-
1
-
-
76549258955
-
Studies on the mechanism of erythropoietic stimulation in parabiotic rats during hypoxia
-
Reissman K. Studies on the mechanism of erythropoietic stimulation in parabiotic rats during hypoxia. Blood 1950; 5:372-380.
-
(1950)
Blood
, vol.5
, pp. 372-380
-
-
Reissman, K.1
-
2
-
-
0000009635
-
Humoral regulation of red cell production
-
Erslev A. Humoral regulation of red cell production. Blood 1953; 8:349-357.
-
(1953)
Blood
, vol.8
, pp. 349-357
-
-
Erslev, A.1
-
3
-
-
27544477195
-
Demonstration of stimulation of erythropoiesis by plasma from anemic rats using Fe59
-
Plzak LF, Fried W, Jacobson LO, Bethard WF. Demonstration of stimulation of erythropoiesis by plasma from anemic rats using Fe59. J Lab Clin Med 1955; 46:671-678.
-
(1955)
J Lab Clin Med
, vol.46
, pp. 671-678
-
-
Plzak, L.F.1
Fried, W.2
Jacobson, L.O.3
Bethard, W.F.4
-
5
-
-
0032525158
-
Human hematopoietic progenitors express erythropoietin
-
Stopka T, Zivny JH, Stopkova P, et al. Human hematopoietic progenitors express erythropoietin. Blood 1998; 91:3766-3772.
-
(1998)
Blood
, vol.91
, pp. 3766-3772
-
-
Stopka, T.1
Zivny, J.H.2
Stopkova, P.3
-
6
-
-
44349193611
-
Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications
-
Tong Z, Yang Z, Patel S, et al. Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications. Proc Natl Acad Sci USA 2008; 105:6998-7003.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 6998-7003
-
-
Tong, Z.1
Yang, Z.2
Patel, S.3
-
7
-
-
33745926802
-
VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis
-
Tam BY, Wei K, Rudge JS, et al. VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis. Nat Med 2006; 12:793-800.
-
(2006)
Nat Med
, vol.12
, pp. 793-800
-
-
Tam, B.Y.1
Wei, K.2
Rudge, J.S.3
-
8
-
-
70449412497
-
The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice
-
Weidemann A, Kerdiles YM, Knaup KX, et al. The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice. J Clin Invest 2009; 119:3373-3383.
-
(2009)
J Clin Invest
, vol.119
, pp. 3373-3383
-
-
Weidemann, A.1
Kerdiles, Y.M.2
Knaup, K.X.3
-
10
-
-
0242611254
-
Cloning and expression of the human erythropoietin gene
-
Lin FK, Suggs S, Lin CH, et al. Cloning and expression of the human erythropoietin gene. Proc Natl Acad Sci USA 1985; 82:7580-7584.
-
(1985)
Proc Natl Acad Sci USA
, vol.82
, pp. 7580-7584
-
-
Lin, F.K.1
Suggs, S.2
Lin, C.H.3
-
11
-
-
0023120533
-
Correction of the anemia of end-stage renal disease with recombinant human erythropoietin. Results of a combined phase i and II clinical trial
-
Eschbach JW, Egrie JC, Downing MR, et al. Correction of the anemia of end-stage renal disease with recombinant human erythropoietin. Results of a combined phase I and II clinical trial. N Engl J Med 1987; 316:73-78.
-
(1987)
N Engl J Med
, vol.316
, pp. 73-78
-
-
Eschbach, J.W.1
Egrie, J.C.2
Downing, M.R.3
-
12
-
-
0024563574
-
Expression cloning of the murine erythropoietin receptor
-
D'Andrea AD, Lodish HF, Wong GG. Expression cloning of the murine erythropoietin receptor. Cell 1989; 57:277-285.
-
(1989)
Cell
, vol.57
, pp. 277-285
-
-
D'Andrea, A.D.1
Lodish, H.F.2
Wong, G.G.3
-
13
-
-
0026063514
-
The cytoplasmic region of the erythropoietin receptor contains nonoverlapping positive and negative growth-regulatory domains
-
D'Andrea AD, Yoshimura A, Youssoufian H, et al. The cytoplasmic region of the erythropoietin receptor contains nonoverlapping positive and negative growth-regulatory domains. Mol Cell Biol 1991; 11:1980-1987.
-
(1991)
Mol Cell Biol
, vol.11
, pp. 1980-1987
-
-
D'Andrea, A.D.1
Yoshimura, A.2
Youssoufian, H.3
-
14
-
-
0025829298
-
Localized cytosolic domains of the erythropoietin receptor regulate growth signaling and down-modulate responsiveness to granulocyte-macrophage colony-stimulating factor
-
Quelle DE, Wojchowski DM. Localized cytosolic domains of the erythropoietin receptor regulate growth signaling and down-modulate responsiveness to granulocyte-macrophage colony-stimulating factor. Proc Natl Acad Sci USA 1991; 88:4801-4805.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 4801-4805
-
-
Quelle, D.E.1
Wojchowski, D.M.2
-
15
-
-
0027327484
-
JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin
-
Witthuhn BA, Quelle FW, Silvennoinen O, et al. JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin. Cell 1993; 74:227-236.
-
(1993)
Cell
, vol.74
, pp. 227-236
-
-
Witthuhn, B.A.1
Quelle, F.W.2
Silvennoinen, O.3
-
16
-
-
0344413478
-
Active and inactive orientations of the transmembrane and cytosolic domains of the erythropoietin receptor dimer
-
Seubert N, Royer Y, Staerk J, et al. Active and inactive orientations of the transmembrane and cytosolic domains of the erythropoietin receptor dimer. Mol Cell 2003; 12:1239-1250.
-
(2003)
Mol Cell
, vol.12
, pp. 1239-1250
-
-
Seubert, N.1
Royer, Y.2
Staerk, J.3
-
17
-
-
0025162844
-
Structural design and molecular evolution of a cytokine receptor superfamily
-
Bazan JF. Structural design and molecular evolution of a cytokine receptor superfamily. Proc Natl Acad Sci USA 1990; 87:6934-6938.
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 6934-6938
-
-
Bazan, J.F.1
-
18
-
-
38349157811
-
Hematopoietic cytokines
-
Metcalf D. Hematopoietic cytokines. Blood 2008; 111:485-491.
-
(2008)
Blood
, vol.111
, pp. 485-491
-
-
Metcalf, D.1
-
19
-
-
0028880455
-
Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor
-
Wu H, Liu X, Jaenisch R, et al. Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor. Cell 1995; 83:59-67.
-
(1995)
Cell
, vol.83
, pp. 59-67
-
-
Wu, H.1
Liu, X.2
Jaenisch, R.3
-
20
-
-
0032076542
-
Jak2 is essential for signaling through a variety of cytokine receptors
-
Parganas E, Wang D, Stravopodis D, et al. Jak2 is essential for signaling through a variety of cytokine receptors. Cell 1998; 93:385-395.
-
(1998)
Cell
, vol.93
, pp. 385-395
-
-
Parganas, E.1
Wang, D.2
Stravopodis, D.3
-
21
-
-
68549112702
-
Erythropoietin and erythropoiesis
-
Fried W. Erythropoietin and erythropoiesis. Exp Hematol 2009; 37:1007-1015.
-
(2009)
Exp Hematol
, vol.37
, pp. 1007-1015
-
-
Fried, W.1
-
22
-
-
14744299761
-
Turning cells red: Signal transduction mediated by erythropoietin
-
Richmond TD, Chohan M, Barber DL. Turning cells red: signal transduction mediated by erythropoietin. Trends Cell Biol 2005; 15:146-155.
