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Volumn 152, Issue 1, 2013, Pages 65-76

An emerging role for Serine Protease Inhibitors in T lymphocyte immunity and beyond

Author keywords

Apoptosis; Cytotoxic lymphocytes; Serine Protease Inhibitor; T lymphocytes

Indexed keywords

CATHEPSIN B; CATHEPSIN H; CATHEPSIN K; CATHEPSIN L; CATHEPSIN V; CYTOKINE RESPONSE MODIFIER A; DNA VACCINE; ERYTHROPOIETIN; GAMMA INTERFERON; GRANZYME A; GRANZYME B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 1; INTERLEUKIN 18; INTERLEUKIN 4; LEUKOCYSTATIN; RECOMBINANT PROTEIN; RECOMBINANT SERINE PROTEASE INHIBITOR 6; RECOMBINANT SERINE PROTEASE INHIBITOR B9; SERINE PROTEASE INHIBITOR 2A; SERINE PROTEASE INHIBITOR 6; SERINE PROTEASE INHIBITOR B3; SERINE PROTEASE INHIBITOR B9; SERINE PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

EID: 84877822326     PISSN: 01652478     EISSN: 18790542     Source Type: Journal    
DOI: 10.1016/j.imlet.2013.04.004     Document Type: Review
Times cited : (33)

References (146)
  • 1
    • 0035823595 scopus 로고    scopus 로고
    • The serpins are an expanding superfamily of structurally similar but functionally diverse proteins
    • Silverman G.A., Bird P.I., Carrell R.W., Church F.C., Coughlin P.B., Gettins P.G.W., et al. The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. J Biol Chem 2001, 276:33293-33296.
    • (2001) J Biol Chem , vol.276 , pp. 33293-33296
    • Silverman, G.A.1    Bird, P.I.2    Carrell, R.W.3    Church, F.C.4    Coughlin, P.B.5    Gettins, P.G.W.6
  • 2
    • 0027393310 scopus 로고
    • The ovalbumin family of serpin proteins
    • Remold-O'Donnell E. The ovalbumin family of serpin proteins. FEBS Lett 1993, 315:105-108.
    • (1993) FEBS Lett , vol.315 , pp. 105-108
    • Remold-O'Donnell, E.1
  • 3
    • 0033568456 scopus 로고    scopus 로고
    • Caspase-1 (interleukin-1 beta-converting enzyme) is inhibited by the human serpin analogue proteinase inhibitor 9
    • Annand R.R., Dahlen J.R., Sprecher C.A., De Dreu P., Foster D.C., Mankovich J.A., et al. Caspase-1 (interleukin-1 beta-converting enzyme) is inhibited by the human serpin analogue proteinase inhibitor 9. Biochem J 1999, 342(Pt 3):655-665.
    • (1999) Biochem J , vol.342 , Issue.PART 3 , pp. 655-665
    • Annand, R.R.1    Dahlen, J.R.2    Sprecher, C.A.3    De Dreu, P.4    Foster, D.C.5    Mankovich, J.A.6
  • 4
    • 0028168514 scopus 로고
    • Inhibition of interleukin-1 beta converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition
    • Komiyama T., Ray C.A., Pickup D.J., Howard A.D., Thornberry N.A., Peterson E.P., et al. Inhibition of interleukin-1 beta converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition. J Biol Chem 1994, 269:19331-19337.
    • (1994) J Biol Chem , vol.269 , pp. 19331-19337
    • Komiyama, T.1    Ray, C.A.2    Pickup, D.J.3    Howard, A.D.4    Thornberry, N.A.5    Peterson, E.P.6
  • 5
    • 0028873964 scopus 로고
    • Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product
    • Tewari M., Dixit V.M. Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product. J Biol Chem 1995, 270:3255-3260.
    • (1995) J Biol Chem , vol.270 , pp. 3255-3260
    • Tewari, M.1    Dixit, V.M.2
  • 6
    • 0030977847 scopus 로고    scopus 로고
    • Target protease specificity of the viral serpin CrmA. Analysis of five caspases
    • Zhou Q., Snipas S., Orth K., Muzio M., Dixit V.M., Salvesen G.S. Target protease specificity of the viral serpin CrmA. Analysis of five caspases. J Biol Chem 1997, 272:7797-7800.
    • (1997) J Biol Chem , vol.272 , pp. 7797-7800
    • Zhou, Q.1    Snipas, S.2    Orth, K.3    Muzio, M.4    Dixit, V.M.5    Salvesen, G.S.6
  • 7
    • 0141753121 scopus 로고    scopus 로고
    • NF-kappaB protects from the lysosomal pathway of cell death
    • Liu N., Raja S.M., Zazzeroni F., Metkar S.S., Shah R., Zhang M., et al. NF-kappaB protects from the lysosomal pathway of cell death. EMBO J 2003, 22:5313-5322.
    • (2003) EMBO J , vol.22 , pp. 5313-5322
    • Liu, N.1    Raja, S.M.2    Zazzeroni, F.3    Metkar, S.S.4    Shah, R.5    Zhang, M.6
  • 8
    • 0037022831 scopus 로고    scopus 로고
    • The serpin SQN-5 is a dual mechanistic-class inhibitor of serine and cysteine proteinases
    • Al-Khunaizi M., Luke C.J., Askew Y.S., Pak S.C., Askew D.J., Cataltepe S., et al. The serpin SQN-5 is a dual mechanistic-class inhibitor of serine and cysteine proteinases. Biochemistry 2002, 41:3189-3199.
    • (2002) Biochemistry , vol.41 , pp. 3189-3199
    • Al-Khunaizi, M.1    Luke, C.J.2    Askew, Y.S.3    Pak, S.C.4    Askew, D.J.5    Cataltepe, S.6
  • 9
    • 0032515939 scopus 로고    scopus 로고
    • Cross-class inhibition of the cysteine proteinases cathepsins K, L, and S by the serpin squamous cell carcinoma antigen 1: a kinetic analysis
    • Schick C., Pemberton P.A., Shi G.P., Kamachi Y., Cataltepe S., Bartuski A.J., et al. Cross-class inhibition of the cysteine proteinases cathepsins K, L, and S by the serpin squamous cell carcinoma antigen 1: a kinetic analysis. Biochemistry 1998, 37:5258-5266.
    • (1998) Biochemistry , vol.37 , pp. 5258-5266
    • Schick, C.1    Pemberton, P.A.2    Shi, G.P.3    Kamachi, Y.4    Cataltepe, S.5    Bartuski, A.J.6
  • 10
    • 34548754372 scopus 로고    scopus 로고
    • An intracellular serpin regulates necrosis by inhibiting the induction and sequelae of lysosomal injury
    • Luke C.J., Pak S.C., Askew Y.S., Naviglia T.L., Askew D.J., Nobar S.M.V., et al. An intracellular serpin regulates necrosis by inhibiting the induction and sequelae of lysosomal injury. Cell 2007, 130:1108-1119.
    • (2007) Cell , vol.130 , pp. 1108-1119
    • Luke, C.J.1    Pak, S.C.2    Askew, Y.S.3    Naviglia, T.L.4    Askew, D.J.5    Nobar, S.M.V.6
  • 11
    • 0032522738 scopus 로고    scopus 로고
    • APs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases
    • Deveraux Q.L., Roy N., Stennicke H.R., Van Arsdale T., Zhou Q., Srinivasula S.M., et al. APs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. EMBO J 1998, 17:2215-2223.
