메뉴 건너뛰기




Volumn 40, Issue 7, 1999, Pages 1177-1184

Rosiglitazone (BRL49653), a PPARγ-selective agonist, causes peroxisome proliferator-like liver effects in obese mice

Author keywords

BRL49653; Insulin resistance; ob ob; Obese mice; Peroxisome proliferation; PPAR; Proteomies; Two dimensional gel electrophoresis; WY14,643

Indexed keywords

FATTY ACID; GLUCOSE; INSULIN; MESSENGER RNA; PEROXISOME PROLIFERATOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PIRINIXIC ACID; ROSIGLITAZONE; TRIACYLGLYCEROL; 2,4 THIAZOLIDINEDIONE DERIVATIVE; ANTIDIABETIC AGENT; CELL RECEPTOR; PYRIMIDINE DERIVATIVE; THIAZOLE DERIVATIVE; TRANSCRIPTION FACTOR;

EID: 0032587268     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (113)

References (41)
  • 1
    • 0029294531 scopus 로고
    • Peroxisome proliferator activated receptors-transcriptional regulators of adipogenesis, lipid metabolism and more
    • Wahli, W., O. Braissant, and B. Desvergne. 1995. Peroxisome proliferator activated receptors-transcriptional regulators of adipogenesis, lipid metabolism and more. Chem Biol. 2: 261-266.
    • (1995) Chem Biol. , vol.2 , pp. 261-266
    • Wahli, W.1    Braissant, O.2    Desvergne, B.3
  • 2
    • 0029994543 scopus 로고    scopus 로고
    • Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression
    • Schoonjans, K., B. Staels, and J. Auwerx. 1996. Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression. J. Lipid Res. 37: 907-925.
    • (1996) J. Lipid Res. , vol.37 , pp. 907-925
    • Schoonjans, K.1    Staels, B.2    Auwerx, J.3
  • 3
    • 0031898610 scopus 로고    scopus 로고
    • PPAR-gamma - Adipogenic regulator and thiazolidinedione receptor
    • Spiegelman, B. M. 1998. PPAR-gamma - adipogenic regulator and thiazolidinedione receptor. Diabetes. 47: 507-514.
    • (1998) Diabetes , vol.47 , pp. 507-514
    • Spiegelman, B.M.1
  • 4
    • 0025132245 scopus 로고
    • Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
    • Issemann, I., and S. Green. 1990. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature. 347: 645-650.
    • (1990) Nature , vol.347 , pp. 645-650
    • Issemann, I.1    Green, S.2
  • 6
    • 0030047806 scopus 로고    scopus 로고
    • Differential expression of peroxisome proliferator-activated receptors (PPARs) - Tissue distribution of PPAR-α, -β, and -γ in the adult rat
    • Braissant, O., F. Foufelle, C. Scotto, M. Dauca, and W. Wahli. 1996. Differential expression of peroxisome proliferator-activated receptors (PPARs) - tissue distribution of PPAR-α, -β, and -γ in the adult rat. Endocrinology. 137: 354-366.
    • (1996) Endocrinology , vol.137 , pp. 354-366
    • Braissant, O.1    Foufelle, F.2    Scotto, C.3    Dauca, M.4    Wahli, W.5
  • 7
    • 0032582349 scopus 로고    scopus 로고
    • PPAR-gamma-3 mRNA - A distinct PPAR-gamma mRNA subtype transcribed from an independent promoter
    • Fajas, L., J. C. Fruchart, and J. Auwerx. 1998. PPAR-gamma-3 mRNA - a distinct PPAR-gamma mRNA subtype transcribed from an independent promoter. FEBS Lett. 438: 55-60.
    • (1998) FEBS Lett. , vol.438 , pp. 55-60
    • Fajas, L.1    Fruchart, J.C.2    Auwerx, J.3
  • 9
    • 0028972025 scopus 로고
    • 15-Deoxy-delta(12,14)-prostaglandin J(2) is a ligand for the adipocyte determination factor PPAR-gamma
    • Forman, B. M., P. Tontonoz, J. Chen, R. P. Brun, B. M. Spiegelman, and R. M. Evans. 1995. 15-Deoxy-delta(12,14)-prostaglandin J(2) is a ligand for the adipocyte determination factor PPAR-gamma. Cell. 83: 803-812.
    • (1995) Cell , vol.83 , pp. 803-812
    • Forman, B.M.1    Tontonoz, P.2    Chen, J.3    Brun, R.P.4    Spiegelman, B.M.5    Evans, R.M.6
  • 10
    • 0030952937 scopus 로고    scopus 로고
    • Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta
