메뉴 건너뛰기




Volumn 1768, Issue 4, 2007, Pages 964-975

G protein-coupled receptor systems and their lipid environment in health disorders during aging

Author keywords

Aging; Fatty acid; G protein coupled receptor; Human pathology; Lipid membrane composition; Signaling protein

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; MEMBRANE LIPID; PROTEIN TYROSINE KINASE;

EID: 33947424778     PISSN: 00052736     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamem.2006.09.024     Document Type: Review
Times cited : (74)

References (187)
  • 2
    • 0030038104 scopus 로고    scopus 로고
    • Replicative senescence: implications for in vivo aging and tumor suppression
    • Smith J.R., and Pereira-Smith O.M. Replicative senescence: implications for in vivo aging and tumor suppression. Science 273 (1996) 63-67
    • (1996) Science , vol.273 , pp. 63-67
    • Smith, J.R.1    Pereira-Smith, O.M.2
  • 3
    • 0036088491 scopus 로고    scopus 로고
    • Agonist-specific differential changes of cellular signal transduction pathways in senescent human diploid fibroblasts
    • Yeo E.J., Jang I.S., Lim H.K., Ha K.S., and Park S.C. Agonist-specific differential changes of cellular signal transduction pathways in senescent human diploid fibroblasts. Exp. Gerontol. 37 (2002) 871-883
    • (2002) Exp. Gerontol. , vol.37 , pp. 871-883
    • Yeo, E.J.1    Jang, I.S.2    Lim, H.K.3    Ha, K.S.4    Park, S.C.5
  • 4
    • 0036860195 scopus 로고    scopus 로고
    • Age-dependent agonist-specific dysregulation of membrane-mediated signal transduction: emergence of the gate theory of aging
    • Yeo E.J., and Park S.C. Age-dependent agonist-specific dysregulation of membrane-mediated signal transduction: emergence of the gate theory of aging. Mech. Ageing Dev. 123 (2002) 1563-1578
    • (2002) Mech. Ageing Dev. , vol.123 , pp. 1563-1578
    • Yeo, E.J.1    Park, S.C.2
  • 5
    • 0032509484 scopus 로고    scopus 로고
    • Neurobiology of the Caenorhabditis elegans genome
    • Bargmann C.I. Neurobiology of the Caenorhabditis elegans genome. Science 282 (1998) 2028-2033
    • (1998) Science , vol.282 , pp. 2028-2033
    • Bargmann, C.I.1
  • 6
    • 0000140263 scopus 로고    scopus 로고
    • Novel GPCRs and their endogenous ligands: expanding the boundaries of physiology and pharmacology
    • Marchese A., George S.R., Kolakowski Jr. L.F., Lynch K.R., and O'Dowd B.F. Novel GPCRs and their endogenous ligands: expanding the boundaries of physiology and pharmacology. Trends Pharmacol. Sci. 20 (1999) 370-375
    • (1999) Trends Pharmacol. Sci. , vol.20 , pp. 370-375
    • Marchese, A.1    George, S.R.2    Kolakowski Jr., L.F.3    Lynch, K.R.4    O'Dowd, B.F.5
  • 7
    • 0025223081 scopus 로고
    • Turning off the signal: desensitization of beta-adrenergic receptor function
    • Hausdorff W.P., Caron M.G., and Lefkowitz R.J. Turning off the signal: desensitization of beta-adrenergic receptor function. FASEB J. 4 (1990) 2881-2889
    • (1990) FASEB J. , vol.4 , pp. 2881-2889
    • Hausdorff, W.P.1    Caron, M.G.2    Lefkowitz, R.J.3
  • 8
    • 0031747997 scopus 로고    scopus 로고
    • The role of receptor kinases and arrestins in G protein-coupled receptor regulation
    • Krupnick J.G., and Benovic J.L. The role of receptor kinases and arrestins in G protein-coupled receptor regulation. Annu. Rev. Pharmacol. Toxicol. 38 (1998) 289-319
    • (1998) Annu. Rev. Pharmacol. Toxicol. , vol.38 , pp. 289-319