    • (1998) EMBO J , vol.17 , pp. 2215-2223
    • Deveraux, Q.L.1    Roy, N.2    Stennicke, H.R.3    Van Arsdale, T.4    Zhou, Q.5    Srinivasula, S.M.6
  • 12
    • 0025817602 scopus 로고
    • The cystatins: protein inhibitors of cysteine proteinases
    • Turk V., Bode W. The cystatins: protein inhibitors of cysteine proteinases. FEBS Lett 1991, 285:213-219.
    • (1991) FEBS Lett , vol.285 , pp. 213-219
    • Turk, V.1    Bode, W.2
  • 13
    • 0035433420 scopus 로고    scopus 로고
    • Four deaths and a funeral: from caspases to alternative mechanisms
    • Leist M., Jaattela M. Four deaths and a funeral: from caspases to alternative mechanisms. Nat Rev Mol Cell Biol 2001, 2:589-598.
    • (2001) Nat Rev Mol Cell Biol , vol.2 , pp. 589-598
    • Leist, M.1    Jaattela, M.2
  • 14
    • 0035736259 scopus 로고    scopus 로고
    • Organelle-specific initiation of cell death pathways
    • Ferri K.F., Kroemer G. Organelle-specific initiation of cell death pathways. Nat Cell Biol 2001, 3:E255-E263.
    • (2001) Nat Cell Biol , vol.3
    • Ferri, K.F.1    Kroemer, G.2
  • 15
    • 0026713818 scopus 로고
    • Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation
    • Schulze-Osthoff K., Bakker A.C., Vanhaesebroeck B., Beyaert R., Jacob W.A., Fiers W. Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation. J Biol Chem 1992, 267:5317-5323.
    • (1992) J Biol Chem , vol.267 , pp. 5317-5323
    • Schulze-Osthoff, K.1    Bakker, A.C.2    Vanhaesebroeck, B.3    Beyaert, R.4    Jacob, W.A.5    Fiers, W.6
  • 16
    • 0032482169 scopus 로고    scopus 로고
    • Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor
    • Vercammen D., Beyaert R., Denecker G., Goossens V., Van Loo G., Declercq W., et al. Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor. J Exp Med 1998, 187:1477-1485.
    • (1998) J Exp Med , vol.187 , pp. 1477-1485
    • Vercammen, D.1    Beyaert, R.2    Denecker, G.3    Goossens, V.4    Van Loo, G.5    Declercq, W.6
  • 17
    • 0032494143 scopus 로고    scopus 로고
    • Dual signaling of the Fas receptor: initiation of both apoptotic and necrotic cell death pathways
    • Vercammen D., Brouckaert G., Denecker G., Van de Craen M., Declercq W., Fiers W., et al. Dual signaling of the Fas receptor: initiation of both apoptotic and necrotic cell death pathways. J Exp Med 1998, 188:919-930.
    • (1998) J Exp Med , vol.188 , pp. 919-930
    • Vercammen, D.1    Brouckaert, G.2    Denecker, G.3    Van de Craen, M.4    Declercq, W.5    Fiers, W.6
  • 18
    • 0033598713 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion
    • Ha H.C., Snyder S.H. Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion. Proc Natl Acad Sci USA 1999, 96:13978-13982.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 13978-13982
    • Ha, H.C.1    Snyder, S.H.2
  • 19
    • 0036479052 scopus 로고    scopus 로고
    • Mitochondrial disappearance from cells: a clue to the role of autophagy in programmed cell death and disease
    • Tolkovsky A.M., Xue L., Fletcher G.C., Borutaite V. Mitochondrial disappearance from cells: a clue to the role of autophagy in programmed cell death and disease. Biochimie 2002, 84:233-240.
    • (2002) Biochimie , vol.84 , pp. 233-240
    • Tolkovsky, A.M.1    Xue, L.2    Fletcher, G.C.3    Borutaite, V.4
  • 20
  • 21
    • 0038725690 scopus 로고    scopus 로고
    • The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal
    • Lieberman J. The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal. Nat Rev Immunol 2003, 3:361-370.
    • (2003) Nat Rev Immunol , vol.3 , pp. 361-370
    • Lieberman, J.1
  • 22
    • 0038731167 scopus 로고    scopus 로고
    • Caspase-independent cell death in T lymphocytes
    • Jaattela M., Tschopp J. Caspase-independent cell death in T lymphocytes. Nat Immunol 2003, 4:416-423.
    • (2003) Nat Immunol , vol.4 , pp. 416-423
    • Jaattela, M.1    Tschopp, J.2
  • 24
    • 0033756474 scopus 로고    scopus 로고
    • Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c
    • Guicciardi M.E., Deussing J., Miyoshi H., Bronk S.F., Svingen P.A., Peters C., et al. Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c. J Clin Invest 2000, 106:1127-1137.
    • (2000) J Clin Invest , vol.106 , pp. 1127-1137
    • Guicciardi, M.E.1    Deussing, J.2    Miyoshi, H.3    Bronk, S.F.4    Svingen, P.A.5    Peters, C.6
  • 25
    • 0033198121 scopus 로고    scopus 로고
    • Germinal center B cell apoptosis requires both caspase and cathepsin activity
    • van Eijk M., de Groot C. Germinal center B cell apoptosis requires both caspase and cathepsin activity. J Immunol 1999, 163:2478-2482.
    • (1999) J Immunol , vol.163 , pp. 2478-2482
    • van Eijk, M.1    de Groot, C.2
  • 26
    • 2142773262 scopus 로고    scopus 로고
    • Cathepsin-dependent apoptosis triggered by supraoptimal activation of T lymphocytes: a possible mechanism of high dose tolerance
    • Michallet M.C., Saltel F., Flacher M., Revillard J.P., Genestier L. Cathepsin-dependent apoptosis triggered by supraoptimal activation of T lymphocytes: a possible mechanism of high dose tolerance. J Immunol 2004, 172:5405-5414.
    • (2004) J Immunol , vol.172 , pp. 5405-5414
    • Michallet, M.C.1    Saltel, F.2    Flacher, M.3    Revillard, J.P.4    Genestier, L.5
  • 28
    • 0031897739 scopus 로고    scopus 로고
    • Oxidative stress causes relocation of the lysosomal enzyme cathepsin D with ensuing apoptosis in neonatal rat cardiomyocytes
    • Roberg K., Ollinger K. Oxidative stress causes relocation of the lysosomal enzyme cathepsin D with ensuing apoptosis in neonatal rat cardiomyocytes. Am J Pathol 1998, 152:1151-1156.
    • (1998) Am J Pathol , vol.152 , pp. 1151-1156
    • Roberg, K.1    Ollinger, K.2
  • 29
    • 0036310279 scopus 로고    scopus 로고
    • Microinjection of cathepsin D induces caspase-dependent apoptosis in fibroblasts
    • Roberg K., Kagedal K., Ollinger K. Microinjection of cathepsin D induces caspase-dependent apoptosis in fibroblasts. Am J Pathol 2002, 161:89-96.
    • (2002) Am J Pathol , vol.161 , pp. 89-96
    • Roberg, K.1    Kagedal, K.2    Ollinger, K.3
  • 30
    • 0035947776 scopus 로고    scopus 로고
    • Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor
    • Foghsgaard L., Wissing D., Mauch D., Lademann U., Bastholm L., Boes M., et al. Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor. J Cell Biol 2001, 153:999-1009.
    • (2001) J Cell Biol , vol.153 , pp. 999-1009
    • Foghsgaard, L.1    Wissing, D.2    Mauch, D.3    Lademann, U.4    Bastholm, L.5    Boes, M.6
  • 31
    • 0035159449 scopus 로고    scopus 로고
    • B cell receptor-stimulated mitochondrial phospholipase A2 activation and resultant disruption of mitochondrial membrane potential correlate with the induction of apoptosis in WEHI-231 B cells
    • Katz E., Deehan M.R., Seatter S., Lord C., Sturrock R.D., Harnett M.M. B cell receptor-stimulated mitochondrial phospholipase A2 activation and resultant disruption of mitochondrial membrane potential correlate with the induction of apoptosis in WEHI-231 B cells. J Immunol 2001, 166:137-147.
