TNF-α impairs insulin signaling and insulin stimulation of glucose uptake in C2C12 muscle cells

American Journal of Physiology - Endocrinology and Metabolism

Volumn 276, Issue 5 39-5, 1999, Pages

  Del Aguila, Luis F ^a   Claffey, Kevin P ^b   Kirwan, John P ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Mitogen activated protein kinase; Phosphatidylinositol 3 kinase; Tumor necrosis factor

Indexed keywords

DEOXYGLUCOSE; GLUCOSE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; TUMOR NECROSIS FACTOR ALPHA; TYROSINE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GLUCOSE TRANSPORT; INSULIN RESISTANCE; INSULIN SENSITIVITY; MOUSE; MUSCLE INJURY; MYOBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN PHOSPHORYLATION;

EID: 0033008005     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1999.276.5.e849     Document Type: Article

References (35)

1. Asp, S., J. B. Daugaard, S. Kristiansen, B. Kiens, and E. A. Richter. Eccentric exercise decreases maximal insulin action in humans: muscle and systemic effects. J. Physiol. (Lond.) 494: 891-898, 1996.
2. Asp, S., and E. A. Richter. Decreased insulin action on muscle glucose transport after eccentric contractions in rats. J. Appl. Physiol. 81: 1924-1928, 1996.
3. Begum, N., and L. Ragolia. Altered regulation of insulin signaling components in adipocytes of insulin-resistant type II diabetic Goto-Kakizaki rats. Metabolism 47: 54-62, 1998.
4. Cannon, J. G., S. N. Meydani, R. A. Fielding, M. A. Fiatarone, M. Meydani, M. Farhangmehr, S. F. Orencole, J. B. Blumberg, and W. J. Evans. Acute phase response in exercise. II. Associations between vitamin E, cytokines, and muscle proteolysis. Am. J. Physiol. 260 (Regulatory Integrative Comp. Physiol. 29): R1235-R1240, 1991.
5. Cheatham, B., and C. R. Kahn. Insulin action and the insulin signaling network. Endocr. Rev. 16: 117-142, 1995.
6. Cheatham, B., C. J. Vlahos, L. Cheatham, L. Wang, J. Blenis, and C. R. Kahn. Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation. Mol. Cell. Biol. 14: 4902-4911, 1994.
7. Costill, D. L., D. D. Pascoe, W. J. Fink, R. A. Robergs, S. I. Barr, and D. Pearson. Impaired muscle glycogen resynthesis after eccentric exercise. J. Appl. Physiol. 69: 46-50, 1990.
8. Cross, D. A., D. R. Alessi, J. R. Vandenheede, H. E. McDowell, H. S. Hundal, and P. Cohen. The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf. Biochem. J. 303: 21-26, 1994.
9. DeFronzo, R. A., R. Gunnarsson, O. Bjorkman, M. Olsson, and J. Wahren. Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus. J. Clin. Invest. 76: 149-155, 1985.
10. Feinstein, R., H. Kanety, M. Z. Papa, B. Lunenfeld, and A. Karasik. Tumor necrosis factor-alpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates. J. Biol. Chem. 268: 26055-26058, 1993.
11. Goodyear, L. J., F. Giorgino, L. A. Sherman, J. Carey, R. J. Smith, and G. L. Dohm. Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects. J. Clin. Invest. 95: 2195-2204, 1995.
12. Heller-Harrison, R. A., A. M. Morin, A. Guilherme, and M. P. Czech. Insulin-mediated targeting of phosphatidylinositol 3-kinase to Glut4-containing vesicles. J. Biol. Chem. 271: 10200-10204, 1996.
13. Heydrick, S. J., D. Jullien, N. Gautier, J.-F. Tanti, S. Giorgetti, E. van Obberghen, and Y. le Marchand-Brustel. Defect in skeletal muscle phosphatidylinositol 3-kinase in obese insulin-resistant mice. J. Clin. Invest. 91: 1358-1566, 1993.
14. Hotamisligil, G. S., A. Budavari, D. Murray, and B. M. Spiegelman. Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha. J. Clin. Invest. 94: 1543-1549, 1994.
15. Hotamisligil, G. S., D. L. Murray, L. N. Choy, and B. M. Spiegelman. Tumor necrosis factor alpha inhibits signaling from the insulin receptor. Proc. Natl. Acad. Sci. USA 91: 4854-4858, 1994.
16. Hotamisligil, G. S., P. Peraldi, A. Budavari, R. Ellis, M. F. White, and B. M. Spiegelman. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha-and obesity-induced insulin resistance. Science 271: 665-668, 1996.