    • Forman, B. M., J. Chen, and R. M. Evans. 1997. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta. Proc. Natl. Acad. Sci USA. 94: 4312-4317.
    • (1997) Proc. Natl. Acad. Sci USA , vol.94 , pp. 4312-4317
    • Forman, B.M.1    Chen, J.2    Evans, R.M.3
  • 12
    • 0028972026 scopus 로고
    • A prostaglandin J(2) metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation
    • Kliewer, S. A., J. M. Lenhard, T. M. Willson, I. Patel, D. C. Morris, and J. M. Lehmann. 1995. A prostaglandin J(2) metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell. 83: 813-819.
    • (1995) Cell , vol.83 , pp. 813-819
    • Kliewer, S.A.1    Lenhard, J.M.2    Willson, T.M.3    Patel, I.4    Morris, D.C.5    Lehmann, J.M.6
  • 13
    • 0027525576 scopus 로고
    • The peroxisome proliferator-activated receptor:Retinoid X receptor heterodimer is activated by fatty acids and fibrate hypolipidaemic drugs
    • Issemann, I., R. A. Prince, J. D. Tugwood, and S. Green. 1993. The peroxisome proliferator-activated receptor:retinoid X receptor heterodimer is activated by fatty acids and fibrate hypolipidaemic drugs. J. Mol. Endocrinol. 11: 37-47.
    • (1993) J. Mol. Endocrinol. , vol.11 , pp. 37-47
    • Issemann, I.1    Prince, R.A.2    Tugwood, J.D.3    Green, S.4
  • 14
    • 0030764696 scopus 로고    scopus 로고
    • Mitochondrion is the principal target for nutritional and pharmacological control of triglyceride metabolism
    • Frøyland, L., L. Madsen, H. Vaagenes, G. K. Totland, J. Auwerx, H. Kryvi, B. Staels, and R. K. Berge. 1997. Mitochondrion is the principal target for nutritional and pharmacological control of triglyceride metabolism. J. Lipid Res. 38: 1851-1858.
    • (1997) J. Lipid Res. , vol.38 , pp. 1851-1858
    • Frøyland, L.1    Madsen, L.2    Vaagenes, H.3    Totland, G.K.4    Auwerx, J.5    Kryvi, H.6    Staels, B.7    Berge, R.K.8
  • 15
    • 0031049745 scopus 로고    scopus 로고
    • The cytochrome P450 4 (CYP4) family
    • Simpson, A. 1997. The cytochrome P450 4 (CYP4) family. Gen. Pharmacol. 28: 351-359.
    • (1997) Gen. Pharmacol. , vol.28 , pp. 351-359
    • Simpson, A.1
  • 16
    • 0029791412 scopus 로고    scopus 로고
    • PPAR-alpha and PPAR-gamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene
    • Schoonjans, K., J. Peinadoonsurbe, A. M. Lefebvre, R. A. Heyman, M. Briggs, S. Deeb, B. Staels, and J. Auwerx. 1996. PPAR-alpha and PPAR-gamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene. EMBO J. 15: 5336-5348.
    • (1996) EMBO J. , vol.15 , pp. 5336-5348
    • Schoonjans, K.1    Peinadoonsurbe, J.2    Lefebvre, A.M.3    Heyman, R.A.4    Briggs, M.5    Deeb, S.6    Staels, B.7    Auwerx, J.8
  • 17
    • 0023850852 scopus 로고
    • Preadipocyte differentiation in vitro: Identification of a highly active adipogenic agent
    • Hiragun, A., M. Sato, and H. Mitsui. 1988. Preadipocyte differentiation in vitro: identification of a highly active adipogenic agent. J. Cell. Physiol. 134: 124-130.
    • (1988) J. Cell. Physiol. , vol.134 , pp. 124-130
    • Hiragun, A.1    Sato, M.2    Mitsui, H.3
  • 18
    • 0026517080 scopus 로고
    • Enhancement of adipocyte differentiation by an insulin-sensitizing agent
    • Kletzien, R. F., S. D. Clarke, and R. G. Ulrich. 1992. Enhancement of adipocyte differentiation by an insulin-sensitizing agent. Mol. Pharmacol. 41: 393-398.
    • (1992) Mol. Pharmacol. , vol.41 , pp. 393-398
    • Kletzien, R.F.1    Clarke, S.D.2    Ulrich, R.G.3
  • 19
    • 0028641559 scopus 로고
    • Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor
    • Tontonoz, P., E. D. Hu, and B. M. Spiegelman. 1994. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell. 79: 1147-1156.
    • (1994) Cell , vol.79 , pp. 1147-1156
    • Tontonoz, P.1    Hu, E.D.2    Spiegelman, B.M.3
  • 21
    • 0028884048 scopus 로고
