The granzyme B inhibitor proteinase inhibitor 9 (PI9) is expressed by human mast cells

European Journal of Immunology

Volumn 35, Issue 4, 2005, Pages 1175-1183

  Bladergroen, Bellinda A ^a,c   Strik, Merel C M ^b,c   Wolbink, Angela M ^b   Wouters, Dorine ^c   Broekhuizen, Roel ^c,d   Kummer, J Alain ^d   Hack, C Erik ^b,c  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b SANQUIN RESEARCH   (Netherlands)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Human mast cells; Mastocytosis; Proteinase inhibitor 9; Serpin

Indexed keywords

CALCIMYCIN; CALCIUM IONOPHORE; GRANZYME B; MONOCLONAL ANTIBODY; SERINE PROTEINASE INHIBITOR;

APOPTOSIS; ARTICLE; CELL LINE; CELL PROTECTION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; ENZYME ACTIVITY; ENZYME RELEASE; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IMMUNOSURVEILLANCE; IN VITRO STUDY; INFLAMMATION; MAST CELL; PRIORITY JOURNAL; REGULATORY MECHANISM; SYSTEMIC MASTOCYTOSIS; TUMOR CELL; TUMOR ESCAPE; URTICARIA PIGMENTOSA;

ENZYME-LINKED IMMUNOSORBENT ASSAY; GRANZYMES; HUMANS; MAST CELLS; MASTOCYTOSIS; SERINE ENDOPEPTIDASES; SERPINS; UP-REGULATION;

EID: 17444408171     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200425949     Document Type: Article

References (28)

