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Volumn 43, Issue 22, 2004, Pages 6899-6908

Lithium, a common drug for bipolar disorder treatment, regulates amyloid-β precursor protein processing

Author keywords

[No Author keywords available]

Indexed keywords

DRUG PRODUCTS; LITHIUM; NEUROLOGY; PATIENT TREATMENT; PROTEINS;

EID: 2642552331     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi035627j     Document Type: Article
Times cited : (298)

References (44)
  • 1
    • 0021572660 scopus 로고
    • The amyloid deposits in Alzheimer's disease: Their nature and pathogenesis
    • Glenner, G. G., Wong, C. W., Quaranta, V., and Eanes, E. D. (1984) The amyloid deposits in Alzheimer's disease: Their nature and pathogenesis, Appl. Pathol. 2 (6), 357-369.
    • (1984) Appl. Pathol. , vol.2 , Issue.6 , pp. 357-369
    • Glenner, G.G.1    Wong, C.W.2    Quaranta, V.3    Eanes, E.D.4
  • 2
    • 0022654027 scopus 로고
    • Isolation of low-molecular-weight proteins from amyloid plaque fibers in Alzheimer's disease
    • Selkoe, D. J., Abraham, C. R., Podlisny, M. B., and Duffy, L. K. (1986) Isolation of low-molecular-weight proteins from amyloid plaque fibers in Alzheimer's disease, J. Neurochem. 46 (6), 1820-1834.
    • (1986) J. Neurochem. , vol.46 , Issue.6 , pp. 1820-1834
    • Selkoe, D.J.1    Abraham, C.R.2    Podlisny, M.B.3    Duffy, L.K.4
  • 3
    • 0038751845 scopus 로고    scopus 로고
    • Secretion and intracellular generation of truncated Aβ in β-site amyloid-β precursor protein-cleaving enzyme expressing human neurons
    • Lee, E. B., Skovronsky, D. M., Abtahian, F., Doms, R. W., and Lee, V. M. (2003) Secretion and intracellular generation of truncated Aβ in β-site amyloid-β precursor protein-cleaving enzyme expressing human neurons, J. Biol. Chem. 278 (7), 4458-4466.
    • (2003) J. Biol. Chem. , vol.278 , Issue.7 , pp. 4458-4466
    • Lee, E.B.1    Skovronsky, D.M.2    Abtahian, F.3    Doms, R.W.4    Lee, V.M.5
  • 4
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • Hardy, J., and Selkoe, D. J. (2002) The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics, Science 297 (5580), 353-356.
    • (2002) Science , vol.297 , Issue.5580 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 5
    • 0000792598 scopus 로고    scopus 로고
    • The transmembrane aspartates in presenilin 1 and 2 are obligatory for γ-secretase activity and amyloid β-protein generation
    • Kimberly, W. T., Xia, W., Rahmati, T., Wolfe, M. S., and Selkoe, D. J. (2000) The transmembrane aspartates in presenilin 1 and 2 are obligatory for γ-secretase activity and amyloid β-protein generation, J. Biol. Chem. 275 (5), 3173-3178.
    • (2000) J. Biol. Chem. , vol.275 , Issue.5 , pp. 3173-3178
    • Kimberly, W.T.1    Xia, W.2    Rahmati, T.3    Wolfe, M.S.4    Selkoe, D.J.5
  • 7
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: Genes, proteins, and therapy
    • Selkoe, D. J. (2001) Alzheimer's disease: Genes, proteins, and therapy, Physiol. Rev. 81 (2), 741-766.
    • (2001) Physiol. Rev. , vol.81 , Issue.2 , pp. 741-766
    • Selkoe, D.J.1
  • 8
    • 0037431082 scopus 로고    scopus 로고
    • Aph-1, Pen-2, and Nicastrin with Presenilin generate an active γ-secretase complex
    • De Strooper, B. (2003) Aph-1, Pen-2, and Nicastrin with Presenilin generate an active γ-secretase complex, Neuron 38 (1), 9-12.
    • (2003) Neuron , vol.38 , Issue.1 , pp. 9-12
    • De Strooper, B.1
  • 10
    • 0034534014 scopus 로고    scopus 로고
    • GSK3 β forms a tetrameric complex with endogenous PS1-CTF/NTF and β-catenin. Effects of the D257/D385A and FAD-linked mutations
    • Tesco, G., and Tanzi, R. E. (2000) GSK3 β forms a tetrameric complex with endogenous PS1-CTF/NTF and β-catenin. Effects of the D257/D385A and FAD-linked mutations, Ann. N.Y. Acad. Sci. 920, 227-232.