    • Krupnick, J.G.1    Benovic, J.L.2
  • 9
    • 0037944235 scopus 로고    scopus 로고
    • Effects of oleic acid and its congeners, elaidic and stearic acids, on the structural properties of phosphatidylethanolamine membranes
    • Funari S.S., Barcelo F., and Escriba P.V. Effects of oleic acid and its congeners, elaidic and stearic acids, on the structural properties of phosphatidylethanolamine membranes. J. Lipid Res. 44 (2003) 567-575
    • (2003) J. Lipid Res. , vol.44 , pp. 567-575
    • Funari, S.S.1    Barcelo, F.2    Escriba, P.V.3
  • 10
    • 4344672986 scopus 로고    scopus 로고
    • The Gbetagamma dimer drives the interaction of heterotrimeric Gi proteins with nonlamellar membrane structures
    • Vogler O., Casas J., Capo D., Nagy T., Borchert G., Martorell G., and Escriba P.V. The Gbetagamma dimer drives the interaction of heterotrimeric Gi proteins with nonlamellar membrane structures. J. Biol. Chem. 279 (2004) 36540-36545
    • (2004) J. Biol. Chem. , vol.279 , pp. 36540-36545
    • Vogler, O.1    Casas, J.2    Capo, D.3    Nagy, T.4    Borchert, G.5    Martorell, G.6    Escriba, P.V.7
  • 11
    • 0028902823 scopus 로고
    • Lipid peroxidation contributes to age-related membrane rigidity
    • Choe M., Jackson C., and Yu B.P. Lipid peroxidation contributes to age-related membrane rigidity. Free Radic. Biol. Med. 18 (1995) 977-984
    • (1995) Free Radic. Biol. Med. , vol.18 , pp. 977-984
    • Choe, M.1    Jackson, C.2    Yu, B.P.3
  • 12
    • 14744296990 scopus 로고    scopus 로고
    • On the importance of fatty acid composition of membranes for aging
    • Hulbert A.J. On the importance of fatty acid composition of membranes for aging. J. Theor. Biol. 234 (2005) 277-288
    • (2005) J. Theor. Biol. , vol.234 , pp. 277-288
    • Hulbert, A.J.1
  • 13
    • 0025316454 scopus 로고
    • Role of membrane lipids in the interaction of daunomycin with plasma membranes from tumor cells: implications in drug-resistance phenomena
    • Escriba P.V., Ferrer-Montiel A.V., Ferragut J.A., and Gonzalez-Ros J.M. Role of membrane lipids in the interaction of daunomycin with plasma membranes from tumor cells: implications in drug-resistance phenomena. Biochemistry 29 (1990) 7275-7282
    • (1990) Biochemistry , vol.29 , pp. 7275-7282
    • Escriba, P.V.1    Ferrer-Montiel, A.V.2    Ferragut, J.A.3    Gonzalez-Ros, J.M.4
  • 14
    • 0029088851 scopus 로고
    • Disruption of cellular signaling pathways by daunomycin through destabilization of nonlamellar membrane structures
    • Escriba P.V., Sastre M., and Garcia-Sevilla J.A. Disruption of cellular signaling pathways by daunomycin through destabilization of nonlamellar membrane structures. Proc. Natl. Acad. Sci. U. S. A. 92 (1995) 7595-7599
    • (1995) Proc. Natl. Acad. Sci. U. S. A. , vol.92 , pp. 7595-7599
    • Escriba, P.V.1    Sastre, M.2    Garcia-Sevilla, J.A.3
  • 15
    • 0028840703 scopus 로고
    • Role of phospholipids containing docosahexaenoyl chains in modulating the activity of protein kinase C
    • Giorgione J., Epand R., Buda C., and Farkas T. Role of phospholipids containing docosahexaenoyl chains in modulating the activity of protein kinase C. Proc. Natl. Acad. Sci. U. S. A. 92 (1995) 9767-9770
    • (1995) Proc. Natl. Acad. Sci. U. S. A. , vol.92 , pp. 9767-9770
    • Giorgione, J.1    Epand, R.2    Buda, C.3    Farkas, T.4
  • 16
    • 0029859762 scopus 로고    scopus 로고
