-
1
-
-
0034949634
-
Development and characterization of novel erythropoiesis stimulating protein (NESP)
-
Egrie JC, Browne KJ: Development and characterization of novel erythropoiesis stimulating protein (NESP). Nephrol Dial Transplant (2001) 16(Suppl 3):3-13.
-
(2001)
Nephrol Dial Transplant
, vol.16
, Issue.SUPPL. 3
, pp. 3-13
-
-
Egrie, J.C.1
Browne, K.J.2
-
2
-
-
0037317083
-
Treatment of anaemia in dialysis patients with unit dosing of darbepoetin alfa at a reduced dose frequency relative to recombinant human erythropoietin (rHuEpo)
-
Locatelli F, Canaud B, Giacardy F, Martin-Malo A, Baker N, Wilson J: Treatment of anaemia in dialysis patients with unit dosing of darbepoetin alfa at a reduced dose frequency relative to recombinant human erythropoietin (rHuEpo). Nephrol Dial Transplant (2003) 18(2):362-369.
-
(2003)
Nephrol Dial Transplant
, vol.18
, Issue.2
, pp. 362-369
-
-
Locatelli, F.1
Canaud, B.2
Giacardy, F.3
Martin-Malo, A.4
Baker, N.5
Wilson, J.6
-
3
-
-
77951167067
-
Population pharmacokinetic/pharmacodynamic model for C.E.R.A. in both ESA-naive and ESA-treated chronic kidney disease patients with renal anemia
-
Chanu P, Gieschke R, Charoin JE, Pannier A, Reigner B: Population pharmacokinetic/pharmacodynamic model for C.E.R.A. in both ESA-naive and ESA-treated chronic kidney disease patients with renal anemia. J Clin Pharmacol (2010) 50(5):507-520.
-
(2010)
J Clin Pharmacol
, vol.50
, Issue.5
, pp. 507-520
-
-
Chanu, P.1
Gieschke, R.2
Charoin, J.E.3
Pannier, A.4
Reigner, B.5
-
4
-
-
3242884347
-
CERA (continuous erythropoiesis receptor activator), a novel erythropoietic agent: Dose-dependent response in phase i studies
-
Reigner B, Jordan P, Panier A, Glaspy J: CERA (continuous erythropoiesis receptor activator), a novel erythropoietic agent: Dose-dependent response in phase I studies. Proc Am Soc Clin Oncol (2003) 22:Abs 2943.
-
(2003)
Proc Am Soc Clin Oncol
, vol.22
, pp. 2943
-
-
Reigner, B.1
Jordan, P.2
Panier, A.3
Glaspy, J.4
-
5
-
-
35348839061
-
MAXIMA study investigators: Intravenous methoxy polyethylene glycol-epoetin â for haemoglobin control in patients with chronic kidney disease who are on dialysis: A randomised non-inferiority trial (MAXIMA)
-
Levin NW, Fishbane S, Cañedo FV, Zeig S, Nassar GM, Moran JE, Villa G, Beyer U, Oguey D, MAXIMA study investigators: Intravenous methoxy polyethylene glycol-epoetin â for haemoglobin control in patients with chronic kidney disease who are on dialysis: A randomised non-inferiority trial (MAXIMA). Lancet (2007) 370(9596):1415-1421.
-
(2007)
Lancet
, vol.370
, Issue.9596
, pp. 1415-1421
-
-
Levin, N.W.1
Fishbane, S.2
Cañedo, F.V.3
Zeig, S.4
Nassar, G.M.5
Moran, J.E.6
Villa, G.7
Beyer, U.8
Oguey, D.9
-
6
-
-
77956258983
-
Maintenance treatment of renal anaemia in haemodialysis patients with methoxy polyethylene glycol-epoetin â versus darbepoetin alfa administered monthly: A randomized comparative trial
-
doi:10.1093/ ndt/gfq305
-
Carrera F, Lok CE, de Francisco A, Locatelli F, Mann JF, Canaud B, Kerr PG, Macdougall IC, Besarab A, Villa G, Kazes I et al: Maintenance treatment of renal anaemia in haemodialysis patients with methoxy polyethylene glycol-epoetin â versus darbepoetin alfa administered monthly: A randomized comparative trial. Nephrol Dial Transplant (2010):doi:10.1093/ ndt/gfq305.
-
(2010)
Nephrol Dial Transplant
-
-
Carrera, F.1
Lok, C.E.2
De Francisco, A.3
Locatelli, F.4
Mann, J.F.5
Canaud, B.6
Kerr, P.G.7
MacDougall, I.C.8
Besarab, A.9
Villa, G.10
Kazes, I.11
-
7
-
-
76649125208
-
C.E.R.A. safety profile: A pooled analysis in patients with chronic kidney disease
-
Locatelli F, Mann JF, Aldigier JC, Sanz Guajardo D, Schmidt R, Van Vlem B, Sulowicz W, Dougherty FC, Beyer U: C.E.R.A. safety profile: A pooled analysis in patients with chronic kidney disease. Clin Nephrol (2010) 73(2):94-103.
-
(2010)
Clin Nephrol
, vol.73
, Issue.2
, pp. 94-103
-
-
Locatelli, F.1
Mann, J.F.2
Aldigier, J.C.3
Sanz Guajardo, D.4
Schmidt, R.5
Van Vlem, B.6
Sulowicz, W.7
Dougherty, F.C.8
Beyer, U.9
-
8
-
-
77956242010
-
-
Merck & Co presents R&D program, including biologics commitment, but drops PEGylated erythropoietin biosimilar: ThePharmaletter, London, UK
-
Merck & Co presents R&D program, including biologics commitment, but drops PEGylated erythropoietin biosimilar: ThePharmaletter, London, UK (2010). www.thepharmaletter.com/file/94912/merck-co-presents-rd-program- including-biologics-commitment-but-drops-pegylated-erythropoietin-biosimilar. html
-
(2010)
-
-
-
9
-
-
74149085504
-
Efficient preparation and PEGylation of recombinant human non-glycosylated erythropoietin expressed as inclusion body in E. coli
-
Wang YJ, Liu YD, Chen J, Hao SJ, Hu T, Ma GH, Su ZG: Efficient preparation and PEGylation of recombinant human non-glycosylated erythropoietin expressed as inclusion body in E. coli. Int J Pharm (2010) 386(1-2):156-164.