    • (2001) J Immunol , vol.166 , pp. 137-147
    • Katz, E.1    Deehan, M.R.2    Seatter, S.3    Lord, C.4    Sturrock, R.D.5    Harnett, M.M.6
  • 32
    • 0029914132 scopus 로고    scopus 로고
    • A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes
    • Sun J., Bird C.H., Sutton V., McDonald L., Coughlin P.B., De Jong T.A., et al. A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes. J Biol Chem 1996, 271:27802-27809.
    • (1996) J Biol Chem , vol.271 , pp. 27802-27809
    • Sun, J.1    Bird, C.H.2    Sutton, V.3    McDonald, L.4    Coughlin, P.B.5    De Jong, T.A.6
  • 33
    • 0031008162 scopus 로고    scopus 로고
    • A new family of 10 murine ovalbumin serpins includes two homologs of proteinase inhibitor 8 and two homologs of the granzyme B inhibitor (proteinase inhibitor 9)
    • Sun J., Ooms L., Bird C.H., Sutton V.R., Trapani J.A., Bird P.I. A new family of 10 murine ovalbumin serpins includes two homologs of proteinase inhibitor 8 and two homologs of the granzyme B inhibitor (proteinase inhibitor 9). J Biol Chem 1997, 272:15434-15441.
    • (1997) J Biol Chem , vol.272 , pp. 15434-15441
    • Sun, J.1    Ooms, L.2    Bird, C.H.3    Sutton, V.R.4    Trapani, J.A.5    Bird, P.I.6
  • 34
    • 3042589745 scopus 로고    scopus 로고
    • Serine protease inhibitor 2A inhibits caspase-independent cell death
    • Liu N., Wang Y., Ashton-Rickardt P.G. Serine protease inhibitor 2A inhibits caspase-independent cell death. FEBS Lett 2004, 569:49-53.
    • (2004) FEBS Lett , vol.569 , pp. 49-53
    • Liu, N.1    Wang, Y.2    Ashton-Rickardt, P.G.3
  • 35
    • 0034935005 scopus 로고    scopus 로고
    • A minimal serpin promoter with high activity in haematopoietic progenitors and activated T cells
    • Hampson L., Hampson I.N., Babichuk C.K., Cotter L., Bleackley R.C., Dexter T.M., et al. A minimal serpin promoter with high activity in haematopoietic progenitors and activated T cells. Hematol J 2001, 2:150-160.
    • (2001) Hematol J , vol.2 , pp. 150-160
    • Hampson, L.1    Hampson, I.N.2    Babichuk, C.K.3    Cotter, L.4    Bleackley, R.C.5    Dexter, T.M.6
  • 36
    • 0024372111 scopus 로고
    • Acquisition of immunologic self-tolerance
    • Schwartz R.H. Acquisition of immunologic self-tolerance. Cell 1989, 57:1073-1081.
    • (1989) Cell , vol.57 , pp. 1073-1081
    • Schwartz, R.H.1
  • 37
    • 0022597528 scopus 로고
    • Identity of cells that imprint H-2-restricted T-cell specificity in the thymus
    • Lo D., Sprent J. Identity of cells that imprint H-2-restricted T-cell specificity in the thymus. Nature 1986, 319:672-675.
    • (1986) Nature , vol.319 , pp. 672-675
    • Lo, D.1    Sprent, J.2
  • 38
    • 0023683669 scopus 로고
    • Positive selection of antigen-specific T cells in thymus by restricting MHC molecules
    • Kisielow P., Teh H.S., Bluthmann H., von Boehmer H. Positive selection of antigen-specific T cells in thymus by restricting MHC molecules. Nature 1988, 335:730-733.
    • (1988) Nature , vol.335 , pp. 730-733
    • Kisielow, P.1    Teh, H.S.2    Bluthmann, H.3    von Boehmer, H.4
  • 39
    • 0024588554 scopus 로고
    • The generation of mature T cells requires interaction of the alpha beta T-cell receptor with major histocompatibility antigens
    • Scott B., Bluthmann H., Teh H.S., von Boehmer H. The generation of mature T cells requires interaction of the alpha beta T-cell receptor with major histocompatibility antigens. Nature 1989, 338:591-593.
    • (1989) Nature , vol.338 , pp. 591-593
    • Scott, B.1    Bluthmann, H.2    Teh, H.S.3    von Boehmer, H.4
  • 40
    • 0023813094 scopus 로고
    • Thymic major histocompatibility complex antigens and the alpha beta T-cell receptor determine the CD4/CD8 phenotype of T cells
    • Teh H.S., Kisielow P., Scott B., Kishi H., Uematsu Y., Bluthmann H., et al. Thymic major histocompatibility complex antigens and the alpha beta T-cell receptor determine the CD4/CD8 phenotype of T cells. Nature 1988, 335:229-233.
    • (1988) Nature , vol.335 , pp. 229-233
    • Teh, H.S.1    Kisielow, P.2    Scott, B.3    Kishi, H.4    Uematsu, Y.5    Bluthmann, H.6
  • 41
    • 0030935007 scopus 로고    scopus 로고
    • The MHC reactivity of the T cell repertoire prior to positive and negative selection
    • Zerrahn J., Held W., Raulet D.H. The MHC reactivity of the T cell repertoire prior to positive and negative selection. Cell 1997, 88:627-636.
    • (1997) Cell , vol.88 , pp. 627-636
    • Zerrahn, J.1    Held, W.2    Raulet, D.H.3
  • 42
    • 9244226573 scopus 로고    scopus 로고
    • A license to remember
    • Ashton-Rickardt P.G. A license to remember. Nat Immunol 2004, 5:1097-1098.
    • (2004) Nat Immunol , vol.5 , pp. 1097-1098
    • Ashton-Rickardt, P.G.1
  • 43
    • 33745062839 scopus 로고    scopus 로고
    • + T-cell memory by cytokines and costimulators
    • + T-cell memory by cytokines and costimulators. Immunol Rev 2006, 211:23-38.
    • (2006) Immunol Rev , vol.211 , pp. 23-38
    • Dooms, H.1    Abbas, A.K.2
  • 44
    • 0036217977 scopus 로고    scopus 로고
    • Lymphocyte-mediated cytotoxicity
    • Russell J.H., Ley T.J. Lymphocyte-mediated cytotoxicity. Annu Rev Immunol 2002, 20:323-370.
    • (2002) Annu Rev Immunol , vol.20 , pp. 323-370
    • Russell, J.H.1    Ley, T.J.2
  • 46
    • 0032005477 scopus 로고    scopus 로고
    • Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection
    • Murali-Krishna K., Altman J.D., Suresh M., Sourdive D.J., Zajac A.J., Miller J.D., et al. Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity 1998, 8:177-187.
    • (1998) Immunity , vol.8 , pp. 177-187
    • Murali-Krishna, K.1    Altman, J.D.2    Suresh, M.3    Sourdive, D.J.4    Zajac, A.J.5    Miller, J.D.6
  • 47
    • 0030001674 scopus 로고    scopus 로고
    • Immunological memory and protective immunity: understanding their relation
    • Ahmed R., Gray D. Immunological memory and protective immunity: understanding their relation. Science 1996, 272:54-60.
    • (1996) Science , vol.272 , pp. 54-60
    • Ahmed, R.1    Gray, D.2
  • 48
    • 0034885547 scopus 로고    scopus 로고
    • + T cell effectors can become memory cells with high efficiency and without further division
    • + T cell effectors can become memory cells with high efficiency and without further division. Nat Immunol 2001, 2:705-710.
