An overview of the modulatory effects of oleic acid in health and disease

Mini-Reviews in Medicinal Chemistry

Volumn 13, Issue 2, 2013, Pages 201-210

  Sales Campos, Helioswilton ^a   de Souza, Patrícia Reis ^a   Peghini, Bethânea Crema ^c   da Silva, João Santana ^b   Cardoso, Cristina Ribeiro ^a  

^a Toxicologicas e Bromatologicas   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c FEDERAL UNIVERSITY OF TRIÂNGULO MINEIRO   (Brazil)

Author keywords

Autoimmune and inflammatory diseases; Cancer; Modulatory effects; Oleic acid; Wound healing

Indexed keywords

C REACTIVE PROTEIN; GELATINASE B; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 6; INTERLEUKIN 8; LOW DENSITY LIPOPROTEIN; NITRIC OXIDE; OLEIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; REACTIVE OXYGEN METABOLITE; STAT PROTEIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

ARTICLE; BLOOD PRESSURE; CARDIOVASCULAR DISEASE; CELL MEMBRANE FLUIDITY; CLINICAL TRIAL (TOPIC); DRUG ABSORPTION; HEALTH; HUMAN; IMMUNE RESPONSE; INFLAMMATORY DISEASE; LEUKOCYTE; METABOLISM; NEOPLASM; NONHUMAN; NUTRITION; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; SKIN INJURY; WOUND HEALING;

EID: 84876825672     PISSN: 13895575     EISSN: 18755607     Source Type: Journal    
DOI: 10.2174/138955713804805193     Document Type: Article

References (155)

1. Burr, G.O.; Burr, M.M. A new deficiency disease produced by rigid exclusion of fat from thediet. J Biol Chem., 1929, 82, 345-367.
2. Hansen, A.E.; Wiese, H.F.; Boelsche, A.N.; Haggard, M.E.; Adam, D.J.D.; Davis, H. Role of linoleic acid in infant nutrition: clinical and chemical study of 428 infants fed on milk mixtures varying in kind and amount of fat. Pediatrics, 1963, 31, 171-192.
3. Caldwell, M.D.; Jonsson, H.T.; Othersen, H.B., Jr. Essential fatty acid deficiency in an infant receiving prolonged parenteral alimentation. J. Pediatr., 1972, 81, 894-898.
4. Paulsrud, J.R.; Pensler, L.; Whitten, C.F.; Stewart, S.; Holman, R.T. Essential fatty acid deficiency in infants induced by fat-free intravenous feeding. Am J Clin Nutr., 1972, 25, 897-904.
5. Miles, E.A.; Calder, P.C. Modulation of immune function by dietary fatty acids. Proc Nutr Soc., 1998, 57, 277-292.
6. Gunstone, F.D. High resolution 13C NMR. A technique for the study of lipid structure and composition. Prog Lipid Res., 1994, 33, 19-28.
7. Hornstra, G. In Biochemical physiology of dietary fats; Martinus Nijhoff Publishers: Boston, 1982, 15-29.
8. Yaqoob, P. Monounsaturated fatty acids and immune function. Eur J Clin Nutr., 2002, 56 Suppl 3, S9-S13.
9. Trichopoulou, A.; Kouris-Blazos, A.; Wahlqvist, M.L.; Gnardellis, C.; Lagiou, P.; Polychronopoulos, E.; Vassilakou, T.; Lipworth, L.; Trichopoulos, D. Diet and overall survival in elderly people. BMJ, 1995, 311, 1457-1460.
10. Owen, R.W.; Mier, W.; Giacosa, A.; Hull, W.E.; Spiegelhalder, B.; Bartsch, H. Phenolic compounds and squalene in olive oils: the concentration and antioxidant potential of total phenols, simple phenols, secoiridoids, lignansand squalene. Food Chem Toxicol., 2000, 38, 647-659.
11. Jossa, F.; Mancini, M. [The Mediterranean diet in the prevention of arteriosclerosis]. Recenti Prog Med., 1996, 87, 175-181.
12. Tsimikas, S.; Reaven, P.D. The role of dietary fatty acids in lipoprotein oxidation and atherosclerosis. Curr Opin Lipidol., 1998, 9, 301-307.
13. Panagiotakos, D.B.; Dimakopoulou, K.; Katsouyanni, K.; Bellander, T.; Grau, M.; Koenig, W.; Lanki, T.; Pistelli, R.; Schneider, A.; Peters, A. Mediterranean diet and inflammatory response in myocardial infarction survivors. Int J Epidemiol., 2009, 38, 856-866.
14. Teres, S.; Barcelo-Coblijn, G.; Benet, M.; Alvarez, R.; Bressani, R.; Halver, J.E.; Escriba, P.V. Oleic acid content is responsible for the reduction in blood pressure induced by olive oil. Proc Natl Acad Sci U S A., 2008, 105, 13811-13816.
15. Bersamin, A.; Luick, B.R.; King, I.B.; Stern, J.S.; Zidenberg-Cherr, S. Westernizing diets influence fat intake, red blood cell fatty acid composition, and health in remote Alaskan Native communities in the center for Alaska Native health study. J Am Diet Assoc., 2008, 108, 266-273.
16. Lardinois, C.K. The role of omega 3 fatty acids on insulin secretion and insulin sensitivity. Med Hypotheses, 1987, 24, 243-248.
