메뉴 건너뛰기




Volumn 299, Issue 11, 2008, Pages 1345-1350

Epigenetics at the epicenter of modern medicine

Author keywords

[No Author keywords available]

Indexed keywords

AGING; BECKWITH WIEDEMANN SYNDROME; DEVELOPMENTAL BIOLOGY; DISEASE PREDISPOSITION; DNA SEQUENCE; ENVIRONMENT; EPIGENETICS; GENE ACTIVITY; GENERAL ASPECTS OF DISEASE; GENETIC VARIABILITY; HEREDITY; HUMAN; PHENOTYPE; PRIORITY JOURNAL; PROPHYLAXIS; REVIEW; ARTICLE; GENETIC EPIGENESIS; GENETICS; GENOTYPE; MEDICAL GENETICS;

EID: 40949093544     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.299.11.1345     Document Type: Review
Times cited : (341)

References (40)
  • 1
    • 0036965325 scopus 로고    scopus 로고
    • Van Speybroeck L. From epigenesis to epigenetics: the case of C. H. Waddington. Ann N Y Acad Sci. 2002;981:61-81.
    • Van Speybroeck L. From epigenesis to epigenetics: the case of C. H. Waddington. Ann N Y Acad Sci. 2002;981:61-81.
  • 2
    • 1042278765 scopus 로고    scopus 로고
    • The history of cancer epigenetics
    • Feinberg AP, Tycko B. The history of cancer epigenetics. Nat Rev Cancer. 2004;4(2):143-153.
    • (2004) Nat Rev Cancer , vol.4 , Issue.2 , pp. 143-153
    • Feinberg, A.P.1    Tycko, B.2
  • 3
    • 4444370528 scopus 로고    scopus 로고
    • Alcohol, one-carbon metabolism, and colorectal cancer: Recent insights from molecular studies
    • Giovannucci E. Alcohol, one-carbon metabolism, and colorectal cancer: recent insights from molecular studies. J Nutr. 2004;134(9):2475S-2481S.
    • (2004) J Nutr , vol.134 , Issue.9
    • Giovannucci, E.1
  • 4
    • 34249299791 scopus 로고    scopus 로고
    • The complex language of chromatin regulation during transcription
    • Berger SL. The complex language of chromatin regulation during transcription. Nature. 2007;447(7143):407-412.
    • (2007) Nature , vol.447 , Issue.7143 , pp. 407-412
    • Berger, S.L.1
  • 5
    • 33947693747 scopus 로고    scopus 로고
    • On the use of the word epigenetic
    • Ptashne M. On the use of the word "epigenetic." Curr Biol. 2007;17(7):R233-R236.
    • (2007) Curr Biol , vol.17 , Issue.7
    • Ptashne, M.1
  • 6
    • 0030447943 scopus 로고    scopus 로고
    • The TAF(II) 250 subunit of TFIID has histone acetyltransferase activity
    • Mizzen CA, Yang XJ, Kokubo T, et al. The TAF(II) 250 subunit of TFIID has histone acetyltransferase activity. Cell. 1996;87(7):1261-1270.
    • (1996) Cell , vol.87 , Issue.7 , pp. 1261-1270
    • Mizzen, C.A.1    Yang, X.J.2    Kokubo, T.3
  • 7
    • 0029932598 scopus 로고    scopus 로고
    • A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p
    • Taunton J, Hassig CA, Schreiber SL. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science. 1996;272(5260):408-411.
    • (1996) Science , vol.272 , Issue.5260 , pp. 408-411
    • Taunton, J.1    Hassig, C.A.2    Schreiber, S.L.3
  • 8
    • 33750465872 scopus 로고    scopus 로고
    • SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes
    • Cai S, Lee CC, Kohwi-Shigematsu T. SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes. Nat Genet. 2006;38(11):1278-1288.
    • (2006) Nat Genet , vol.38 , Issue.11 , pp. 1278-1288
    • Cai, S.1    Lee, C.C.2    Kohwi-Shigematsu, T.3
  • 9
    • 33750203582 scopus 로고    scopus 로고
    • Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra-and interchromosomal interactions
    • Zhao Z, Tavoosidana G, Sjolinder M, et al. Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra-and interchromosomal interactions. Nat Genet. 2006;38(11):1341-1347.
    • (2006) Nat Genet , vol.38 , Issue.11 , pp. 1341-1347
    • Zhao, Z.1    Tavoosidana, G.2    Sjolinder, M.3
  • 10
    • 3543018516 scopus 로고    scopus 로고
    • Interaction between differentially methylated regions partitions the imprinted genes Igf2 and H19 into parent-specific chromatin loops
    • Murrell A, Heeson S, Reik W. Interaction between differentially methylated regions partitions the imprinted genes Igf2 and H19 into parent-specific chromatin loops. Nat Genet. 2004;36(8):889-893.