    • (2000) Ann. N.Y. Acad. Sci. , vol.920 , pp. 227-232
    • Tesco, G.1    Tanzi, R.E.2
  • 11
    • 0033035485 scopus 로고    scopus 로고
    • Modulation of CNS signal transduction pathways and gene expression by mood-stabilizing agents: Therapeutic implications
    • discussion 40-41 and 113-116
    • Manji, H. K., Bebchuk, J. M., Moore, G. J., Glitz, D., Hasanat, K. A., and Chen, G. (1999) Modulation of CNS signal transduction pathways and gene expression by mood-stabilizing agents: Therapeutic implications, J. Clin. Psychiatry 60 (Suppl 2), 27-39, discussion 40-41 and 113-116.
    • (1999) J. Clin. Psychiatry , vol.60 , Issue.SUPPL. 2 , pp. 27-39
    • Manji, H.K.1    Bebchuk, J.M.2    Moore, G.J.3    Glitz, D.4    Hasanat, K.A.5    Chen, G.6
  • 12
    • 0034859101 scopus 로고    scopus 로고
    • The multifaceted roles of glycogen synthase kinase 3β in cellular signaling
    • Grimes, C. A., and Jope, R. S. (2001) The multifaceted roles of glycogen synthase kinase 3β in cellular signaling, Prog. Neurobiol. 65 (4), 391-426.
    • (2001) Prog. Neurobiol. , vol.65 , Issue.4 , pp. 391-426
    • Grimes, C.A.1    Jope, R.S.2
  • 13
    • 0030868557 scopus 로고    scopus 로고
    • Lithium reduces τ phosphorylation by inhibition of glycogen synthase kinase-3
    • Hong, M., Chen, D. C., Klein, P. S., and Lee, V. M. (1997) Lithium reduces τ phosphorylation by inhibition of glycogen synthase kinase-3, J. Biol. Chem. 272 (40), 25326-25332.
    • (1997) J. Biol. Chem. , vol.272 , Issue.40 , pp. 25326-25332
    • Hong, M.1    Chen, D.C.2    Klein, P.S.3    Lee, V.M.4
  • 15
    • 0029776032 scopus 로고    scopus 로고
    • A molecular mechanism for the effect of lithium on development
    • Klein, P. S., and Melton, D. A. (1996) A molecular mechanism for the effect of lithium on development, Proc. Natl. Acad. Sci. U.S.A. 93 (16), 8455-8459.
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , Issue.16 , pp. 8455-8459
    • Klein, P.S.1    Melton, D.A.2
  • 16
    • 0030449964 scopus 로고    scopus 로고
    • Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signaling in intact cells
    • Stambolic, V., Ruel, L., and Woodgett, J. R. (1996) Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signaling in intact cells, Curr. Biol. 6 (12), 1664-1668.
    • (1996) Curr. Biol. , vol.6 , Issue.12 , pp. 1664-1668
    • Stambolic, V.1    Ruel, L.2    Woodgett, J.R.3
  • 17
    • 0034306450 scopus 로고    scopus 로고
    • Specificity and mechanism of action of some commonly used protein kinase inhibitors
    • Davies, S. P., Reddy, H., Caivano, M., and Cohen, P. (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors, Biochem. J. 351 (Part 1), 95-105.
    • (2000) Biochem. J. , vol.351 , Issue.PART 1 , pp. 95-105
    • Davies, S.P.1    Reddy, H.2    Caivano, M.3    Cohen, P.4
  • 18
    • 0033593573 scopus 로고    scopus 로고
    • Valproate robustly enhances AP-1 mediated gene expression
    • Chen, G., Yuan, P. X., Jiang, Y. M., Huang, L. D., and Manji, H. K. (1999) Valproate robustly enhances AP-1 mediated gene expression, Mol. Brain Res. 64 (1), 52-58.