-
(2005)
Trends Cell Biol
, vol.15
, pp. 146-155
-
-
Richmond, T.D.1
Chohan, M.2
Barber, D.L.3
-
23
-
-
0033000191
-
The erythropoietin receptor: Structure, activation and intracellular signal transduction
-
Constantinescu SN, Ghaffari S, Lodish HF. The erythropoietin receptor: structure, activation and intracellular signal transduction. Trends Endocrinol Metab 1999; 10:18-23.
-
(1999)
Trends Endocrinol Metab
, vol.10
, pp. 18-23
-
-
Constantinescu, S.N.1
Ghaffari, S.2
Lodish, H.F.3
-
24
-
-
33646381647
-
Active conformation of the erythropoietin receptor: Random and cysteine-scanning mutagenesis of the extracellular juxtamembrane and transmembrane domains
-
Lu X, Gross AW, Lodish HF. Active conformation of the erythropoietin receptor: random and cysteine-scanning mutagenesis of the extracellular juxtamembrane and transmembrane domains. J Biol Chem 2006; 281:7002-7011.
-
(2006)
J Biol Chem
, vol.281
, pp. 7002-7011
-
-
Lu, X.1
Gross, A.W.2
Lodish, H.F.3
-
25
-
-
34347207939
-
STAT5 signaling in normal and pathologic hematopoiesis
-
Bunting KD. STAT5 signaling in normal and pathologic hematopoiesis. Front Biosci 2007; 12:2807-2820.
-
(2007)
Front Biosci
, vol.12
, pp. 2807-2820
-
-
Bunting, K.D.1
-
26
-
-
11244333356
-
New avenues of exploration for erythropoietin
-
Maiese K, Li F, Chong ZZ. New avenues of exploration for erythropoietin. JAMA 2005; 293:90-95.
-
(2005)
JAMA
, vol.293
, pp. 90-95
-
-
Maiese, K.1
Li, F.2
Chong, Z.Z.3
-
27
-
-
40449087690
-
The nonhaematopoietic biological effects of erythropoietin
-
Arcasoy MO. The nonhaematopoietic biological effects of erythropoietin. Br J Haematol 2008; 141:14-31.
-
(2008)
Br J Haematol
, vol.141
, pp. 14-31
-
-
Arcasoy, M.O.1
-
29
-
-
34447093331
-
Erythropoietin and treatment of nonanemic conditions: Cardiovascular protection
-
Fliser D, Haller H. Erythropoietin and treatment of nonanemic conditions: cardiovascular protection. Semin Hematol 2007; 44:212-217.
-
(2007)
Semin Hematol
, vol.44
, pp. 212-217
-
-
Fliser, D.1
Haller, H.2
-
30
-
-
6944237300
-
Erythropoietin mediates tissue protection through an erythropoietin and common beta-subunit heterore-ceptor
-
Brines M, Grasso G, Fiordaliso F, et al. Erythropoietin mediates tissue protection through an erythropoietin and common beta-subunit heterore-ceptor. Proc Natl Acad Sci USA 2004; 101:14907-14912.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 14907-14912
-
-
Brines, M.1
Grasso, G.2
Fiordaliso, F.3
-
31
-
-
34247201113
-
Protective role of endogenous erythropoietin system in nonhematopoietic cells against pressure overload-induced left ventricular dysfunction in mice
-
Asaumi Y, Kagaya Y, Takeda M, et al. Protective role of endogenous erythropoietin system in nonhematopoietic cells against pressure overload-induced left ventricular dysfunction in mice. Circulation 2007; 115:2022-2032.
-
(2007)
Circulation
, vol.115
, pp. 2022-2032
-
-
Asaumi, Y.1
Kagaya, Y.2
Takeda, M.3
-
32
-
-
53549097076
-
Erythropoietin-mediated tissue protection: Reducing collateral damage from the primary injury response
-
Brines M, Cerami A. Erythropoietin-mediated tissue protection: reducing collateral damage from the primary injury response. J Intern Med 2008; 264:405-432.
-
(2008)
J Intern Med
, vol.264
, pp. 405-432
-
-
Brines, M.1
Cerami, A.2
-
33
-
-
43149122020
-
TNF receptor i sensitizes neurons to erythropoietin-and VEGF-mediated neuroprotection after ischemic and excitotoxic injury
-
Taoufik E, Petit E, Divoux D, et al. TNF receptor I sensitizes neurons to erythropoietin-and VEGF-mediated neuroprotection after ischemic and excitotoxic injury. Proc Natl Acad Sci USA 2008; 105:6185-6190.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 6185-6190
-
-
Taoufik, E.1
Petit, E.2
Divoux, D.3
-
34
-
-
70349249832
-
NADPH oxidase Nox2 is required for hypoxia-induced mobilization of endothelial progenitor cells
-
Schroder K, Kohnen A, Aicher A, et al. NADPH oxidase Nox2 is required for hypoxia-induced mobilization of endothelial progenitor cells. Circ Res 2009;105:537-544.
-
(2009)
Circ Res
, vol.105
, pp. 537-544
-
-
Schroder, K.1
Kohnen, A.2
Aicher, A.3
-
35
-
-
34548446804
-
Does erythropoietin have a dark side? Epo signaling and cancer cells
-
Sytkowski AJ. Does erythropoietin have a dark side? Epo signaling and cancer cells. Sci STKE 2007; 2007:e38.
-
(2007)
Sci STKE
, vol.2007
-
-
Sytkowski, A.J.1
-
36
-
-
34250349152
-
Weighing the hazards of erythropoiesis stimulation in patients with cancer
-
Khuri FR. Weighing the hazards of erythropoiesis stimulation in patients with cancer. N Engl J Med 2007; 356:2445-2448.
-
(2007)
N Engl J Med
, vol.356
, pp. 2445-2448
-
-
Khuri, F.R.1
-
37
-
-
34047227171
-
Erythropoietin: High profile, high scrutiny
-
Crawford J. Erythropoietin: high profile, high scrutiny. J Clin Oncol 2007; 25:1021-1023.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1021-1023
-
-
Crawford, J.1
-
38
-
-
51049088625
-
Erythropoiesis-stimulating agent use in cancer: Preclinical and clinical perspectives
-
Arcasoy MO. Erythropoiesis-stimulating agent use in cancer: preclinical and clinical perspectives. Clin Cancer Res 2008; 14:4685-4690.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 4685-4690
-
-
Arcasoy, M.O.1
-
39
-
-
53149088549
-
Erythropoietin in cancer: An update
-
Tovari J, Pirker R, Timar J, et al. Erythropoietin in cancer: an update. Curr Mol Med 2008; 8:481-491.
-
(2008)
Curr Mol Med
, vol.8
, pp. 481-491
-
-
Tovari, J.1
Pirker, R.2
Timar, J.3
-
40
-
-
0041976976
-
Breast cancer trial with erythropoietin terminated unexpectedly
-
DOI 10.1016/S1470-2045(03)01163-X
-
Leyland-Jones B, and Group BIaS. Breast cancer trial with erythropoietin terminated unexpectedly. Lancet Oncol 2003; 4:459-460. (Pubitemid 37009952)
-
(2003)
Lancet Oncology
, vol.4
, Issue.8
, pp. 459-460
-
-
Leyland-Jones, B.1
-
41
-
-
0142186283
-
Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: Randomised, double-blind, placebo-controlled trial
-
Henke M, Laszig R, Rube C, et al. Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: randomised, double-blind, placebo-controlled trial. Lancet 2003; 362:1255-1260.
-
(2003)
Lancet
, vol.362
, pp. 1255-1260
-
-
Henke, M.1
Laszig, R.2
Rube, C.3
-
42
-
-
20344380430
-
Erythropoietin signaling promotes invasiveness of human head and neck squamous cell carcinoma
-
Mohyeldin A, Lu H, Dalgard C, et al. Erythropoietin signaling promotes invasiveness of human head and neck squamous cell carcinoma. Neoplasia 2005; 7:537-543.