    • (2001) Nat Immunol , vol.2 , pp. 705-710
    • Hu, H.1    Huston, G.2    Duso, D.3    Lepak, N.4    Roman, E.5    Swain, S.L.6
  • 49
    • 38749121326 scopus 로고    scopus 로고
    • Long-lived virus-reactive memory T cells generated from purified cytokine-secreting T helper type 1 and type 2 effectors
    • Lohning M., Hegazy A.N., Pinschewer D.D., Busse D., Lang K.S., Hofer T., et al. Long-lived virus-reactive memory T cells generated from purified cytokine-secreting T helper type 1 and type 2 effectors. J Exp Med 2008, 205:53-61.
    • (2008) J Exp Med , vol.205 , pp. 53-61
    • Lohning, M.1    Hegazy, A.N.2    Pinschewer, D.D.3    Busse, D.4    Lang, K.S.5    Hofer, T.6
  • 50
    • 0033548496 scopus 로고    scopus 로고
    • Linear differentiation of cytotoxic effectors into memory T lymphocytes
    • Opferman J.T., Ober B.T., Ashton-Rickardt P.G. Linear differentiation of cytotoxic effectors into memory T lymphocytes. Science 1999, 283:1745-1748.
    • (1999) Science , vol.283 , pp. 1745-1748
    • Opferman, J.T.1    Ober, B.T.2    Ashton-Rickardt, P.G.3
  • 51
    • 12444303174 scopus 로고    scopus 로고
    • Bone marrow is a preferred site for homeostatic proliferation of memory CD8 T cells
    • Becker T.C., Coley S.M., Wherry E.J., Ahmed R. Bone marrow is a preferred site for homeostatic proliferation of memory CD8 T cells. J Immunol 2005, 174:1269-1273.
    • (2005) J Immunol , vol.174 , pp. 1269-1273
    • Becker, T.C.1    Coley, S.M.2    Wherry, E.J.3    Ahmed, R.4
  • 52
    • 34548856484 scopus 로고    scopus 로고
    • Bone marrow CD8 cells down-modulate membrane IL-7Ralpha expression and exhibit increased STAT-5 and p38 MAPK phosphorylation in the organ environment
    • Cassese G., Parretta E., Pisapia L., Santoni A., Guardiola J., Di Rosa F. Bone marrow CD8 cells down-modulate membrane IL-7Ralpha expression and exhibit increased STAT-5 and p38 MAPK phosphorylation in the organ environment. Blood 2007, 110:1960-1969.
    • (2007) Blood , vol.110 , pp. 1960-1969
    • Cassese, G.1    Parretta, E.2    Pisapia, L.3    Santoni, A.4    Guardiola, J.5    Di Rosa, F.6
  • 55
  • 56
    • 0021273768 scopus 로고
    • Purification and properties of cytoplasmic granules from cytotoxic rat LGL tumors
    • Millard P.J., Henkart M.P., Reynolds C.W., Henkart P.A. Purification and properties of cytoplasmic granules from cytotoxic rat LGL tumors. J Immunol 1984, 132:3197-3204.
    • (1984) J Immunol , vol.132 , pp. 3197-3204
    • Millard, P.J.1    Henkart, M.P.2    Reynolds, C.W.3    Henkart, P.A.4
  • 57
    • 0001041396 scopus 로고
    • Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell granules
    • Podack E.R., Young J.D., Cohn Z.A. Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell granules. Proc Natl Acad Sci USA 1985, 82:8629-8633.
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 8629-8633
    • Podack, E.R.1    Young, J.D.2    Cohn, Z.A.3
  • 58
    • 0028219791 scopus 로고
    • Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice
    • Kagi D., Ledermann B., Burki K., Seiler P., Odermatt B., Olsen K.J., et al. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature 1994, 369:31-37.
    • (1994) Nature , vol.369 , pp. 31-37
    • Kagi, D.1    Ledermann, B.2    Burki, K.3    Seiler, P.4    Odermatt, B.5    Olsen, K.J.6
  • 59
    • 0026474805 scopus 로고
    • Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions
    • Shi L., Kam C.M., Powers J.C., Aebersold R., Greenberg A.H. Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions. J Exp Med 1992, 176:1521-1529.
    • (1992) J Exp Med , vol.176 , pp. 1521-1529
    • Shi, L.1    Kam, C.M.2    Powers, J.C.3    Aebersold, R.4    Greenberg, A.H.5
  • 60
    • 0028110928 scopus 로고
    • Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity
    • Kagi D., Vignaux F., Ledermann B., Burki K., Depraetere V., Nagata S., et al. Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity. Science 1994, 265:528-530.
    • (1994) Science , vol.265 , pp. 528-530
    • Kagi, D.1    Vignaux, F.2    Ledermann, B.3    Burki, K.4    Depraetere, V.5    Nagata, S.6
  • 61
    • 0022592627 scopus 로고
    • On the mechanism of unidirectional killing in mixtures of two cytotoxic T lymphocytes. Unidirectional polarization of cytoplasmic organelles and the membrane-associated cytoskeleton in the effector cell
    • Kupfer A., Singer S.J., Dennert G. On the mechanism of unidirectional killing in mixtures of two cytotoxic T lymphocytes. Unidirectional polarization of cytoplasmic organelles and the membrane-associated cytoskeleton in the effector cell. J Exp Med 1986, 163:489-498.
    • (1986) J Exp Med , vol.163 , pp. 489-498
    • Kupfer, A.1    Singer, S.J.2    Dennert, G.3
  • 62
    • 0035654722 scopus 로고    scopus 로고
    • Role of calcium influx in cytotoxic T lymphocyte lytic granule exocytosis during target cell killing
    • Lyubchenko T.A., Wurth G.A., Zweifach A. Role of calcium influx in cytotoxic T lymphocyte lytic granule exocytosis during target cell killing. Immunity 2001, 15:847-859.
    • (2001) Immunity , vol.15 , pp. 847-859
    • Lyubchenko, T.A.1    Wurth, G.A.2    Zweifach, A.3
  • 63
    • 0035655587 scopus 로고    scopus 로고
    • The immunological synapse of CTL contains a secretory domain and membrane bridges
    • Stinchcombe J.C., Bossi G., Booth S., Griffiths G.M. The immunological synapse of CTL contains a secretory domain and membrane bridges. Immunity 2001, 15:751-761.
    • (2001) Immunity , vol.15 , pp. 751-761
    • Stinchcombe, J.C.1    Bossi, G.2    Booth, S.3    Griffiths, G.M.4
  • 65
    • 0030044052 scopus 로고    scopus 로고
    • Localization of granzyme B in the nucleus. A putative role in the mechanism of cytotoxic lymphocyte-mediated apoptosis
    • Trapani J.A., Browne K.A., Smyth M.J., Jans D.A. Localization of granzyme B in the nucleus. A putative role in the mechanism of cytotoxic lymphocyte-mediated apoptosis. J Biol Chem 1996, 271:4127-4133.
    • (1996) J Biol Chem , vol.271 , pp. 4127-4133
    • Trapani, J.A.1    Browne, K.A.2    Smyth, M.J.3    Jans, D.A.4
  • 66
    • 0025971396 scopus 로고
    • Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins
    • Odake S., Kam C.M., Narasimhan L., Poe M., Blake J.T., Krahenbuhl O.T., et al. Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins. Biochemistry 1991, 30:2217-2227.