    • (1999) Mol. Brain Res. , vol.64 , Issue.1 , pp. 52-58
    • Chen, G.1    Yuan, P.X.2    Jiang, Y.M.3    Huang, L.D.4    Manji, H.K.5
  • 19
    • 0024341795 scopus 로고
    • Neural and developmental actions of lithium: A unifying hypothesis
    • Berridge, M. J., Downes, C. P., and Hanley, M. R. (1989) Neural and developmental actions of lithium: A unifying hypothesis, Cell 59 (3), 411-419.
    • (1989) Cell , vol.59 , Issue.3 , pp. 411-419
    • Berridge, M.J.1    Downes, C.P.2    Hanley, M.R.3
  • 20
    • 0019127799 scopus 로고
    • The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain
    • Hallcher, L. M., and Sherman, W. R. (1980) The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain, J. Biol. Chem. 255 (22), 10896-10901.
    • (1980) J. Biol. Chem. , vol.255 , Issue.22 , pp. 10896-10901
    • Hallcher, L.M.1    Sherman, W.R.2
  • 21
    • 0029776032 scopus 로고    scopus 로고
    • A molecular mechanism for the effect of lithium on development
    • Klein, P. S., and Melton, D. A. (1996) A molecular mechanism for the effect of lithium on development, Proc. Natl. Acad. Sci. U.S.A. 93 (16), 8455-8459.
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , Issue.16 , pp. 8455-8459
    • Klein, P.S.1    Melton, D.A.2
  • 23
    • 0027418609 scopus 로고
    • Novel diet consumption and body weight gain are reduced in rats chronically infused with lithium chloride: Mediation by the chemosensifive area postrema
    • Eckel, L. A., and Ossenkopp, K. P. (1993) Novel diet consumption and body weight gain are reduced in rats chronically infused with lithium chloride: Mediation by the chemosensifive area postrema, Brain Res. Bull. 31 (5), 613-619.
    • (1993) Brain Res. Bull. , vol.31 , Issue.5 , pp. 613-619
    • Eckel, L.A.1    Ossenkopp, K.P.2
  • 24
    • 0023754389 scopus 로고
    • Expression and regulation of the pituitary- and placenta-specific human glycoprotein hormone α-subunit gene is restricted to the pituitary in transgenic mice
    • Fox, N., and Solter, D. (1988) Expression and regulation of the pituitary- and placenta-specific human glycoprotein hormone α-subunit gene is restricted to the pituitary in transgenic mice, Mol. Cell. Biol. 8 (12), 5470-5476.
    • (1988) Mol. Cell. Biol. , vol.8 , Issue.12 , pp. 5470-5476
    • Fox, N.1    Solter, D.2
  • 25
  • 26
    • 0035863055 scopus 로고    scopus 로고
    • Age-dependent changes in brain, CSF, and plasma amyloid (β) protein in the Tg2576 transgenic mouse model of Alzheimer's disease
    • Kawarabayashi, T., Younkin, L. H., Saido, T. C., Shoji, M., Ashe, K. H., and Younkin, S. G. (2001) Age-dependent changes in brain, CSF, and plasma amyloid (β) protein in the Tg2576 transgenic mouse model of Alzheimer's disease, J. Neurosci. 21 (2), 372-381.
    • (2001) J. Neurosci. , vol.21 , Issue.2 , pp. 372-381
    • Kawarabayashi, T.1    Younkin, L.H.2    Saido, T.C.3    Shoji, M.4    Ashe, K.H.5    Younkin, S.G.6
  • 27
    • 0038439081 scopus 로고    scopus 로고
    • Regulation of amyloid precursor protein expression and secretion via activation of ERK 1/2 by hepatocyte growth factor in HEK293 cells transfected with APP751
    • Liu, F., Su, Y., Li, B., and Ni, B. (2003) Regulation of amyloid precursor protein expression and secretion via activation of ERK 1/2 by hepatocyte growth factor in HEK293 cells transfected with APP751, Exp. Cell Res. 287 (2), 387-396.
    • (2003) Exp. Cell Res. , vol.287 , Issue.2 , pp. 387-396
    • Liu, F.1    Su, Y.2    Li, B.3    Ni, B.4
  • 28
    • 0029811140 scopus 로고    scopus 로고
    • Expression and characterization of glycogen synthase kinase-3 mutants and their effect on glycogen synthase activity in intact cells
    • Eldar-Finkelman, H., Argast, G. M., Foord, O., Fischer, E. H., and Krebs, E. G. (1996) Expression and characterization of glycogen synthase kinase-3 mutants and their effect on glycogen synthase activity in intact cells, Proc. Natl. Acad. Sci. U.S.A. 93 (19), 10228-10233.
