The skinny on fat: lipolysis and fatty acid utilization in adipocytes

Trends in Endocrinology and Metabolism

Volumn 20, Issue 9, 2009, Pages 424-428

  Ahmadian, Maryam ^a   Duncan, Robin E ^a   Sul, Hei Sook ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; FATTY ACID; INSULIN; LIPOPROTEIN LIPASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PHOSPHOLIPASE A2; PROSTAGLANDIN E2; TOLL LIKE RECEPTOR; TRIACYLGLYCEROL LIPASE; UNCOUPLING PROTEIN 1;

ADIPOCYTE; AUTOCRINE EFFECT; ENERGY EXPENDITURE; ENERGY METABOLISM; FATTY ACID BLOOD LEVEL; FATTY ACID OXIDATION; HORMONAL REGULATION; HUMAN; INSULIN RESISTANCE; LIPOLYSIS; NONHUMAN; OBESITY; PARACRINE SIGNALING; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; WHITE ADIPOSE TISSUE;

ADIPOCYTES; ADIPOSE TISSUE; ANIMALS; ENERGY METABOLISM; FATTY ACIDS; HUMANS; INSULIN RESISTANCE; LIPOLYSIS; MODELS, BIOLOGICAL;

EID: 72049114437     PISSN: 10432760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tem.2009.06.002     Document Type: Review

References (63)