    • (1991) Biochemistry , vol.30 , pp. 2217-2227
    • Odake, S.1    Kam, C.M.2    Narasimhan, L.3    Poe, M.4    Blake, J.T.5    Krahenbuhl, O.T.6
  • 67
    • 0032520769 scopus 로고    scopus 로고
    • A role for perforin in activation-induced cell death
    • Spaner D., Raju K., Rudvanyi L., Lin Y., Miller R.G. A role for perforin in activation-induced cell death. J Immunol 1998, 160:2655-2664.
    • (1998) J Immunol , vol.160 , pp. 2655-2664
    • Spaner, D.1    Raju, K.2    Rudvanyi, L.3    Lin, Y.4    Miller, R.G.5
  • 69
    • 0033555391 scopus 로고    scopus 로고
    • A role for perforin in activation-induced T cell death in vivo: increased expansion of allogeneic perforin-deficient T cells in SCID mice
    • Spaner D., Raju K., Rabinovich B., Miller R.G. A role for perforin in activation-induced T cell death in vivo: increased expansion of allogeneic perforin-deficient T cells in SCID mice. J Immunol 1999, 162:1192-1199.
    • (1999) J Immunol , vol.162 , pp. 1192-1199
    • Spaner, D.1    Raju, K.2    Rabinovich, B.3    Miller, R.G.4
  • 71
    • 0032980707 scopus 로고    scopus 로고
    • A role for perforin in downregulating T-cell responses during chronic viral infection
    • Matloubian M., Suresh M., Glass A., Galvan M., Chow K., Whitmire J.K., et al. A role for perforin in downregulating T-cell responses during chronic viral infection. J Virol 1999, 73:2527-2536.
    • (1999) J Virol , vol.73 , pp. 2527-2536
    • Matloubian, M.1    Suresh, M.2    Glass, A.3    Galvan, M.4    Chow, K.5    Whitmire, J.K.6
  • 72
    • 0034680811 scopus 로고    scopus 로고
    • Regulation of antigen-specific T cell homeostasis by perforin and interferon-γ
    • Badovinac V.P., Tvinnereim A.R., Harty J.T. Regulation of antigen-specific T cell homeostasis by perforin and interferon-γ. Science 2000, 290:1354-1357.
    • (2000) Science , vol.290 , pp. 1354-1357
    • Badovinac, V.P.1    Tvinnereim, A.R.2    Harty, J.T.3
  • 73
    • 0242417491 scopus 로고    scopus 로고
    • + T cell expansion and mortality in vaccinated perforin-deficient mice
    • + T cell expansion and mortality in vaccinated perforin-deficient mice. Immunity 2003, 18:463-474.
    • (2003) Immunity , vol.18 , pp. 463-474
    • Badovinac, V.P.1    Hamilton, S.E.2    Harty, J.T.3
  • 78
    • 0033615606 scopus 로고    scopus 로고
    • TCR-mediated internalization of peptide-MHC complexes acquired by T cells
    • Huang J.F., Yang Y., Sepulveda H., Shi W., Hwang I., Peterson P.A., et al. TCR-mediated internalization of peptide-MHC complexes acquired by T cells. Science 1999, 286:952-954.
    • (1999) Science , vol.286 , pp. 952-954
    • Huang, J.F.1    Yang, Y.2    Sepulveda, H.3    Shi, W.4    Hwang, I.5    Peterson, P.A.6
  • 79
    • 0037350690 scopus 로고    scopus 로고
    • Perforin-dependent activation-induced cell death acts through caspase 3 but not through caspases 8 or 9
    • Chen L., Woo M., Hakem R., Miller R.G. Perforin-dependent activation-induced cell death acts through caspase 3 but not through caspases 8 or 9. Eur J Immunol 2003, 33:769-778.
    • (2003) Eur J Immunol , vol.33 , pp. 769-778
    • Chen, L.1    Woo, M.2    Hakem, R.3    Miller, R.G.4
  • 80
    • 0028914352 scopus 로고
    • Serial killing by cytotoxic T lymphocytes: T cell receptor triggers degranulation, re-filling of the lytic granules and secretion of lytic proteins via a non-granule pathway
    • Isaaz S., Baetz K., Olsen K., Podack E., Griffiths G.M. Serial killing by cytotoxic T lymphocytes: T cell receptor triggers degranulation, re-filling of the lytic granules and secretion of lytic proteins via a non-granule pathway. Eur J Immunol 1995, 25:1071-1079.
    • (1995) Eur J Immunol , vol.25 , pp. 1071-1079
    • Isaaz, S.1    Baetz, K.2    Olsen, K.3    Podack, E.4    Griffiths, G.M.5
  • 81
    • 10744233370 scopus 로고    scopus 로고
    • Granzyme B leakage-induced cell death: a new type of activation-induced natural killer cell death
    • Ida H., Nakashima T., Kedersha N.L., Yamasaki S., Huang M., Izumi Y., et al. Granzyme B leakage-induced cell death: a new type of activation-induced natural killer cell death. Eur J Immunol 2003, 33:3284-3292.
    • (2003) Eur J Immunol , vol.33 , pp. 3284-3292
    • Ida, H.1    Nakashima, T.2    Kedersha, N.L.3    Yamasaki, S.4    Huang, M.5    Izumi, Y.6
  • 82
    • 0037438474 scopus 로고    scopus 로고
    • The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency
    • Hirst C.E., Buzza M.S., Bird C.H., Warren H.S., Cameron P.U., Zhang M., et al. The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency. J Immunol 2003, 170:805-815.
    • (2003) J Immunol , vol.170 , pp. 805-815
    • Hirst, C.E.1    Buzza, M.S.2    Bird, C.H.3    Warren, H.S.4    Cameron, P.U.5    Zhang, M.6
  • 84
    • 33645973995 scopus 로고    scopus 로고
    • Serine protease inhibitor 6 protects cytotoxic T cells from self-inflicted injury by ensuring the integrity of cytotoxic granules
    • Zhang M., Park S.M., Wang Y., Shah R., Liu N., Murmann A.E., et al. Serine protease inhibitor 6 protects cytotoxic T cells from self-inflicted injury by ensuring the integrity of cytotoxic granules. Immunity 2006, 24:451-461.
    • (2006) Immunity , vol.24 , pp. 451-461
    • Zhang, M.1    Park, S.M.2    Wang, Y.3    Shah, R.4    Liu, N.5    Murmann, A.E.6
  • 89
    • 77955480167 scopus 로고    scopus 로고
    • Serine protease inhibitor 6 protects iNKT cells from self-inflicted damage
    • Ansari A.W., Temblay J.N., Alyahya S.H., Ashton-Rickardt P.G. Serine protease inhibitor 6 protects iNKT cells from self-inflicted damage. J Immunol 2010, 185:877-883.
    • (2010) J Immunol , vol.185 , pp. 877-883
    • Ansari, A.W.1    Temblay, J.N.2    Alyahya, S.H.3    Ashton-Rickardt, P.G.4
  • 90
    • 0033542458 scopus 로고    scopus 로고
    • Modelling T-cell memory by genetic marking of memory T cells in vivo
    • Jacob J., Baltimore D. Modelling T-cell memory by genetic marking of memory T cells in vivo. Nature 1999, 399:593-597.
    • (1999) Nature , vol.399 , pp. 593-597
    • Jacob, J.1    Baltimore, D.2
  • 91
    • 0037074012 scopus 로고    scopus 로고
    • Molecular and functional profiling of memory CD8 T cell differentiation
    • Kaech S.M., Hemby S., Kersh E., Ahmed R. Molecular and functional profiling of memory CD8 T cell differentiation. Cell 2002, 111:837-851.