    • Origin of the lag period in the phospholipase C cleavage of phospholipids in membranes. Concomitant vesicle aggregation and enzyme activation
    • Basanez G., Nieva J.L., Goni F.M., and Alonso A. Origin of the lag period in the phospholipase C cleavage of phospholipids in membranes. Concomitant vesicle aggregation and enzyme activation. Biochemistry 35 (1996) 15183-15187
    • (1996) Biochemistry , vol.35 , pp. 15183-15187
    • Basanez, G.1    Nieva, J.L.2    Goni, F.M.3    Alonso, A.4
  • 17
    • 23944484438 scopus 로고    scopus 로고
    • Modulation of PI-specific phospholipase C by membrane curvature and molecular order
    • Ahyayauch H., Villar A.V., Alonso A., and Goni F.M. Modulation of PI-specific phospholipase C by membrane curvature and molecular order. Biochemistry 44 (2005) 11592-11600
    • (2005) Biochemistry , vol.44 , pp. 11592-11600
    • Ahyayauch, H.1    Villar, A.V.2    Alonso, A.3    Goni, F.M.4
  • 18
    • 0033104357 scopus 로고    scopus 로고
    • Abnormalities of membrane function and lipid metabolism in hypertension
    • Zicha J., Kunes J., and Devycnk M.A. Abnormalities of membrane function and lipid metabolism in hypertension. Am. J. Hypertens. 12 (1999) 315-331
    • (1999) Am. J. Hypertens. , vol.12 , pp. 315-331
    • Zicha, J.1    Kunes, J.2    Devycnk, M.A.3
  • 19
    • 0034576327 scopus 로고    scopus 로고
    • Alzheimer's disease: its origin at the membrane, evidence and questions
    • Buchet R., and Pikula S. Alzheimer's disease: its origin at the membrane, evidence and questions. Acta Biochim. Pol. 47 (2000) 725-733
    • (2000) Acta Biochim. Pol. , vol.47 , pp. 725-733
    • Buchet, R.1    Pikula, S.2
  • 22
    • 0033403333 scopus 로고    scopus 로고
    • Effect of age on plasma membrane asymmetry and membrane fluidity in human leukocytes and platelets
    • Noble J.M., Thomas T.H., and Ford G.A. Effect of age on plasma membrane asymmetry and membrane fluidity in human leukocytes and platelets. J. Gerontol., A, Biol. Sci. Med. Sci. 54 (1999) M601-M606
    • (1999) J. Gerontol., A, Biol. Sci. Med. Sci. , vol.54
    • Noble, J.M.1    Thomas, T.H.2    Ford, G.A.3
  • 25
    • 0033727839 scopus 로고    scopus 로고
    • Effect of minor components of virgin olive oil on topical antiinflammatory assays
    • De la Puerta R., Martinez-Dominguez E., and Ruiz-Gutierrez V. Effect of minor components of virgin olive oil on topical antiinflammatory assays. Z. Naturforsch., C 55 (2000) 814-819
    • (2000) Z. Naturforsch., C , vol.55 , pp. 814-819
    • De la Puerta, R.1    Martinez-Dominguez, E.2    Ruiz-Gutierrez, V.3
  • 27
    • 0035503597 scopus 로고    scopus 로고
    • The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse
    • Lim G.P., Chu T., Yang F., Beech W., Frautschy S.A., and Cole G.M. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J. Neurosci. 21 (2001) 8370-8377
    • (2001) J. Neurosci. , vol.21 , pp. 8370-8377
    • Lim, G.P.1    Chu, T.2    Yang, F.3    Beech, W.4    Frautschy, S.A.5    Cole, G.M.6
  • 29
    • 0038018156 scopus 로고    scopus 로고
    • Gene expression and molecular composition of phospholipids in rat brain in relation to dietary n-6 to n-3 fatty acid ratio
    • Barcelo-Coblijn G., Kitajka K., Puskas L.G., Hogyes E., Zvara A., Hackler Jr. L., and Farkas T. Gene expression and molecular composition of phospholipids in rat brain in relation to dietary n-6 to n-3 fatty acid ratio. Biochim. Biophys. Acta 1632 (2003) 72-79
    • (2003) Biochim. Biophys. Acta , vol.1632 , pp. 72-79
