Effects of variations in the proportions of saturated, monounsaturated and polyunsaturated fatty acids in the rat diet on spleen lymphocyte functions

British Journal of Nutrition

Volumn 77, Issue 5, 1997, Pages 805-823

  Jeffery, Nicola M ^a   Cortina, Mario ^b   Newsholme, Eric A ^a   Calder, Philip C ^a,c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

Dietary lipids; Fatty acids; Lymphocytes; Natural killer cell

Indexed keywords

LINOLEIC ACID; MONOUNSATURATED FATTY ACID; OLEIC ACID; PALMITIC ACID; POLYUNSATURATED FATTY ACID; SATURATED FATTY ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; CELL PROLIFERATION; FAT INTAKE; LIPID COMPOSITION; LYMPHOCYTE FUNCTION; MALE; NATURAL KILLER CELL; NONHUMAN; RAT; SPLEEN LYMPHOCYTE;

ALPHA-LINOLENIC ACID; ANIMALS; CELL DIVISION; DIETARY FATS; FATTY ACIDS; FATTY ACIDS, UNSATURATED; KILLER CELLS, NATURAL; LINOLEIC ACIDS; LYMPHOCYTES; MALE; OLEIC ACID; PALMITIC ACID; RATS; RATS, INBRED LEW; SPLEEN; WEANING;

ANIMALIA;

EID: 0343035607     PISSN: 00071145     EISSN: None     Source Type: Journal    
DOI: 10.1079/BJN19970077     Document Type: Article

References (59)

