Reduction with age in methylcytosine in the promoter region -224~-101 of the amyloid precursor protein gene in autopsy human cortex

Molecular Brain Research

Volumn 70, Issue 2, 1999, Pages 288-292

  Tohgi, Hideo ^a   Utsugisawa, Kimiaki ^a   Nagane, Yuriko ^a   Yoshimura, Masahiro ^b   Genda, Yasuko ^a   Ukitsu, Miyuki ^a  

^a IWATE MEDICAL UNIVERSITY   (Japan)

^b Kyoto Municipal Zoo   (Japan)

Author keywords

Amyloid precursor protein gene; Brain; DNA methylcytosine; Promoter

Indexed keywords

AMYLOID; AMYLOID PRECURSOR PROTEIN; METHYLCYTOSINE; UNCLASSIFIED DRUG;

AGING; AUTOPSY; BRAIN CORTEX; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; METHYLATION; PRIORITY JOURNAL; PROMOTER REGION; SHORT SURVEY; TRANSCRIPTION REGULATION;

EID: 0033052929     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(99)00163-1     Document Type: Article

References (27)

1. Araki E., Shimada F., Uzawa H., Mori M., Ebina Y. Characterization of the promoter region of the human insulin receptor gene. Evidence for promoter activity. J. Biol. Chem. 262:1987;16186-16191.
2. Bendotti C., Forloni G.L., Morgan R.A., O'Hara B.F., Oster-Granite M.L., Reeves R.H., Gearhart J.D., Coyle J.T. Neuroanatomical localization and quantification of amyloid precursor protein mRNA by in situ hybridization in the brains of normal, aneuploid, and lesioned mice. Proc. Natl. Acad. Sci. U.S.A. 85:1988;3628-3632.
3. Cedar H., Razin A. DNA methylation and development. Biochim. Biophys. Acta. 1049:1990;1-8.
4. Clark S.J., Harrison J., Paul C.L., Frommer M. High sensitivity mapping of methylated cytosines. Nucl. Acids Res. 22:1994;2990-2997.
5. Cooney C.A. Are somatic cells inherently deficient in methylation metabolism? A proposed mechanism for DNA methylation loss, senescence aging. Growth Dev. Aging. 57:1993;261-273.
6. Frommer M., McDonald L.E., Millar D.S., Collis C.M., Watt F., Grigg G.W., Molloy P.L., Paul C.L. A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands. Proc. Natl. Acad. Sci. U.S.A. 89:1992;1827-1831.
7. J.W. Gaubatz, Genomic instability during aging of postmitotic mammalian cells, in: A. Macierira-Coelho (Ed.), Molecular Basis of Aging, CRC Press, Boca Raton, 1995, pp. 71-135.
8. Holliday R.A. A new theory of carcinogenesis. Br. J. Cancer. 40:1979;513-522.
9. Iguchi-Ariga S., Schaffner W. CpG methylation of the cAMP-responsive enhancer/promoter sequence TGACGTCA abolishes specific factor binding as well as transcriptional activation. Genes Dev. 3:1989;612-619.
10. Jaenisch R., Jahner D. Methylation, expression and chromosomal position of genes in mammals. Biochim. Biophys. Acta. 782:1984;1-9.
11. La Fauci G., Lahiri D.K., Salton S.R., Robakis N.K. Characterization of the 5′-end region and the first two exons of the beta-protein precursor gene. Biochem. Biophys. Res. Commun. 159:1989;297-304.
12. Levine A., Cantoni G.L., Razin A. Inhibition of promoter activity by methylation: possible involvement of protein mediators. Proc. Natl. Acad. Sci. U.S.A. 88:1991;6515-6518.
13. Levine A., Cantoni G.L., Razin A. Methylation in the preinitiation domain suppresses gene transcription by an indirect mechanism. Proc. Natl. Acad. Sci. U.S.A. 89:1992;10119-10123.
14. Milici A., Salbaum J.M., Beyereuther K. Study of the Alzheimer's A4 precursor gene promoter region by genomic sequencing using Taq polymerase. Biochim. Biophys. Res. Commun. 169:1990;46-50.
15. O'Hara B.F., Fisher S., Oster-Granite M.L., Gearhart J.D., Reeves R.H. Developmental expression of the amyloid precursor protein, growth-associated protein 43, and somatostatin in normal and trisomy 16 mice. Dev. Brain Res. 49:1989;300-304.
16. Platt T. Transcription termination and the regulation of gene expression. Annu. Rev. Biochem. 55:1986;339-372.
17. Pollwein P., Masters C.L., Beyreuther K. The expression of the amyloid precursor protein (APP) is regulated by two GC-elements in the promoter. Nucl. Acids Res. 20:1992;63-68.
18. W.W. Quitschke, D. Goldgaber, Transcriptional control of amyloid β-protein precursor expression, in: A. Goate, F. Ashall (Ed.), Pathobiology of Alzheimer's Disease, Academic Press, San Diego, pp. 79-98.
19. Quitschke W.W. Two nuclear factor binding domains activate expression from the human amyloid beta-protein precursor promoter. J. Biol. Chem. 269:1994;21229-21233.
20. Raizis A.M., Schmitt F., Jost J.P. A bisulfite method of 5-methylcytosine mapping that minimizes template degradation. Anal. Biochem. 226:1995;161-166.
21. Riggs A.D., Jones P.A. 5-Methylcytosine, gene regulation, and cancer. Adv. Cancer Res. 40:1983;1-30.
22. Salbaum J.M., Weidemann A., Lemaire H.G., Masters C.L., Beyreuther K. The promoter of Alzheimer's disease amyloid A4 precursor gene. EMBO J. 7:1988;2807-2813.
23. B.E. Tomlinson, G. Henderson, Some quantitative cerebral findings in normal and demented old people, In: R.D. Terry, S. Gershon (Eds.), Neurobiology of Aging, Raven Press, New York, 1976, pp. 183-204.
24. Watt F., Molloy P.L. Cytosine methylation prevents binding to DNA of a HeLa cell transcription factor required for optional expression of the adenovirus major late promoter. Genes Dev. 2:1988;1136-1143.
25. Wilson V.L., Jones P.A. DNA methylation decreases in aging but not in immortal cells. Science. 220:1983;1055-1057.
26. Wilson V.L., Smith R.S., Ma S., Cutler R.G. Genomic 5-methyldeoxycytidine decreases with age. J. Biol. Chem. 262:1987;9948-9951.
27. Wisniewski K.E., Wisniewski H.M., Wen G.Y. Occurrence of neuropathological changes dementia of Alzheimer's disease in Down's syndrome. Ann. Neurol. 17:1985;278-282.