17. Kahn, C. R., and F. Folli. Molecular determinants of insulin action. Horm. Res. 39: 93-101, 1993.
18. Kanety, H., R. Feinstein, M. Z. Papa, R. Hemi, and A. Karasik. Tumor necrosis factor alpha-induced phosphorylation of insulin receptor substrate-1 (IRS-1). Possible mechanism for suppression of insulin-stimulated tyrosine phosphorylation of IRS-1. J. Biol. Chem. 270: 23780-23784, 1995.
19. Kirwan, J. P., R. E. Bourey, W. M. Kohrt, M. A. Staten, and J. O. Holloszy. Effects of treadmill exercise to exhaustion on the insulin response to hyperglycemia in untrained men. J. Appl. Physiol. 70: 246-250, 1991.
20. Kirwan, J. P., R. C. Hickner, K. E. Yarasheski, W. M. Kohrt, B. V. Wiethop, and J. O. Holloszy. Eccentric exercise induces transient insulin resistance in healthy individuals. J. Appl. Physiol. 72: 2197-2202, 1992.
21. Krishnan, R. K., J. M. Hernandez, D. L. Williamson, D. J. O'Gorman, W. J. Evans, and J. P. Kirwan. Age-related differences in the pancreatic β-cell response to hyperglycemia after eccentric exercise. Am. J. Physiol. 275 (Endocrinol. Metab. 38): E463-E470, 1998.
22. Lang, C. H., C. Dobrescu, and G. J. Bagby. Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output. Endocrinology 130: 43-52, 1992.
23. Ogihara, T., B. C. Shin, M. Anai, H. Katagiri, K. Inukai, M. Funaki, Y. Fukushima, H. Ishihara, K. Takata, M. Kikuchi, Y. Yazaki, Y. Oka, and T. Asano. Insulin receptor substrate (IRS)-2 is dephosphorylated more rapidly than IRS-1 via its association with phosphatidylinositol 3-kinase in skeletal muscle cells. J. Biol. Chem. 272: 12868-12873, 1997.
24. Okada, T., Y. Kawano, T. Sakakibara, O. Hazeki, and M. Ui. Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. J. Biol. Chem. 269: 3568-3573, 1994.
25. Patti, M. E., X. J. Sun, J. C. Bruening, E. Araki, M. A. Lipes, M. F. White, and C. R. Kahn. 4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deflcient mice. J. Biol. Chem. 270: 24670-24673, 1995.
26. Paz, K., R. Hemi, D. LeRoith, A. Karasik, E. Elhanany, H. Kanety, and Y. Zick. A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation. J. Biol. Chem. 272: 29911-29918, 1997.
27. Ragolia, L., and N. Begum. Protein phosphatase-1 and insulin action. Mol. Cell. Biochem. 182: 49-58, 1998.
28. Stephens, J. M., and P. H. Pekala. Transcriptional repression of the Glut-4 and C/EBP genes in adipocytes by tumor necrosis factor alpha. J. Biol. Chem. 266: 21839-21845, 1991.
29. Sun, X. J., D. L. Crimmins, M. G. Myers, Jr., M. Miralpeix, and M. F. White. Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1. Mol. Cell. Biol. 13: 7418-7428, 1993.
30. Sun, X. J., L. M. Wang, Y. Zhang, L. Yenush, M. G. Myers, Jr., E. Glasheen, W. S. Lane, J. H. Pierce, and M. F. White. Role of IRS-2 in insulin and cytokine signaling. Nature 377: 173-177 1995.
31. Tobe, K., H. Tamemoto, T. Yamauchi, S. Aizawa, Y. Yazaki, and T. Kadowaki. Identification of a 190-kDa protein as a novel substrate for the insulin receptor kinase functionally similar to insulin receptor substrate-1. J. Biol. Chem. 270: 5698-5702, 1994.
32. Tobe, K., K. Ueki, H. Tamemoto, Y. Kaburagi, R. Honda, and T. Kadowaki. The role of phosphorylation cascade in insulin action. Nippon Rinsho 52: 2673-2685, 1994.
33. White, M. F., R. Maron, and C. R. Kahn. Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells. Nature 318: 183-186, 1985.
34. Yamamura, M., X. H. Wang, J. D. Ohmen, K. Uyemura, T. H. Rea, B. R. Bloom, and R. L. Modlin. Cytokine patterns of immunologically mediated tissue damage. J. Immunol. 149: 1470-1475, 1992.
35. Yamauchi, T., K. Tobe, H. Tamemoto, K. Ueki, Y. Kaburagi, R. Yamamoto-Honda, Y. Takahashi, F. Yoshizawa, S. Aizawa, Y. Akanuma, N. Sonenberg, Y. Yazaki, and T. Kadowaki. Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice. Mol. Cell. Biol. 16: 3074-3084, 1996.