-
(2005)
Neoplasia
, vol.7
, pp. 537-543
-
-
Mohyeldin, A.1
Lu, H.2
Dalgard, C.3
-
43
-
-
33845739772
-
Expression of erythropoietin and erythropoietin receptor in cervical cancer and relationship to survival, hypoxia, and apoptosis
-
Leo C, Horn LC, Rauscher C, et al. Expression of erythropoietin and erythropoietin receptor in cervical cancer and relationship to survival, hypoxia, and apoptosis. Clin Cancer Res 2006; 12:6894-6900.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 6894-6900
-
-
Leo, C.1
Horn, L.C.2
Rauscher, C.3
-
44
-
-
33846844805
-
Survival and invasiveness of astrocytomas promoted by erythropoietin
-
Mohyeldin A, Dalgard CL, Lu H, et al. Survival and invasiveness of astrocytomas promoted by erythropoietin. J Neurosurg 2007; 106:338-350.
-
(2007)
J Neurosurg
, vol.106
, pp. 338-350
-
-
Mohyeldin, A.1
Dalgard, C.L.2
Lu, H.3
-
45
-
-
37149013962
-
Effects of recombinant erythropoietin on breast cancer-initiating cells
-
Phillips TM, Kim K, Vlashi E, et al. Effects of recombinant erythropoietin on breast cancer-initiating cells. Neoplasia 2007; 9:1122-1129.
-
(2007)
Neoplasia
, vol.9
, pp. 1122-1129
-
-
Phillips, T.M.1
Kim, K.2
Vlashi, E.3
-
46
-
-
70349313947
-
Evaluating erythropoietin-associated tumor progression using archival tissues from a phase III clinical trial
-
Miller CP, Lowe KA, Valliant-Saunders K, et al. Evaluating erythropoietin-associated tumor progression using archival tissues from a phase III clinical trial. Stem Cells 2009; 27:2353-2361.
-
(2009)
Stem Cells
, vol.27
, pp. 2353-2361
-
-
Miller, C.P.1
Lowe, K.A.2
Valliant-Saunders, K.3
-
47
-
-
33846883294
-
New agents that stimulate erythropoiesis
-
Bunn HF. New agents that stimulate erythropoiesis. Blood 2007; 109:868-873.
-
(2007)
Blood
, vol.109
, pp. 868-873
-
-
Bunn, H.F.1
-
48
-
-
60949098752
-
Hematopoietic growth factor mi-metics: From concept to clinic
-
Perugini M, Varelias A, Sadlon T, et al. Hematopoietic growth factor mi-metics: from concept to clinic. Cytokine Growth Factor Rev 2009; 20:87-94.
-
(2009)
Cytokine Growth Factor Rev
, vol.20
, pp. 87-94
-
-
Perugini, M.1
Varelias, A.2
Sadlon, T.3
-
49
-
-
0029798402
-
Functional mimicry of a protein hormone by a peptide agonist: The EPO receptor complex at 2.8 A
-
Livnah O, Stura EA, Johnson DL, et al. Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 A. Science 1996; 273:464-471.
-
(1996)
Science
, vol.273
, pp. 464-471
-
-
Livnah, O.1
Stura, E.A.2
Johnson, D.L.3
-
50
-
-
13144252172
-
Amino-terminal dimerization of an erythropoietin mimetic peptide results in increased erythropoietic activity
-
Johnson DL, Farrell FX, Barbone FP, et al. Amino-terminal dimerization of an erythropoietin mimetic peptide results in increased erythropoietic activity. Chem Biol 1997; 4:939-950.
-
(1997)
Chem Biol
, vol.4
, pp. 939-950
-
-
Johnson, D.L.1
Farrell, F.X.2
Barbone, F.P.3
-
51
-
-
0032539954
-
Identification of a 13 amino acid peptide mimetic of erythropoietin and description of amino acids critical for the mimetic activity of EMP1
-
Johnson DL, Farrell FX, Barbone FP, et al. Identification of a 13 amino acid peptide mimetic of erythropoietin and description of amino acids critical for the mimetic activity of EMP1. Biochemistry 1998; 37:3699-3710.
-
(1998)
Biochemistry
, vol.37
, pp. 3699-3710
-
-
Johnson, D.L.1
Farrell, F.X.2
Barbone, F.P.3
-
52
-
-
35248889086
-
C.E.R.A.: Pharmacodynamics, pharmacokinetics and efficacy in patients with chronic kidney disease
-
Locatelli F, Reigner B. C.E.R.A.: pharmacodynamics, pharmacokinetics and efficacy in patients with chronic kidney disease. Expert Opin Investig Drugs 2007; 16:1649-1661.
-
(2007)
Expert Opin Investig Drugs
, vol.16
, pp. 1649-1661
-
-
Locatelli, F.1
Reigner, B.2
-
53
-
-
41949135761
-
Continuous erythropoietin receptor activator (Mircera) for renal anemia
-
McGahan L. Continuous erythropoietin receptor activator (Mircera) for renal anemia. Issues Emerg Health Technol 2008:1-6.
-
(2008)
Issues Emerg Health Technol
, pp. 1-6
-
-
McGahan, L.1
-
54
-
-
41949126749
-
CERA: Third-generation erythropoiesis-stimulating agent
-
Topf JM. CERA: third-generation erythropoiesis-stimulating agent. Expert Opin Pharmacother 2008; 9:839-849.
-
(2008)
Expert Opin Pharmacother
, vol.9
, pp. 839-849
-
-
Topf, J.M.1
-
55
-
-
33748704406
-
Hematide, a synthetic peptide-based erythropoiesis stimulating agent (ESA), demonstrates erythropoietic activity in a phase 2 single dose, dose escalating study in patients with chronic kidney disease (CKD) [abstract #3532]
-
Duliege AM, Macdougall I, Duncan N, et al. Hematide, a synthetic peptide-based erythropoiesis stimulating agent (ESA), demonstrates erythropoietic activity in a phase 2 single dose, dose escalating study in patients with chronic kidney disease (CKD) [abstract #3532]. Blood 2005; 106.
-
(2005)
Blood
, vol.106
-
-
Duliege, A.M.1
MacDougall, I.2
Duncan, N.3
-
56
-
-
33748690610
-
Preclinical evaluation of Hematide, a novel erythropoiesis stimulating agent, for the treatment of anemia
-
Fan Q, Leuther KK, Holmes CP, et al. Preclinical evaluation of Hematide, a novel erythropoiesis stimulating agent, for the treatment of anemia. Exp Hematol 2006; 34:1303-1311.
-
(2006)
Exp Hematol
, vol.34
, pp. 1303-1311
-
-
Fan, Q.1
Leuther, K.K.2
Holmes, C.P.3
-
57
-
-
33748679131
-
Evaluation of the safety and pharmacodynamics of Hematide, a novel erythropoietic agent, in a phase 1, double-blind, placebo-controlled, dose-escalation study in healthy volunteers
-
Stead RB, Lambert J, Wessels D, et al. Evaluation of the safety and pharmacodynamics of Hematide, a novel erythropoietic agent, in a phase 1, double-blind, placebo-controlled, dose-escalation study in healthy volunteers. Blood 2006; 108:1830-1834.