    • (2002) Cell , vol.111 , pp. 837-851
    • Kaech, S.M.1    Hemby, S.2    Kersh, E.3    Ahmed, R.4
  • 92
    • 4644295842 scopus 로고    scopus 로고
    • Serine protease inhibitor 2A is a protective factor for memory T cell development
    • Liu N., Phillips T., Zhang M., Wang Y., Opferman J.T., Shah R., et al. Serine protease inhibitor 2A is a protective factor for memory T cell development. Nat Immunol 2004, 5:919-926.
    • (2004) Nat Immunol , vol.5 , pp. 919-926
    • Liu, N.1    Phillips, T.2    Zhang, M.3    Wang, Y.4    Opferman, J.T.5    Shah, R.6
  • 93
    • 0037343426 scopus 로고    scopus 로고
    • A review and comparison of the murine alpha1-antitrypsin and alpha1-antichymotrypsin multigene clusters with the human clade A serpins
    • Forsyth S., Horvath A., Coughlin P. A review and comparison of the murine alpha1-antitrypsin and alpha1-antichymotrypsin multigene clusters with the human clade A serpins. Genomics 2003, 81:336-345.
    • (2003) Genomics , vol.81 , pp. 336-345
    • Forsyth, S.1    Horvath, A.2    Coughlin, P.3
  • 97
    • 19344377193 scopus 로고    scopus 로고
    • Dendritic cells maximize the memory CD8 T cell response to infection
    • Zammit D.J., Cauley L.S., Pham Q.M., Lefrancois L. Dendritic cells maximize the memory CD8 T cell response to infection. Immunity 2005, 22:561-570.
    • (2005) Immunity , vol.22 , pp. 561-570
    • Zammit, D.J.1    Cauley, L.S.2    Pham, Q.M.3    Lefrancois, L.4
  • 99
    • 2942541735 scopus 로고    scopus 로고
    • Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens
    • Heath W.R., Belz G.T., Behrens G.M., Smith C.M., Forehan S.P., Parish I.A., et al. Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens. Immunol Rev 2004, 199:9-26.
    • (2004) Immunol Rev , vol.199 , pp. 9-26
    • Heath, W.R.1    Belz, G.T.2    Behrens, G.M.3    Smith, C.M.4    Forehan, S.P.5    Parish, I.A.6
  • 100
    • 0034653828 scopus 로고    scopus 로고
    • T cell-dependent elimination of dendritic cells in vivo limits the induction of antitumor immunity
    • Ronchese F.C.D.8.+.
    • Hermans I.F., Ritchie D.S., Yang J., Roberts J.M., Ronchese F.C.D8+ T cell-dependent elimination of dendritic cells in vivo limits the induction of antitumor immunity. J Immunol 2000, 164:3095-3101.
    • (2000) J Immunol , vol.164 , pp. 3095-3101
    • Hermans, I.F.1    Ritchie, D.S.2    Yang, J.3    Roberts, J.M.4
  • 102
    • 38149001476 scopus 로고    scopus 로고
    • Dendritic cell-induced memory T cell activation in nonlymphoid tissues
    • Wakim L.M., Waithman J., van Rooijen N., Heath W.R., Carbone F.R. Dendritic cell-induced memory T cell activation in nonlymphoid tissues. Science 2008, 319:198-202.
    • (2008) Science , vol.319 , pp. 198-202
    • Wakim, L.M.1    Waithman, J.2    van Rooijen, N.3    Heath, W.R.4    Carbone, F.R.5
  • 103
    • 0037398404 scopus 로고    scopus 로고
    • Feedback regulation of pathogen-specific T cell priming
    • Wong P., Pamer E.G. Feedback regulation of pathogen-specific T cell priming. Immunity 2003, 18:499-511.
    • (2003) Immunity , vol.18 , pp. 499-511
    • Wong, P.1    Pamer, E.G.2
  • 104
    • 0035949570 scopus 로고    scopus 로고
    • Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors
    • Medema J.P., de Jong J., Peltenburg L.T., Verdegaal E.M., Gorter A., Bres S.A., et al. Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors. Proc Natl Acad Sci USA 2001, 98:11515-11520.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 11515-11520
    • Medema, J.P.1    de Jong, J.2    Peltenburg, L.T.3    Verdegaal, E.M.4    Gorter, A.5    Bres, S.A.6
  • 105
    • 84863042239 scopus 로고    scopus 로고
    • Serine protease inhibitor 6 is required to protect dendritic cells from the kiss of death
    • Lovo E., Zhang M., Wang L., Ashton-Rickardt P.G. Serine protease inhibitor 6 is required to protect dendritic cells from the kiss of death. J Immunol 2012, 188:1057-1063.
    • (2012) J Immunol , vol.188 , pp. 1057-1063
    • Lovo, E.1    Zhang, M.2    Wang, L.3    Ashton-Rickardt, P.G.4
  • 106
    • 0030823702 scopus 로고    scopus 로고
    • Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation
    • Graubert T.A., DiPersio J.F., Russell J.H., Ley T.J. Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation. J Clin Invest 1997, 100:904-911.
    • (1997) J Clin Invest , vol.100 , pp. 904-911
    • Graubert, T.A.1    DiPersio, J.F.2    Russell, J.H.3    Ley, T.J.4
  • 107
    • 1342266385 scopus 로고    scopus 로고
    • Cytolytic effector mechanisms and gene expression in autologous graft-versus-host disease: distinct roles of perforin and Fas ligand
    • Miura Y., Thoburn C.J., Bright E.C., Hess A.D. Cytolytic effector mechanisms and gene expression in autologous graft-versus-host disease: distinct roles of perforin and Fas ligand. Biol Blood Marrow Transplant 2004, 10:156-170.
    • (2004) Biol Blood Marrow Transplant , vol.10 , pp. 156-170
    • Miura, Y.1    Thoburn, C.J.2    Bright, E.C.3    Hess, A.D.4
  • 108
    • 17644427742 scopus 로고    scopus 로고
    • Raised granzyme B levels are associated with erosions in patients with early rheumatoid factor positive rheumatoid arthritis
    • Goldbach-Mansky R., Suson S., Wesley R., Hack C.E., El-Gabalawy H.S., Tak P.P. Raised granzyme B levels are associated with erosions in patients with early rheumatoid factor positive rheumatoid arthritis. Ann Rheum Dis 2005, 64:715-721.
    • (2005) Ann Rheum Dis , vol.64 , pp. 715-721
    • Goldbach-Mansky, R.1    Suson, S.2    Wesley, R.3    Hack, C.E.4    El-Gabalawy, H.S.5    Tak, P.P.6
  • 110
    • 20044372704 scopus 로고    scopus 로고
    • Granzyme B induces endothelial cell apoptosis and contributes to the development of transplant vascular disease
    • Choy J.C., Cruz R.P., Kerjner A., Geisbrecht J., Sawchuk T., Fraser S.A., et al. Granzyme B induces endothelial cell apoptosis and contributes to the development of transplant vascular disease. Am J Transplant 2005, 5:494-499.
    • (2005) Am J Transplant , vol.5 , pp. 494-499
    • Choy, J.C.1    Cruz, R.P.2    Kerjner, A.3    Geisbrecht, J.4    Sawchuk, T.5    Fraser, S.A.6
  • 111
    • 0038146941 scopus 로고    scopus 로고
    • Granzyme B in atherosclerosis and transplant vascular disease: association with cell death and atherosclerotic disease severity
    • Choy J.C., McDonald P.C., Suarez A.C., Hung V.H., Wilson J.E., McManus B.M., et al. Granzyme B in atherosclerosis and transplant vascular disease: association with cell death and atherosclerotic disease severity. Mod Pathol 2003, 16:460-470.