-
(2010)
Int J Pharm
, vol.386
, Issue.1-2
, pp. 156-164
-
-
Wang, Y.J.1
Liu, Y.D.2
Chen, J.3
Hao, S.J.4
Hu, T.5
Ma, G.H.6
Su, Z.G.7
-
10
-
-
77954314305
-
PEGylation markedly enhances the in vivo potency of recombinant human non-glycosylated erythropoietin: A comparison with glycosylated erythropoietin
-
Wang YJ, Hao SJ, Liu YD, Hu T, Zhang GF, Zhang X, Qi QS, Ma GH, Su ZG: PEGylation markedly enhances the in vivo potency of recombinant human non-glycosylated erythropoietin: A comparison with glycosylated erythropoietin. J Control Release (2010) 145(3):306-313.
-
(2010)
J Control Release
, vol.145
, Issue.3
, pp. 306-313
-
-
Wang, Y.J.1
Hao, S.J.2
Liu, Y.D.3
Hu, T.4
Zhang, G.F.5
Zhang, X.6
Qi, Q.S.7
Ma, G.H.8
Su, Z.G.9
-
11
-
-
0032477808
-
Human erythropoietin dimers with markedly enhanced in vivo activity
-
Sytkowski AJ, Lunn ED, Davis KL, Feldman L, Siekman S: Human erythropoietin dimers with markedly enhanced in vivo activity. Proc Natl Acad Sci USA (1998) 95(3):1184-1188.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, Issue.3
, pp. 1184-1188
-
-
Sytkowski, A.J.1
Lunn, E.D.2
Davis, K.L.3
Feldman, L.4
Siekman, S.5
-
12
-
-
0035877998
-
Dimeric erythropoietin fusion protein with enhanced erythropoietic activity in vitro and in vivo
-
Dalle B, Henri A, Rouyer-Fessard P, Bettan M, Scherman D, Beuzard Y, Payen E: Dimeric erythropoietin fusion protein with enhanced erythropoietic activity in vitro and in vivo. Blood (2001) 97(12):3776-3782.
-
(2001)
Blood
, vol.97
, Issue.12
, pp. 3776-3782
-
-
Dalle, B.1
Henri, A.2
Rouyer-Fessard, P.3
Bettan, M.4
Scherman, D.5
Beuzard, Y.6
Payen, E.7
-
13
-
-
34748812412
-
Development of a long-acting erythropoietin by fusing the carboxyl-terminal peptide of human chorionic gonadotropin â-subunit to the coding sequence of human erythropoietin
-
Fares F, Ganem S, Hajouj T, Agai E: Development of a long-acting erythropoietin by fusing the carboxyl-terminal peptide of human chorionic gonadotropin â-subunit to the coding sequence of human erythropoietin. Endocrinology (2007) 148(10):5081-5087.
-
(2007)
Endocrinology
, vol.148
, Issue.10
, pp. 5081-5087
-
-
Fares, F.1
Ganem, S.2
Hajouj, T.3
Agai, E.4
-
14
-
-
33748809512
-
Biochemical characterization of rhEpo-Fc fusion protein expressed in CHO cells
-
Schriebl K, Trummer E, Lattenmayer C, Weik R, Kunert R, Müller D, Katinger H, Vorauer-Uhl K: Biochemical characterization of rhEpo-Fc fusion protein expressed in CHO cells. Protein Expr Purif (2006) 49(2):265-275.
-
(2006)
Protein Expr Purif
, vol.49
, Issue.2
, pp. 265-275
-
-
Schriebl, K.1
Trummer, E.2
Lattenmayer, C.3
Weik, R.4
Kunert, R.5
Müller, D.6
Katinger, H.7
Vorauer-Uhl, K.8
-
15
-
-
21044443734
-
Improvement of Fc-erythropoietin structure and pharmacokinetics by modification at a disulfide bond
-
Way JC, Lauder S, Brunkhorst B, Kong SM, Qi A, Webster G, Campbell I, McKenzie S, Lan Y, Marelli B, Nguyen LA et al: Improvement of Fc-erythropoietin structure and pharmacokinetics by modification at a disulfide bond. Protein Eng Des Sel (2005) 18(3):111-118.
-
(2005)
Protein Eng des Sel
, vol.18
, Issue.3
, pp. 111-118
-
-
Way, J.C.1
Lauder, S.2
Brunkhorst, B.3
Kong, S.M.4
Qi, A.5
Webster, G.6
Campbell, I.7
McKenzie, S.8
Lan, Y.9
Marelli, B.10
Nguyen, L.A.11
-
16
-
-
25844528107
-
Delivery of an erythropoietin-Fc fusion protein by inhalation in humans through an immunoglobulin transport pathway
-
Dumont JA, Bitonti AJ, Clark D, Evans S, Pickford M, Newman SP: Delivery of an erythropoietin-Fc fusion protein by inhalation in humans through an immunoglobulin transport pathway. J Aerosol Med (2005) 18(3):294-303.
-
(2005)
J Aerosol Med
, vol.18
, Issue.3
, pp. 294-303
-
-
Dumont, J.A.1
Bitonti, A.J.2
Clark, D.3
Evans, S.4
Pickford, M.5
Newman, S.P.6
-
17
-
-
77952303814
-
Production of recombinant human erythropoietin/Fc fusion protein by genetically manipulated chickens
-
Penno CA, Kawabe Y, Ito A, Kamihira M: Production of recombinant human erythropoietin/Fc fusion protein by genetically manipulated chickens. Transgenic Res (2010) 19(2):187-195.
