhibition of sirtuin 2 with sulfobenzoic acid derivative AK1 is non-toxic and potentially neuroprotective in a mouse model of frontotemporal dementia Front Pharmacol 3 2012 42
    • (2012) Front Pharmacol , vol.3 , pp. 42
    • Spires-Jones, T.L.1    Fox, L.M.2    Rozkalne, A.3    Pitstick, R.4    Carlson, G.A.5    Kazantsev, A.G.6
  • 178
    • 83455218662 scopus 로고    scopus 로고
    • Sirtuin 1 (SIRT1): The misunderstood HDAC
    • W. Stunkel, and R.M. Campbell Sirtuin 1 (SIRT1): The misunderstood HDAC J Biomol Screen 16 2011 1153 1169
    • (2011) J Biomol Screen , vol.16 , pp. 1153-1169
    • Stunkel, W.1    Campbell, R.M.2
  • 179
    • 2642552331 scopus 로고    scopus 로고
    • Lithium, a common drug for bipolar disorder treatment, regulates amyloid-beta precursor protein processing
    • Y. Su, J. Ryder, B. Li, X. Wu, N. Fox, and P. Solenberg Lithium, a common drug for bipolar disorder treatment, regulates amyloid-beta precursor protein processing Biochemistry 43 2004 6899 6908
    • (2004) Biochemistry , vol.43 , pp. 6899-6908
    • Su, Y.1    Ryder, J.2    Li, B.3    Wu, X.4    Fox, N.5    Solenberg, P.6
  • 180
  • 181
    • 79955134157 scopus 로고    scopus 로고
    • Epigenetic mechanisms in memory and synaptic function
    • F.A. Sultan, and J.J. Day Epigenetic mechanisms in memory and synaptic function Epigenomics 3 2011 157 181
    • (2011) Epigenomics , vol.3 , pp. 157-181
    • Sultan, F.A.1    Day, J.J.2
  • 182
    • 84868549261 scopus 로고    scopus 로고
    • Mercaptoacetamide-based class II HDAC inhibitor lowers Abeta levels and improves learning and memory in a mouse model of Alzheimer's disease
    • Y.M. Sung, T. Lee, H. Yoon, A.M. Dibattista, J.M. Song, and Y. Sohn Mercaptoacetamide-based class II HDAC inhibitor lowers Abeta levels and improves learning and memory in a mouse model of Alzheimer's disease Exp Neurol 239 2013 192 201
    • (2013) Exp Neurol , vol.239 , pp. 192-201
    • Sung, Y.M.1    Lee, T.2    Yoon, H.3    Dibattista, A.M.4    Song, J.M.5    Sohn, Y.6
  • 183
    • 82255192294 scopus 로고    scopus 로고
    • 5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging
    • K.E. Szulwach, X. Li, Y. Li, C.X. Song, H. Wu, and Q. Dai 5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging Nat Neurosci 14 2011 1607 1616
    • (2011) Nat Neurosci , vol.14 , pp. 1607-1616
    • Szulwach, K.E.1    Li, X.2    Li, Y.3    Song, C.X.4    Wu, H.5    Dai, Q.6
  • 186
    • 79953191540 scopus 로고    scopus 로고
    • Prodynorphin CpG-SNPs associated with alcohol dependence: Elevated methylation in the brain of human alcoholics
    • M.M. Taqi, I. Bazov, H. Watanabe, D. Sheedy, C. Harper, and K. Alkass Prodynorphin CpG-SNPs associated with alcohol dependence: Elevated methylation in the brain of human alcoholics Addict Biol 16 2011 499 509
    • (2011) Addict Biol , vol.16 , pp. 499-509
    • Taqi, M.M.1    Bazov, I.2    Watanabe, H.3    Sheedy, D.4    Harper, C.5    Alkass, K.6
  • 188
    • 0033052929 scopus 로고    scopus 로고
    • Reduction with age in methylcytosine in the promoter region -224 approximately -101 of the amyloid precursor protein gene in autopsy human cortex
    • H. Tohgi, K. Utsugisawa, Y. Nagane, M. Yoshimura, Y. Genda, and M. Ukitsu Reduction with age in methylcytosine in the promoter region -224 approximately -101 of the amyloid precursor protein gene in autopsy human cortex Brain Res Mol Brain Res 70 1999 288 292
    • (1999) Brain Res Mol Brain Res , vol.70 , pp. 288-292
    • Tohgi, H.1    Utsugisawa, K.2    Nagane, Y.3    Yoshimura, M.4    Genda, Y.5    Ukitsu, M.6
  • 189
    • 79955663447 scopus 로고    scopus 로고
    • When will Alzheimer's disease be cured? A pharmaceutical perspective
    • M. Townsend When will Alzheimer's disease be cured? A pharmaceutical perspective J Alzheimers Dis 24 Suppl. 2 2011 43 52
    • (2011) J Alzheimers Dis , vol.24 , Issue.SUPPL. 2 , pp. 43-52
    • Townsend, M.1
  • 190
    • 84872287771 scopus 로고    scopus 로고