1. Bates, D., Cartlidge, N. E. F., French, J. M., Jackson, M. J., Nightingale, S., Shaw, D. A., Smith, S., Woo, E., Hawkins, S. A., Millar, J. H. D., Belin, J., Conroy, D. M., Gill, S. K., Sidey, M., Smith, A. D., Thompson, R. H. S., Zilkha, K., Gale, M. & Sinclair, H. M. (1989). A double-blind controlled trial of long chain n-3 polyunsaturated fatty acids in the treatment of multiple sclerosis. Journal of Neurology, Neurosurgery and Psychiatry 52, 18-22.
2. Berger, A., German, J. B., Chiang, B. L., Ansari, A. A., Keen, C. L., Fletcher, M. P. & Gershwin, M. R. (1993). Influence of feeding unsaturated fats on growth and immune status of mice. Journal of Nutrition 123, 225-233.
3. Bittiner, S. B., Tucker, W. F. G., Cartwright, I. & Bleehen, S. S. (1988). A double-blind, randomised, placebo-controlled trial of fish oil in psoriasis. Lancet i, 378-380.
4. Calder, P. C. (1995). Fatty acids, dietary lipids and lymphocyte functions. Biochemical Society Transactions 23, 302-309.
5. Calder, P. C. (1996a). Effects of fatty acids and dietary lipids on cells of the immune system. Proceedings of the Nutrition Society 55, 127-150.
6. Calder, P. C. (1996b). Immunomodulatory and anti-inflammatory effects of n-3 polyunsaturated fatty acids. Proceedings of the Nutrition Society 55, 737-774.
7. Calder, P. C., Bevan, S. J. & Newsholme, E. A. (1992). The inhibition of T-lymphocyte proliferation by fatty acids is via an eicosanoid-independent mechanism. Immunology 75, 108-115.
8. Calder, P. C., Bond, J. A., Bevan, S. J., Hunt, S. V. & Newsholme, E. A. (1991). Effect of fatty acids on the proliferation of concanavalin A-stimulated rat lymph node lymphocytes. International Journal of Biochemistry 23, 579-588.
9. Calder, P. C., Costa-Rosa, L. F. B. P. & Curi, R. (1995). Effects of feeding lipids of different fatty acid compositions upon rat lymphocyte proliferation. Life Sciences 56, 455-463.
10. Calder, P. C. & Newsholme, E. A. (1992a). Unsaturated fatty acids suppress interleukin-2 production and transferrin receptor expression by concanavalin A-stimulated rat lymphocytes. Mediators of Inflammation 1, 107-115.
11. Calder, P. C. & Newsholme, E. A. (1992b). Polyunsaturated fatty acids suppress human peripheral blood lymphocyte proliferation and interleukin-2 production. Clinical Science 82, 695-700.
12. Calder, P. C., Yaqoob, P., Harvey, D. J., Watts, A. & Newsholme, E. A. (1994a). The incorporation of fatty acids by lymphocytes and the effect on fatty acid composition and membrane fluidity. Biochemical Journal 300, 509-518.
13. Calder, P. C., Yaqoob, P. & Newsholme, E. A. (1994b). Triacylglycerol metabolism by lymphocytes and the effect of triacylglycerols upon lymphocyte proliferation. Biochemical Journal 298, 605-611.
14. Cleland, L. G., French, J. K., Betts, W. H., Murphy, G. A. & Elliott, M. J. (1988). Clinical and biochemical effects of dietary fish oil supplements in rheumatoid arthritis. Journal of Rheumatology 15, 1471-1475.
15. Das, U. N. (1994). Beneficial effect of eicosapentaenoic and docosahexaenoic acids in the management of systemic lupus erythematosus and its relationship to the cytokine network. Prostaglandins, Leukotrienes and Essential Fatty Acids 51, 207-213.
16. Erickson, K. L. (1984). Dietary fat influences on murine melanoma growth and lymphocyte-mediated cytotoxicity. Journal of the National Cancer Institute 72, 115-120.
17. Fowler, K. H., McMurray, D. N., Fan, Y.-Y., Aukema, H. M. & Chapkin, R. S. (1993). Purified dietary n-3 polyunsaturated fatty acids alter diacylglycerol mass and molecular species composition in concanavalin A-stimulated murine splenocytes. Biochimica et Biophysica Acta 1210, 89-96.
18. Fritsche, K. L. & Cassity, N. A. (1992) Dietary n-3 fatty acids reduce antibody-dependent cell cytotoxicity and alter eicosanoid release by chicken immune cells. Poultry Science 71, 1646-1657.
19. Fritsche, K. L., Cassity, N. A. & Huang, S.-C. (1991). Effect of dietary fat source on antibody production and lymphocyte proliferation in chickens. Poultry Science 70, 611-617.
20. Fritsche, K. L. & Johnston, P. V. (1989). Modulation of eicosanoid production and cell-mediated cytotoxicity by dietary α-linolenic acid in BALB/c mice. Lipids 24, 305-311.
21. Fritsche, K. L. & Johnstone, P. V. (1990). Effect of dietary omega-3 fatty acids on cell-mediated cytotoxicity in BALB/c mice. Nutrition Research 10, 577-588.