-
(2010)
Transgenic Res
, vol.19
, Issue.2
, pp. 187-195
-
-
Penno, C.A.1
Kawabe, Y.2
Ito, A.3
Kamihira, M.4
-
18
-
-
70349472940
-
Production and characterization of long-acting recombinant human albumin-EPO fusion protein expressed in CHO cell
-
Joung CH, Shin JY, Koo JK, Lim JJ, Wang JS, Lee SJ, Tan HK, Kim SL, Lim SM: Production and characterization of long-acting recombinant human albumin-EPO fusion protein expressed in CHO cell. Protein Expr Purif (2009) 68(2):137-145.
-
(2009)
Protein Expr Purif
, vol.68
, Issue.2
, pp. 137-145
-
-
Ch, J.1
Shin, J.Y.2
Koo, J.K.3
Lim, J.J.4
Wang, J.S.5
Lee, S.J.6
Tan, H.K.7
Kim, S.L.8
Lim, S.M.9
-
19
-
-
0032469128
-
The rhGM-CSF-EPO hybrid protein MEN 11300 induces anti-EPO antibodies and severe anaemia in rhesus monkeys
-
Coscarella A, Liddi R, Di Loreto M, Bach S, Faiella A, van der Meide PH, Mele A, De Santis R: The rhGM-CSF-EPO hybrid protein MEN 11300 induces anti-EPO antibodies and severe anaemia in rhesus monkeys. Cytokine (1998) 10(12):964-969.
-
(1998)
Cytokine
, vol.10
, Issue.12
, pp. 964-969
-
-
Coscarella, A.1
Liddi, R.2
Di Loreto, M.3
Bach, S.4
Faiella, A.5
Van Der Meide, P.H.6
Mele, A.7
De Santis, R.8
-
20
-
-
0037423148
-
Design and chemical synthesis of a homogeneous polymer-modified erythropoiesis protein
-
Kochendoerfer GG, Chen SY, Mao F, Cressman S, Traviglia S, Shao H, Hunter CL, Low DW, Cagle EN, Carnevali M, Gueriguian V et al: Design and chemical synthesis of a homogeneous polymer-modified erythropoiesis protein. Science (2003) 299(5608):884-887.
-
(2003)
Science
, vol.299
, Issue.5608
, pp. 884-887
-
-
Kochendoerfer, G.G.1
Chen, S.Y.2
Mao, F.3
Cressman, S.4
Traviglia, S.5
Shao, H.6
Hunter, C.L.7
Low, D.W.8
Cagle, E.N.9
Carnevali, M.10
Gueriguian, V.11
-
21
-
-
20144371341
-
Synthetic erythropoietic proteins: Tuning biological performance by site-specific polymer attachment
-
Chen SY, Cressman S, Mao F, Shao H, Low DW, Beilan HS, Cagle EN, Carnevali M, Gueriguian V, Keogh PJ, Porter H et al: Synthetic erythropoietic proteins: Tuning biological performance by site-specific polymer attachment. Chem Biol (2005) 12(3):371-383.
-
(2005)
Chem Biol
, vol.12
, Issue.3
, pp. 371-383
-
-
Chen, S.Y.1
Cressman, S.2
Mao, F.3
Shao, H.4
Low, D.W.5
Beilan, H.S.6
Cagle, E.N.7
Carnevali, M.8
Gueriguian, V.9
Keogh, P.J.10
Porter, H.11
-
22
-
-
67849097425
-
Toward homogeneous erythropoietin: Chemical synthesis of the Ala1-Gly28 glycopeptide domain by 'alanine' ligation
-
Kan C, Trzupek JD, Wu B, Wan Q, Chen G, Tan Z, Yuan Y, Danishefsky SJ: Toward homogeneous erythropoietin: Chemical synthesis of the Ala1-Gly28 glycopeptide domain by 'alanine' ligation. J Am Chem Soc (2009) 131(15):5438-5443.
-
(2009)
J Am Chem Soc
, vol.131
, Issue.15
, pp. 5438-5443
-
-
Kan, C.1
Trzupek, J.D.2
Wu, B.3
Wan, Q.4
Chen, G.5
Tan, Z.6
Yuan, Y.7
Danishefsky, S.J.8
-
23
-
-
67849092526
-
Toward homogeneous erythropoietin: Non-NCL-based chemical synthesis of the GlnArg166 glycopeptide domain
-
Tan Z, Shang S, Halkina T, Yuan Y, Danishefsky SJ: Toward homogeneous erythropoietin: Non-NCL-based chemical synthesis of the GlnArg166 glycopeptide domain. J Am Chem Soc (2009) 131(15):5424-5431.
-
(2009)
J Am Chem Soc
, vol.131
, Issue.15
, pp. 5424-5431
-
-
Tan, Z.1
Shang, S.2
Halkina, T.3
Yuan, Y.4
Danishefsky, S.J.5
-
24
-
-
9444236174
-
Small peptides as potent mimetics of the protein hormone erythropoietin
-
Wrighton NC, Farrell FX, Chang R, Kashyap AK, Barbone FP, Mulcahy LS, Johnson DL, Barrett RW, Jolliffe LK, Dower WJ: Small peptides as potent mimetics of the protein hormone erythropoietin. Science (1996) 273(5274):458-464.
-
(1996)
Science
, vol.273
, Issue.5274
, pp. 458-464
-
-
Wrighton, N.C.1
Farrell, F.X.2
Chang, R.3
Kashyap, A.K.4
Barbone, F.P.5
Mulcahy, L.S.6
Johnson, D.L.7
Barrett, R.W.8
Jolliffe, L.K.9
Dower, W.J.10
-
25
-
-
33748690610
-
Preclinical evaluation of Hematide, a novel erythropoiesis stimulating agent, for the treatment of anemia
-
Fan Q, Leuther KK, Holmes CP, Fong KL, Zhang J, Velkovska S, Chen MJ, Mortensen RB, Leu K, Green JM, Schatz PJ et al: Preclinical evaluation of Hematide, a novel erythropoiesis stimulating agent, for the treatment of anemia. Exp Hematol (2006) 34(10):1303-1311.