    • (2004) Nat Genet , vol.36 , Issue.8 , pp. 889-893
    • Murrell, A.1    Heeson, S.2    Reik, W.3
  • 11
    • 38049187707 scopus 로고    scopus 로고
    • Reprogramming of human somatic cells to pluripotency with defined factors
    • Park IH, Zhao R, West JA, et al. Reprogramming of human somatic cells to pluripotency with defined factors. Nature. 2008;451(7175):141-146.
    • (2008) Nature , vol.451 , Issue.7175 , pp. 141-146
    • Park, I.H.1    Zhao, R.2    West, J.A.3
  • 12
    • 3543073392 scopus 로고    scopus 로고
    • Reprogramming of a melanoma genome by nuclear transplantation
    • Hochedlinger K, Blelloch R, Brennan C, et al. Reprogramming of a melanoma genome by nuclear transplantation. Genes Dev. 2004;18(15):1875-1885.
    • (2004) Genes Dev , vol.18 , Issue.15 , pp. 1875-1885
    • Hochedlinger, K.1    Blelloch, R.2    Brennan, C.3
  • 13
    • 33646070846 scopus 로고    scopus 로고
    • A bivalent chromatin structure marks key developmental genes in embryonic stem cells
    • Bernstein BE, Mikkelsen TS, Xie X, et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell. 2006;125(2):315-326.
    • (2006) Cell , vol.125 , Issue.2 , pp. 315-326
    • Bernstein, B.E.1    Mikkelsen, T.S.2    Xie, X.3
  • 14
    • 0020699979 scopus 로고
    • Hypomethylation distinguishes genes of some human cancers from their normal counterparts
    • Feinberg AP, Vogelstein B. Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature. 1983;301(5895):89-92.
    • (1983) Nature , vol.301 , Issue.5895 , pp. 89-92
    • Feinberg, A.P.1    Vogelstein, B.2
  • 15
    • 30144433414 scopus 로고    scopus 로고
    • Hypomethylation-linked activation of PAX2 mediates tamoxifen-stimulated endometrial carcinogenesis
    • Wu H, Chen Y, Liang J, et al. Hypomethylation-linked activation of PAX2 mediates tamoxifen-stimulated endometrial carcinogenesis. Nature. 2005;438(7070):981-987.
    • (2005) Nature , vol.438 , Issue.7070 , pp. 981-987
    • Wu, H.1    Chen, Y.2    Liang, J.3
  • 16
    • 16844384464 scopus 로고    scopus 로고
    • Discovery of aberrant expression of R-RAS by cancer-linked DNA hypomethylation in gastric cancer using microarrays
    • Nishigaki M, Aoyagi K, Danjoh I, et al. Discovery of aberrant expression of R-RAS by cancer-linked DNA hypomethylation in gastric cancer using microarrays. Cancer Res. 2005;65(6):2115-2124.
    • (2005) Cancer Res , vol.65 , Issue.6 , pp. 2115-2124
    • Nishigaki, M.1    Aoyagi, K.2    Danjoh, I.3
  • 17
    • 0042674172 scopus 로고    scopus 로고
    • Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma
    • Sato N, Maitra A, Fukushima N, et al. Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma. Cancer Res. 2003;63(14):4158-4166.
    • (2003) Cancer Res , vol.63 , Issue.14 , pp. 4158-4166
    • Sato, N.1    Maitra, A.2    Fukushima, N.3
  • 18
    • 0032830639 scopus 로고    scopus 로고
    • Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2
    • Amir RE, Van den Veyver IB, Wan M, Tran CQ, Francke U, Zoghbi HY. Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nat Genet. 1999;23(2):185-188.
    • (1999) Nat Genet , vol.23 , Issue.2 , pp. 185-188
    • Amir, R.E.1    Van den Veyver, I.B.2    Wan, M.3    Tran, C.Q.4    Francke, U.5    Zoghbi, H.Y.6
  • 19
    • 0033547330 scopus 로고    scopus 로고
    • Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene
    • Xu GL, Bestor TH, Bourc'his D, et al. Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene. Nature. 1999;402(6758):187-191.
    • (1999) Nature , vol.402 , Issue.6758 , pp. 187-191
    • Xu, G.L.1    Bestor, T.H.2    Bourc'his, D.3
  • 20
    • 34249275353 scopus 로고    scopus 로고
    • Phenotypic plasticity and the epigenetics of human disease
    • Feinberg AP. Phenotypic plasticity and the epigenetics of human disease. Nature. 2007;447(7143):443-440.
    • (2007) Nature , vol.447 , Issue.7143 , pp. 443-440
    • Feinberg, A.P.1
  • 21
    • 3242663659 scopus 로고    scopus 로고