    • Barcelo-Coblijn, G.1    Kitajka, K.2    Puskas, L.G.3    Hogyes, E.4    Zvara, A.5    Hackler Jr., L.6    Farkas, T.7
  • 31
    • 23744487059 scopus 로고    scopus 로고
    • Lipid homeostasis and apolipoprotein E in the development and progression of Alzheimer's disease
    • Lane R.M., and Farlow M.R. Lipid homeostasis and apolipoprotein E in the development and progression of Alzheimer's disease. J. Lipid Res. 46 (2005) 949-968
    • (2005) J. Lipid Res. , vol.46 , pp. 949-968
    • Lane, R.M.1    Farlow, M.R.2
  • 34
    • 25444489309 scopus 로고    scopus 로고
    • Screening for colorectal, breast, and cervical cancer in the elderly: a review of the evidence
    • Walter L.C., Lewis C.L., and Barton M.B. Screening for colorectal, breast, and cervical cancer in the elderly: a review of the evidence. Am. J. Med. 118 (2005) 1078-1086
    • (2005) Am. J. Med. , vol.118 , pp. 1078-1086
    • Walter, L.C.1    Lewis, C.L.2    Barton, M.B.3
  • 35
    • 0036787611 scopus 로고    scopus 로고
    • Epidemiology of primary brain tumors: current concepts and review of the literature
    • Wrensch M., Minn Y., Chew T., Bondy M., and Berger M.S. Epidemiology of primary brain tumors: current concepts and review of the literature. Neuro-oncol. 4 (2002) 278-299
    • (2002) Neuro-oncol. , vol.4 , pp. 278-299
    • Wrensch, M.1    Minn, Y.2    Chew, T.3    Bondy, M.4    Berger, M.S.5
  • 37
  • 39
    • 17344362824 scopus 로고    scopus 로고
    • Cell growth control by G protein-coupled receptors: from signal transduction to signal integration
    • Gutkind J.S. Cell growth control by G protein-coupled receptors: from signal transduction to signal integration. Oncogene 17 (1998) 1331-1342
    • (1998) Oncogene , vol.17 , pp. 1331-1342
    • Gutkind, J.S.1
  • 40
    • 33644662506 scopus 로고    scopus 로고
    • Overexpression of G protein-coupled receptors in cancer cells: involvement in tumor progression
    • Li S., Huang S., and Peng S.B. Overexpression of G protein-coupled receptors in cancer cells: involvement in tumor progression. Int. J. Oncol. 27 (2005) 1329-1339
    • (2005) Int. J. Oncol. , vol.27 , pp. 1329-1339
    • Li, S.1    Huang, S.2    Peng, S.B.3
  • 41
    • 0029011084 scopus 로고
    • G protein-coupled receptor systems involved in cell growth and oncogenesis
    • Dhanasekaran N., Heasley L.E., and Johnson G.L. G protein-coupled receptor systems involved in cell growth and oncogenesis. Endocr. Rev. 16 (1995) 259-270
    • (1995) Endocr. Rev. , vol.16 , pp. 259-270
    • Dhanasekaran, N.1    Heasley, L.E.2    Johnson, G.L.3
  • 42
    • 0034110277 scopus 로고    scopus 로고
    • Contribution of receptor/G protein signaling to cell growth and transformation
    • Gudermann T., Grosse R., and Schultz G. Contribution of receptor/G protein signaling to cell growth and transformation. Naunyn-Schmiedeberg's Arch. Pharmacol. 361 (2000) 345-362
    • (2000) Naunyn-Schmiedeberg's Arch. Pharmacol. , vol.361 , pp. 345-362
    • Gudermann, T.1    Grosse, R.2    Schultz, G.3
  • 43
    • 0026681259 scopus 로고
    • Growth of small cell lung cancer cells: stimulation by multiple neuropeptides and inhibition by broad spectrum antagonists in vitro and in vivo
    • Sethi T., Langdon S., Smyth J., and Rozengurt E. Growth of small cell lung cancer cells: stimulation by multiple neuropeptides and inhibition by broad spectrum antagonists in vitro and in vivo. Cancer Res. 52 (1992) 2737s-2742s
    • (1992) Cancer Res. , vol.52