-
(2006)
Exp Hematol
, vol.34
, Issue.10
, pp. 1303-1311
-
-
Fan, Q.1
Leuther, K.K.2
Holmes, C.P.3
Fong, K.L.4
Zhang, J.5
Velkovska, S.6
Chen, M.J.7
Mortensen, R.B.8
Leu, K.9
Green, J.M.10
Schatz, P.J.11
-
26
-
-
77953404537
-
HematideTM for the treatment of chronic kidney disease-related anemia
-
Locatelli F, Del Vecchio L: HematideTM for the treatment of chronic kidney disease-related anemia. Expert Rev Hematol (2009) 2 (4):377-383.
-
(2009)
Expert Rev Hematol
, vol.2
, Issue.4
, pp. 377-383
-
-
Locatelli, F.1
Del Vecchio, L.2
-
27
-
-
50849113099
-
Chronic preclinical safety evaluation of Hematide, a PEGylated peptidic erythropoiesis stimulating agent in monkeys
-
Woodburn KW, Wilson SD, Fong KL, Schatz PJ, Ferrell T, Spainhour CB, Norton D: Chronic preclinical safety evaluation of Hematide, a PEGylated peptidic erythropoiesis stimulating agent in monkeys. Haematologica (2008) 93(9):1376-1379.
-
(2008)
Haematologica
, vol.93
, Issue.9
, pp. 1376-1379
-
-
Woodburn, K.W.1
Wilson, S.D.2
Fong, K.L.3
Schatz, P.J.4
Ferrell, T.5
Spainhour, C.B.6
Norton, D.7
-
28
-
-
77951751861
-
Erythropoiesis equivalence, pharmacokinetics and immune response following repeat Hematide administration in cynomolgus monkeys
-
Woodburn KW, Schatz PJ, Fong KL, Beaumier P: Erythropoiesis equivalence, pharmacokinetics and immune response following repeat Hematide administration in cynomolgus monkeys. Int J Immunopathol Pharmacol (2010) 23(1):121-129.
-
(2010)
Int J Immunopathol Pharmacol
, vol.23
, Issue.1
, pp. 121-129
-
-
Woodburn, K.W.1
Schatz, P.J.2
Fong, K.L.3
Beaumier, P.4
-
29
-
-
34447636387
-
Hematide is immunologically distinct from erythropoietin and corrects anemia induced by antierythropoietin antibodies in a rat pure red cell aplasia model
-
Woodburn KW, Fan Q, Winslow S, Chen MJ, Mortensen RB, Casadevall N, Stead RB, Schatz PJ: Hematide is immunologically distinct from erythropoietin and corrects anemia induced by antierythropoietin antibodies in a rat pure red cell aplasia model. Exp Hematol (2007) 35(8):1201-1208.
-
(2007)
Exp Hematol
, vol.35
, Issue.8
, pp. 1201-1208
-
-
Woodburn, K.W.1
Fan, Q.2
Winslow, S.3
Chen, M.J.4
Mortensen, R.B.5
Casadevall, N.6
Stead, R.B.7
Schatz, P.J.8
-
30
-
-
70350774297
-
A peptide-based erythropoietin-receptor agonist for pure red-cell aplasia
-
Macdougall IC, Rossert J, Casadevall N, Stead RB, Duliege AM, Froissart M, Eckardt KU: A peptide-based erythropoietin-receptor agonist for pure red-cell aplasia. N Engl J Med (2009) 361(19):1848-1855.
-
(2009)
N Engl J Med
, vol.361
, Issue.19
, pp. 1848-1855
-
-
MacDougall, I.C.1
Rossert, J.2
Casadevall, N.3
Stead, R.B.4
Duliege, A.M.5
Froissart, M.6
Eckardt, K.U.7
-
31
-
-
33748679131
-
Evaluation of the safety and pharmacodynamics of Hematide, a novel erythropoietic agent, in a phase 1, double-blind, placebo-controlled, dose-escalation study in healthy volunteers
-
Stead RB, Lambert J, Wessels D, Iwashita JS, Leuther KK, Woodburn KW, Schatz PJ, Okamoto DM, Naso R, Duliege AM: Evaluation of the safety and pharmacodynamics of Hematide, a novel erythropoietic agent, in a phase 1, double-blind, placebo-controlled, dose-escalation study in healthy volunteers. Blood (2006) 108(6):1830-1834.
-
(2006)
Blood
, vol.108
, Issue.6
, pp. 1830-1834
-
-
Stead, R.B.1
Lambert, J.2
Wessels, D.3
Iwashita, J.S.4
Leuther, K.K.5
Woodburn, K.W.6
Schatz, P.J.7
Okamoto, D.M.8
Naso, R.9
Duliege, A.M.10
-
32
-
-
77956233581
-
Hematide, a synthetic peptide-based erythropoiesis stimulating agent, maintains hemoglobin in hemodialysis patients previously treated with epoetin alfa (EPO)
-
Besarab A, Zeig S, Geronemus R, Pergola P, Whittier F, Zabaneh R, Schiller B, Kaplan M, Levin N, Wright S, Swan S et al: Hematide, a synthetic peptide-based erythropoiesis stimulating agent, maintains hemoglobin in hemodialysis patients previously treated with epoetin alfa (EPO). Am J Kidney Dis (2007) 49(4):Abs B30.
-
(2007)
Am J Kidney Dis
, vol.49
, Issue.4
-
-
Besarab, A.1
Zeig, S.2
Geronemus, R.3
Pergola, P.4
Whittier, F.5
Zabaneh, R.6
Schiller, B.7
Kaplan, M.8
Levin, N.9
Wright, S.10
Swan, S.11
-
33
-
-
70350770543
-
Hematide, a synthetic peptide-based erythropoiesis stimulating agent (ESA), assessed for correction of anemia in oncology patients receiving chemotherapy
-
Pickering LM, Cwiertka K, Jassem J, Petera J, Pettengell R, Ramlau R, Vorlicek J, Vyzula R, Andresen C, Chang S, Duliege A-M et al: Hematide, a synthetic peptide-based erythropoiesis stimulating agent (ESA), assessed for correction of anemia in oncology patients receiving chemotherapy. Blood (2006) 108:Abs 1290.