22. Fujikawa, M., Yamashita, N., Yamazaki, K., Sugiyama, E., Suzuki, H. & Hamazaki, T. (1992). Eicosapentaenoic acid inhibits antigen-presenting cell function of murine splenocytes. Immunology 75, 330-335.
23. Gallai, V., Sarchielli, P., Trequattrini, A., Franceschini, M., Floridi, A., Firenze, C., Alberti, A., Di Benedetto, D. & Stragliotto, E. (1993). Cytokine secretion and eicosanoid production in the peripheral blood mononuclear cells of MS patients undergoing dietary supplementation with n-3 polyunsaturated fatty acids. Journal of Neuroimmunology 56, 143-153.
24. Gibney, M. J. & Hunter, B. (1993). The effects of short-and long-term supplementation with fish oil on the incorporation of n-3 polyunsaturated fatty acids into cells of the immune system in healthy volunteers. European Journal of Clinical Nutrition 47, 255-259.
25. Grimminger, F., Fuhrer, D., Papavassilis, C., Schlotzer, E., Mayer, K., Heuer, K.-U., Kiss, L., Walmrath, D., Piberhofer, S., Lubbecke, F., Kramer, H.-J., Stevens, J., Schutterle, G. & Seeger, W. (1993). Influence of intravenous n-3 lipid supplementation on fatty acid profiles and lipid mediator generation in a patient with severe ulcerative colitis. European Journal of Clinical Investigation 23, 706-715.
26. Hinds, A. & Sanders, T. A. B. (1993). The effect of increasing levels of dietary fish oil rich in eicosapentaenoic and docosahexaenoic acids on lymphocyte phospholipid fatty acid composition and cell-mediated immunity in the mouse. British Journal of Nutrition 69, 423-429.
27. Hodge, L., Peat, J. K. & Salome, C. (1994). Increased consumption of polyunsaturated oils may be a cause of increased prevalence of childhood asthma. Australian and New Zealand Journal of Medicine 24, 727.
28. Homan van der Heide, J. J., Bilo, H. J. G., Donker, J. M., Wilmink, J. M. & Tegzess, A. M. (1993). Effect of dietary fish oil on renal function and rejection in cyclosporine-treated recipients of renal transplants. New England Journal of Medicine 329, 769-773.
29. Jeffery, N. M., Sanderson, P., Newsholme, E. A. & Calder, P. C. (1997). Effects of varying the type of saturated fatty acid in the rat diet upon serum lipid levels and spleen lymphocyte functions. Biochimica et Biophysica Acta (In the Press).
30. Jeffery, N. M., Sanderson, P., Sherrington, E. J., Newsholme, E. A. & Calder, P. C. (1996a). The ratio of n-6 to n-3 polyunsaturated fatty acids in the rat diet alters serum lipid levels and lymphocyte functions. Lipids 31, 737-745.
31. Jeffery, N. M., Yaqoob, P., Newsholme, E. A. & Calder, P. C. (1996b). The effects of olive oil upon rat serum lipid levels and lymphocyte functions appear to be due to oleic acid. Annals of Nutrition and Metabolism 40, 71-80.
32. Kelley, D. S., Nelson, G. J., Serrato, C. M., Schmidt, P. C. & Branch, L. B. (1988). Effects of type of dietary fat on indices of immune status of rabbits. Journal of Nutrition 118, 1376-1384.
33. Kremer, J. M., Lawrence, D. A., Jubiz, W., Di Giacomo, R., Rynes, K., Bartholomew, L. E. & Sherman, M. (1990). Dietary fish oil and olive oil supplementation in patients with rheumatoid arthritis. Arthritis and Rheumatism 33, 810-820.
34. Kromann, N. & Green, A. (1980). Epidemiological studies in the Upernavik District, Greenland. Acta Medica Scandinavica 208, 401-406.
35. Kumar, G. S., Das, U. N., Kumar, K. V., Madhavi, N., Das, N. P. & Tan, B. K. H. (1992). Effect of n-6 and n-3 fatty acids on the proliferation of human lymphocytes and their secretion of TNF-α and IL-2 in vitro. Nutrition Research 12, 815-823.
36. Linos, A., Kaklamanis, E., Kontomerkos, A., Koumantaki, Y., Gazi, S., Vaiopoulos, G., Tsokos, G.C. & Kaklamanis, P. (1991). The effect of olive oil and fish consumption on rheumatoid arthritis - A case control study. Scandinavian Journal of Rheumatology 20, 419-426.
37. Marshall, L. A. & Johnston, P. V. (1985) The influence of dietary essential fatty acids on rat immunocompetent cell prostaglandin synthesis and mitogen-induced blastogenesis. Journal of Nutrition 115, 1572-1580.
38. Mertin, J. & Hunt, R. (1976). Influence of polyunsaturated fatty acids on survival of skin allografts and tumor incidence in mice. Proceedings of the National Academy of Science USA 73, 928-931.
39. Mertin, J., Hughes, D. & Stewart-Wynne, E. (1974). PHA transformation in MS: inhibition by linoleic acid. Lancet i, 1005-1006.