17. Mulvad, G.; Pedersen, H.S.; Hansen, J.C.; Dewailly, E.; Jul, E.; Pedersen, M.; Deguchi, Y.; Newman, W.P.; Malcom, G.T.; Tracy, R.E.; Middaugh, J.P.; Bjerregaard, P. The Inuit diet. Fatty acids and antioxidants, their role in ischemic heart disease, and exposure to organochlorines and heavy metals. An international study. Arctic Med Res., 1996, 55, 20-24.
18. Drosos, A.A.; Moutsopoulos, H.M. Rheumatoid arthritis in Greece: clinical, serological and genetic considerations. Clin Exp Rheumatol., 1995, 13, 7-12.
19. Besler, H.T.; Grimble, R.F. Comparison of the modulatory influence of maize and olive oils and butter on metabolic responses to endotoxin in rats. Clin Sci (Lond)., 1995, 88, 59-66.
20. Yaqoob, P. Monounsaturated fats and immune function. Braz J Med Biol Res., 1998, 31, 453-465.
21. Mulrooney, H.M.; Grimble, R.F. Influence of butter and of corn, coconut and fish oils on the effects of recombinant human tumour necrosis factor-alpha in rats. Clin Sci (Lond)., 1993, 84, 105-112.
22. Sanderson, P.; Yaqoob, P.; Calder, P.C. Effects of dietary lipid manipulation upon graft vs host and host vs graft responses in the rat. Cell Immunol., 1995, 164, 240-247.
23. Ferrara, L.A.; Raimondi, A.S.; d'Episcopo, L.; Guida, L.; Dello Russo, A.; Marotta, T. Olive oil and reduced need for antihypertensive medications. Arch Intern Med., 2000, 160, 837-842.
24. Linos, A.; Kaklamanis, E.; Kontomerkos, A.; Koumantaki, Y.; Gazi, S.; Vaiopoulos, G.; Tsokos, G.C.; Kaklamanis, P. The effect of olive oil and fish consumption on rheumatoid arthritis--a case control study. Scand J Rheumatol., 1991, 20, 419-426.
25. Kremer, J.M.; Lawrence, D.A.; Jubiz, W.; DiGiacomo, R.; Rynes, R.; Bartholomew, L.E.; Sherman, M. Dietary fish oil and olive oil supplementation in patients with rheumatoid arthritis. Clinical and immunologic effects. Arthritis Rheum., 1990, 33, 810-820.
26. Lipworth, L.; Martinez, M.E.; Angell, J.; Hsieh, C.C.; Trichopoulos, D. Olive oil and human cancer: an assessment of the evidence. Prev Med., 1997, 26, 181-190.
27. Assmann, G.; de Backer, G.; Bagnara, S.; Betteridge, J.; Crepaldi, G.; Fernandez-Cruz, A.; Godtfredsen, J.; Jacotot, B.; Paoletti, R.; Renaud, S.; Ricci, G.; Rocha, E.; Trautwein, E.; Urbinati, G.C.; Varela, G.; Williams, C. International consensus statement on olive oil and the Mediterranean diet: implications for health in Europe. The Olive Oil and the Mediterranean Diet Panel. Eur J Cancer Prev., 1997, 6, 418-421.
28. Martin-Moreno, J.M.; Willett, W.C.; Gorgojo, L.; Banegas, J.R.; Rodriguez-Artalejo, F.; Fernandez-Rodriguez, J.C.; Maisonneuve, P.; Boyle, P. Dietary fat, olive oil intake and breast cancer risk. Int J Cancer, 1994, 58, 774-780.
29. Simonsen, N.R.; Fernandez-Crehuet Navajas, J.; Martin-Moreno, J.M.; Strain, J.J.; Huttunen, J.K.; Martin, B.C.; Thamm, M.; Kardinaal, A.F.; van't Veer, P.; Kok, F.J.; Kohlmeier, L. Tissue stores of individual monounsaturated fatty acids and breast cancer: the EURAMIC study. European Community Multicenter Study on Antioxidants, Myocardial Infarction, and Breast Cancer. Am J Clin Nutr., 1998, 68, 134-141.
30. Solanas, M.; Hurtado, A.; Costa, I.; Moral, R.; Menendez, J.A.; Colomer, R.; Escrich, E. Effects of a high olive oil diet on the clinical behavior and histopathological features of rat DMBA-induced mammary tumors compared with a high corn oil diet. Int J Oncol., 2002, 21, 745-753.
31. Calder, P.C. N-3 polyunsaturated fatty acids and inflammation: from molecular biology to the clinic. Lipids, 2003, 38, 343-352.
32. de Pablo, M.A.; Alvarez de Cienfuegos, G. Modulatory effects of dietary lipids on immune system functions. Immunol Cell Biol., 2000, 78, 31-39.
33. Cury-Boaventura, M.F.; Gorjao, R.; de Lima, T.M.; Fiamoncini, J.; Torres, R.P.; Mancini-Filho, J.; Soriano, F.G.; Curi, R. Effect of olive oil-based emulsion on human lymphocyte and neutrophil death. JPEN J Parenter Enteral Nutr., 2008, 32, 81-87.
34. Cury-Boaventura, M.F.; Gorjao, R.; de Lima, T.M.; Piva, T.M.; Peres, C.M.; Soriano, F.G.; Curi, R. Toxicity of a soybean oil emulsion on human lymphocytes and neutrophils. J Parenter Enteral Nutr., 2006, 30, 115-123.
35. Reimund, J.M.; Rahmi, G.; Escalin, G.; Pinna, G.; Finck, G.; Muller, C.D.; Duclos, B.; Baumann, R. Efficacy and safety of an olive oil-based intravenous fat emulsion in adult patients on home parenteral nutrition. Aliment Pharmacol Ther., 2005, 21, 445-454.