    • An integrated epigenetic and genetic approach to common human disease
    • Bjornsson HT, Fallin MD, Feinberg AP. An integrated epigenetic and genetic approach to common human disease. Trends Genet. 2004;20(8):350-358.
    • (2004) Trends Genet , vol.20 , Issue.8 , pp. 350-358
    • Bjornsson, H.T.1    Fallin, M.D.2    Feinberg, A.P.3
  • 22
    • 0043093697 scopus 로고    scopus 로고
    • Transposable elements: Targets for early nutritional effects on epigenetic gene regulation
    • Waterland RA, Jirtle RL. Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol. 2003;23(15):5293-5300.
    • (2003) Mol Cell Biol , vol.23 , Issue.15 , pp. 5293-5300
    • Waterland, R.A.1    Jirtle, R.L.2
  • 23
    • 0021368041 scopus 로고
    • Hypomethylation of hepatic nuclear DNA in rats fed with a carcinogenic methyl-deficient diet
    • Wilson MJ, Shivapurkar N, Poirier LA. Hypomethylation of hepatic nuclear DNA in rats fed with a carcinogenic methyl-deficient diet. Biochem J. 1984;218(3):987-990.
    • (1984) Biochem J , vol.218 , Issue.3 , pp. 987-990
    • Wilson, M.J.1    Shivapurkar, N.2    Poirier, L.A.3
  • 24
    • 33746525415 scopus 로고    scopus 로고
    • Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways
    • Lehner B, Crombie C, Tischler J, Fortunato A, Fraser AG. Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways. Nat Genet. 2006;38(8):896-903.
    • (2006) Nat Genet , vol.38 , Issue.8 , pp. 896-903
    • Lehner, B.1    Crombie, C.2    Tischler, J.3    Fortunato, A.4    Fraser, A.G.5
  • 25
    • 0032569851 scopus 로고    scopus 로고
    • Hsp90 as a capacitor for morphological evolution
    • Rutherford SL, Lindquist S. Hsp90 as a capacitor for morphological evolution. Nature. 1998;396(6709):336-342.
    • (1998) Nature , vol.396 , Issue.6709 , pp. 336-342
    • Rutherford, S.L.1    Lindquist, S.2
  • 26
    • 0037228526 scopus 로고    scopus 로고
    • Evidence for an epigenetic mechanism by which Hsp90 acts as a capacitor for morphological evolution
    • Sollars V, Lu X, Xiao L, Wang X, Garfinkel MD, Ruden DM. Evidence for an epigenetic mechanism by which Hsp90 acts as a capacitor for morphological evolution. Nat Genet. 2003;33(1):70-74.
    • (2003) Nat Genet , vol.33 , Issue.1 , pp. 70-74
    • Sollars, V.1    Lu, X.2    Xiao, L.3    Wang, X.4    Garfinkel, M.D.5    Ruden, D.M.6
  • 27
    • 23044514669 scopus 로고    scopus 로고
    • Epigenetic differences arise during the lifetime of monozygotic twins
    • Fraga MF, Ballestar E, Paz MF, et al. Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci U S A. 2005;102(30):10604-10609.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , Issue.30 , pp. 10604-10609
    • Fraga, M.F.1    Ballestar, E.2    Paz, M.F.3
  • 28
    • 33751505540 scopus 로고    scopus 로고
    • DNA methylation profiling of human chromosomes 6, 20 and 22
    • Eckhardt F, Lewin J, Cortese R, et al. DNA methylation profiling of human chromosomes 6, 20 and 22. Nat Genet. 2006;38(12):1378-1385.
    • (2006) Nat Genet , vol.38 , Issue.12 , pp. 1378-1385
    • Eckhardt, F.1    Lewin, J.2    Cortese, R.3
  • 29
    • 0036182963 scopus 로고    scopus 로고
    • Epigenetic alterations of H19 and LIT1 distinguish patients with Beckwith-Wiedemann syndrome with cancer and birth defects
    • DeBaun MR, Niemitz EL, McNeil DE, Brandenburg SA, Lee MP, Feinberg AP. Epigenetic alterations of H19 and LIT1 distinguish patients with Beckwith-Wiedemann syndrome with cancer and birth defects. Am J Hum Genet. 2002;70(3):604-611.
    • (2002) Am J Hum Genet , vol.70 , Issue.3 , pp. 604-611
    • DeBaun, M.R.1    Niemitz, E.L.2    McNeil, D.E.3    Brandenburg, S.A.4    Lee, M.P.5    Feinberg, A.P.6
  • 30
    • 0025633582 scopus 로고
    • Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms
    • Malkin D, Li FP, Strong LC, et al. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science. 1990;250 (4985):1233-1238.
    • (1990) Science , vol.250 , Issue.4985 , pp. 1233-1238
    • Malkin, D.1    Li, F.P.2    Strong, L.C.3
  • 31
