Tumour necrosis factor-α-induced glucose-stimulated insulin secretion inhibition in INS-1 cells is ascribed to a reduction of the glucose-stimulated Ca2+ influx

Journal of Endocrinology

Volumn 198, Issue 3, 2008, Pages 549-560

  Kim, Hyo Eun ^a   Choi, Sung E ^a   Lee, Soo Jin ^a   Lee, Ji Hyun ^a   Lee, Youn Jung ^a   Kang, Sang Sun ^b   Chun, Jaesun ^c   Kang, Yup ^a  

^a Ajou University School of Medicine   (South Korea)

^b Chungbuk National University   (South Korea)

^c Korea National University of Education   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; CALCIUM CHANNEL; CALCIUM ION; GLUCOKINASE; GLUCOSE; GLUCOSE TRANSPORTER 2; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR PDX 1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CANCER CELL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; GENE OVEREXPRESSION; INSULIN RELEASE; INSULINOMA; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

ADENOSINE TRIPHOSPHATE; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; CALCIUM; CALCIUM CHANNELS; CELL LINE, TUMOR; CELL SURVIVAL; GENE EXPRESSION; GLUCOKINASE; GLUCOSE; GLUCOSE TRANSPORTER TYPE 2; HOMEODOMAIN PROTEINS; IMMUNOBLOTTING; INSULIN; INSULINOMA; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE KINASE 3; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; P38 MITOGEN-ACTIVATED PROTEIN KINASES; POTASSIUM CHANNELS, INWARDLY RECTIFYING; RADIOIMMUNOASSAY; RATS; RECEPTORS, DRUG; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANS-ACTIVATORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 53349160464     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1677/JOE-08-0131     Document Type: Article

References (46)