36. Yaqoob, P.; Newsholme, E.A.; Calder, P.C. Inhibition of natural killer cell activity by dietary lipids. Immunol Lett., 1994, 41, 241-247.
37. Yaqoob, P.; Newsholme, E.A.; Calder, P.C. The effect of dietary lipid manipulation on rat lymphocyte subsets and proliferation. Immunology, 1994, 82, 603-610.
38. Yaqoob, P.; Newsholme, E.A.; Calder, P.C.; Phil, D. The effect of fatty acids on leucocyte subsets and proliferation in rat whole blood. Nutrional Research, 1995, 15, 279-287.
39. Yaqoob, P.; Knapper, J.A.; Webb, D.H.; Williams, C.M.; Newsholme, E.A.; Calder, P.C. Effect of olive oil on immune function in middle-aged men. Am J Clin Nutr., 1998, 67, 129-135.
40. Jeffery, N.M.; Cortina, M.; Newsholme, E.A.; Calder, P.C. Effects of variations in the proportions of saturated, monounsaturated and polyunsaturated fatty acids in the rat diet on spleen lymphocyte functions. Br J Nutr., 1997, 77, 805-823.
41. Moussa, M.; Le Boucher, J.; Garcia, J.; Tkaczuk, J.; Ragab, J.; Dutot, G.; Ohayon, E.; Ghisolfi, J.; Thouvenot, J.P. In vivo effects of olive oil-based lipid emulsion on lymphocyte activation in rats. Clin Nutr., 2000, 19, 49-54.
42. Garnacho-Montero, J.; Ortiz-Leyba, C.; Garnacho-Montero, M.C.; Garcia-Garmendia, J.L.; Perez-Paredes, C.; Moyano-Del Estad, M.R.; Barrero-Almodovar, A.; Jimenez-Jimenez, F.J. Effects of three intravenous lipid emulsions on the survival and mononuclear phagocyte function of septic rats. Nutrition, 2002, 18, 751-754.
43. Buenestado, A.; Cortijo, J.; Sanz, M.J.; Naim-Abu-Nabah, Y.; Martinez-Losa, M.; Mata, M.; Issekutz, A.C.; Marti-Bonmati, E.; Morcillo, E.J. Olive oil-based lipid emulsion's neutral effects on neutrophil functions and leukocyte-endothelial cell interactions. J Parenter Enteral Nutr., 2006, 30, 286-296.
44. Jeffery, N.M.; Yaqoob, P.; Newsholme, E.A.; Calder, P.C. The effects of olive oil upon rat serum lipid levels and lymphocyte functions appear to be due to oleic acid. Ann Nutr Metab., 1996, 40, 71-80.
45. De Caterina, R.; Cybulsky, M.I.; Clinton, S.K.; Gimbrone, M.A.; Libby, P. The omega-3 fatty acid docosahexaenoate reduces cytokine-induced expression of proatherogenic and proinflammatory proteins in human endothelial cells. Arterioscler Thromb., 1994, 14, 1829-1836.
46. Mata, P.; Alonso, R.; Lopez-Farre, A.; Ordovas, J.M.; Lahoz, C.; Garces, C.; Caramelo, C.; Codoceo, R.; Blazquez, E.; de Oya, M. Effect of dietary fat saturation on LDL oxidation and monocyte adhesion to human endothelial cells in vitro. Arterioscler Thromb Vasc Biol., 1996, 16, 1347-1355.
47. Borniquel, S.; Jansson, E.A.; Cole, M.P.; Freeman, B.A.; Lundberg, J.O. Nitrated oleic acid up-regulates PPARgamma and attenuates experimental inflammatory bowel disease. Free Radic Biol Med., 2010, 48, 499-505.
48. Rudolph, V.; Schopfer, F.J.; Khoo, N.K.; Rudolph, T.K.; Cole, M.P.; Woodcock, S.R.; Bonacci, G.; Groeger, A.L.; Golin-Bisello, F.; Chen, C.S.; Baker, P.R.; Freeman, B.A. Nitro-fatty acid metabolome: saturation, desaturation, beta-oxidation, and protein adduction. J Biol Chem., 2009, 284, 1461-1473.
49. Baker, P.R.; Schopfer, F.J.; Sweeney, S.; Freeman, B.A. Red cell membrane and plasma linoleic acid nitration products: synthesis, clinical identification, and quantitation. Proc Natl Acad Sci U S A, 2004, 101, 11577-11582.
50. Cui, T.; Schopfer, F.J.; Zhang, J.; Chen, K.; Ichikawa, T.; Baker, P.R.; Batthyany, C.; Chacko, B.K.; Feng, X.; Patel, R.P.; Agarwal, A.; Freeman, B.A.; Chen, Y.E. Nitrated fatty acids: Endogenous anti-inflammatory signaling mediators. J Biol Chem., 2006, 281, 35686-35698.
51. Dubuquoy, L.; Rousseaux, C.; Thuru, X.; Peyrin-Biroulet, L.; Romano, O.; Chavatte, P.; Chamaillard, M.; Desreumaux, P. PPARgamma as a new therapeutic target in inflammatory bowel diseases. Gut, 2006, 55, 1341-1349.
52. Sanchez-Fidalgo, S.; Sanchez de Ibarguen, L.; Cardeno, A.; Alarcon de la Lastra, C. Influence of extra virgin olive oil diet enriched with hydroxytyrosol in a chronic DSS colitis model. Eur J Nutr., 2012, 51, 497-506.