-
(2006)
Blood
, vol.108
, pp. 1830-1834
-
-
Stead, R.B.1
Lambert, J.2
Wessels, D.3
-
58
-
-
70350774297
-
A peptide-based erythropoietin-receptor agonist for pure red-cell aplasia
-
Macdougall IC, Rossert J, Casadevall N, et al. A peptide-based erythropoietin-receptor agonist for pure red-cell aplasia. N Engl J Med 2009; 361:1848-1855
-
(2009)
N Engl J Med
, vol.361
, pp. 1848-1855
-
-
MacDougall, I.C.1
Rossert, J.2
Casadevall, N.3
-
59
-
-
51849094530
-
A phase I, single and fractionated, ascending-dose study evaluating the safety, pharmacokinetics, pharmacodynamics, and immunogenicity of an erythropoietin mimetic antibody fusion protein (CNTO 528) in healthy male subjects
-
Bouman-Thio E, Franson K, Miller B, et al. A phase I, single and fractionated, ascending-dose study evaluating the safety, pharmacokinetics, pharmacodynamics, and immunogenicity of an erythropoietin mimetic antibody fusion protein (CNTO 528) in healthy male subjects. J Clin Pharmacol 2008; 48:1197-1207.
-
(2008)
J Clin Pharmacol
, vol.48
, pp. 1197-1207
-
-
Bouman-Thio, E.1
Franson, K.2
Miller, B.3
-
60
-
-
66549127370
-
CNTO 530 functions as a potent EPO mimetic via unique sustained effects on bone marrow proery throblast pools
-
Sathyanarayana P, Houde E, Marshall D, et al. CNTO 530 functions as a potent EPO mimetic via unique sustained effects on bone marrow proery throblast pools. Blood 2009; 113:4955-4962.
-
(2009)
Blood
, vol.113
, pp. 4955-4962
-
-
Sathyanarayana, P.1
Houde, E.2
Marshall, D.3
-
61
-
-
34548829081
-
HIF prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques
-
Hsieh MM, Linde NS, Wynter A, et al. HIF prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques. Blood 2007; 110:2140-2147.
-
(2007)
Blood
, vol.110
, pp. 2140-2147
-
-
Hsieh, M.M.1
Linde, N.S.2
Wynter, A.3
-
62
-
-
34948831582
-
A potent erythropoietin-mimicking human antibody interacts through a novel binding site
-
Liu Z, Stoll VS, Devries PJ, et al. A potent erythropoietin-mimicking human antibody interacts through a novel binding site. Blood 2007; 110:2408-2413.
-
(2007)
Blood
, vol.110
, pp. 2408-2413
-
-
Liu, Z.1
Stoll, V.S.2
Devries, P.J.3
-
63
-
-
49049105016
-
The potency of erythropoietin-mimic antibodies correlates inversely with affinity
-
Lacy SE, DeVries PJ, Xie N, et al. The potency of erythropoietin-mimic antibodies correlates inversely with affinity. J Immunol 2008; 181:1282-1287.
-
(2008)
J Immunol
, vol.181
, pp. 1282-1287
-
-
Lacy, S.E.1
Devries, P.J.2
Xie, N.3
-
64
-
-
0033597715
-
Fetal anemia and apoptosis of red cell progenitors in Stat5a\/\5b\/\mice: A direct role for Stat5 in Bcl-X(L) induction
-
Socolovsky M, Fallon AE, Wang S, et al. Fetal anemia and apoptosis of red cell progenitors in Stat5a\/\5b\/\mice: a direct role for Stat5 in Bcl-X(L) induction. Cell 1999; 98:181-191.
-
(1999)
Cell
, vol.98
, pp. 181-191
-
-
Socolovsky, M.1
Fallon, A.E.2
Wang, S.3
-
65
-
-
0030980933
-
Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors
-
Klingmuller U, Wu H, Hsiao JG, et al. Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors. Proc Natl Acad Sci USA 1997; 94:3016-3021.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 3016-3021
-
-
Klingmuller, U.1
Wu, H.2
Hsiao, J.G.3
-
66
-
-
13044269652
-
Phosphatidylinositol 3-kinase is involved in the protection of primary cultured human erythroid precursor cells from apoptosis
-
Haseyama Y, Sawada K, Oda A, et al. Phosphatidylinositol 3-kinase is involved in the protection of primary cultured human erythroid precursor cells from apoptosis. Blood 1999; 94:1568-1577.
-
(1999)
Blood
, vol.94
, pp. 1568-1577
-
-
Haseyama, Y.1
Sawada, K.2
Oda, A.3
-
67
-
-
0033635616
-
Conditional deletion of the Bcl-x gene from erythroid cells results in hemolytic anemia and profound splenomegaly
-
Wagner KU, Claudio E, Rucker EB3rd, et al. Conditional deletion of the Bcl-x gene from erythroid cells results in hemolytic anemia and profound splenomegaly. Development 2000; 127:4949-4958.
-
(2000)
Development
, vol.127
, pp. 4949-4958
-
-
Wagner, K.U.1
Claudio, E.2
Ebrd, R.3
-
68
-
-
23944463463
-
Bcl-x(L) prevents apoptosis of late-stage erythroblasts but does not mediate the antiapoptotic effect of erythropoietin
-
Rhodes MM, Kopsombut P, Bondurant MC, et al. Bcl-x(L) prevents apoptosis of late-stage erythroblasts but does not mediate the antiapoptotic effect of erythropoietin. Blood 2005; 106:1857-1863.
-
(2005)
Blood
, vol.106
, pp. 1857-1863
-
-
Rhodes, M.M.1
Kopsombut, P.2
Bondurant, M.C.3
-
69
-
-
45949109873
-
EPO receptor circuits for primary erythroblast survival
-
Sathyanarayana P, Dev A, Fang J, et al. EPO receptor circuits for primary erythroblast survival. Blood 2008; 111:5390-5399.
-
(2008)
Blood
, vol.111
, pp. 5390-5399
-
-
Sathyanarayana, P.1
Dev, A.2
Fang, J.3
-
70
-
-
34948895031
-
EPO modulation of cell-cycle regulatory genes, and cell division, in primary bone marrow erythroblasts
-
Fang J, Menon M, Kapelle W, et al. EPO modulation of cell-cycle regulatory genes, and cell division, in primary bone marrow erythroblasts. Blood 2007; 110:2361-2370.
-
(2007)
Blood
, vol.110
, pp. 2361-2370
-
-
Fang, J.1
Menon, M.2
Kapelle, W.3
-
71
-
-
34547116218
-
Erythropoietin modulation of podocalyxin and a proposed erythroblast niche
-
Sathyanarayana P, Menon MP, Bogacheva O, et al. Erythropoietin modulation of podocalyxin and a proposed erythroblast niche. Blood 2007; 110:509-518.
-
(2007)
Blood
, vol.110
, pp. 509-518
-
-
Sathyanarayana, P.1
Menon, M.P.2
Bogacheva, O.3
-
72
-
-
18844370979
-
Erythropoietin hypersensitivity in primary familial and congenital polycythemia: Role of tyrosines Y285 and Y344 in erythropoietin receptor cytoplasmic domain
-
Arcasoy MO, Karayal AF. Erythropoietin hypersensitivity in primary familial and congenital polycythemia: role of tyrosines Y285 and Y344 in erythropoietin receptor cytoplasmic domain. Biochim Biophys Acta 2005; 1740: 17-28.
-
(2005)
Biochim Biophys Acta
, vol.1740
, pp. 17-28
-
-
Arcasoy, M.O.1
Karayal, A.F.2
-
73
-
-
3042519411
-
Polycythemia and oxygen sensing
-
Maran J, Prchal J. Polycythemia and oxygen sensing. Pathol Biol (Paris) 2004; 52:280-284.
-
(2004)
Pathol Biol (Paris)
, vol.52
, pp. 280-284
-
-
Maran, J.1
Prchal, J.2
-
74
-
-
33645525963
-
Core erythropoietin receptor signals for late erythroblast development
-
Menon MP, Fang J, Wojchowski DM. Core erythropoietin receptor signals for late erythroblast development. Blood 2006; 107:2662-2672.
