MeCP2, a key contributor to neurological disease, activates and represses transcription

Science

Volumn 320, Issue 5880, 2008, Pages 1224-1229

  Chahrour, Maria ^a   Sung, Yun Jung ^a   Shaw, Chad ^a   Zhou, Xiaobo ^b   Wong, Stephen T C ^b   Qin, Jun ^a   Zoghbi, Huda Y ^a,c  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c TEXAS CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DNA; METHYL CPG BINDING PROTEIN 2; CREB1 PROTEIN, MOUSE; MECP2 PROTEIN, MOUSE; NERVE PROTEIN; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR;

GENE EXPRESSION; MOLECULAR ANALYSIS; NEUROLOGY; PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; BINDING SITE; DEVELOPMENTAL DISORDER; GENE DOSAGE; GENE EXPRESSION; GENE REPRESSION; HYPOTHALAMUS; MOUSE; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RETT SYNDROME; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; DISEASE MODEL; DNA MICROARRAY; GENE EXPRESSION REGULATION; GENETICS; HYPOTHALAMUS DISEASE; MALE; METABOLISM; PHYSIOLOGY; PROTEIN BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSACTIVATION;

MUS;

ANIMALS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HYPOTHALAMIC DISEASES; HYPOTHALAMUS; MALE; METHYL-CPG-BINDING PROTEIN 2; MICE; MICE, INBRED C57BL; NERVE TISSUE PROTEINS; NERVOUS SYSTEM DISEASES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEIN BINDING; REPRESSOR PROTEINS; RETT SYNDROME; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS;

EID: 45849105557     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1153252     Document Type: Article

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24. We thank members of the Zoghbi laboratory for their thoughtful comments, Z. Yin for technical assistance, M. Shinawi and A. Tawil for technical advice, Y. Klisch for the art work, and J. Lim, J. Neul, and M. Greenberg for reagents. The Baylor College of Medicine Microarray Core Facility performed the microarray experiments. This work was funded by NIH/National Institute of Neurological Disorders and Stroke grant NS057819 (H.Z.), National Institute of Child Health and Human Development Mental Retardation and Developmental Disabilities Research Center HD024064 (H.Z.), the International Rett Syndrome Foundation, and the Simons Foundation. H.Z. is a Howard Hughes Medical Institute investigator. The microarray data have been deposited in the National Center for Biotechnology Information Gene Expression Omnibus (GEO) (www.ncbi.nlm.nih.gov/geo) and are accessible through GEO Series accession number GSE11150.