40. Mertin, J. & Meade, C. J. (1977) Relevance of fatty acids to multiple sclerosis. British Medical Bulletin 33, 67-71.
41. Mertin, J., Stackpole, A. & Shumway, S. (1985). Nutrition and immunity: the immunoregulatory effect of n-6 essential fatty acids is mediated through prostaglandin E. International Archives of Allergy and Applied Immunology 77, 390-395.
42. 2 synthesis in young and old mice. Journal of Nutrition 118, 1245-1252.
43. Olson, L. M., Clinton, S. K., Everitt, J. I., Johnston, P. V. & Visek, W. J. (1987). Lymphocyte activation, cell-mediated cytotoxicity and their relationship to dietary fat-enhanced mammary tumorigenesis in C3H/OUJ mice. Journal of Nutrition 117, 955-963.
44. Rola-Pleszczynski, M., Gagnon, L. & Sirois, P. (1983). Leukotriene B4 augments human natural cytotoxic cell activity. Biochemical and Biophysical Research Communications 113, 531-537.
45. Sanderson, P., Yaqoob, P. & Calder, P. C. (1995a) Effects of dietary lipid manipulation upon graft vs. host and host vs. graft responses in the rat. Cellular Immunology 164, 240-247.
46. Sanderson, P., Yaqoob, P. & Calder, P. C. (1995b). Effects of dietary lipid manipulation upon rat spleen lymphocyte functions and the expression of lymphocyte surface molecules. Journal of Nutritional and Environmental Medicine 5, 119-132.
47. Sherrington, E. J., Yaqoob, P. & Calder, P. C. (1994). Differential effects of high fat diets on adipose tissue deposition in the rat. Proceedings of the Nutrition Society 53, 69A.
48. Shoda, R., Matsueda, K., Yamato, S. & Umeda, N. (1996). Epidemiologic analysis of Crohn disease in Japan: increased dietary intake of n-6 polyunsaturated fatty acids and animal protein relates to the increased incidence of Crohn disease in Japan. American Journal of Clinical Nutrition 63, 741-745.
49. Soyland, E., Nenseter, M. S., Braathen, L. & Drevon, C. A. (1993) Very long chain n-3 and n-6 polyunsaturated fatty acids inhibit proliferation of human T-lymphocytes in vitro. European Journal of Clinical Investigation 23, 112-121.
50. Sperling, R. I., Weinblatt, M. E., Robin, J. L., Ravalese, J., Hoover, R. L., House, F., Coblyn, J. S., Fraser, P. A., Spur, B. W., Robinson, D. R., Lewis, R. A. & Austen, K. F. (1987). Effects of dietary supplementation with marine fish oil on leukocyte lipid mediator generation and function in rheumatoid arthritis. Arthritis and Rheumatism 30, 987-988.
51. Swank, R. L. (1950). Multiple sclerosis: a correlation of its incidence with dietary fat. American Journal of Medical Science 220, 421-430.
52. Tiwari, R. K., Clandinin, M. T., Cinader, B. & Goh, Y. K. (1987). Effect of high polyunsaturated fat diets on the composition of B cell and T cell membrane lipids. Nutrition Research 7, 489-498.
53. Yamashita, N., Maruyama, M., Yamazaki, K., Hamazaki, T. & Yano, S. (1991). Effect of eicosapentaenoic and docosahexaenoic acid on natural killer cell activity in human peripheral blood lymphocytes. Clinical Immunology and Immunopathology 59, 335-345.
54. Yaqoob, P. & Calder, P. C. (1995). The effects of dietary lipid manipulation on the production of murine T-cell-derived cytokines. Cytokine 7, 548-553.
55. Yaqoob, P., Newsholme, E. A. & Calder, P. C. (1994a). The effect of dietary lipid manipulation on rat lymphocyte subsets and proliferation. Immunology 82, 603-610.
56. Yaqoob, P., Newsholme, E. A. & Calder, P. C. (1994b). Inhibition of natural killer cell activity by dietary lipids. Immunology Letters 41, 241-247.
57. Yaqoob, P., Newsholme, E. A. & Calder, P. C. (1995a). Influence of cell culture conditions on diet-induced changes in lymphocyte fatty acid composition. Biochimica et Biophysica Acta 1255, 333-340.
58. Yaqoob, P., Sherrington, E. J., Jeffery, N. M., Sanderson, P., Harvey, D. J., Newsholme, E. A. & Calder, P. C. (1995b). Comparison of the effects of a range of dietary lipids upon serum and tissue lipid composition in the rat. International Journal of Biochemistry and Cell Biology 27, 297-310.
59. Ziboh, V. A., Cohen, K. A., Ellis, C. N., Miller, C., Hamilton, T. A., Kragballe, K., Hydrick, C. R. & Voorhees, J. J. (1986). Effects of dietary supplementation of fish oil on neutrophil and epidermal fatty acids: modulation of clinical course of psoriatic lesions. Archives of Dermatology 122, 1277-1282.