    • Repeat treatment of obese mice with BRL 49653, a new potent insulin sensitizer, enhances insulin action in white adipocytes. Association with increased insulin binding and cell-surface GLUT4 as measured by photoaffinity labeling
    • Young, P. W., M. A. Cawthorne, P. J. Coyle, J. C. Holder, G. D. Holman, I. J. Kozka, D. M. Kirkham, C. A. Lister, and S. A. Smith. 1995. Repeat treatment of obese mice with BRL 49653, a new potent insulin sensitizer, enhances insulin action in white adipocytes. Association with increased insulin binding and cell-surface GLUT4 as measured by photoaffinity labeling. Diabetes. 44: 1087-1092.
    • (1995) Diabetes , vol.44 , pp. 1087-1092
    • Young, P.W.1    Cawthorne, M.A.2    Coyle, P.J.3    Holder, J.C.4    Holman, G.D.5    Kozka, I.J.6    Kirkham, D.M.7    Lister, C.A.8    Smith, S.A.9
  • 23
    • 0020572164 scopus 로고
    • Ciglitazone, a new hypoglycemic agent. II. Effect on glucose and lipid metabolisms and insulin binding in the adipose tissue of C57BL/6J-ob/ob and -+/? mice
    • Chang, A. Y., B. M. Wyse, and B. J. Gilchrist. 1983. Ciglitazone, a new hypoglycemic agent. II. Effect on glucose and lipid metabolisms and insulin binding in the adipose tissue of C57BL/6J-ob/ob and -+/? mice. Diabetes. 32: 839-845.
    • (1983) Diabetes , vol.32 , pp. 839-845
    • Chang, A.Y.1    Wyse, B.M.2    Gilchrist, B.J.3
  • 24
    • 0027972524 scopus 로고
    • Altered gene expression for tumor necrosis factor-α and its receptor during drug and dietary modulation of insulin resistance
    • Hofmann, C., K. Lorenz, S. S. Braithwaite, J. R. Colca, B. J. Palazuk, G. S. Hotamisligil, and B. M. Spiegelman. 1994. Altered gene expression for tumor necrosis factor-α and its receptor during drug and dietary modulation of insulin resistance. Endocrinology. 134: 264-270.
    • (1994) Endocrinology , vol.134 , pp. 264-270
    • Hofmann, C.1    Lorenz, K.2    Braithwaite, S.S.3    Colca, J.R.4    Palazuk, B.J.5    Hotamisligil, G.S.6    Spiegelman, B.M.7
  • 25
    • 0029078449 scopus 로고
    • Regulated expression of the obese gene product (Leptin) in white adipose tissue and 3T3-L1 adipocytes
    • Macdougald, O. A., C. S. Hwang, H. Y. Fan, and M. D. Lane. 1995. Regulated expression of the obese gene product (Leptin) in white adipose tissue and 3T3-L1 adipocytes. Proc. Natl. Acad. Sci. USA. 92: 9034-9037.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 9034-9037
    • Macdougald, O.A.1    Hwang, C.S.2    Fan, H.Y.3    Lane, M.D.4
  • 27
    • 0030040740 scopus 로고    scopus 로고
    • Regulation of ob gene mRNA levels in cultured adipocytes
    • Rentsch, J., and M. Chiesi. 1996. Regulation of ob gene mRNA levels in cultured adipocytes. FEBS Lett. 379: 55-59.
    • (1996) FEBS Lett. , vol.379 , pp. 55-59
    • Rentsch, J.1    Chiesi, M.2
  • 28
    • 0028817459 scopus 로고
    • Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme a oxidase - A potential mechanism for the hypolipidemic action of fibrates
    • Staels, B., N. Vudac, V. A. Kosykh, R. Saladin, J. C. Fruchart, J. Dallongeville, and J. Auwerx. 1995. Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme a oxidase - a potential mechanism for the hypolipidemic action of fibrates. J. Clin. Invest. 95: 705-712.
    • (1995) J. Clin. Invest. , vol.95 , pp. 705-712
    • Staels, B.1    Vudac, N.2    Kosykh, V.A.3    Saladin, R.4    Fruchart, J.C.5    Dallongeville, J.6    Auwerx, J.7
  • 29
    • 0028998129 scopus 로고
    • Mode of action of peroxisome proliferators as hypolipidemic drugs - Suppression of apolipoprotein C-III
    • Hertz, R., J. Bisharashieban, and J. Bartana. 1995. Mode of action of peroxisome proliferators as hypolipidemic drugs - suppression of apolipoprotein C-III. J. Biol. Chem. 270: 13470-13475.
    • (1995) J. Biol. Chem. , vol.270 , pp. 13470-13475
    • Hertz, R.1    Bisharashieban, J.2    Bartana, J.3
  • 31