    • 0023529174 scopus 로고
    • Takamatsu memorial lecture: Rare cancers: clues to genetic mechanisms
    • Knudson AG Jr. Prince Takamatsu memorial lecture: rare cancers: clues to genetic mechanisms. Princess Takamatsu Symp. 1987;18:221-231.
    • (1987) Princess Takamatsu Symp , vol.18 , pp. 221-231
    • Prince Jr., K.A.G.1
  • 32
    • 0037436509 scopus 로고    scopus 로고
    • Loss of IGF2 imprinting: A potential marker of colorectal cancer risk
    • Cui H, Cruz-Correa M, Giardiello FM, et al. Loss of IGF2 imprinting: a potential marker of colorectal cancer risk. Science. 2003;299(5613):1753- 1755.
    • (2003) Science , vol.299 , Issue.5613 , pp. 1753-1755
    • Cui, H.1    Cruz-Correa, M.2    Giardiello, F.M.3
  • 33
    • 0035930134 scopus 로고    scopus 로고
    • Loss of imprinting of insulin-like growth factor-II (IGF2) gene in distinguishing specific biologic subtypes of Wilms tumor
    • Ravenel JD, Broman KW, Perlman EJ, et al. Loss of imprinting of insulin-like growth factor-II (IGF2) gene in distinguishing specific biologic subtypes of Wilms tumor. J Natl Cancer Inst. 2001;93(22):1698-1703.
    • (2001) J Natl Cancer Inst , vol.93 , Issue.22 , pp. 1698-1703
    • Ravenel, J.D.1    Broman, K.W.2    Perlman, E.J.3
  • 34
    • 41149099132 scopus 로고    scopus 로고
    • Comprehensive high-throughput arrays for restriction endonuclease-based methylation (CHARM)
    • In press
    • Irizarry RA, Ladd-Acosta C, Carvalho B, et al. Comprehensive high-throughput arrays for restriction endonuclease-based methylation (CHARM). Genome Res. In press.
    • Genome Res
    • Irizarry, R.A.1    Ladd-Acosta, C.2    Carvalho, B.3
  • 35
    • 33746756014 scopus 로고    scopus 로고
    • Comparative isoschizomer profiling of cytosine methylation: The HELP assay
    • Khulan B, Thompson RF, Ye K, et al. Comparative isoschizomer profiling of cytosine methylation: the HELP assay. Genome Res. 2006;16(8):1046-1055.
    • (2006) Genome Res , vol.16 , Issue.8 , pp. 1046-1055
    • Khulan, B.1    Thompson, R.F.2    Ye, K.3
  • 36
    • 23044514626 scopus 로고    scopus 로고
    • Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells
    • Weber M, Davies JJ, Wittig D, et al. Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells. Nat Genet. 2005;37(8):853-862.
    • (2005) Nat Genet , vol.37 , Issue.8 , pp. 853-862
    • Weber, M.1    Davies, J.J.2    Wittig, D.3
  • 37
    • 29144535324 scopus 로고    scopus 로고
    • Clinical experience with decitabine in North American patients with myelodysplastic syndrome
    • Yee KW, Jabbour E, Kantarjian HM, Giles FJ. Clinical experience with decitabine in North American patients with myelodysplastic syndrome. Ann Hematol. 2005;84(suppl 1):18-24.
    • (2005) Ann Hematol , vol.84 , Issue.SUPPL. 1 , pp. 18-24
    • Yee, K.W.1    Jabbour, E.2    Kantarjian, H.M.3    Giles, F.J.4
  • 38
    • 5444227862 scopus 로고    scopus 로고
    • Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach
    • Gius D, Cui H, Bradbury CM, et al. Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach. Cancer Cell. 2004;6(4):361-371.
    • (2004) Cancer Cell , vol.6 , Issue.4 , pp. 361-371
    • Gius, D.1    Cui, H.2    Bradbury, C.M.3
  • 39
    • 38049170553 scopus 로고    scopus 로고
    • Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk
    • Kaneda A, Wang CJ, Cheong R, et al. Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk. Proc Natl Acad Sci U S A. 2007;104(52):20926-20931.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.52 , pp. 20926-20931
    • Kaneda, A.1    Wang, C.J.2    Cheong, R.3
  • 40
    • 41149084107 scopus 로고    scopus 로고
    • Fracastoro H. De Sympathia et Antipathia Rerum: De Contagione et Contagiosis Morbis et Eorum Curatione. Venice, Italy: Heirs of Lucantonio Giunta; 1546.
    • Fracastoro H. De Sympathia et Antipathia Rerum: De Contagione et Contagiosis Morbis et Eorum Curatione. Venice, Italy: Heirs of Lucantonio Giunta; 1546.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.