-
(2006)
Blood
, vol.107
, pp. 2662-2672
-
-
Menon, M.P.1
Fang, J.2
Wojchowski, D.M.3
-
75
-
-
0038644640
-
Functional p85alpha gene is required for normal murine fetal erythropoiesis
-
Huddleston H, Tan B, Yang FC, et al. Functional p85alpha gene is required for normal murine fetal erythropoiesis. Blood 2003; 102:142-145.
-
(2003)
Blood
, vol.102
, pp. 142-145
-
-
Huddleston, H.1
Tan, B.2
Yang, F.C.3
-
76
-
-
34250163897
-
GATA-1 and Gfi-1B interplay to regulate Bcl-xL transcription
-
Kuo YY, Chang ZF. GATA-1 and Gfi-1B interplay to regulate Bcl-xL transcription. Mol Cell Biol 2007; 27:4261-4272.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 4261-4272
-
-
Kuo, Y.Y.1
Chang, Z.F.2
-
77
-
-
70350061670
-
LRF is an essential downstream target of GATA1 in erythroid development and regulates BIM-dependent apoptosis
-
Maeda T, Ito K, Merghoub T, et al. LRF is an essential downstream target of GATA1 in erythroid development and regulates BIM-dependent apoptosis. Dev Cell 2009; 17:527-540.
-
(2009)
Dev Cell
, vol.17
, pp. 527-540
-
-
Maeda, T.1
Ito, K.2
Merghoub, T.3
-
78
-
-
77951436573
-
TRIB3 pseudokinase is induced via an EPO/EPOR/STAT5 pathway markedly up-modulated in late-stage erythroblasts and plays an essential non-redundant role during stress erythropoiesis [abstract # 1985]
-
Dev A, Wojchowski DM. TRIB3 pseudokinase is induced via an EPO/EPOR/STAT5 pathway, markedly up-modulated in late-stage erythroblasts, and plays an essential non-redundant role during stress erythropoiesis [abstract #1985]. In: Proceedings of the ASH Annual Meeting Abstracts 2009.
-
Proceedings of the ASH Annual Meeting Abstracts 2009
-
-
Dev, A.1
Wojchowski, D.M.2
-
79
-
-
4644295842
-
Serine protease inhibitor 2A is a protective factor for memory T cell development
-
DOI 10.1038/ni1107
-
Liu N, Phillips T, Zhang M, et al. Serine protease inhibitor 2A is a protective factor for memory T cell development. Nat Immunol 2004; 5:919-926. (Pubitemid 39276236)
-
(2004)
Nature Immunology
, vol.5
, Issue.9
, pp. 919-926
-
-
Liu, N.1
Phillips, T.2
Zhang, M.3
Wang, Y.4
Opferman, J.T.5
Shah, R.6
Ashton-Rickardt, P.G.7
-
80
-
-
3042589745
-
Serine protease inhibitor 2A inhibits caspase-independent cell death
-
DOI 10.1016/j.febslet.2004.05.061, PII S0014579304006416
-
Liu N, Wang Y, Ashton-Rickardt PG. Serine protease inhibitor 2A inhibits caspase-independent cell death. FEBS Lett 2004; 569:49-53. (Pubitemid 38844591)
-
(2004)
FEBS Letters
, vol.569
, Issue.1-3
, pp. 49-53
-
-
Liu, N.1
Wang, Y.2
Ashton-Rickardt, P.G.3
-
81
-
-
33745498417
-
TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism
-
Qi L, Heredia JE, Altarejos JY, et al. TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. Science 2006; 312:1763-1766.
-
(2006)
Science
, vol.312
, pp. 1763-1766
-
-
Qi, L.1
Heredia, J.E.2
Altarejos, J.Y.3
-
82
-
-
0025343574
-
Erythropoietin retards DNA breakdown and prevents programmed death in erythroid progenitor cells
-
Koury MJ, Bondurant MC. Erythropoietin retards DNA breakdown and prevents programmed death in erythroid progenitor cells. Science 1990; 248:378-381.
-
(1990)
Science
, vol.248
, pp. 378-381
-
-
Koury, M.J.1
Bondurant, M.C.2
-
83
-
-
0027225619
-
Cytokine-induced selective expansion and maturation of erythroid versus myeloid progenitors from purified cord blood precursor cells
-
Mayani H, Dragowska W, Lansdorp PM. Cytokine-induced selective expansion and maturation of erythroid versus myeloid progenitors from purified cord blood precursor cells. Blood 1993; 81:3252-3258.
-
(1993)
Blood
, vol.81
, pp. 3252-3258
-
-
Mayani, H.1
Dragowska, W.2
Lansdorp, P.M.3
-
84
-
-
0030956717
-
Receptors that induce erythroid differentiation of Ba/F3 cells: Structural requirements and effect on STAT5 binding
-
Pless M, Norga K, Carroll M, et al. Receptors that induce erythroid differentiation of Ba/F3 cells: structural requirements and effect on STAT5 binding. Blood 1997; 89:3175-3185.
-
(1997)
Blood
, vol.89
, pp. 3175-3185
-
-
Pless, M.1
Norga, K.2
Carroll, M.3
-
85
-
-
0037071391
-
Hematopoietic cytokines, transcription factors and lineage commitment
-
Zhu J, Emerson SG. Hematopoietic cytokines, transcription factors and lineage commitment. Oncogene 2002; 21:3295-3313.
-
(2002)
Oncogene
, vol.21
, pp. 3295-3313
-
-
Zhu, J.1
Emerson, S.G.2
-
86
-
-
35348875375
-
Cytokine receptors and hematopoietic differentiation
-
Robb L. Cytokine receptors and hematopoietic differentiation. Oncogene 2007; 26:6715-6723.
-
(2007)
Oncogene
, vol.26
, pp. 6715-6723
-
-
Robb, L.1
-
87
-
-
0033582243
-
Permissive role of thrombopoietin and granulocyte colony-stimulating factor receptors in hematopoietic cell fate decisions in vivo
-
Stoffel R, ZieglerS, Ghilardi N, et al. Permissive role of thrombopoietin and granulocyte colony-stimulating factor receptors in hematopoietic cell fate decisions in vivo. Proc Natl Acad Sci USA 1999; 96:698-702.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 698-702
-
-
Stoffel, R.1
Zieglers Ghilardi, N.2
-
88
-
-
70349684846
-
Integrating extrinsic and intrinsic cues into a minimal model of lineage commitment for hematopoietic progenitors
-
Palani S, Sarkar CA. Integrating extrinsic and intrinsic cues into a minimal model of lineage commitment for hematopoietic progenitors. PLoS Comput Biol 2009; 5:e1000518.
-
(2009)
PLoS Comput Biol
, vol.5
-
-
Palani, S.1
Sarkar, C.A.2
-
89
-
-
38649136568
-
ICA512 signaling enhances pancreatic beta-cell proliferation by regulating cyclins D through STATs
-
Mziaut H, Kersting S, Knoch KP, et al. ICA512 signaling enhances pancreatic beta-cell proliferation by regulating cyclins D through STATs. Proc Natl Acad Sci USA 2008; 105:674-679.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 674-679
-
-
Mziaut, H.1
Kersting, S.2
Knoch, K.P.3
-
90
-
-
0037960023
-
Signal transducer and activator of transcription 5 activation is sufficient to drive transcriptional induction of cyclin D2 gene and proliferation of rat pancreatic beta-cells
-
Friedrichsen BN, Richter HE, Hansen JA, et al. Signal transducer and activator of transcription 5 activation is sufficient to drive transcriptional induction of cyclin D2 gene and proliferation of rat pancreatic beta-cells. Mol Endocrinol 2003; 17:945-958.