53. Clark, M.E.; Rafferty, M. The sickness that won't heal. Health care for the nation's homeless. Health PAC Bull., 1985, 16, 20-28.
54. Frank, S.; Kampfer, H.; Wetzler, C.; Pfeilschifter, J. Nitric oxide drives skin repair: novel functions of an established mediator. Kidney Int., 2002, 61, 882-888.
55. Schaffer, M.R.; Tantry, U.; Gross, S.S.; Wasserburg, H.L.; Barbul, A. Nitric oxide regulates wound healing. J Surg Res., 1996, 63, 237-240.
56. Cardoso, C.R.; Souza, M.A.; Ferro, E.A.; Favoreto, S.; Pena, J.D. Influence of topical administration of n-3 and n-6 essential and n-9 nonessential fatty acids on the healing of cutaneous wounds. Wound Repair Regen., 2004, 12, 235-243.
57. Cardoso, C.R.; Favoreto, S.; Oliveira, L.L.; Vancim, J.O.; Barban, G.B.; Ferraz, D.B.; Silva, J.S. Oleic acid modulation of the immune response in wound healing: a new approach for skin repair. Immunobiology, 2011, 216, 409-415.
58. Pereira, L.M.; Hatanaka, E.; Martins, E.F.; Oliveira, F.; Liberti, E.A.; Farsky, S.H.; Curi, R.; Pithon-Curi, T.C. Effect of oleic and linoleic acids on the inflammatory phase of wound healing in rats. Cell Biochem Funct., 2008, 26, 197-204.
59. Rodrigues, H.G.; Vinolo, M.A.; Magdalon, J.; Vitzel, K.; Nachbar, R.T.; Pessoa, A.F.; dos Santos, M.F.; Hatanaka, E.; Calder, P.C.; Curi, R. Oral administration of oleic or linoleic acid accelerates the inflammatory phase of wound healing. J Invest Dermatol., 2012, 132, 208-215.
60. Kremer, J.M. n-3 fatty acid supplements in rheumatoid arthritis. Am J Clin Nutr., 2000, 71, 349S-351S.
61. Anderson, M.; Fritsche, K.L. (n-3) Fatty acids and infectious disease resistance. J Nutr., 2002, 132, 3566-3576.
62. de Pablo, M.A.; Puertollano, M.A.; Galvez, A.; Ortega, E.; Gaforio, J.J.; Alvarez de Cienfuegos, G. Determination of natural resistance of mice fed dietary lipids to experimental infection induced by Listeria monocytogenes. FEMS Immunol Med Microbiol., 2000, 27, 127-133.
63. Fritsche, K.L.; Shahbazian, L.M.; Feng, C.; Berg, J.N. Dietary fish oil reduces survival and impairs bacterial clearance in C3H/Hen mice challenged with Listeria monocytogenes. Clin Sci (Lond)., 1997, 92, 95-101.
64. de Pablo, M.A.; Puertollano, M.A.; Alvarez de Cienfuegos, G. Biological and clinical significance of lipids as modulators of immune system functions. Clin Diagn Lab Immunol., 2002, 9, 945-950.
65. Edelson, B.T.; Unanue, E.R. MyD88-dependent but Toll-like receptor 2-independent innate immunity to Listeria: no role for either in macrophage listericidal activity. J Immunol., 2002, 169, 3869-3875.
66. Cruz-Chamorro, L.; Puertollano, E.; de Cienfuegos, G.A.; Puertollano, M.A.; de Pablo, M.A. Acquired resistance to Listeria monocytogenes during a secondary infection in a murine model fed dietary lipids. Nutrition, 2011.
67. Puertollano, M.A.; Puertollano, E.; Alvarez de Cienfuegos, G.; de Pablo Martinez, M.A. [Olive oil, immune system and infection]. Nutr Hosp., 2010, 25, 1-8.
68. Verschoor, A.; Neuenhahn, M.; Navarini, A.A.; Graef, P.; Plaumann, A.; Seidlmeier, A.; Nieswandt, B.; Massberg, S.; Zinkernagel, R.M.; Hengartner, H.; Busch, D.H. A platelet-mediated system for shuttling blood-borne bacteria to CD8alpha+ dendritic cells depends on glycoprotein GPIb and complement C3. Nat Immunol., 2011, 12, 1194-1201.
69. Romero, C.; Medina, E.; Vargas, J.; Brenes, M.; De Castro, A. In vitro activity of olive oil polyphenols against Helicobacter pylori. J Agric Food Chem., 2007, 55, 680-686.
70. Oarada, M.; Igarashi, M.; Tsuzuki, T.; Kurita, N.; Gonoi, T.; Nikawa, T.; Hirasaka, K.; Miyazawa, T.; Nakagawa, K.; Kamei, K. Effect of dietary oils on host resistance to fungal infection in psychologically stressed mice. Biosci Biotechnol Biochem., 2009, 73, 1994-1998.
71. Wu, W.; Yamaura, T.; Murakami, K.; Murata, J.; Matsumoto, K.; Watanabe, H.; Saiki, I. Social isolation stress enhanced liver metastasis of murine colon 26-L5 carcinoma cells by suppressing immune responses in mice. Life Sci., 2000, 66, 1827-1838.
72. Oarada, M.; Gonoi, T.; Tsuzuki, T.; Igarashi, M.; Hirasaka, K.; Nikawa, T.; Onishi, Y.; Toyotome, T.; Kamei, K.; Miyazawa, T.; Nakagawa, K.; Kashima, M.; Kurita, N. Effect of dietary oils on lymphocyte immunological activity in psychologically stressed mice. Biosci Biotechnol Biochem., 2007, 71, 174-182.