    • 0001844288 scopus 로고
    • Antihyperglycaemic thiazolidinediones: Ciglitazone and its analogues
    • C. J. Bailey and P. R. Flatt, editors. Eldered Smith-Gordon, London
    • Colca, J. R., and D. R. Morton. 1990. Antihyperglycaemic thiazolidinediones: ciglitazone and its analogues. In New Antidiabetic Drugs. C. J. Bailey and P. R. Flatt, editors. Eldered Smith-Gordon, London. 255-261.
    • (1990) New Antidiabetic Drugs , pp. 255-261
    • Colca, J.R.1    Morton, D.R.2
  • 33
    • 0029016829 scopus 로고
    • An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR-gamma)
    • Lehmann, J. M., L. B. Moore, T. A. Smith-Oliver, W. O. Wilkison, T. M. Willson, and S. A. Kliewer. 1995. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR-gamma). J. Biol. Chem. 270: 12953-12956.
    • (1995) J. Biol. Chem. , vol.270 , pp. 12953-12956
    • Lehmann, J.M.1    Moore, L.B.2    Smith-Oliver, T.A.3    Wilkison, W.O.4    Willson, T.M.5    Kliewer, S.A.6
  • 34
    • 0031909945 scopus 로고    scopus 로고
    • Troglitazone - Review and assessment of its role in the treatment of patients with impaired glucose tolerance and diabetes mellitus
    • Johnson, M. D., L. K. Campbell, and R. K. Campbell. 1998. Troglitazone - review and assessment of its role in the treatment of patients with impaired glucose tolerance and diabetes mellitus. Ann. Pharmacother. 32: 337-348.
    • (1998) Ann. Pharmacother. , vol.32 , pp. 337-348
    • Johnson, M.D.1    Campbell, L.K.2    Campbell, R.K.3
  • 35
    • 0001677801 scopus 로고    scopus 로고
    • Rosiglitazone (BRL49653) monotherapy has significant glucose lowering effect in type 2 diabetic patients
    • Patel, J., E. Miller, and R. Patwardhan. 1998. Rosiglitazone (BRL49653) monotherapy has significant glucose lowering effect in type 2 diabetic patients. Diabetes. 47: A17.
    • (1998) Diabetes , vol.47
    • Patel, J.1    Miller, E.2    Patwardhan, R.3
  • 37
    • 0029095434 scopus 로고
    • Two-dimensional polyacrylamide gel electrophoresis with immobilized pH gradients in the first dimension (IPG-Dalt): The state of the art and the controversy of vertical versus horizontal systems
    • Görg, A., G. Boguth, C. Obermaier, A. Posch, and W. Weiss. 1995. Two-dimensional polyacrylamide gel electrophoresis with immobilized pH gradients in the first dimension (IPG-Dalt): the state of the art and the controversy of vertical versus horizontal systems. Electrophoresis. 16: 1079-1086.
    • (1995) Electrophoresis , vol.16 , pp. 1079-1086
    • Görg, A.1    Boguth, G.2    Obermaier, C.3    Posch, A.4    Weiss, W.5
  • 38
    • 0029927505 scopus 로고    scopus 로고
    • Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels
    • Shevchenko, A., M. Wilm, O. Vorm, and M. Mann. 1996. Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Anal. Chem. 68: 850-858.
    • (1996) Anal. Chem. , vol.68 , pp. 850-858
    • Shevchenko, A.1    Wilm, M.2    Vorm, O.3    Mann, M.4
  • 39
    • 0024978195 scopus 로고
    • The QUEST system for quantitative analysis of two-dimensional gels
    • Garrels, J. I. 1989. The QUEST system for quantitative analysis of two-dimensional gels. J. Biol. Chem. 264: 5269-5282.
    • (1989) J. Biol. Chem. , vol.264 , pp. 5269-5282
    • Garrels, J.I.1
  • 41
    • 0032491614 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor α-isoform defiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis
    • Costet, P., C. Legendre, J. More, A. Edgar, P. Galtier, and T. Pineau. 1998. Peroxisome proliferator-activated receptor α-isoform defiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis. J. Biol. Chem. 273: 29577-29585.
    • (1998) J. Biol. Chem. , vol.273 , pp. 29577-29585
    • Costet, P.1    Legendre, C.2    More, J.3    Edgar, A.4    Galtier, P.5    Pineau, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.