1. Abderrahmani A, Cheviet S, FerdaoussiM, Coppola T, Waeber G & Regazzi R 2006 ICER induced by hyperglycemia represses the expression of genes essential for insulin exocytosis. EMBO Journal 8 977-986.
2. Aschcroft FM & Rorsman P 2004 Molecular defects in insulin secretion in type-2 diabetes. Reviews in Endocrine and Metabolic Disorders 5 135-142.
3. Bratanova-Tochkova TK, Cheng H, Daniel S, Gunawardana S, Liu YJ, Mulvaney-Musa J, Schermerhorn T, Straub SG, Yajima H & Sharp GW 2002 Triggering and augmentation mechanisms, granule pools, and biphasic insulin secretion. Diabetes 51 S83-S90.
4. Burns CJ, Howell SL, Jones PM & Persaud SJ 1999 The p38 mitogen-activated protein kinase cascade is not required for the stimulation of insulin secretion from rat islets of Langerhans. Molecular and Cellular Endocrinology 148 29-35.
5. Campbell IL, Iscaro A & Harrison LC 1988 IFN-γ and tumor necrosis factor-alpha. Cytotoxicity to routine islets of Langerhans. Journal of Immunology 141 2325-2329.
6. Conger I, Fernandez-Alvarez J, Ferrer J, Sarri Y, Novials A, Somoza N, Pujol-Borrell R, Casamitjana R & Gornis R 1993 Human pancreatic islet function at the onset of type 1 (insulin-dependent) diabetes mellitus. Diabetologia 36 358-360.
7. Del Guerra S, Lupi R, Marselli L, Masini M, Bugliani M, Sbrana S, Torri S, Pollera M, Boggi U, Mosca F et al. 2005 Functional and molecular defects of pancreatic islets in human type 2 diabetes. Diabetes 54 727-735.
8. Donath MY, Storling J, Maedler K & Mandrup-Poulsen T 2003 Inflammatory mediators ad islet beta-cell failure: a link between type 1 and type 2 diabetes. Journal of Molecular Medicine 81 455-470.
9. Dubois M, Vacher P, Roger B, Huyghe D, Vandewalle B, Kerr-Conte J, Pattou F, Moustaid-Moussa N & Lang J 2007 Glucotoxicity inhibits late steps of insulin exocytosis. Endocrinology 148 1605-1614.
10. Dunger A, Cunningham JM, Delaney CA, Lowe JE, Green MH, Bone AJ & Green IC 1996 Tumor necrosis factor-alpha and interferon-gamma inhibit insulin secretion and cause DNA damage in unweaned-rat islets. Extent of nitric oxide involvement. Diabetes 45 183-189.
11. Grill V & Bjorklund A 2000 Dysfunctional insulin secretion in type 2 diabetes: role of metabolic abnormalities. Cellular and Molecular Life Sciences 57 429-440.
12. Hammar EB, Irminger JC, Rickenbach K, Parnaud G, Ribaux P, Bosco D, Rouiller DG & Halban PA 2005 Activation of NF-κB by extracellular matrix is involved in spreading and glucose-stimulated insulin secretion of pancreatic beta cells. Journal of Biological Chemistry 280 30630-30637.
13. Henquin JC, Ravier MA, Nenquin M, Jonas JC & Gilon P 2003 Hierarchy of the β-cell signals controlling insulin secretion. European Journal of Clinical Investigation 33 742-750.
14. Huang Q, Yang J, Lin Y, Walker C, Cheng J, Liu ZG & Su B 2004 Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3. Nature Immunology 5 98-103.
15. Kaneto H, Nakatani Y, Kawamori D, Miyatsuka T, Matsuoka TA, Matsuhisa M & Yamasaki Y 2006 Role of oxidative stress, endoplasmic reticulum stress, and N-Jun N-terminal kinase in pancreatic β-cell dysfunction and insulin resistance. International Journal of Biochemistry and Cell Biology 38 782-793.
16. Kjorholt C, Akerfeldt MC, Biden TJ & Laybutt DR 2005 Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of β-cell differentiation and secretory finiction in the db/db mouse model of diabetes. Diabetes 54 2755-2763.
17. Locksley RM, Killeen V & Lenardo MJ 2001 The TNF and TNF receptor superfamilies integrating mammalian biology. Cell 104 487-501.
18. Lupi R, Marselli L, Dionisi S, Del Guerra S, Boggi U, Del Chiaro M, Lencioni C, Bugliani M, Mosca F, Di Mario U et al. 2004 Improved insulin secretory function and reduced chemotactic properties after tissue culture of islets from type 1 diabetic patients. Diabetes/ Metabolism Research and Reviews 20 246-251.
19. Marchetti P, Del Guerra S, Marselli L, Lupi R, Masini M, Pollera M, Bugliani M, Boggi U, Vistoli F, Mosca F et al. 2004 Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin. Journal of Clinical Endocrinology and Metabolism 89 5535-5541.
20. McGarry JD 2002 Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes 51 7-18.
21. Nesher R, Anteby E, Yedovizky M, Warwar N, Kaiser N & Cerasi E 2002 β-cell protein kinases and the dynamics of the insulin response to glucose. Diabetes 51 S68-S73.