73. Adams, D.H., TA. In The Natural Immune System: The Macrophage. Lewis, C.M., JOD, Ed.; Oxford: IRL Press: OXford, 1992, 75-105.
74. Martins de Lima-Salgado, T.; Coccuzzo Sampaio, S.; Cury-Boaventura, M.F.; Curi, R. Modulatory effect of fatty acids on fungicidal activity, respiratory burst and TNF-alpha and IL-6 production in J774 murine macrophages. Br J Nutr., 2011, 105, 1173-1179.
75. Trichopoulou, A.; Lagiou, P.; Kuper, H.; Trichopoulos, D. Cancer and Mediterranean dietary traditions. Cancer Epidemiol Biomarkers Prev., 2000, 9, 869-873.
76. Harwood, J.L., Yaqoob, P. Nutritional and health aspects of olive oil. European Journal of Lipid and Science Technology, 2002, 104, 685-697.
77. Keys, A.; Menotti, A.; Karvonen, M.J.; Aravanis, C.; Blackburn, H.; Buzina, R.; Djordjevic, B.S.; Dontas, A.S.; Fidanza, F.; Keys, M.H. et al. The diet and 15-year death rate in the seven countries study. Am J Epidemiol., 1986, 124, 903-915.
78. Owen, R.W.; Giacosa, A.; Hull, W.E.; Haubner, R.; Wurtele, G.; Spiegelhalder, B.; Bartsch, H. Olive-oil consumption and health: the possible role of antioxidants. Lancet Oncol., 2000, 1, 107-112.
79. Owen, R.W.; Haubner, R.; Wurtele, G.; Hull, E.; Spiegelhalder, B.; Bartsch, H. Olives and olive oil in cancer prevention. Eur J Cancer Prev., 2004, 13, 319-326.
80. Trichopoulou, A.; Lagiou, P. Healthy traditional Mediterranean diet: an expression of culture, history, and lifestyle. Nutr Rev., 1997, 55, 383-389.
81. Binukumar, B.; Mathew, A. Dietary fat and risk of breast cancer. World J Surg Oncol., 2005, 3, 45.
82. Llor, X.; Pons, E.; Roca, A.; Alvarez, M.; Mane, J.; Fernandez-Banares, F.; Gassull, M.A. The effects of fish oil, olive oil, oleic acid and linoleic acid on colorectal neoplastic processes. Clin Nutr., 2003, 22, 71-79.
83. Escrich, E.; Solanas, M.; Moral, R.; Costa, I.; Grau, L. Are the olive oil and other dietary lipids related to cancer? Experimental evidence. Clin Transl Oncol., 2006, 8, 868-883.
84. Costa, I.; Moral, R.; Solanas, M.; Escrich, E. High-fat corn oil diet promotes the development of high histologic grade rat DMBA-induced mammary adenocarcinomas, while high olive oil diet does not. Breast Cancer Res Treat., 2004, 86, 225-235.
85. Menendez, J.A.; Vellon, L.; Colomer, R.; Lupu, R. Oleic acid, the main monounsaturated fatty acid of olive oil, suppresses Her-2/neu (erbB-2) expression and synergistically enhances the growth inhibitory effects of trastuzumab (Herceptin) in breast cancer cells with Her-2/neu oncogene amplification. Ann Oncol., 2005, 16, 359-371.
86. Hansen, L.M.; Hardie, B.S.; Hidalgo, J. Fat emulsion for intravenous administration: clinical experience with intralipid 10%. Ann Surg., 1976, 184, 80-88.
87. Waitzberg, D.L.; Torrinhas, R.S.; Jacintho, T.M. New parenteral lipid emulsions for clinical use. J Parenter Enteral Nutr., 2006, 30, 351-367.
88. Huschak, G.; Zur Nieden, K.; Hoell, T.; Riemann, D.; Mast, H.; Stuttmann, R. Olive oil based nutrition in multiple trauma patients: a pilot study. Intensive Care Med., 2005, 31, 1202-1208.
89. Fischer, G.W.; Hunter, K.W.; Wilson, S.R.; Mease, A.D. Diminished bacterial defences with intralipid. Lancet, 1980, 2, 819-820.
90. Freeman, J.; Goldmann, D.A.; Smith, N.E.; Sidebottom, D.G.; Epstein, M.F.; Platt, R. Association of intravenous lipid emulsion and coagulase-negative staphylococcal bacteremia in neonatal intensive care units. N Engl J Med., 1990, 323, 301-308.
91. Muller, J.M.; Keller, H.W.; Brenner, U.; Walter, M.; Holzmuller, W. Indications and effects of preoperative parenteral nutrition. World J Surg., 1986, 10, 53-63.
92. Sosenko, I.R.; Rodriguez-Pierce, M.; Bancalari, E. Effect of early initiation of intravenous lipid administration on the incidence and severity of chronic lung disease in premature infants. J Pediatr., 1993, 123, 975-982.
93. Battistella, F.D.; Widergren, J.T.; Anderson, J.T.; Siepler, J.K.; Weber, J.C.; MacColl, K. A prospective, randomized trial of intravenous fat emulsion administration in trauma victims requiring total parenteral nutrition. J Trauma., 1997, 43, 52-58;
94. Cury-Boaventura, M.F.; Gorjao, R.; de Lima, T.M.; Newsholme, P.; Curi, R. Comparative toxicity of oleic and linoleic acid on human lymphocytes. Life Sci., 2006, 78, 1448-1456.