-
(2006)
Blood
, vol.108
, pp. 1290
-
-
Pickering, L.M.1
Cwiertka, K.2
Jassem, J.3
Petera, J.4
Pettengell, R.5
Ramlau, R.6
Vorlicek, J.7
Vyzula, R.8
Andresen, C.9
Chang, S.10
Duliege, A.-M.11
-
35
-
-
39649085543
-
CNTO 530: Molecular pharmacology in human UT-7EPO cells and pharmacokinetics and pharmacodynamics in mice
-
Bugelski PJ, Capocasale RJ, Makropoulos D, Marshall D, Fisher PW, Lu J, Achuthanandam R, Spinka-Doms T, Kwok D, Graden D, Volk A et al: CNTO 530: Molecular pharmacology in human UT-7EPO cells and pharmacokinetics and pharmacodynamics in mice. J Biotechnol (2008) 134(1-2):171-180.
-
(2008)
J Biotechnol
, vol.134
, Issue.1-2
, pp. 171-180
-
-
Bugelski, P.J.1
Capocasale, R.J.2
Makropoulos, D.3
Marshall, D.4
Fisher, P.W.5
Lu, J.6
Achuthanandam, R.7
Spinka-Doms, T.8
Kwok, D.9
Graden, D.10
Volk, A.11
-
36
-
-
66549127370
-
CNTO 530 functions as a potent EPO mimetic via unique sustained effects on bone marrow proerythroblast pools
-
Sathyanarayana P, Houde E, Marshall D, Volk A, Makropoulos D, Emerson C, Pradeep A, Bugelski PJ, Wojchowski DM: CNTO 530 functions as a potent EPO mimetic via unique sustained effects on bone marrow proerythroblast pools. Blood (2009) 113(20):4955-4962.
-
(2009)
Blood
, vol.113
, Issue.20
, pp. 4955-4962
-
-
Sathyanarayana, P.1
Houde, E.2
Marshall, D.3
Volk, A.4
Makropoulos, D.5
Emerson, C.6
Pradeep, A.7
Bugelski, P.J.8
Wojchowski, D.M.9
-
37
-
-
69849106825
-
Pharmacokinetics and pharmacodynamics of the erythropoietin mimetibody construct CNTO 528 in healthy subjects
-
Pérez-Ruixo JJ, Krzyzanski W, Bouman-Thio E, Miller B, Jang H, Bai SA, Zhou H, Yohrling J, Cohen A, Burggraaf J, Franson K et al: Pharmacokinetics and pharmacodynamics of the erythropoietin mimetibody construct CNTO 528 in healthy subjects. Clin Pharmacokinet (2009) 48(9):601-613.
-
(2009)
Clin Pharmacokinet
, vol.48
, Issue.9
, pp. 601-613
-
-
Pérez-Ruixo, J.J.1
Krzyzanski, W.2
Bouman-Thio, E.3
Miller, B.4
Jang, H.5
Bai, S.A.6
Zhou, H.7
Yohrling, J.8
Cohen, A.9
Burggraaf, J.10
Franson, K.11
-
38
-
-
39749104199
-
Hypoxia-inducible factor prolyl-hydroxylase: Purification and assays of PHD2
-
Hewitson KS, Schofield CJ, Ratcliffe PJ: Hypoxia-inducible factor prolyl-hydroxylase: Purification and assays of PHD2. Methods Enzymol (2007) 435:25-42.
-
(2007)
Methods Enzymol
, vol.435
, pp. 25-42
-
-
Hewitson, K.S.1
Schofield, C.J.2
Ratcliffe, P.J.3
-
39
-
-
30444445382
-
Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: Assessment of an oral agent that stimulates erythropoietin production
-
Safran M, Kim WY, O'Connell F, Flippin L, Günzler V, Horner JW, Depinho RA, Kaelin WG Jr: Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: Assessment of an oral agent that stimulates erythropoietin production. Proc Natl Acad Sci USA (2006) 103(1):105-110.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, Issue.1
, pp. 105-110
-
-
Safran, M.1
Kim, W.Y.2
O'Connell, F.3
Flippin, L.4
Günzler, V.5
Horner, J.W.6
Depinho, R.A.7
Kaelin Jr., W.G.8
-
41
-
-
1642535393
-
Hepatic erythropoietin gene regulation by GATA-4
-
Dame C, Sola MC, Lim KC, Leach KM, Fandrey J, Ma Y, Knöpfle G, Engel JD, Bungert J: Hepatic erythropoietin gene regulation by GATA-4. J Biol Chem (2004) 279(4):2955-2961.
-
(2004)
J Biol Chem
, vol.279
, Issue.4
, pp. 2955-2961
-
-
Dame, C.1
Sola, M.C.2
Lim, K.C.3
Leach, K.M.4
Fandrey, J.5
Ma, Y.6
Knöpfle, G.7
Engel, J.D.8
Bungert, J.9
-
42
-
-
0031043063
-
Negative regulation of the erythropoietin gene expression by the GATA transcription factors
-
Imagawa S, Yamamoto M, Miura Y: Negative regulation of the erythropoietin gene expression by the GATA transcription factors. Blood (1997) 89(4):1430-1439.