    • (2003) Mod Pathol , vol.16 , pp. 460-470
    • Choy, J.C.1    McDonald, P.C.2    Suarez, A.C.3    Hung, V.H.4    Wilson, J.E.5    McManus, B.M.6
  • 112
    • 0033981007 scopus 로고    scopus 로고
    • Differential levels of granzyme B, regulatory cytokines, and apoptosis in Crohn's disease and ulcerative colitis at first presentation
    • Jenkins D., Seth R., Kummer J.A., Scott B.B., Hawkey C.J., Robins R.A. Differential levels of granzyme B, regulatory cytokines, and apoptosis in Crohn's disease and ulcerative colitis at first presentation. J Pathol 2000, 190:184-189.
    • (2000) J Pathol , vol.190 , pp. 184-189
    • Jenkins, D.1    Seth, R.2    Kummer, J.A.3    Scott, B.B.4    Hawkey, C.J.5    Robins, R.A.6
  • 113
    • 0036198111 scopus 로고    scopus 로고
    • Destruction of neurons by cytotoxic T cells: a new pathogenic mechanism in Rasmussen's encephalitis
    • Bien C.G., Bauer J., Deckwerth T.L., Wiendl H., Deckert M., Wiestler O.D., et al. Destruction of neurons by cytotoxic T cells: a new pathogenic mechanism in Rasmussen's encephalitis. Ann Neurol 2002, 51:311-318.
    • (2002) Ann Neurol , vol.51 , pp. 311-318
    • Bien, C.G.1    Bauer, J.2    Deckwerth, T.L.3    Wiendl, H.4    Deckert, M.5    Wiestler, O.D.6
  • 116
    • 0035284891 scopus 로고    scopus 로고
    • The granzyme B inhibitor, protease inhibitor 9, is mainly expressed by dendritic cells and at immune-privileged sites
    • Bladergroen B.A., Strik M.C.M., Bovenschen N., van Berkum O., Scheffer G.L., Meijer C.J.L.M., et al. The granzyme B inhibitor, protease inhibitor 9, is mainly expressed by dendritic cells and at immune-privileged sites. J Immunol 2001, 166:3218-3225.
    • (2001) J Immunol , vol.166 , pp. 3218-3225
    • Bladergroen, B.A.1    Strik, M.C.M.2    Bovenschen, N.3    van Berkum, O.4    Scheffer, G.L.5    Meijer, C.J.L.M.6
  • 117
    • 0034194055 scopus 로고    scopus 로고
    • The serpin proteinase inhibitor 9 is an endogenous inhibitor of interleukin 1 beta-converting enzyme (caspase-1) activity in human vascular smooth muscle cells
    • Young J.L., Sukhova G.K., Foster D., Kisiel W., Libby P., Schonbeck U. The serpin proteinase inhibitor 9 is an endogenous inhibitor of interleukin 1 beta-converting enzyme (caspase-1) activity in human vascular smooth muscle cells. J Exp Med 2000, 191:1535-1544.
    • (2000) J Exp Med , vol.191 , pp. 1535-1544
    • Young, J.L.1    Sukhova, G.K.2    Foster, D.3    Kisiel, W.4    Libby, P.5    Schonbeck, U.6
  • 118
    • 0028955325 scopus 로고
    • Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A
    • Quan L., Caputo A., Bleackley R., Pickup D.J., Salvesen G.S. Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A. J Biol Chem 1995, 270:3-8.
    • (1995) J Biol Chem , vol.270 , pp. 3-8
    • Quan, L.1    Caputo, A.2    Bleackley, R.3    Pickup, D.J.4    Salvesen, G.S.5
  • 119
    • 0029808217 scopus 로고    scopus 로고
    • Differential inhibition of the Fas- and granule-mediated cytolysis pathways by the orthopoxvirus cytokine response modifier A/SPI-2 and SPI-1 protein
    • Macen J.L., Garner R.S., Musy P.Y., Brooks M.A., Turner P.C., Moyer R.W., et al. Differential inhibition of the Fas- and granule-mediated cytolysis pathways by the orthopoxvirus cytokine response modifier A/SPI-2 and SPI-1 protein. Proc Natl Acad Sci USA 1996, 93:9108-9113.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 9108-9113
    • Macen, J.L.1    Garner, R.S.2    Musy, P.Y.3    Brooks, M.A.4    Turner, P.C.5    Moyer, R.W.6
  • 120
    • 0036095702 scopus 로고    scopus 로고
    • Expression of the granzyme B inhibitor, protease inhibitor 9, by tumor cells in patients with non-Hodgkin and Hodgkin lymphoma: a novel protective mechanism for tumor cells to circumvent the immune system?
    • Bladergroen B.A., Meijer C.J., ten Berge R.L., Hack C.E., Muris J.J., Dukers D.F.C., et al. Expression of the granzyme B inhibitor, protease inhibitor 9, by tumor cells in patients with non-Hodgkin and Hodgkin lymphoma: a novel protective mechanism for tumor cells to circumvent the immune system?. Blood 2002, 99:232-237.
    • (2002) Blood , vol.99 , pp. 232-237
    • Bladergroen, B.A.1    Meijer, C.J.2    ten Berge, R.L.3    Hack, C.E.4    Muris, J.J.5    Dukers, D.F.C.6
  • 121
    • 0037097821 scopus 로고    scopus 로고
    • Expression levels of apoptosis-related proteins predict clinical outcome in anaplastic large cell lymphoma
    • ten Berge R.L., Meijer C.J., Dukers D.F., Kummer J.A., Bladergroen B.A., Vos W., et al. Expression levels of apoptosis-related proteins predict clinical outcome in anaplastic large cell lymphoma. Blood 2002, 99:4540-4546.
    • (2002) Blood , vol.99 , pp. 4540-4546
    • ten Berge, R.L.1    Meijer, C.J.2    Dukers, D.F.3    Kummer, J.A.4    Bladergroen, B.A.5    Vos, W.6
  • 122
    • 0029819310 scopus 로고    scopus 로고
    • Erythropoietin production by interstitial cells of hypoxic monkey kidneys
    • Fisher J.W., Koury S., Ducey T., Mendel S. Erythropoietin production by interstitial cells of hypoxic monkey kidneys. Br J Haematol 1996, 95:27-32.
    • (1996) Br J Haematol , vol.95 , pp. 27-32
    • Fisher, J.W.1    Koury, S.2    Ducey, T.3    Mendel, S.4
  • 124
    • 0028880455 scopus 로고
    • Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor
    • Wu H., Liu X., Jaenisch R., Lodish H.F. Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor. Cell 1995, 83:59-67.
    • (1995) Cell , vol.83 , pp. 59-67
    • Wu, H.1    Liu, X.2    Jaenisch, R.3    Lodish, H.F.4
  • 125
    • 84874557275 scopus 로고    scopus 로고
    • Erythropoietin-directed erythropoiesis depends on serpin inhibition of erythroblast lysosomal cathepsins
    • Dev A., Byrne S.M., Verma R., Ashton-Rickardt P.G., Wojchowski D.M. Erythropoietin-directed erythropoiesis depends on serpin inhibition of erythroblast lysosomal cathepsins. J Exp Med 2013, 210:225-232.
    • (2013) J Exp Med , vol.210 , pp. 225-232
    • Dev, A.1    Byrne, S.M.2    Verma, R.3    Ashton-Rickardt, P.G.4    Wojchowski, D.M.5
  • 127
    • 34247849157 scopus 로고    scopus 로고
    • Cathepsin-cleaved Bid promotes apoptosis in human neutrophils via oxidative stress-induced lysosomal membrane permeabilization
    • Blomgran R., Zheng L., Stendahl O. Cathepsin-cleaved Bid promotes apoptosis in human neutrophils via oxidative stress-induced lysosomal membrane permeabilization. J Leukoc Biol 2007, 81:1213-1223.