95. Cury-Boaventura, M.F.; Pompeia, C.; Curi, R. Comparative toxicity of oleic acid and linoleic acid on Jurkat cells. Clin Nutr. 2004, 23, 721-732.
96. Cury-Boaventura, M.F.; Pompeia, C.; Curi, R. Comparative toxicity of oleic acid and linoleic acid on Raji cells. Nutrition, 2005, 21, 395-405.
97. Martins de Lima, T.; Cury-Boaventura, M.F.; Giannocco, G.; Nunes, M.T.; Curi, R. Comparative toxicity of fatty acids on a macrophage cell line (J774). Clin Sci (Lond)., 2006, 111, 307-317.
98. Wanten, G. An update on parenteral lipids and immune function: only smoke, or is there any fire? Curr Opin Clin Nutr Metab Care, 2006, 9, 79-83.
99. Granato, D.; Blum, S.; Rossle, C.; Le Boucher, J.; Malnoe, A.; Dutot, G. Effects of parenteral lipid emulsions with different fatty acid composition on immune cell functions in vitro. JPEN J Parenter Enteral Nutr., 2000, 24, 113-118.
100. NIH; NIH - National Institute of Health: Bethesda-Md, 2001.
101. Reaven, G.M. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes, 1988, 37, 1595-1607.
102. Alberti, K.G.; Zimmet, P.Z. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med., 1998, 15, 539-553.
103. Grundy, S.M.; Brewer, H.B.; Cleeman, J.I.; Smith, S.C.; Lenfant, C. Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Arterioscler Thromb Vasc Biol., 2004, 24, e13-18.
104. Catalan, V.; Gomez-Ambrosi, J.; Ramirez, B.; Rotellar, F.; Pastor, C.; Silva, C.; Rodriguez, A.; Gil, M.J.; Cienfuegos, J.A.; Fruhbeck, G. Proinflammatory cytokines in obesity: impact of type 2 diabetes mellitus and gastric bypass. Obes Surg., 2007, 17, 1464-1474.
105. Lichtenstein, A.H.; Ausman, L.M.; Carrasco, W.; Jenner, J.L.; Ordovas, J.M.; Schaefer, E.J. Hydrogenation impairs the hypolipidemic effect of corn oil in humans. Hydrogenation, trans fatty acids, and plasma lipids. Arterioscler Thromb., 1993, 13, 154-161.
106. Kim, H.E.; Choi, S.E.; Lee, S.J.; Lee, J.H.; Lee, Y.J.; Kang, S.S.; Chun, J.; Kang, Y. Tumour necrosis factor-alpha-induced glucose-stimulated insulin secretion inhibition in INS-1 cells is ascribed to a reduction of the glucose-stimulated Ca2+ influx. J Endocrinol., 2008, 198, 549-560.
107. Yudkin, J.S. Inflammation, obesity, and the metabolic syndrome. Horm Metab Res., 2007, 39, 707-709.
108. Vassiliou, E.; Jing, H.; Ganea, D. Prostaglandin E2 inhibits TNF production in murine bone marrow-derived dendritic cells. Cell Immunol., 2003, 223, 120-132.
109. Zhang, S.; Kim, K.H. TNF-alpha inhibits glucose-induced insulin secretion in a pancreatic beta-cell line (INS-1). FEBS Lett., 1995, 377, 237-239.
110. del Aguila, L.F.; Claffey, K.P.; Kirwan, J.P. TNF-alpha impairs insulin signaling and insulin stimulation of glucose uptake in C2C12 muscle cells. Am J Physiol., 1999, 276, 849-855.
111. Plomgaard, P.; Nielsen, A.R.; Fischer, C.P.; Mortensen, O.H.; Broholm, C.; Penkowa, M.; Krogh-Madsen, R.; Erikstrup, C.; Lindegaard, B.; Petersen, A.M.; Taudorf, S.; Pedersen, B.K. Associations between insulin resistance and TNF-alpha in plasma, skeletal muscle and adipose tissue in humans with and without type 2 diabetes. Diabetologia, 2007, 50, 2562-2571.
112. Vassiliou, E.K.; Gonzalez, A.; Garcia, C.; Tadros, J.H.; Chakraborty, G.; Toney, J.H. Oleic acid and peanut oil high in oleic acid reverse the inhibitory effect of insulin production of the inflammatory cytokine TNF-alpha both in vitro and in vivo systems. Lipids Health Dis., 2009, 8, 25.
113. Martinez-Gonzalez, M.A.; Sanchez-Villegas, A. The emerging role of Mediterranean diets in cardiovascular epidemiology: monounsaturated fats, olive oil, red wine or the whole pattern? Eur J Epidemiol., 2004, 19, 9-13.
114. Menotti, A.; Keys, A.; Kromhout, D.; Nissinen, A.; Blackburn, H.; Fidanza, F.; Giampaoli, S.; Karvonen, M.J.; Pekkanen, J.; Punsar, S. et al. Twenty-five-year mortality from coronary heart disease and its prediction in five cohorts of middle-aged men in Finland, The Netherlands, and Italy. Prev Med., 1990, 19, 270-278.
115. Zambon, D.; Sabate, J.; Munoz, S.; Campero, B.; Casals, E.; Merlos, M.; Laguna, J.C.; Ros, E. Substituting walnuts for monounsaturated fat improves the serum lipid profile of hypercholesterolemic men and women. A randomized crossover trial. Ann Intern Med., 2000, 132, 538-546.