1. Silverman, G. A., Bird, P. I., Carrell, R. W., Church, F. C., Coughlin, P. B., Gettins, P. G., Irving, J. A., Lomas, D. A., Luke, C. J., Moyer, R. W. et al., The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature. J. Biol. Chem. 2001. 276: 33293-33296.
2. Irving, J. A., Pike, R. N., Lesk, A. M. and Whisstock, J. C., Phylogeny of the serpin superfamily: implications of patterns of amino acid conservation for structure and function. Genome Res. 2000. 10: 1845-1864.
3. Gettins, P. G., Serpin structure, mechanism, and function. Chem. Rev. 2002. 102: 4751-4804.
4. Remold-O'Donnell, E., The ovalbumin family of serpin proteins. FEBS Lett. 1993. 315: 105-108.
5. Bird, C. H., Blink, E. J., Hirst, C. E., Buzza, M. S., Steele, P. M., Sun, J., Jans, D. A. and Bird, P. I., Nucleocytoplasmic distribution of the ovalbumin serpin PI-9 requires a nonconventional nuclear import pathway and the export factor Crm1. Mol. Cell Biol. 2001. 21: 5396-5407.
6. Annand, R. R., Dahlen, J. R., Sprecher, C. A., De Dreu P., Foster, D. C., Mankovich, J. A., Talanian, R. V., Kisiel, W. and Giegel, D. A., Caspase-1 (interleukin-1beta-converting enzyme) is inhibited by the human serpin analogue proteinase inhibitor 9. Biochem. J. 1999. 342: 655-665.
7. Young, J. I., Sukhova, G. K., Foster, D., Kisiel, W., Libby, P. and Schonbeck, U., The serpin proteinase inhibitor 9 is an endogenous inhibitor of interleukin 1beta-converting enzyme (caspase-1) activity in human vascular smooth muscle cells. J. Exp. Med. 2000. 191: 1535-1544.
8. Bird, C. H., Sutton, V., Sun, J., Hirst, C. E., Novak, A., Kumar, S., Trapani, J. A. and Bird, P. I., Selective regulation of apoptosis: the cytotoxic lymphocyte serpin proteinase inhibitor 9 protects against granzyme B-mediated apoptosis without perturbing the Fas cell death pathway. Mol. Cell Biol. 1998. 18: 6387-6398.
9. Sun, J., Bird, C. H., Sutton, V., McDonald, L., Coughlin, P. B., De Jong, T. A., Trapani, J. A. and Bird, P. I., A cytosolic granzyme B inhibitor related to the viral apoptosic regulator cytokine response modifier A is present in cytotoxic lymphocytes. J. Biol. Chem. 1996. 271: 27802-27809.
10. Bladergroen, B. A., Strik, M. C. M., Bovenschen, N., van Berkum, O., Scheffer, G. L., Meijer, C. J. L. M., Hack, C. E. and Kummer, J. A., The granzyme B inhibitor, protease inhibitor 9, is mainly expressed by dendritic cells and at immune privileged sites. J. Immunol. 2001. 166: 3218-3225.
11. Buzza, M. S., Hirst, C. E., Bird, C. H., Hosking, P., McKendrick, J. and Bird, P. I., The granzyme B inhibitor, PI-9, is present in endothelial and mesothelial cells, suggesting that it protects bystander cells during immune responses. Cell Immunol. 2001. 210: 21-29.
12. Bladergroen, B. A., Meijer, C. J., ten Berge, R. L., Hack, C. E., Muris, J. J., Dukers, D. F., Chott, A., Kazama, Y., Oudejans, J. J., van Berkum, O. and Kummer, J. A., Expression of the granzyme B inhibitor, protease inhibitor 9, by tumor cells in patients with non-Hodgkin and Hodgkin lymphoma: a novel protective mechanism for tumor cells to circumvent the immune system? Blood 2002. 99: 232-237.
13. Oudejans, J. J., Harijadi, H., Kummer, J. A., Tan, I. B., Bloemena, E., Middeldorp, J. M., Bladergroen, B., Dukers, D. F., Vos, W. and Meijer, C. J., High numbers of granzyme B/CD8-positive tumour-infiltrating lymphocytes in nasopharyngeal carcinoma biopsies predict rapid fatal outcome in patients treated with curative intent. J. Pathol. 2002. 198: 468-475.
14. Medema, J. P., de Jong, J., Peltenburg, L. T., Verdegaal, E. M., Gorter, A., Bres, S. A., Franken, K. L., Hahne, M., Albar, J. P., Melief, C. J. and Offringa, R., Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors. Proc. Natl. Acad. Sci. USA 2001. 98: 11515-11520.
15. ten Berge, R. L., Meijer, C. J., Dukers, D., Kummer, J. A., Bladergroen, B. A., Vos, W., Hack, C. E., Ossenkoppele, G. J. and Oudejans, J. J., Expression levels of apoptosis-related proteins predict clinical outcome in anaplastic large cell lymphoma. Blood 2002. 99: 4540-4546.
16. Strik, M. C., Wolbink, A., Wouters, D., Bladergroen, B. A., Verlaan, A. R., Van Houdt, I. S., Hijlkema, S., Hack, C. E. and Kummer, J. A., The intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with [beta]-tryptase monomers. Blood 2004. 103: 2710-2717.
17. Miller, H. R. and Pemberton, A. D., Tissue-specific expression of mast cell granule serine proteinases and their role in inflammation in the lung and gut. Immunology 2002. 105: 375-390.
18. Schick, C., Kamachi, Y., Bartuski, A. J., Cataltepe, S., Schechter, N. M., Pemberton, P. A. and Silverman, G. A., Squamous cell carcinoma antigen 2 is a novel serpin that inhibits the chymotrypsin-like proteinases cathepsin G and mast cell chymase. J. Biol. Chem. 1997. 272: 1849-1855.
19. Cooley, J., Takayama, T. K., Shapiro, S. D., Schechter, N. M. and Remold-O'Donnell, E., The serpin MNEI inhibits elastase-like and chymotrypsin-like serine proteases through efficient reactions at two active sites. Biochemistry 2001. 40: 15762-15770.
20. Lutzelschwab, C., Huang, M. R., Kullberg, M. C., Aveskogh, M. and Hellman, L., Characterization of mouse mast cell protease-8, the first member of a novel subfamily of mouse mast cell serine proteases, distinct from both the classical chymases and tryptases. Eur. J. Immunol. 1998. 28: 1022-1033.
21. Lutzelschwab, C., Lunderius, C., Enerback, L. and Hellman, L., A kinetic analysis of the expression of mast cell protease mRNA in the intestines of Nippostrongylus brasiliensis-infected rats. Eur. J. Immunol. 1998. 28: 3730-3737.
22. Kawakami, T. and Galli, S. J., Regulation of mast-cell and basophil function and survival by IgE. Nat. Rev. Immunol. 2002. 2: 773-786.
23. Cho, S. H., Tam, S. W., Demissie-Sanders, S., Filler, S. A. and Oh, C. K., Production of plasminogen activator inhibitor-1 by human mast cells and its possible role in asthma. J. Immunol. 2000. 165: 3154-3161.
24. Kannan-Thulasiraman, P. and Shapiro, D. J., Modulators of inflammation use nuclear factor-kappa B and activator protein-1 sites to induce the caspase-1 and granzyme B inhibitor, proteinase inhibitor 9. J. Biol. Chem. 2002. 277: 41230-41239.
25. Butterfield, J. H., Weiler, D., Dewald, G. and Gleich, G. J., Establishment of an immature mast cell line from a patient with mast cell leukemia. Leuk. Res. 1988. 12: 345-355.
26. Dahlen, J. R., Foster, D. C. and Kisiel, W., Expression, purification, and inhibitory properties of human proteinase inhibitor 8. Biochemistry 1997. 36: 14874-14882.
27. Hack, C. E., Paardekooper, J., Smeenk, R. J., Abbink, J., Eerenberg, A. J. and Nuijens, J. H., Disruption of the internal thioester bond in the third component of complement (C3) results in the exposure of neodeterminants also present on activation products of C3. An analysis with monoclonal antibodies. J. Immunol. 1988. 141: 1602-1609.
28. Vassault, A., Lactate dehydrogenase. In Bergmeyer, H. U., Bergmeyer, J. and Graßl, M. (Eds.) Methods of enzymatic analysis. Verlag Chemie, Weinheim 1983, pp 118-126.