    • Efficacy of cognitive enhancers for Alzheimer's disease: Protocol for a systematic review and network meta-analysis
    • A.C. Tricco, S. Vandervaart, C. Soobiah, E. Lillie, L. Perrier, and M.H. Chen Efficacy of cognitive enhancers for Alzheimer's disease: Protocol for a systematic review and network meta-analysis Syst Rev 1 2012 31
    • (2012) Syst Rev , vol.1 , pp. 31
    • Tricco, A.C.1    Vandervaart, S.2    Soobiah, C.3    Lillie, E.4    Perrier, L.5    Chen, M.H.6
  • 191
    • 20844459491 scopus 로고    scopus 로고
    • Pilot study of the reducing effect on amyloidosis in vivo by three FDA pre-approved drugs via the Alzheimer's APP 5′ untranslated region
    • S. Tucker, M. Ahl, A. Bush, D. Westaway, X. Huang, and J.T. Rogers Pilot study of the reducing effect on amyloidosis in vivo by three FDA pre-approved drugs via the Alzheimer's APP 5′ untranslated region Curr Alzheimer Res 2 2005 249 254
    • (2005) Curr Alzheimer Res , vol.2 , pp. 249-254
    • Tucker, S.1    Ahl, M.2    Bush, A.3    Westaway, D.4    Huang, X.5    Rogers, J.T.6
  • 192
    • 33745602472 scopus 로고    scopus 로고
    • RNA therapeutics directed to the non coding regions of APP mRNA, in vivo anti-amyloid efficacy of paroxetine, erythromycin, and N-acetyl cysteine
    • S. Tucker, M. Ahl, H.H. Cho, S. Bandyopadhyay, G.D. Cuny, and A.I. Bush RNA therapeutics directed to the non coding regions of APP mRNA, in vivo anti-amyloid efficacy of paroxetine, erythromycin, and N-acetyl cysteine Curr Alzheimer Res 3 2006 221 227
    • (2006) Curr Alzheimer Res , vol.3 , pp. 221-227
    • Tucker, S.1    Ahl, M.2    Cho, H.H.3    Bandyopadhyay, S.4    Cuny, G.D.5    Bush, A.I.6
  • 193
    • 34250026412 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activation
    • C.G. Vecsey, J.D. Hawk, K.M. Lattal, J.M. Stein, S.A. Fabian, and M.A. Attner Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activation J Neurosci 27 2007 6128 6140
    • (2007) J Neurosci , vol.27 , pp. 6128-6140
    • Vecsey, C.G.1    Hawk, J.D.2    Lattal, K.M.3    Stein, J.M.4    Fabian, S.A.5    Attner, M.A.6
  • 194
    • 77953319294 scopus 로고    scopus 로고
    • MicroRNA-101 regulates amyloid precursor protein expression in hippocampal neurons
    • E. Vilardo, C. Barbato, M. Ciotti, C. Cogoni, and F. Ruberti MicroRNA-101 regulates amyloid precursor protein expression in hippocampal neurons J Biol Chem 285 2010 18344 18351
    • (2010) J Biol Chem , vol.285 , pp. 18344-18351
    • Vilardo, E.1    Barbato, C.2    Ciotti, M.3    Cogoni, C.4    Ruberti, F.5
  • 195
    • 77953421120 scopus 로고    scopus 로고
    • The role of Sirt1: At the crossroad between promotion of longevity and protection against Alzheimer's disease neuropathology
    • J. Wang, H. Fivecoat, L. Ho, Y. Pan, E. Ling, and G.M. Pasinetti The role of Sirt1: At the crossroad between promotion of longevity and protection against Alzheimer's disease neuropathology Biochim Biophys Acta 1804 2010 1690 1694
    • (2010) Biochim Biophys Acta , vol.1804 , pp. 1690-1694
    • Wang, J.1    Fivecoat, H.2    Ho, L.3    Pan, Y.4    Ling, E.5    Pasinetti, G.M.6
  • 196
    • 49949108971 scopus 로고    scopus 로고
    • Age-specific epigenetic drift in late-onset Alzheimer's disease
    • S.C. Wang, B. Oelze, and A. Schumacher Age-specific epigenetic drift in late-onset Alzheimer's disease PLoS One 3 2008 e2698
    • (2008) PLoS One , vol.3 , pp. 2698
    • Wang, S.C.1    Oelze, B.2    Schumacher, A.3
  • 197
    • 38749095507 scopus 로고    scopus 로고
    • The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1
    • W.X. Wang, B.W. Rajeev, A.J. Stromberg, N. Ren, G. Tang, and Q. Huang The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1 J Neurosci 28 2008 1213 1223
    • (2008) J Neurosci , vol.28 , pp. 1213-1223
    • Wang, W.X.1    Rajeev, B.W.2    Stromberg, A.J.3    Ren, N.4    Tang, G.5    Huang, Q.6
  • 198
    • 33745153095 scopus 로고    scopus 로고
    • Cilostazol protects against brain white matter damage and cognitive impairment in a rat model of chronic cerebral hypoperfusion