116. Bemelmans, W.J.; Broer, J.; Feskens, E.J.; Smit, A.J.; Muskiet, F.A.; Lefrandt, J.D.; Bom, V.J.; May, J.F.; Meyboom-de Jong, B. Effect of an increased intake of alpha-linolenic acid and group nutritional education on cardiovascular risk factors: the Mediterranean Alpha-linolenic Enriched Groningen Dietary Intervention (MARGARIN) study. Am J Clin Nutr., 2002, 75, 221-227.
117. Fuentes, F.; Lopez-Miranda, J.; Sanchez, E.; Sanchez, F.; Paez, J.; Paz-Rojas, E.; Marin, C.; Gomez, P.; Jimenez-Pereperez, J.; Ordovas, J.M.; Perez-Jimenez, F. Mediterranean and low-fat diets improve endothelial function in hypercholesterolemic men. Ann Intern Med., 2001, 134, 1115-1119.
118. Chrysohoou, C.; Panagiotakos, D.B.; Pitsavos, C.; Das, U.N.; Stefanadis, C. Adherence to the Mediterranean diet attenuates inflammation and coagulation process in healthy adults: The ATTICA Study. J Am Coll Cardiol., 2004, 44, 152-158.
119. de Lorgeril, M.; Salen, P. The Mediterranean diet in secondary prevention of coronary heart disease. Clin Invest Med., 2006, 29, 154-158.
120. de Lorgeril, M.; Salen, P. The Mediterranean-style diet for the prevention of cardiovascular diseases. Public Health Nutr., 2006, 9, 118-123.
121. Visioli, F.; Bogani, P.; Grande, S.; Galli, C. Mediterranean food and health: building human evidence. J Physiol Pharmacol., 2005, 56, 37-49.
122. Visioli, F.; Grande, S.; Bogani, P.; Galli, C. The role of antioxidants in the mediterranean diets: focus on cancer. Eur J Cancer Prev., 2004, 13, 337-343.
123. Carrillo, C.; del Mar Cavia, M.; Alonso-Torre, S.R. Oleic acid versus linoleic and alpha-linolenic acid. different effects on Ca2+ signaling in rat thymocytes. Cell Physiol Biochem., 2011, 27, 373-380.
124. Psaltopoulou, T.; Naska, A.; Orfanos, P.; Trichopoulos, D.; Mountokalakis, T.; Trichopoulou, A. Olive oil, the Mediterranean diet, and arterial blood pressure: the Greek European Prospective Investigation into Cancer and Nutrition (EPIC) study. Am J Clin Nutr., 2004, 80, 1012-1018.
125. Herrera, M.D.; Perez-Guerrero, C.; Marhuenda, E.; Ruiz-Gutierrez, V. Effects of dietary oleic-rich oils (virgin olive and high-oleic-acid sunflower) on vascular reactivity in Wistar-Kyoto and spontaneously hypertensive rats. Br J Nutr., 2001, 86, 349-357.
126. Alemany, R.; Teres, S.; Baamonde, C.; Benet, M.; Vogler, O.; Escriba, P.V. 2-hydroxyoleic acid: a new hypotensive molecule. Hypertension, 2004, 43, 249-254.
127. Yang, Q.; Alemany, R.; Casas, J.; Kitajka, K.; Lanier, S.M.; Escriba, P.V. Influence of the membrane lipid structure on signal processing via G protein-coupled receptors. Mol Pharmacol., 2005, 68, 210-217.
128. Funari, S.S.; Barcelo, F.; Escriba, P.V. Effects of oleic acid and its congeners, elaidic and stearic acids, on the structural properties of phosphatidylethanolamine membranes. J Lipid Res., 2003, 44, 567-575.
129. Ruiz-Gutierrez, V.; Muriana, F.J.; Guerrero, A.; Cert, A.M.; Villar, J. Plasma lipids, erythrocyte membrane lipids and blood pressure of hypertensive women after ingestion of dietary oleic acid from two different sources. J Hypertens., 1996, 14, 1483-1490.
130. Visioli, F.; Galli, C. Antiatherogenic components of olive oil. Curr Atheroscler Rep., 2001, 3, 64-67.
131. Beauchamp, G.K.; Keast, R.S.; Morel, D.; Lin, J.; Pika, J.; Han, Q.; Lee, C.H.; Smith, A.B.; Breslin, P.A. Phytochemistry: ibuprofen-like activity in extra-virgin olive oil. Nature, 2005, 437, 45-46.
132. Rodriguez-Rodriguez, R.; Herrera, M.D.; de Sotomayor, M.A.; Ruiz-Gutierrez, V. Pomace olive oil improves endothelial function in spontaneously hypertensive rats by increasing endothelial nitric oxide synthase expression. Am J Hypertens., 2007, 20, 728-734.
133. Alemany, R.; Vogler, O.; Teres, S.; Egea, C.; Baamonde, C.; Barcelo, F.; Delgado, C.; Jakobs, K.H.; Escriba, P.V. Antihypertensive action of 2-hydroxyoleic acid in SHRs via modulation of the protein kinase A pathway and Rho kinase. J Lipid Res., 2006, 47, 1762-1770.
134. Clark, C.J.; Milligan, G.; McLellan, A.R.; Connell, J.M. Guanine nucleotide regulatory protein levels and function in spontaneously hypertensive rat vascular smooth-muscle cells. Biochim Biophys Acta, 1992, 1136, 290-296.