-
(1997)
Blood
, vol.89
, Issue.4
, pp. 1430-1439
-
-
Imagawa, S.1
Yamamoto, M.2
Miura, Y.3
-
43
-
-
10244260353
-
Oral administration of K-11706 inhibits GATA binding activity, enhances hypoxia-inducible factor 1 binding activity, and restores indicators in an in vivo mouse model of anemia of chronic disease
-
Nakano Y, Imagawa S, Matsumoto K, Stockmann C, Obara N, Suzuki N, Doi T, Kodama T, Takahashi S, Nagasawa T, Yamamoto M: Oral administration of K-11706 inhibits GATA binding activity, enhances hypoxia-inducible factor 1 binding activity, and restores indicators in an in vivo mouse model of anemia of chronic disease. Blood (2004) 104(13):4300-4307.
-
(2004)
Blood
, vol.104
, Issue.13
, pp. 4300-4307
-
-
Nakano, Y.1
Imagawa, S.2
Matsumoto, K.3
Stockmann, C.4
Obara, N.5
Suzuki, N.6
Doi, T.7
Kodama, T.8
Takahashi, S.9
Nagasawa, T.10
Yamamoto, M.11
-
44
-
-
34247208149
-
Progress toward a nonviral gene therapy protocol for the treatment of anemia
-
Sebestyén MG, Hegge JO, Noble MA, Lewis DL, Herweijer H, Wolff JA: Progress toward a nonviral gene therapy protocol for the treatment of anemia. Hum Gene Ther (2007) 18(3): 269-285.
-
(2007)
Hum Gene Ther
, vol.18
, Issue.3
, pp. 269-285
-
-
Sebestyén, M.G.1
Hegge, J.O.2
Ma, N.3
Lewis, D.L.4
Herweijer, H.5
Wolff, J.A.6
-
45
-
-
20044392832
-
Gene electro-transfer of an improved erythropoietin plasmid in mice and non-human primates
-
Fattori E, Cappelletti M, Zampaglione I, Mennuni C, Calvaruso F, Arcuri M, Rizzuto G, Costa P, Perretta G, Ciliberto G, La Monica N: Gene electro-transfer of an improved erythropoietin plasmid in mice and non-human primates. J Gene Med (2005) 7(2):228-236.
-
(2005)
J Gene Med
, vol.7
, Issue.2
, pp. 228-236
-
-
Fattori, E.1
Cappelletti, M.2
Zampaglione, I.3
Mennuni, C.4
Calvaruso, F.5
Arcuri, M.6
Rizzuto, G.7
Costa, P.8
Perretta, G.9
Ciliberto, G.10
La Monica, N.11
-
46
-
-
33646903235
-
Erythropoietin delivery by genetically engineered bone marrow stromal cells for correction of anemia in mice with chronic renal failure
-
Eliopoulos N, Gagnon RF, Francois M, Galipeau J: Erythropoietin delivery by genetically engineered bone marrow stromal cells for correction of anemia in mice with chronic renal failure. J Am Soc Nephrol (2006) 17(6):1576-1584.
-
(2006)
J Am Soc Nephrol
, vol.17
, Issue.6
, pp. 1576-1584
-
-
Eliopoulos, N.1
Gagnon, R.F.2
Francois, M.3
Galipeau, J.4
-
47
-
-
33748702530
-
Correction of anemia in uremic rats by intramuscular injection of lentivirus carrying an erythropoietin gene
-
Oh TK, Quan GH, Kim HY, Park F, Kim ST: Correction of anemia in uremic rats by intramuscular injection of lentivirus carrying an erythropoietin gene. Am J Nephrol (2006) 26(4): 326-334.
-
(2006)
Am J Nephrol
, vol.26
, Issue.4
, pp. 326-334
-
-
Oh, T.K.1
Quan, G.H.2
Kim, H.Y.3
Park, F.4
Kim, S.T.5
-
48
-
-
18844424225
-
Human artificial chromosome (HAC) vector provides long-term therapeutic transgene expression in normal human primary fibroblasts
-
Kakeda M, Hiratsuka M, Nagata K, Kuroiwa Y, Kakitani M, Katoh M, Oshimura M, Tomizuka K: Human artificial chromosome (HAC) vector provides long-term therapeutic transgene expression in normal human primary fibroblasts. Gene Ther (2005) 12(10): 852-856.
-
(2005)
Gene Ther
, vol.12
, Issue.10
, pp. 852-856
-
-
Kakeda, M.1
Hiratsuka, M.2
Nagata, K.3
Kuroiwa, Y.4
Kakitani, M.5
Katoh, M.6
Oshimura, M.7
Tomizuka, K.8
-
49
-
-
77954538411
-
Duration and level of transgene expression after gene electrotransfer to skin in mice
-
Gothelf A, Eriksen J, Hojman P, Gehl J: Duration and level of transgene expression after gene electrotransfer to skin in mice. Gene Ther (2010) 17(7):839-845.
-
(2010)
Gene Ther
, vol.17
, Issue.7
, pp. 839-845
-
-
Gothelf, A.1
Eriksen, J.2
Hojman, P.3
Gehl, J.4
-
50
-
-
70949108082
-
A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease
-
Pfeffer MA, Burdmann EA, Chen CY, Cooper ME, de Zeeuw D, Eckardt KU, Feyzi JM, Ivanovich P, Kewalramani R, Levey AS, Lewis EF et al: A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease. N Engl J Med (2009) 361(21): 2019-2032.
-
(2009)
N Engl J Med
, vol.361
, Issue.21
, pp. 2019-2032
-
-
Ma, P.1
Burdmann, E.A.2
Chen, C.Y.3
Cooper, M.E.4
De Zeeuw, D.5
Eckardt, K.U.6
Feyzi, J.M.7
Ivanovich, P.8
Kewalramani, R.9
Levey, A.S.10
Lewis, E.F.11
-
51
-
-
43549093318
-
A novel intravenous iron formulation for treatment of anemia in inflammatory bowel disease: The ferric carboxymaltose (FERINJECT) randomized controlled trial
-
Kulnigg S, Stoinov S, Simanenkov V, Dudar LV, Karnafel W, Garcia LC, Sambuelli AM, D'Haens G, Gasche C: A novel intravenous iron formulation for treatment of anemia in inflammatory bowel disease: The ferric carboxymaltose (FERINJECT) randomized controlled trial. Am J Gastroenterol (2008) 103(5):1182-1192.