-
(2003)
Mol Endocrinol
, vol.17
, pp. 945-958
-
-
Friedrichsen, B.N.1
Richter, H.E.2
Hansen, J.A.3
-
91
-
-
33846187999
-
STAT5 represses BCL6 expression by binding to a regulatory region frequently mutated in lymphomas
-
Walker SR, Nelson EA, Frank DA. STAT5 represses BCL6 expression by binding to a regulatory region frequently mutated in lymphomas. Oncogene 2007; 26:224-233.
-
(2007)
Oncogene
, vol.26
, pp. 224-233
-
-
Walker, S.R.1
Nelson, E.A.2
Frank, D.A.3
-
92
-
-
33846419491
-
Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals
-
Villarino AV, Tato CM, Stumhofer JS, et al. Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals. J Exp Med 2007; 204:65-71.
-
(2007)
J Exp Med
, vol.204
, pp. 65-71
-
-
Villarino, A.V.1
Tato, C.M.2
Stumhofer, J.S.3
-
93
-
-
33644647514
-
Signals for stress erythropoiesis are integrated via an erythropoietin receptor-phosphotyrosine-343-Stat5 axis
-
Menon MP, KarurV, Bogacheva O, et al. Signals for stress erythropoiesis are integrated via an erythropoietin receptor-phosphotyrosine-343-Stat5 axis. J Clin Invest 2006; 116:683-694.
-
(2006)
J Clin Invest
, vol.116
, pp. 683-694
-
-
Menon, M.P.1
Karurv Bogacheva, O.2
-
94
-
-
67651155966
-
An erythropoietin autocrine/paracrine axis modulates the growth and survival of human prostate cancer cells
-
Jeong JY, Hoxhaj G, Socha AL, et al. An erythropoietin autocrine/paracrine axis modulates the growth and survival of human prostate cancer cells. Mol Cancer Res 2009; 7:1150-1157.
-
(2009)
Mol Cancer Res
, vol.7
, pp. 1150-1157
-
-
Jeong, J.Y.1
Hoxhaj, G.2
Socha, A.L.3
-
95
-
-
58549086379
-
Constitutively active erythropoietin receptor expression in breast cancer cells promotes cellular proliferation and migration through a MAP-kinase dependent pathway
-
Fu P, Jiang X, Arcasoy MO. Constitutively active erythropoietin receptor expression in breast cancer cells promotes cellular proliferation and migration through a MAP-kinase dependent pathway. Biochem Biophys Res Commun 2009; 379:696-701.
-
(2009)
Biochem Biophys Res Commun
, vol.379
, pp. 696-701
-
-
Fu, P.1
Jiang, X.2
Arcasoy, M.O.3
-
96
-
-
67650418221
-
Hematopoietic cytokines caninstruct lineage choice
-
Rieger MA, Hoppe PS, Smejkal BM, et al. Hematopoietic cytokines caninstruct lineage choice. Science 2009; 325:217-218.
-
(2009)
Science
, vol.325
, pp. 217-218
-
-
Rieger, M.A.1
Hoppe, P.S.2
Smejkal, B.M.3
-
97
-
-
67650590934
-
MafB restricts M-CSF-dependent myeloid commitment divisions of hematopoietic stem cells
-
Sarrazin S, Mossadegh-Keller N, Fukao T, et al. MafB restricts M-CSF-dependent myeloid commitment divisions of hematopoietic stem cells. Cell 2009; 138:300-313.
-
(2009)
Cell
, vol.138
, pp. 300-313
-
-
Sarrazin, S.1
Mossadegh-Keller, N.2
Fukao, T.3
-
98
-
-
35348875999
-
Transcriptional control of granulocyte and monocyte development
-
Friedman AD. Transcriptional control of granulocyte and monocyte development. Oncogene 2007; 26:6816-6828.
-
(2007)
Oncogene
, vol.26
, pp. 6816-6828
-
-
Friedman, A.D.1
-
99
-
-
57549101047
-
Podocalyxin selectively marks erythroid-committed progenitors during anemic stress but is dispensable for efficient recovery
-
Maltby S, Hughes MR, Zbytnuik L, et al. Podocalyxin selectively marks erythroid-committed progenitors during anemic stress but is dispensable for efficient recovery. Exp Hematol 2009; 37:10-18.
-
(2009)
Exp Hematol
, vol.37
, pp. 10-18
-
-
Maltby, S.1
Hughes, M.R.2
Zbytnuik, L.3
-
100
-
-
19344367487
-
Podocalyxin is a CD34-related marker of murine hematopoietic stem cells and embryonic erythroid cells
-
Doyonnas R, Nielsen JS, Chelliah S, et al. Podocalyxin is a CD34-related marker of murine hematopoietic stem cells and embryonic erythroid cells. Blood 2005; 105:4170-4178.
-
(2005)
Blood
, vol.105
, pp. 4170-4178
-
-
Doyonnas, R.1
Nielsen, J.S.2
Chelliah, S.3
-
101
-
-
59549100452
-
Novel functions of the CD34 family
-
Nielsen JS, McNagny KM. Novel functions of the CD34 family. J Cell Sci 2008; 121:3683-3692.
-
(2008)
J Cell Sci
, vol.121
, pp. 3683-3692
-
-
Nielsen, J.S.1
McNagny, K.M.2
-
102
-
-
34547815735
-
Podocyte protection by darbepoetin: Preservation of the cytoskeleton and nephrin expression
-
Eto N, Wada T, Inagi R, et al. Podocyte protection by darbepoetin: preservation of the cytoskeleton and nephrin expression. Kidney Int 2007; 72:455-463.
-
(2007)
Kidney Int
, vol.72
, pp. 455-463
-
-
Eto, N.1
Wada, T.2
Inagi, R.3
-
103
-
-
57649201070
-
Erythropoietin prevents diabetes-induced podocyte damage
-
Schiffer M, Park JK, Tossidou I, et al. Erythropoietin prevents diabetes-induced podocyte damage. Kidney Blood Press Res 2008; 31:411-415.
-
(2008)
Kidney Blood Press Res
, vol.31
, pp. 411-415
-
-
Schiffer, M.1
Park, J.K.2
Tossidou, I.3
-
104
-
-
27344448624
-
Reactive oxygen species generated by hematopoietic cytokines play roles in activation of receptor-mediated signaling and in cell cycle progression
-
Iiyama M, Kakihana K, Kurosu T, et al. Reactive oxygen species generated by hematopoietic cytokines play roles in activation of receptor-mediated signaling and in cell cycle progression. Cell Signal 2006; 18:174-182.
-
(2006)
Cell Signal
, vol.18
, pp. 174-182
-
-
Iiyama, M.1
Kakihana, K.2
Kurosu, T.3
-
105
-
-
34547699517
-
Foxo3 is required for the regulation of oxidative stress in erythropoiesis
-
Marinkovic D, Zhang X, Yalcin S, et al. Foxo3 is required for the regulation of oxidative stress in erythropoiesis. J Clin Invest 2007; 117:2133-2144.
-
(2007)
J Clin Invest
, vol.117
, pp. 2133-2144
-
-
Marinkovic, D.1
Zhang, X.2
Yalcin, S.3
-
106
-
-
38849162389
-
Erythropoietin deficiency decreases vascular stability in mice
-
Chen J, Connor KM, Aderman CM, et al. Erythropoietin deficiency decreases vascular stability in mice. J Clin Invest 2008; 118:526-533.
-
(2008)
J Clin Invest
, vol.118
, pp. 526-533
-
-
Chen, J.1
Connor, K.M.2
Aderman, C.M.3
-
107
-
-
0035833541
-
Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades
-
Digicaylioglu M, Lipton SA. Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades. Nature 2001; 412:641-647.