135. Marcil, J.; de Champlain, J.; Anand-Srivastava, M.B. Overexpression of Gi-proteins precedes the development of DOCA-salt-induced hypertension: relationship with adenylyl cyclase. Cardiovasc Res., 1998, 39, 492-505.
136. Feldman, R.D.; Chorazyczewski, J. G-protein function is reduced in hypertension. Hypertension, 1997, 29, 422-427.
137. Escriba, P.V.; Sanchez-Dominguez, J.M.; Alemany, R.; Perona, J.S.; Ruiz-Gutierrez, V. Alteration of lipids, G proteins, and PKC in cell membranes of elderly hypertensives. Hypertension, 2003, 41, 176-182.
138. Alemany, R.; Perona, J.S.; Sanchez-Dominguez, J.M.; Montero, E.; Canizares, J.; Bressani, R.; Escriba, P.V.; Ruiz-Gutierrez, V. G protein-coupled receptor systems and their lipid environment in health disorders during aging. Biochim Biophys Acta, 2007, 1768, 964-975.
139. Rodriguez Cristobal, J.J.; Benavides Marquez, F.; Villaverde Grote, C.; Pena Sendra, E.; Flor Serra, F.; Trave Mercade, P. [Randomised clinical trial of an intensive intervention into lifestyles of patients with hyperfibrinogenaemia in primary prevention of cardiovascular pathology in primary health care]. Aten Primaria, 2005, 35, 260-264.
140. Forsyth, C.B.; Solovjov, D.A.; Ugarova, T.P.; Plow, E.F. Integrin alpha(M)beta(2)-mediated cell migration to fibrinogen and its recognition peptides. J Exp Med., 2001, 193, 1123-1133.
141. Danesh, J.; Collins, R.; Appleby, P.; Peto, R. Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease: meta-analyses of prospective studies. JAMA, 1998, 279, 1477-1482.
142. Oosthuizen, W.; Vorster, H.H.; Jerling, J.C.; Barnard, H.C.; Smuts, C.M.; Silvis, N.; Kruger, A.; Venter, C.S. Both fish oil and olive oil lowered plasma fibrinogen in women with high baseline fibrinogen levels. Thromb Haemost., 1994, 72, 557-562.
143. Dehmer, G.J.; Popma, J.J.; van den Berg, E.K.; Eichhorn, E.J.; Prewitt, J.B.; Campbell, W.B.; Jennings, L.; Willerson, J.T.; Schmitz, J.M. Reduction in the rate of early restenosis after coronary angioplasty by a diet supplemented with n-3 fatty acids. N Engl J Med., 1988, 319, 733-740.
144. Simons, K.; Ikonen, E. Functional rafts in cell membranes. Nature, 1997, 387, 569-572.
145. Munro, S. Lipid rafts: elusive or illusive? Cell, 2003, 115, 377-388.
146. Shaikh, S.R.; Brzustowicz, M.R.; Gustafson, N.; Stillwell, W.; Wassall, S.R. Monounsaturated PE does not phase-separate from the lipid raft molecules sphingomyelin and cholesterol: role for polyunsaturation? Biochemistry, 2002, 41, 10593-10602.
147. Ehehalt, R.; Sparla, R.; Kulaksiz, H.; Herrmann, T.; Fullekrug, J.; Stremmel, W. Uptake of long chain fatty acids is regulated by dynamic interaction of FAT/CD36 with cholesterol/sphingolipid enriched microdomains (lipid rafts). BMC Cell Biol., 2008, 9, 45.
148. Hinz, B.; Renner, B.; Cheremina, O.; Besz, D.; Zolk, O.; Brune, K. Lumiracoxib inhibits cyclo-oxygenase 2 completely at the 50 mg dose: is liver toxicity avoidable by adequate dosing? Ann Rheum Dis., 2009, 68, 289-291.
149. Moreira, T.S.; de Sousa, V.P.; Pierre, M.B. A novel transdermal delivery system for the anti-inflammatory lumiracoxib: influence of oleic acid on in vitro percutaneous absorption and in vivo potential cutaneous irritation. AAPS PharmSciTech., 2010, 11, 621-629.
150. El Maghraby, G.M.; Campbell, M.; Finnin, B.C. Mechanisms of action of novel skin penetration enhancers: phospholipid versus skin lipid liposomes. Int J Pharm., 2005, 305, 90-104.
151. Singh, S.K.; Durrani, M.J.; Reddy, I.K.; Khan, M.A. Effect of permeation enhancers on the release of ketoprofen through transdermal drug delivery systems. Pharmazie, 1996, 51, 741-744.
152. Santoyo, S.; Ygartua, P. Effect of skin pretreatment with fatty acids on percutaneous absorption and skin retention of piroxicam after its topical application. Eur J Pharm Biopharm., 2000, 50, 245-250.
153. Larrucea, E.; Arellano, A.; Santoyo, S.; Ygartua, P. Combined effect of oleic acid and propylene glycol on the percutaneous penetration of tenoxicam and its retention in the skin. Eur J Pharm Biopharm., 2001, 52, 113-119.
154. Gwak, H.S.; Chun, I.K. Effect of vehicles and penetration enhancers on the in vitro percutaneous absorption of tenoxicam through hairless mouse skin. Int J Pharm., 2002, 236, 57-64.
155. Kim, M.J.; Doh, H.J.; Choi, M.K.; Chung, S.J.; Shim, C.K.; Kim, D.D.; Kim, J.S.; Yong, C.S.; Choi, H.G. Skin permeation enhancement of diclofenac by fatty acids. Drug Deliv., 2008, 15, 373-379.