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , Issue.19 , pp. 10228-10233
    • Eldar-Finkelman, H.1    Argast, G.M.2    Foord, O.3    Fischer, E.H.4    Krebs, E.G.5
  • 29
    • 0027168725 scopus 로고
    • Evaluation of 2′-modified oligonucleotides containing 2′-deoxy gaps as antisense inhibitors of gene expression
    • Monia, B. P., Lesnik, E. A., Gonzalez, C., Lima, W. F., McGee, D., Guinosso, C. J., Kawasaki, A. M., Cook, P. D., and Freier, S. M. (1993) Evaluation of 2′-modified oligonucleotides containing 2′-deoxy gaps as antisense inhibitors of gene expression, J. Biol. Chem. 268 (19), 14514-14522.
    • (1993) J. Biol. Chem. , vol.268 , Issue.19 , pp. 14514-14522
    • Monia, B.P.1    Lesnik, E.A.2    Gonzalez, C.3    Lima, W.F.4    McGee, D.5    Guinosso, C.J.6    Kawasaki, A.M.7    Cook, P.D.8    Freier, S.M.9
  • 30
    • 0344011653 scopus 로고    scopus 로고
    • RIFLE: A novel ring zinc finger-leucine-rich repeat containing protein, regulates select cell adhesion molecules in PC12 cells
    • Li, B., Su, Y., Ryder, J., Yan, L., Na, S., and Ni, B. (2003) RIFLE: A novel ring zinc finger-leucine-rich repeat containing protein, regulates select cell adhesion molecules in PC12 cells, J. Cell. Biochem. 90 (6), 1224-1241.
    • (2003) J. Cell. Biochem. , vol.90 , Issue.6 , pp. 1224-1241
    • Li, B.1    Su, Y.2    Ryder, J.3    Yan, L.4    Na, S.5    Ni, B.6
  • 33
    • 0032527597 scopus 로고    scopus 로고
    • Selective deposition of amyloid-β protein in the entorhinal-dentate projection of a transgenic mouse model of Alzheimer's disease
    • Su, Y., and Ni, B. (1998) Selective deposition of amyloid-β protein in the entorhinal-dentate projection of a transgenic mouse model of Alzheimer's disease, J. Neurosci. Res. 53 (2), 177-186.
    • (1998) J. Neurosci. Res. , vol.53 , Issue.2 , pp. 177-186
    • Su, Y.1    Ni, B.2
  • 34
    • 0036122349 scopus 로고    scopus 로고
    • Lithium blocks the PKB and GSK3 dephosphorylation induced by ceramide through protein phosphatase-2A
    • Mora, A., Sabio, G., Risco, A. M., Cuenda, A., Alonso, J. C., Soler, G., and Centeno, F. (2002) Lithium blocks the PKB and GSK3 dephosphorylation induced by ceramide through protein phosphatase-2A, Cell Signalling 14 (6), 557-562.
    • (2002) Cell Signalling , vol.14 , Issue.6 , pp. 557-562
    • Mora, A.1    Sabio, G.2    Risco, A.M.3    Cuenda, A.4    Alonso, J.C.5    Soler, G.6    Centeno, F.7
  • 35
    • 0037155824 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 couples AKT-dependent signaling to the regulation of p21Cip1 degradation
    • Rossig, L., Badorff, C., Holzmann, Y., Zeiher, A. M., and Dimmeler, S. (2002) Glycogen synthase kinase-3 couples AKT-dependent signaling to the regulation of p21Cip1 degradation, J. Biol. Chem. 277 (12), 9684-9689.
    • (2002) J. Biol. Chem. , vol.277 , Issue.12 , pp. 9684-9689
    • Rossig, L.1    Badorff, C.2    Holzmann, Y.3    Zeiher, A.M.4    Dimmeler, S.5
  • 36
    • 0037087220 scopus 로고    scopus 로고
    • Lithium inhibits amyloid secretion in COS7 cells transfected with amyloid precursor protein C100
    • Sun, X., Sato, S., Murayama, O., Murayama, M., Park, J. M., Yamaguchi, H., and Takashima, A. (2002) Lithium inhibits amyloid secretion in COS7 cells transfected with amyloid precursor protein C100, Neurosci. Lett. 321 (1-2), 61-64.