    • T. Watanabe, N. Zhang, M. Liu, R. Tanaka, Y. Mizuno, and T. Urabe Cilostazol protects against brain white matter damage and cognitive impairment in a rat model of chronic cerebral hypoperfusion Stroke 37 2006 1539 1545
    • (2006) Stroke , vol.37 , pp. 1539-1545
    • Watanabe, T.1    Zhang, N.2    Liu, M.3    Tanaka, R.4    Mizuno, Y.5    Urabe, T.6
  • 199
    • 0037131401 scopus 로고    scopus 로고
    • Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning
    • E.J. Weeber, U. Beffert, C. Jones, J.M. Christian, E. Forster, and J.D. Sweatt Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning J Biol Chem 277 2002 39944 39952
    • (2002) J Biol Chem , vol.277 , pp. 39944-39952
    • Weeber, E.J.1    Beffert, U.2    Jones, C.3    Christian, J.M.4    Forster, E.5    Sweatt, J.D.6
  • 201
    • 0029440466 scopus 로고
    • Hypomethylation of the amyloid precursor protein gene in the brain of an Alzheimer's disease patient
    • R.L. West, J.M. Lee, and L.E. Maroun Hypomethylation of the amyloid precursor protein gene in the brain of an Alzheimer's disease patient J Mol Neurosci 6 1995 141 146
    • (1995) J Mol Neurosci , vol.6 , pp. 141-146
    • West, R.L.1    Lee, J.M.2    Maroun, L.E.3
  • 202
    • 17144374869 scopus 로고    scopus 로고
    • Transgenic mice expressing a truncated form of CREB-binding protein (CBP) exhibit deficits in hippocampal synaptic plasticity and memory storage
    • M.A. Wood, M.P. Kaplan, A. Park, E.J. Blanchard, A.M. Oliveira, and T.L. Lombardi Transgenic mice expressing a truncated form of CREB-binding protein (CBP) exhibit deficits in hippocampal synaptic plasticity and memory storage Learn Mem 12 2005 111 119
    • (2005) Learn Mem , vol.12 , pp. 111-119
    • Wood, M.A.1    Kaplan, M.P.2    Park, A.3    Blanchard, E.J.4    Oliveira, A.M.5    Lombardi, T.L.6
  • 203
    • 38149024924 scopus 로고    scopus 로고
    • Alzheimer's disease (AD)-like pathology in aged monkeys after infantile exposure to environmental metal lead (Pb): Evidence for a developmental origin and environmental link for AD
    • J. Wu, M.R. Basha, B. Brock, D.P. Cox, F. Cardozo-Pelaez, and C.A. McPherson Alzheimer's disease (AD)-like pathology in aged monkeys after infantile exposure to environmental metal lead (Pb): Evidence for a developmental origin and environmental link for AD J Neurosci 28 2008 3 9
    • (2008) J Neurosci , vol.28 , pp. 3-9
    • Wu, J.1    Basha, M.R.2    Brock, B.3    Cox, D.P.4    Cardozo-Pelaez, F.5    McPherson, C.A.6
  • 204
    • 40749117651 scopus 로고    scopus 로고
    • The environment, epigenetics and amyloidogenesis
    • J. Wu, M.R. Basha, and N.H. Zawia The environment, epigenetics and amyloidogenesis J Mol Neurosci 34 2008 1 7
    • (2008) J Mol Neurosci , vol.34 , pp. 1-7
    • Wu, J.1    Basha, M.R.2    Zawia, N.H.3
  • 205
    • 34547864236 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Molecular mechanisms of action
    • W.S. Xu, R.B. Parmigiani, and P.A. Marks Histone deacetylase inhibitors: Molecular mechanisms of action Oncogene 26 2007 5541 5552
    • (2007) Oncogene , vol.26 , pp. 5541-5552
    • Xu, W.S.1    Parmigiani, R.B.2    Marks, P.A.3
  • 206
    • 20044370990 scopus 로고    scopus 로고
    • Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo
    • F. Yang, G.P. Lim, A.N. Begum, O.J. Ubeda, M.R. Simmons, and S.S. Ambegaokar Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo J Biol Chem 280 2005 5892 5901
    • (2005) J Biol Chem , vol.280 , pp. 5892-5901
    • Yang, F.1    Lim, G.P.2    Begum, A.N.3    Ubeda, O.J.4    Simmons, M.R.5    Ambegaokar, S.S.6
  • 208
    • 31844433942 scopus 로고    scopus 로고
    • Environmental risk factors and the developmental basis for Alzheimer's disease
    • N.H. Zawia, and M.R. Basha Environmental risk factors and the developmental basis for Alzheimer's disease Rev Neurosci 16 2005 325 337
    • (2005) Rev Neurosci , vol.16 , pp. 325-337
    • Zawia, N.H.1    Basha, M.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.