    • (2007) J Leukoc Biol , vol.81 , pp. 1213-1223
    • Blomgran, R.1    Zheng, L.2    Stendahl, O.3
  • 128
    • 77955905915 scopus 로고    scopus 로고
    • The role of antioxidants and iron chelators in the treatment of oxidative stress in thalassemia
    • Fibach E., Rachmilewitz E.A. The role of antioxidants and iron chelators in the treatment of oxidative stress in thalassemia. Ann N Y Acad Sci 2010, 1202:10-16.
    • (2010) Ann N Y Acad Sci , vol.1202 , pp. 10-16
    • Fibach, E.1    Rachmilewitz, E.A.2
  • 129
    • 33644746220 scopus 로고    scopus 로고
    • Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells
    • Luckey C.J., Bhattacharya D., Goldrath A.W., Weissman I.L., Benoist C., Mathis D. Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells. Proc Natl Acad Sci USA 2006, 103:3304-3309.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 3304-3309
    • Luckey, C.J.1    Bhattacharya, D.2    Goldrath, A.W.3    Weissman, I.L.4    Benoist, C.5    Mathis, D.6
  • 130
    • 17944376032 scopus 로고    scopus 로고
    • Expression of the serpin serine protease inhibitor 6 protects dendritic cells from cytotoxic T lymphocyte-induced apoptosis: differential modulation by T helper type 1 and type 2 cells
    • Medema J.P., Schuurhuis D.H., Rea D., van Tongeren J., de Jong J., Bres S.A., et al. Expression of the serpin serine protease inhibitor 6 protects dendritic cells from cytotoxic T lymphocyte-induced apoptosis: differential modulation by T helper type 1 and type 2 cells. J Exp Med 2001, 194:657-667.
    • (2001) J Exp Med , vol.194 , pp. 657-667
    • Medema, J.P.1    Schuurhuis, D.H.2    Rea, D.3    van Tongeren, J.4    de Jong, J.5    Bres, S.A.6
  • 132
    • 51149114868 scopus 로고    scopus 로고
    • DNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoire
    • Rice J., Dossett M.L., Ohlen C., Buchan S.L., Kendall T.J., Dunn S.N., et al. DNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoire. Eur J Immunol 2008, 38:2118-2130.
    • (2008) Eur J Immunol , vol.38 , pp. 2118-2130
    • Rice, J.1    Dossett, M.L.2    Ohlen, C.3    Buchan, S.L.4    Kendall, T.J.5    Dunn, S.N.6
  • 134
    • 1642453782 scopus 로고    scopus 로고
    • Enhancement of DNA vaccine potency by coadministration of a tumor antigen gene and DNA encoding serine protease inhibitor-6
    • Kim T.W., Hung C.F., Boyd D.A., He L., Lin C.T., Kaiserman D., et al. Enhancement of DNA vaccine potency by coadministration of a tumor antigen gene and DNA encoding serine protease inhibitor-6. Cancer Res 2004, 64:400-405.
    • (2004) Cancer Res , vol.64 , pp. 400-405
    • Kim, T.W.1    Hung, C.F.2    Boyd, D.A.3    He, L.4    Lin, C.T.5    Kaiserman, D.6
  • 135
    • 79251590238 scopus 로고    scopus 로고
    • Mesenchymal stem cells express serine protease inhibitor to evade the host immune response
    • El Haddad N., Heathcote D., Moore R., Yang S., Azzi J., Mfarrej B., et al. Mesenchymal stem cells express serine protease inhibitor to evade the host immune response. Blood 2011, 117:1176-1183.
    • (2011) Blood , vol.117 , pp. 1176-1183
    • El Haddad, N.1    Heathcote, D.2    Moore, R.3    Yang, S.4    Azzi, J.5    Mfarrej, B.6
  • 136
    • 80052651871 scopus 로고    scopus 로고
    • The novel role of SERPINB9 in cytotoxic protection of human mesenchymal stem cells
    • El Haddad N., Moore R., Heathcote D., Mounayar M., Azzi J., Mfarrej B., et al. The novel role of SERPINB9 in cytotoxic protection of human mesenchymal stem cells. J Immunol 2011, 187:2252-2260.
    • (2011) J Immunol , vol.187 , pp. 2252-2260
    • El Haddad, N.1    Moore, R.2    Heathcote, D.3    Mounayar, M.4    Azzi, J.5    Mfarrej, B.6
  • 138
    • 4644372395 scopus 로고    scopus 로고
    • Hyperexpression of the granzyme B inhibitor PI-9 in human renal allografts: a potential mechanism for stable renal function in patients with subclinical rejection
    • Rowshani A.T., Florquin S., Bemelman F., Kummer J.A., Hack C.E., Ten Berge I.J. Hyperexpression of the granzyme B inhibitor PI-9 in human renal allografts: a potential mechanism for stable renal function in patients with subclinical rejection. Kidney Int 2004, 66:1417-1422.
    • (2004) Kidney Int , vol.66 , pp. 1417-1422
    • Rowshani, A.T.1    Florquin, S.2    Bemelman, F.3    Kummer, J.A.4    Hack, C.E.5    Ten Berge, I.J.6
  • 140
    • 77953916219 scopus 로고    scopus 로고
    • Erythropoietin in cancer patients: pros and cons
    • Dicato M., Plawny L. Erythropoietin in cancer patients: pros and cons. Curr Opin Oncol 2010, 22:307-311.
    • (2010) Curr Opin Oncol , vol.22 , pp. 307-311
    • Dicato, M.1    Plawny, L.2
  • 142
    • 73349121307 scopus 로고    scopus 로고
    • Anemia management in oncology and hematology
    • Spivak J.L., Gascon P., Ludwig H. Anemia management in oncology and hematology. Oncologist 2009, 14(Suppl. 1):43-56.
    • (2009) Oncologist , vol.14 , Issue.SUPPL. 1 , pp. 43-56
    • Spivak, J.L.1    Gascon, P.2    Ludwig, H.3
  • 143
    • 77954698283 scopus 로고    scopus 로고
    • Erythropoiesis stimulating agents and anaemia of end-stage renal disease
    • Schmid H., Schiffl H. Erythropoiesis stimulating agents and anaemia of end-stage renal disease. Cardiovasc Hematol Agents Med Chem 2010, 8:164-172.
    • (2010) Cardiovasc Hematol Agents Med Chem , vol.8 , pp. 164-172
    • Schmid, H.1    Schiffl, H.2
  • 144
    • 27144467425 scopus 로고    scopus 로고
    • Molecular signatures distinguish human central memory from effector memory CD8 T cell subsets
    • Willinger T., Freeman T., Hasegawa H., McMichael A.J., Callan M.F. Molecular signatures distinguish human central memory from effector memory CD8 T cell subsets. J Immunol 2005, 175:5895-5903.
    • (2005) J Immunol , vol.175 , pp. 5895-5903
    • Willinger, T.1    Freeman, T.2    Hasegawa, H.3    McMichael, A.J.4    Callan, M.F.5
  • 145
    • 0032569023 scopus 로고    scopus 로고
    • Leukocystatin, a new Class II cystatin expressed selectively by hematopoietic cells
    • Halfon S., Ford J., Foster J., Dowling L., Lucian L., Sterling M., et al. Leukocystatin, a new Class II cystatin expressed selectively by hematopoietic cells. J Biol Chem 1998, 273:16400-16408.
    • (1998) J Biol Chem , vol.273 , pp. 16400-16408
    • Halfon, S.1    Ford, J.2    Foster, J.3    Dowling, L.4    Lucian, L.5    Sterling, M.6


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