    • (2002) Neurosci. Lett. , vol.321 , Issue.1-2 , pp. 61-64
    • Sun, X.1    Sato, S.2    Murayama, O.3    Murayama, M.4    Park, J.M.5    Yamaguchi, H.6    Takashima, A.7
  • 37
    • 0031930118 scopus 로고    scopus 로고
    • Lithium increases tyrosine hydroxylase levels both in vivo and in vitro
    • Chen, G., Yuan, P. X., Jiang, Y. M., Huang, L. D., and Manji, H. K. (1998) Lithium increases tyrosine hydroxylase levels both in vivo and in vitro, J. Neurochem. 70 (4), 1768-1771.
    • (1998) J. Neurochem. , vol.70 , Issue.4 , pp. 1768-1771
    • Chen, G.1    Yuan, P.X.2    Jiang, Y.M.3    Huang, L.D.4    Manji, H.K.5
  • 38
    • 0038187674 scopus 로고    scopus 로고
    • GSK-3α regulates production of Alzheimer's disease amyloid-β peptides
    • Phiel, C. J., Wilson, C. A., Lee, V. M., and Klein, P. S. (2003) GSK-3α regulates production of Alzheimer's disease amyloid-β peptides, Nature 423 (6938), 435-439.
    • (2003) Nature , vol.423 , Issue.6938 , pp. 435-439
    • Phiel, C.J.1    Wilson, C.A.2    Lee, V.M.3    Klein, P.S.4
  • 39
    • 0030830304 scopus 로고    scopus 로고
    • τ phosphorylation in transgenic mice expressing glycogen synthase kinase-3β transgenes
    • Brownlees, J., Irving, N. G., Brion, J. P., Gibb, B. J., Wagner, U., Woodgett, J., and Miller, C. C. (1997) τ phosphorylation in transgenic mice expressing glycogen synthase kinase-3β transgenes, NeuroReport 8 (15), 3251-3255.
    • (1997) NeuroReport , vol.8 , Issue.15 , pp. 3251-3255
    • Brownlees, J.1    Irving, N.G.2    Brion, J.P.3    Gibb, B.J.4    Wagner, U.5    Woodgett, J.6    Miller, C.C.7
  • 40
    • 0035863188 scopus 로고    scopus 로고
    • Decreased nuclear β-catenin, τ hyperphosphorylation and neurodegeneration in GSK-3β conditional transgenic mice
    • Lucas, J. J., Hernandez, F., Gomez-Ramos, P., Moran, M. A., Hen, R., and Avila, J. (2001) Decreased nuclear β-catenin, τ hyperphosphorylation and neurodegeneration in GSK-3β conditional transgenic mice, EMBO J. 20 (1-2), 27-39.
    • (2001) EMBO J. , vol.20 , Issue.1-2 , pp. 27-39
    • Lucas, J.J.1    Hernandez, F.2    Gomez-Ramos, P.3    Moran, M.A.4    Hen, R.5    Avila, J.6
  • 43
    • 0031149476 scopus 로고    scopus 로고
    • Activation of the Wnt signaling pathway: A molecular mechanism for lithium action
    • Hedgepeth, C. M., Conrad, L. J., Zhang, J., Huang, H. C., Lee, V. M., and Klein, P. S. (1997) Activation of the Wnt signaling pathway: A molecular mechanism for lithium action, Dev. Biol. 185 (1), 82-91.
    • (1997) Dev. Biol. , vol.185 , Issue.1 , pp. 82-91
    • Hedgepeth, C.M.1    Conrad, L.J.2    Zhang, J.3    Huang, H.C.4    Lee, V.M.5    Klein, P.S.6
  • 44
    • 0034718211 scopus 로고    scopus 로고
    • Effects of lithium and insulin on glycogen synthesis in L6 myocytes: Additive effects on inactivation of glycogen synthase kinase-3
    • Choi, W. S., and Sung, C. K. (2000) Effects of lithium and insulin on glycogen synthesis in L6 myocytes: Additive effects on inactivation of glycogen synthase kinase-3, Biochim. Biophys. Acta 1475 (3), 225-230.
    • (2000) Biochim. Biophys. Acta , vol.1475 , Issue.3 , pp. 225-230
    • Choi, W.S.1    Sung, C.K.2


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