1. Jaworski K., et al. Regulation of triglyceride metabolism. IV. Hormonal regulation of lipolysis in adipose tissue. Am. J. Physiol. Gastrointest. Liver Physiol. 293 (2007) G1-4
2. Duncan R.E., et al. Regulation of lipolysis in adipocytes. Annu. Rev. Nutr. 27 (2007) 79-101
3. Ahmadian M., et al. Triacylglycerol metabolism in adipose tissue. Future Lipidol. 2 (2007) 229-237
4. Martin S., and Parton R.G. Lipid droplets: a unified view of a dynamic organelle. Nat. Rev. Mol. Cell. Biol. 7 (2006) 373-378
5. Wolins N.E., et al. TIP47 associates with lipid droplets. J. Biol. Chem. 276 (2001) 5101-5108
6. Brasaemle D.L., et al. Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein. J. Lipid Res. 38 (1997) 2249-2263
7. Brasaemle D.L. Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis. J. Lipid. Res 48 (2007) 2547-2559
8. Brasaemle D.L., et al. Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes. J. Biol. Chem. 279 (2004) 46835-46842
9. Guo Y., et al. Functional genomic screen reveals genes involved in lipid-droplet formation and utilization. Nature 453 (2008) 657-661
10. Nishino N., et al. FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets. J. Clin. Invest. 118 (2008) 2808-2821
11. Cohen A.W., et al. Role of caveolin-1 in the modulation of lipolysis and lipid droplet formation. Diabetes 53 (2004) 1261-1270
12. Fujimoto T., et al. Caveolin-2 is targeted to lipid droplets, a new "membrane domain" in the cell. J. Cell Biol. 152 (2001) 1079-1085
13. Pol A., et al. Dynamic and regulated association of caveolin with lipid bodies: modulation of lipid body motility and function by a dominant negative mutant. Mol. Biol. Cell 15 (2004) 99-110
14. Ortegren U., et al. A new role for caveolae as metabolic platforms. Trends Endocrinol. Metab. 18 (2007) 344-349
15. Wolins N.E., et al. A proposed model of fat packaging by exchangeable lipid droplet proteins. FEBS Lett. 580 (2006) 5484-5491
16. Zimmermann R., et al. Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science 306 (2004) 1383-1386
17. Villena J.A., et al. Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysis. J. Biol. Chem. 279 (2004) 47066-47075
18. Jenkins C.M., et al. Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities. J. Biol. Chem. 279 (2004) 48968-48975
19. Fischer J., et al. The gene encoding adipose triglyceride lipase (PNPLA2) is mutated in neutral lipid storage disease with myopathy. Nat. Genet. 39 (2007) 28-30
20. Gronke S., et al. Brummer lipase is an evolutionary conserved fat storage regulator in Drosophila. Cell Metab. 1 (2005) 323-330
21. Kurat C.F., et al. Obese yeast: triglyceride lipolysis is functionally conserved from mammals to yeast. J. Biol. Chem. 281 (2006) 491-500
22. Kurat C.F., et al. Cdk1/Cdc28-dependent activation of the major triacylglycerol lipase Tgl4 in yeast links lipolysis to cell-cycle progression. Mol. Cell 33 (2009) 53-63
23. Eastmond P.J. SUGAR-DEPENDENT1 encodes a patatin domain triacylglycerol lipase that initiates storage oil breakdown in germinating Arabidopsis seeds. Plant Cell 18 (2006) 665-675
24. Schweiger M., et al. Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism. J. Biol. Chem. 281 (2006) 40236-40241
25. Haemmerle G., et al. Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. Science 312 (2006) 734-737
26. Ahmadian M., et al. Adipose overexpression of desnutrin promotes fatty acid use and attenuates diet-induced obesity. Diabetes 58 (2009) 855-866
27. Granneman J.G., and Moore H.P. Location, location: protein trafficking and lipolysis in adipocytes. Trends Endocrinol. Metab. 19 (2008) 3-9
28. Tunaru S., et al. PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect. Nat. Med. 9 (2003) 352-355
29. Birkenfeld A.L., et al. Lipid mobilization with physiological atrial natriuretic peptide concentrations in humans. J. Clin. Endocrinol. Metab. 90 (2005) 3622-3628
30. Langin D. Adipose tissue lipolysis as a metabolic pathway to define pharmacological strategies against obesity and the metabolic syndrome. Pharmacol. Res. 53 (2006) 482-491
31. Arner P., et al. FGF21 attenuates lipolysis in human adipocytes - a possible link to improved insulin sensitivity. FEBS Lett. 582 (2008) 1725-1730
32. Daval M., et al. Anti-lipolytic action of AMP-activated protein kinase in rodent adipocytes. J. Biol. Chem. 280 (2005) 25250-25257
33. Taggart A.K., et al. (D)-beta-Hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G. J. Biol. Chem. 280 (2005) 26649-26652
34. Lafontan M., et al. Control of lipolysis by natriuretic peptides and cyclic GMP. Trends Endocrinol. Metab. 19 (2008) 130-137
35. Wang S., et al. Lipolysis and the integrated physiology of lipid energy metabolism. Mol. Genet. Metab. 95 (2008) 117-126
36. Lafontan M. Advances in adipose tissue metabolism. Int J. Obes (Lond) 32 Suppl 7 (2008) S39-51
37. Langin D., and Arner P. Importance of TNFalpha and neutral lipases in human adipose tissue lipolysis. Trends Endocrinol. Metab. 17 (2006) 314-320
38. Jaworski K., et al. AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency. Nat. Med. 15 (2009) 159-168
39. Duncan R.E., et al. Identification and functional characterization of adipose-specific phospholipase A2 (AdPLA). J. Biol. Chem. 283 (2008) 25428-25436
40. Saha P.K., et al. Metabolic adaptations in the absence of perilipin: increased beta-oxidation and decreased hepatic glucose production associated with peripheral insulin resistance but normal glucose tolerance in perilipin-null mice. J. Biol. Chem. 279 (2004) 35150-35158
41. Puri V., et al. Fat-specific protein 27, a novel lipid droplet protein that enhances triglyceride storage. J. Biol. Chem. 282 (2007) 34213-34218
42. Martinez-Botas J., et al. Absence of perilipin results in leanness and reverses obesity in Lepr(db/db) mice. Nat. Genet. 26 (2000) 474-479
43. Tansey J.T., et al. Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 6494-6499
44. Tiraby C., and Langin D. Conversion from white to brown adipocytes: a strategy for the control of fat mass?. Trends Endocrinol. Metab. 14 (2003) 439-441
45. Polak P., et al. Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration. Cell Metab. 8 (2008) 399-410
46. Christian M., et al. Metabolic regulation by the nuclear receptor corepressor RIP140. Trends Endocrinol. Metab. 17 (2006) 243-250
47. Christian M., et al. RIP140-targeted repression of gene expression in adipocytes. Mol. Cell Biol. 25 (2005) 9383-9391
48. Parker M.G., et al. The nuclear receptor co-repressor RIP140 controls the expression of metabolic gene networks. Biochem. Soc. Trans 34 (2006) 1103-1106
49. Tsukiyama-Kohara K., et al. Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1. Nat. Med. 7 (2001) 1128-1132
50. Rosen E.D., and Spiegelman B.M. Adipocytes as regulators of energy balance and glucose homeostasis. Nature 444 (2006) 847-853
51. Kopecky J., et al. Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity. J. Clin. Invest. 96 (1995) 2914-2923
52. Orci L., et al. Rapid transformation of white adipocytes into fat-oxidizing machines. PNAS 101 (2004) 2058-2063
53. Yamada T., et al. Signals from intra-abdominal fat modulate insulin and leptin sensitivity through different mechanisms: neuronal involvement in food-intake regulation. Cell Metab. 3 (2006) 223-229
54. Guilherme A., et al. Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat. Rev. Mol. Cell Biol. 9 (2008) 367-377
55. Savage B., et al. Disordered lipid metabolism and the pathogenesis of insulin resistance. Physiol. Rev. 87 (2007) 507-520
56. Schenk S., et al. Insulin sensitivity: modulation by nutrients and inflammation. J. Clin. Invest. 118 (2008) 2992-3002
57. Cinti S., et al. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J. Lipid Res. 46 (2005) 2347-2355
58. Nguyen M.T., et al. A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways. J. Biol. Chem. 282 (2007) 35279-35292
59. Randle P.J., et al. The glucose fatty acid cycle in obesity and maturity onset diabetes mellitus. Ann. N. Y. Acad. Sci. 131 (1965) 324-333
60. Herman M.A., and Kahn B.B. Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony. J. Clin. Invest. 116 (2006) 1767-1775
61. Bluher M., et al. Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. Dev. Cell 3 (2002) 25-38
62. Michalik L., et al. International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors. Pharmacol. Rev. 58 (2006) 726-741
63. Palanker L., et al. Drosophila HNF4 regulates lipid mobilization and beta-oxidation. Cell Metab. 9 (2009) 228-239