-
(2001)
Nature
, vol.412
, pp. 641-647
-
-
Digicaylioglu, M.1
Lipton, S.A.2
-
108
-
-
72649083409
-
Erythropoietin receptor signaling regulates both erythropoiesis and megakaryopoiesis in vivo
-
Huang X, Pierce LJ, Chen GL, et al. Erythropoietin receptor signaling regulates both erythropoiesis and megakaryopoiesis in vivo. Blood Cells Mol Dis 2010; 44:1-6.
-
(2010)
Blood Cells Mol Dis
, vol.44
, pp. 1-6
-
-
Huang, X.1
Pierce, L.J.2
Chen, G.L.3
-
109
-
-
70349568677
-
A common bipotent progenitor generates the erythroid and megakaryocyte lineages in embryonic stem cell-derived primitive hematopoiesis
-
Klimchenko O, Mori M, Distefano A, et al. A common bipotent progenitor generates the erythroid and megakaryocyte lineages in embryonic stem cell-derived primitive hematopoiesis. Blood 2009; 114:1506-1517.
-
(2009)
Blood
, vol.114
, pp. 1506-1517
-
-
Klimchenko, O.1
Mori, M.2
Distefano, A.3
-
110
-
-
0035694582
-
The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor
-
Huang LJ, Constantinescu SN, Lodish HF. The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor. Mol Cell 2001; 8:1327-1338.
-
(2001)
Mol Cell
, vol.8
, pp. 1327-1338
-
-
Huang, L.J.1
Constantinescu, S.N.2
Lodish, H.F.3
-
111
-
-
40749093314
-
Jak2 FERM domain interaction with the erythropoietin receptor regulates Jak2 kinase activity
-
Funakoshi-Tago M, Pelletier S, Moritake H, et al. Jak2 FERM domain interaction with the erythropoietin receptor regulates Jak2 kinase activity. Mol Cell Biol 2008; 28:1792-1801.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 1792-1801
-
-
Funakoshi-Tago, M.1
Pelletier, S.2
Moritake, H.3
-
112
-
-
34249728880
-
The myeloproliferative disorder-associated JAK2 V617F mutant escapes negative regulation by suppressor of cytokine signaling 3
-
Hookham MB, Elliott J, Suessmuth Y, et al. The myeloproliferative disorder-associated JAK2 V617F mutant escapes negative regulation by suppressor of cytokine signaling 3. Blood 2007; 109:4924-4929.
-
(2007)
Blood
, vol.109
, pp. 4924-4929
-
-
Hookham, M.B.1
Elliott, J.2
Suessmuth, Y.3
-
114
-
-
69449087032
-
SOCS-mediated downregulation of mutant Jak2 (V617F, T875N and K539L) counteracts cytokine-independent signaling
-
Haan S, WullerS, Kaczor J, et al. SOCS-mediated downregulation of mutant Jak2 (V617F, T875N and K539L) counteracts cytokine-independent signaling. Oncogene 2009; 28:3069-3080.
-
(2009)
Oncogene
, vol.28
, pp. 3069-3080
-
-
Haan, S.1
Wullers Kaczor, J.2
-
115
-
-
58249133797
-
Deletion of the SOCS box of suppressor of cytokine signaling 3 (SOCS3) in embryonic stem cells reveals SOCS box-dependent regulation of JAK but not STAT phosphorylation
-
Boyle K, Zhang JG, Nicholson SE, et al. Deletion of the SOCS box of suppressor of cytokine signaling 3 (SOCS3) in embryonic stem cells reveals SOCS box-dependent regulation of JAK but not STAT phosphorylation. Cell Signal 2009; 21:394-404.
-
(2009)
Cell Signal
, vol.21
, pp. 394-404
-
-
Boyle, K.1
Zhang, J.G.2
Nicholson, S.E.3
-
116
-
-
26444496530
-
SOCS2 can enhance interleukin-2 (IL-2) and IL-3 signaling by accelerating SOCS3 degradation
-
Tannahill GM, Elliott J, Barry AC, et al. SOCS2 can enhance interleukin-2 (IL-2) and IL-3 signaling by accelerating SOCS3 degradation. Mol Cell Biol 2005; 25:9115-9126.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 9115-9126
-
-
Tannahill, G.M.1
Elliott, J.2
Barry, A.C.3
-
117
-
-
70449676511
-
Regulation of multiple cytokine signalling pathways by SOCS3 is independent of SOCS2
-
Kiu H, Greenhalgh CJ, Thaus A, et al. Regulation of multiple cytokine signalling pathways by SOCS3 is independent of SOCS2. Growth Factors 2009; 27:384-393.
-
(2009)
Growth Factors
, vol.27
, pp. 384-393
-
-
Kiu, H.1
Greenhalgh, C.J.2
Thaus, A.3
-
118
-
-
57949086449
-
SOCS2: Inhibitor of JAK2V617F-mediated signal transduction
-
Quentmeier H, Geffers R, Jost E, et al. SOCS2: inhibitor of JAK2V617F-mediated signal transduction. Leukemia 2008; 22:2169-2175.
-
(2008)
Leukemia
, vol.22
, pp. 2169-2175
-
-
Quentmeier, H.1
Geffers, R.2
Jost, E.3
-
119
-
-
45249103554
-
The suppressors of cytokine signalling E3 ligases behave as tumour suppressors
-
Elliott J, Hookham MB, Johnston JA. The suppressors of cytokine signalling E3 ligases behave as tumour suppressors. Biochem Soc Trans 2008; 36:464-468.
-
(2008)
Biochem Soc Trans
, vol.36
, pp. 464-468
-
-
Elliott, J.1
Hookham, M.B.2
Johnston, J.A.3
-
120
-
-
50549085051
-
Epigenetic alteration of SOCS family members is a possible pathogenetic mechanism in JAK2 wild type myeloproliferative diseases
-
Teofili L, Martini M, Cenci T, et al. Epigenetic alteration of SOCS family members is a possible pathogenetic mechanism in JAK2 wild type myeloproliferative diseases. Int J Cancer 2008; 123:1586-1592.
-
(2008)
Int J Cancer
, vol.123
, pp. 1586-1592
-
-
Teofili, L.1
Martini, M.2
Cenci, T.3
-
121
-
-
70350506791
-
Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies
-
Fandy TE, Herman JG, Kerns P, et al. Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies. Blood 2009; 114:2764-2773.
-
(2009)
Blood
, vol.114
, pp. 2764-2773
-
-
Fandy, T.E.1
Herman, J.G.2
Kerns, P.3
-
122
-
-
61349119266
-
The SOCS box encodes a hierarchy of affinities for Cullin5: Implications for ubiquitin ligase formation and cytokine signalling suppression
-
Babon JJ, Sabo JK, Zhang JG, et al. The SOCS box encodes a hierarchy of affinities for Cullin5: implications for ubiquitin ligase formation and cytokine signalling suppression. J Mol Biol 2009; 387:162-174.
-
(2009)
J Mol Biol
, vol.387
, pp. 162-174
-
-
Babon, J.J.1
Sabo, J.K.2
Zhang, J.G.3
-
124
-
-
20444426803
-
Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways
-
Tong W, Zhang J, Lodish HF. Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways. Blood 2005; 105: 4604-4612.
-
(2005)
Blood
, vol.105
, pp. 4604-4612
-
-
Tong, W.1
Zhang, J.2
Lodish, H.F.3
-
125
-
-
67149083222
-
Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617F
-
Gery S, Cao Q, Gueller S, et al. Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617F. J Leukoc Biol 2009; 85:957-965.
-
(2009)
J Leukoc Biol
, vol.85
, pp. 957-965
-
-
Gery, S.1
Cao, Q.2
Gueller, S.3
-
126
-
-
33746591727
-
Cytokines regulate postnatal hematopoietic stem cell expansion: Opposing roles of thrombopoietin and LNK
-
Buza-Vidas N, Antonchuk J, Qian H, et al. Cytokines regulate postnatal hematopoietic stem cell expansion: opposing roles of thrombopoietin and LNK. Genes Dev 2006; 20:2018-2023.