22. Norlin S, Ahlgren U & Edlund H 2005 Nuclear factor-κB activity in β-cells is required for glucose-stimulated insulin secretion. Diabetes 54 125-132.
23. Orris F, Cardozo AK, Crispim D, Storling J, Mandrup-Poulsen T & Eizirik DL 2006 Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-κB activation. Molecular Endocrinology 20 1867-1879.
24. Park C, Kim JR, Shim JK, Kang BS, Park YG, Nam KS, Lee YC & Kim CH 1999 Inhibitory effects of streptozotocin, tumor necrosis factor-α, and interleukin-1β on glucokinase activity in pancreatic islets and gene expression of GLUT2 and glucokinase. Archives of Biochemistry and Biophysics 362 217-224.
25. Polonsky KS, Given BD, Hirsch LJ, Tillil H, Shapiro ET, Beebe C, Frank BH, Galloway JA & Van Cauter E 1988 Abnormal patterns of insulin secretion in non-insulin-dependent diabetes mellitus. New England Journal of Medicine 318 1231-1239.
26. Porte D Jr 1991 β-cells in type II diabetes mellitus. Diabetes 40 166-180.
27. 2+ channel activity. American Journal of Physiology 270 E133-E140.
28. Rorsman P, Eliasson L, Renstrom E, Gromada J, Barg S & Gopel S 2000 The cell physiology of biphasic insulin secretion. News in Physiological Sciences 15 72-77.
29. Rustenbeck I, Wienbergen A, Bleck C & Jorns A 2004 Desensitization of insulin secretion by depolarizing insulin secretagogues. Diabetes 53 S14-S150.
30. Scheen AJ 2003 Pathophysiology of type 2 diabetes. Acta Clinica Belgica 58 335-341.
31. Scheen AJ 2004 Pathophysiology of insulin secretion. Annales d'Endocrinologie 65 29-36.
32. Seino S & Miki T 2003 Physiological and pathophysiological roles of ATP-sensitive K + channels. Progress in Biophysics and Molecular Biology 81 133-176.
33. Sherry NA, Tsai EB & Herold KC 2005 Natural history of β-cell function in type 1 diabetes. Diabetes 54 S32-S39.
34. Strandell E, Eizirik DL & Sandler S 1990 Reversal of β-cell suppression in vitro in pancreatic islets isolated from nonobese diabetic mice during the phase preceding insulin-dependent diabetes mellitus. Journal of Clinical Investigation 85 1944-1950.
35. Tran PO, Gleason CE & Robertson RP 2002 Inhibition of interleukin-1β-induced COX-2 and EP3 gene expression by sodium salicylate enhances pancreatic islet β-cell function. Diabetes 51 1772-1778.
36. Tsiotra PC, Tsigos C & Raptis SA 2001 TNF α and leptin inhibit basal and glucose-stimulated insulin secretion and gene transcription in the HIT-T15 pancreatic cells. International Journal of Obesity and Related Metabolic Disorders 25 1018-1026.
37. Tsuboi T, Ravier MA, Parton LE & Rutter GA 2006 Sustained exposure to high glucose concentrations modifies glucose signaling and the mechanics of secretory vesicle fusion in primary rat pancreatic β-cells. Diabetes 55 1057-1065.
38. 2+ response to glucose in pancreatic beta cells of streptozocin-induced non-insulin-dependent diabetic rats. Metabolism 42 1424-1428.
39. Veluthakal R, Kaur H, Goalstone M & Kowluru A 2007 Dominant-negative α-subunit of farnesyl- and geranyltransferase inhibits glucose-stimulated, but not KCI-stimulated, insulin secretion in INS 832/ 13 cells. Diabetes 56 204-210.
40. Wajant H, Pfizenmaier K & Scheurich P 2003 Tumor necrosis factor signaling. Cell Death and Differentiation 10 45-65.
41. Weyer C, Bogardus C, Mott DM & Pratley RE 2006 The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. Journal of Clinical Investigation 104 787-794.
42. Wiederkehr A & Wollheim CB 2006 Minireview: implication of mitochondria in insulin secretion and action. Endocrinology 147 2643-2649.
43. Xu LG, Li LY & Shu HB 2004 TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis. Journal of Biological Chemistry 279 17278-17282.
44. Yang J, Lin Y, Guo Z, Cheng J, Huang J, Deng L, Liao W, Chen Z, Liu Z & Su B 2001 The essential role of MEKK3 in TNF-induced NF-κB activation. Nature Immunology 2 620-624.
45. Zeender E, Maedler K, Bosco D, Berney T, Donath MY & Halban PA 2004 Pioglitazone and sodium salicylate protect human β-cells against apoptosis and impaired function induced by glucose and interleukin-1β. Journal of Clinical Endocrinology and Metabolism 89 5059-5066.
46. Zhang S & Kim KH 1995 TNF-alpha inhibits glucose-induced insulin secretion in a pancreatic β-cell line (INS-1). FEBS Letters 377 237-239.