-
(2008)
Am J Gastroenterol
, vol.103
, Issue.5
, pp. 1182-1192
-
-
Kulnigg, S.1
Stoinov, S.2
Simanenkov, V.3
Dudar, L.V.4
Karnafel, W.5
Garcia, L.C.6
Sambuelli, A.M.7
D'Haens, G.8
Gasche, C.9
-
52
-
-
65949094763
-
Iron carboxymaltose, a new intravenous iron agent for iron deficiency anemia in heavy uterine bleeding
-
Gordon SS, Hadley PE, Van Wyck DB et al: Iron carboxymaltose, a new intravenous iron agent for iron deficiency anemia in heavy uterine bleeding. Obstet Gynecol (2007) 109(4 Suppl): Abs 108S.
-
(2007)
Obstet Gynecol
, vol.109
, Issue.4 SUPPL.
-
-
Gordon, S.S.1
Hadley, P.E.2
Van Wyck, D.B.3
-
53
-
-
40649100958
-
Comparative efficacy and safety of intravenous ferric carboxymaltose in the treatment of postpartum iron deficiency anemia
-
Breymann C, Gliga F, Bejenariu C, Strizhova N: Comparative efficacy and safety of intravenous ferric carboxymaltose in the treatment of postpartum iron deficiency anemia. Int J Gynaecol Obstet (2008) 101(1):67-73.
-
(2008)
Int J Gynaecol Obstet
, vol.101
, Issue.1
, pp. 67-73
-
-
Breymann, C.1
Gliga, F.2
Bejenariu, C.3
Strizhova, N.4
-
54
-
-
77954797927
-
The safety and efficacy of intravenous ferric carboxymaltose in anaemic patients undergoing haemodialysis: A multi-centre, open-label, clinical study
-
Covic A, Mircescu G: The safety and efficacy of intravenous ferric carboxymaltose in anaemic patients undergoing haemodialysis: A multi-centre, open-label, clinical study. Nephrol Dial Transplant (2010) 25(8):2722-2730.
-
(2010)
Nephrol Dial Transplant
, vol.25
, Issue.8
, pp. 2722-2730
-
-
Covic, A.1
Mircescu, G.2
-
55
-
-
64549090727
-
Safety and tolerability of ferric carboxymaltose (FCM) for treatment of iron deficiency in patients with chronic kidney disease and in kidney transplant recipients
-
Grimmelt AC, Cohen CD, Fehr T, Serra AL, Wuethrich RP: Safety and tolerability of ferric carboxymaltose (FCM) for treatment of iron deficiency in patients with chronic kidney disease and in kidney transplant recipients. Clin Nephrol (2009) 71(2): 125-129.
-
(2009)
Clin Nephrol
, vol.71
, Issue.2
, pp. 125-129
-
-
Grimmelt, A.C.1
Cohen, C.D.2
Fehr, T.3
Serra, A.L.4
Wuethrich, R.P.5
-
57
-
-
72449156527
-
Ferric carboxymaltose in patients with heart failure and iron deficiency
-
Anker SD, Comin Colet J, Filippatos G, Willenheimer R, Dickstein K, Drexler H, Lüscher TF, Bart B, Banasiak W, Niegowska J, Kirwan BA et al: Ferric carboxymaltose in patients with heart failure and iron deficiency. N Engl J Med (2009) 361(25):2436-2448.
-
(2009)
N Engl J Med
, vol.361
, Issue.25
, pp. 2436-2448
-
-
Anker, S.D.1
Comin Colet, J.2
Filippatos, G.3
Willenheimer, R.4
Dickstein, K.5
Drexler, H.6
Lüscher, T.F.7
Bart, B.8
Banasiak, W.9
Niegowska, J.10
Kirwan, B.A.11
-
58
-
-
77956243658
-
Galenica Group increases profits by more than 40%
-
March 17
-
Galenica AG: Galenica Group increases profits by more than 40%. Press Release (2009): March 17.
-
(2009)
Press Release
-
-
Galenica, A.G.1
-
59
-
-
65949107825
-
Ferric carboxymaltose: A review of its use in iron-deficiency anaemia
-
Lyseng-Williamson KA, Keating GM: Ferric carboxymaltose: A review of its use in iron-deficiency anaemia. Drugs (2009) 69(6):739-756.
-
(2009)
Drugs
, vol.69
, Issue.6
, pp. 739-756
-
-
Lyseng-Williamson, K.A.1
Keating, G.M.2
-
60
-
-
49649099818
-
Ferumoxytol for treating iron deficiency anemia in CKD
-
Spinowitz BS, Kausz AT, Baptista J, Noble SD, Sothinathan R, Bernardo MV, Brenner L, Pereira BJ: Ferumoxytol for treating iron deficiency anemia in CKD. J Am Soc Nephrol (2008) 19(8):1599-1605.
-
(2008)
J Am Soc Nephrol
, vol.19
, Issue.8
, pp. 1599-1605
-
-
Spinowitz, B.S.1
Kausz, A.T.2
Baptista, J.3
Noble, S.D.4
Sothinathan, R.5
Bernardo, M.V.6
Brenner, L.7
Pereira, B.J.8
-
61
-
-
66849104249
-
Ferumoxytol as an intravenous iron replacement therapy in hemodialysis patients
-
Provenzano R, Schiller B, Rao M, Coyne D, Brenner L, Pereira BJ: Ferumoxytol as an intravenous iron replacement therapy in hemodialysis patients. Clin J Am Soc Nephrol (2009) 4(2): 386-393.
-
(2009)
Clin J Am Soc Nephrol
, vol.4
, Issue.2
, pp. 386-393
-
-
Provenzano, R.1
Schiller, B.2
Rao, M.3
Coyne, D.4
Brenner, L.5
Pereira, B.J.6
-
62
-
-
54149119169
-
Safety of ferumoxytol in patients with anemia and CKD
-
Singh A, Patel T, Hertel J, Bernardo M, Kausz A, Brenner L: Safety of ferumoxytol in patients with anemia and CKD. Am J Kidney Dis (2008) 52(5):907-915.