-
(2006)
Genes Dev
, vol.20
, pp. 2018-2023
-
-
Buza-Vidas, N.1
Antonchuk, J.2
Qian, H.3
-
127
-
-
64249098439
-
Expression of the adaptor protein Lnk in leukemia cells
-
Gery S, Gueller S, Nowak V, et al. Expression of the adaptor protein Lnk in leukemia cells. Exp Hematol 2009; 37:585-592.
-
(2009)
Exp Hematol
, vol.37
, pp. 585-592
-
-
Gery, S.1
Gueller, S.2
Nowak, V.3
-
128
-
-
70149101855
-
The Drosophila SH2B family adaptor Lnk acts in parallel to chico in the insulin signaling pathway
-
Werz C, Kohler K, Hafen E, et al. The Drosophila SH2B family adaptor Lnk acts in parallel to chico in the insulin signaling pathway. PLoS Genet 2009; 5:e1000596.
-
(2009)
PLoS Genet
, vol.5
-
-
Werz, C.1
Kohler, K.2
Hafen, E.3
-
129
-
-
67649888820
-
Site-specific ubiquitination determines lysosomal sorting and signal attenuation of the granulocyte colony-stimulating factor receptor
-
Wolfler A, Irandoust M, Meenhuis A, et al. Site-specific ubiquitination determines lysosomal sorting and signal attenuation of the granulocyte colony-stimulating factor receptor. Traffic 2009; 10:1168-1179.
-
(2009)
Traffic
, vol.10
, pp. 1168-1179
-
-
Wolfler, A.1
Irandoust, M.2
Meenhuis, A.3
-
130
-
-
34247242299
-
Suppressor of cytokine signaling 3 controls lysosomal routing of G-CSF receptor
-
Irandoust MI, Aarts LH, Roovers O, et al. Suppressor of cytokine signaling 3 controls lysosomal routing of G-CSF receptor. EMBO J 2007; 26:1782-1793.
-
(2007)
EMBO J
, vol.26
, pp. 1782-1793
-
-
Irandoust, M.I.1
Aarts, L.H.2
Roovers, O.3
-
131
-
-
34250027624
-
Beta-Trcp mediates ubiquitination and degradation of the erythropoietin receptor and controls cell proliferation
-
Meyer L, Deau B, Forejtnikova H, et al. beta-Trcp mediates ubiquitination and degradation of the erythropoietin receptor and controls cell proliferation. Blood 2007; 109:5215-5222.
-
(2007)
Blood
, vol.109
, pp. 5215-5222
-
-
Meyer, L.1
Deau, B.2
Forejtnikova, H.3
-
132
-
-
0038711771
-
Erythropoietin receptors associate with a ubiquitin ligase, p33RUL, and require its activity for erythropoietin-induced proliferation
-
Friedman AD, Nimbalkar D, Quelle FW. Erythropoietin receptors associate with a ubiquitin ligase, p33RUL, and require its activity for erythropoietin-induced proliferation. J Biol Chem 2003; 278:26851-26861.
-
(2003)
J Biol Chem
, vol.278
, pp. 26851-26861
-
-
Friedman, A.D.1
Nimbalkar, D.2
Quelle, F.W.3
-
133
-
-
67149106146
-
Ligand-induced EpoR internalization is mediated by JAK2 and p85 and is impaired by mutations responsible for primary familial and congenital polycythemia
-
Sulahian R, Cleaver O, Huang LJ. Ligand-induced EpoR internalization is mediated by JAK2 and p85 and is impaired by mutations responsible for primary familial and congenital polycythemia. Blood 2009; 113:5287-5297.
-
(2009)
Blood
, vol.113
, pp. 5287-5297
-
-
Sulahian, R.1
Cleaver, O.2
Huang, L.J.3
-
134
-
-
0037075272
-
Pure red-cell aplasia and antierythropoietin antibodies in patients treated with recombinant erythropoietin
-
DOI 10.1056/NEJMoa011931
-
Casadevall N, Nataf J, Viron B, et al. Pure red-cell aplasia and antierythro-poietin antibodies in patients treated with recombinant erythropoietin. N Engl J Med 2002; 346:469-475. (Pubitemid 34441737)
-
(2002)
New England Journal of Medicine
, vol.346
, Issue.7
, pp. 469-475
-
-
Casadevall, N.1
Nataf, J.2
Viron, B.3
Kolta, A.4
Kiladjian, J.-J.5
Martin-Dupont, P.6
Michaud, P.7
Papo, T.8
Ugo, V.9
Teyssandier, I.10
Varet, B.11
Mayeux, P.12
-
135
-
-
39649085543
-
CNTO 530: Molecular pharmacology in human UT-7EPO cells and pharmacokinetics and pharmacodynamics in mice
-
Bugelski PJ, Capocasale RJ, Makropoulos D, et al. CNTO 530: molecular pharmacology in human UT-7EPO cells and pharmacokinetics and pharmacodynamics in mice. J Biotechnol 2008; 134:171-180.
-
(2008)
J Biotechnol
, vol.134
, pp. 171-180
-
-
Bugelski, P.J.1
Capocasale, R.J.2
Makropoulos, D.3
-
136
-
-
17944375360
-
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydro-xylation
-
Epstein AC, Gleadle JM, McNeill LA, et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydro-xylation. Cell 2001; 107:43-54.
-
(2001)
Cell
, vol.107
, pp. 43-54
-
-
Epstein, A.C.1
Gleadle, J.M.2
McNeill, L.A.3
-
137
-
-
0035834409
-
A conserved family of prolyl-4-hydroxylases that modify HIF
-
Bruick RK, McKnight SL. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 2001; 294:1337-1340.
-
(2001)
Science
, vol.294
, pp. 1337-1340
-
-
Bruick, R.K.1
McKnight, S.L.2
-
140
-
-
66449124596
-
HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice
-
Mastrogiannaki M, Matak P, Keith B, et al. HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice. J Clin Invest 2009; 119:1159-1166.
-
(2009)
J Clin Invest
, vol.119
, pp. 1159-1166
-
-
Mastrogiannaki, M.1
Matak, P.2
Keith, B.3
-
141
-
-
65649138377
-
Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment
-
Chan DA, KawaharaTL, Sutphin PD, et al. Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment. Cancer Cell 2009; 15:527-538.
-
(2009)
Cancer Cell
, vol.15
, pp. 527-538
-
-
Chan, D.A.1
Kawahara, T.L.2
Sutphin, P.D.3
-
142
-
-
33847223121
-
Epigenetic alterations complement mutation of JAK2 tyrosine kinase in patients with BCR/ABL-negative myeloproliferative disorders
-
Jost E, do ON, Dahl E, et al. Epigenetic alterations complement mutation of JAK2 tyrosine kinase in patients with BCR/ABL-negative myeloproliferative disorders. Leukemia 2007; 21:505-510.
-
(2007)
Leukemia
, vol.21
, pp. 505-510
-
-
Jost, E.1
Do, O.N.2
Dahl, E.3
-
143
-
-
0026765013
-
Mutations in the WSAWSE and cytosolic domains of the erythropoietin receptor affect signal transduction and ligand binding and internalization
-
Quelle DE, Quelle FW, Wojchowski DM. Mutations in the WSAWSE and cytosolic domains of the erythropoietin receptor affect signal transduction and ligand binding and internalization. Mol Cell Biol 1992; 12:4553-4561.
-
(1992)
Mol Cell Biol
, vol.12
, pp. 4553-4561
-
-
Quelle, D.E.1
Quelle, F.W.2
Wojchowski, D.M.3
|