-
(2008)
Am J Kidney Dis
, vol.52
, Issue.5
, pp. 907-915
-
-
Singh, A.1
Patel, T.2
Hertel, J.3
Bernardo, M.4
Kausz, A.5
Brenner, L.6
-
63
-
-
77956251216
-
AMAG Pharmaceuticals announces U.S. launch of Feraheme (ferumoxytol) injection
-
AMAG Pharmaceuticals Inc. July 14
-
AMAG Pharmaceuticals Inc: AMAG Pharmaceuticals announces U.S. launch of Feraheme (ferumoxytol) injection. Press Release (2009): July 14.
-
(2009)
Press Release
-
-
-
64
-
-
77956240367
-
Monofer (iron isomaltoside 1000), a novel intravenous iron for treatment of iron deficiency in chronic kidney disease (CKD) patients
-
Wikstrom B, Bhandari S, Barany P, Kalra PA, Ladefoged S, Wilske J, Thomsen LL: Monofer (iron isomaltoside 1000), a novel intravenous iron for treatment of iron deficiency in chronic kidney disease (CKD) patients. Transfus Altern Transf Med (2010) 11(S2):14-40.
-
(2010)
Transfus Altern Transf Med
, vol.11
, Issue.S2
, pp. 14-40
-
-
Wikstrom, B.1
Bhandari, S.2
Barany, P.3
Kalra, P.A.4
Ladefoged, S.5
Wilske, J.6
Thomsen, L.L.7
-
65
-
-
84858808312
-
Intravenous iron supplementation with Monofer improved quality of life assessments in patients with chronic heart failure
-
Hildebrandt P, Bruun NE, Nielsen OW, Pantev E, Shiva F, Videbaek L, Wikstrom G, Thomsen LL: Intravenous iron supplementation with Monofer improved quality of life assessments in patients with chronic heart failure. Transfus Altern Transf Med (2010) 11(S2):14-40.
-
(2010)
Transfus Altern Transf Med
, vol.11
, Issue.S2
, pp. 14-40
-
-
Hildebrandt, P.1
Bruun, N.E.2
Nielsen, O.W.3
Pantev, E.4
Shiva, F.5
Videbaek, L.6
Wikstrom, G.7
Thomsen, L.L.8
-
66
-
-
77956235615
-
-
Holbaek, Denmark
-
Pharmacosmos obtains first marketing authorisations for Monofer: Pharmacosmos A/S, Holbaek, Denmark (2010). www.pharmacosmos.com/media/news/2010/ 2010-01-26-pharmacosmos-first-marketing-authorisations-for-monofer.aspx
-
(2010)
-
-
-
67
-
-
77956252290
-
-
Congress of the European Renal Association and the European Dialysis and Transplant Association, Stockholm, Sweden
-
Qunibi WY, Benjamin J: Safety and tolerability profile of ferric carboxymaltose (FCM), a new high dose IV iron, across ten multi-center clinical trials. Congress of the European Renal Association and the European Dialysis and Transplant Association, Stockholm, Sweden (2008) 45:Abs MP383.
-
(2008)
Safety and Tolerability Profile of Ferric Carboxymaltose (FCM), A New High Dose IV Iron, Across Ten Multi-center Clinical Trials
, vol.45
-
-
Qunibi, W.Y.1
Benjamin, J.2
-
68
-
-
65949107825
-
Ferric carboxymaltose: A review of its use in iron-deficiency anaemia
-
Lyseng-Williamson KA, Keating GM: Ferric carboxymaltose: A review of its use in iron-deficiency anaemia. Drugs (2009) 69(6):739-756.
-
(2009)
Drugs
, vol.69
, Issue.6
, pp. 739-756
-
-
Lyseng-Williamson, K.A.1
Keating, G.M.2
-
69
-
-
65449117261
-
Recombinant human erythropoiesis-stimulating agents and mortality in patients with cancer: A meta-analysis of randomised trials
-
Bohlius J, Schmidlin K, Brillant C, Schwarzer G, Trelle S, Seidenfeld J, Zwahlen M, Clarke M, Weingart O, Kluge S, Piper M et al: Recombinant human erythropoiesis-stimulating agents and mortality in patients with cancer: A meta-analysis of randomised trials. Lancet (2009) 373(9674):1532-1542.
-
(2009)
Lancet
, vol.373
, Issue.9674
, pp. 1532-1542
-
-
Bohlius, J.1
Schmidlin, K.2
Brillant, C.3
Schwarzer, G.4
Trelle, S.5
Seidenfeld, J.6
Zwahlen, M.7
Clarke, M.8
Weingart, O.9
Kluge, S.10
Piper, M.11
-
70
-
-
77956255701
-
Target haemoglobin to aim for with erythropoiesis-stimulating agents: A position statement by ERBP following publication of the Trial to Reduce Cardiovascular Events with Aranesp Therapy (TREAT) Study
-
On behalf of the Anaemia Working Group of European Renal Best Practice (ERBP) doi:10.1093/ndt/gfq336
-
Locatelli F, Aljama P, Canaud B, Covic A, De Francisco A, Macdougall IC, Wiecek A, Vanholder R, On behalf of the Anaemia Working Group of European Renal Best Practice (ERBP): Target haemoglobin to aim for with erythropoiesis- stimulating agents: A position statement by ERBP following publication of the Trial to Reduce Cardiovascular Events with Aranesp Therapy (TREAT) Study. Nephrol Dial Transplant (2010): doi:10.1093/ndt/gfq336.
-
(2010)
Nephrol Dial Transplant
-
-
Locatelli, F.1
Aljama, P.2
Canaud, B.3
Covic, A.4
De Francisco, A.5
MacDougall, I.C.6
Wiecek, A.7
Vanholder, R.8
|