    • Sethi, T.1    Langdon, S.2    Smyth, J.3    Rozengurt, E.4
  • 44
    • 0032995692 scopus 로고    scopus 로고
    • Autocrine loops, signal transduction, and cell cycle abnormalities in the molecular biology of lung cancer
    • Rozengurt E. Autocrine loops, signal transduction, and cell cycle abnormalities in the molecular biology of lung cancer. Curr. Opin. Oncol. 11 (1999) 116-122
    • (1999) Curr. Opin. Oncol. , vol.11 , pp. 116-122
    • Rozengurt, E.1
  • 45
    • 0042854927 scopus 로고    scopus 로고
    • Peptide receptors as molecular targets for cancer diagnosis and therapy
    • Reubi J.C. Peptide receptors as molecular targets for cancer diagnosis and therapy. Endocr. Rev. 24 (2003) 389-427
    • (2003) Endocr. Rev. , vol.24 , pp. 389-427
    • Reubi, J.C.1
  • 46
    • 0032032681 scopus 로고    scopus 로고
    • Expression of catalytically inactive phospholipase Cbeta disrupts phospholipase Cbeta and mitogen-activated protein kinase signaling and inhibits small cell lung cancer growth
    • Beekman A., Helfrich B., Bunn Jr. P.A., and Heasley L.E. Expression of catalytically inactive phospholipase Cbeta disrupts phospholipase Cbeta and mitogen-activated protein kinase signaling and inhibits small cell lung cancer growth. Cancer Res. 58 (1998) 910-913
    • (1998) Cancer Res. , vol.58 , pp. 910-913
    • Beekman, A.1    Helfrich, B.2    Bunn Jr., P.A.3    Heasley, L.E.4
  • 47
    • 0029730774 scopus 로고    scopus 로고
    • Galanin, neurotensin, and phorbol esters rapidly stimulate activation of mitogen-activated protein kinase in small cell lung cancer cells
    • Seufferlein T., and Rozengurt E. Galanin, neurotensin, and phorbol esters rapidly stimulate activation of mitogen-activated protein kinase in small cell lung cancer cells. Cancer Res. 56 (1996) 5758-5764
    • (1996) Cancer Res. , vol.56 , pp. 5758-5764
    • Seufferlein, T.1    Rozengurt, E.2
  • 48
    • 0031031499 scopus 로고    scopus 로고
    • Preclinical studies on the broad-spectrum neuropeptide growth factor antagonist G
    • Jones D.A., Cummings J., Langdon S.P., and Smyth J.F. Preclinical studies on the broad-spectrum neuropeptide growth factor antagonist G. Gen. Pharmacol. 28 (1997) 183-189
    • (1997) Gen. Pharmacol. , vol.28 , pp. 183-189
    • Jones, D.A.1    Cummings, J.2    Langdon, S.P.3    Smyth, J.F.4
  • 49
    • 0030725173 scopus 로고    scopus 로고
    • The thyrotropin receptor in thyroid diseases
    • Paschke R., and Ludgate M. The thyrotropin receptor in thyroid diseases. N. Engl. J. Med. 337 (1997) 1675-1681
    • (1997) N. Engl. J. Med. , vol.337 , pp. 1675-1681
    • Paschke, R.1    Ludgate, M.2
  • 52
    • 0026743033 scopus 로고
    • The thyrotropin receptor and the regulation of thyrocyte function and growth
    • Vassart G., and Dumont J.E. The thyrotropin receptor and the regulation of thyrocyte function and growth. Endocr. Rev. 13 (1992) 596-611
    • (1992) Endocr. Rev. , vol.13 , pp. 596-611
    • Vassart, G.1    Dumont, J.E.2
  • 55
    • 0027372340 scopus 로고
    • A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty
    • Shenker A., Laue L., Kosugi S., Merendino Jr. J.J., Minegishi T., and Cutler Jr. G.B. A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty. Nature 365 (1993) 652-654
    • (1993) Nature , vol.365 , pp. 652-654
    • Shenker, A.1    Laue, L.2    Kosugi, S.3    Merendino Jr., J.J.4    Minegishi, T.5    Cutler Jr., G.B.6
  • 56
    • 4043174174 scopus 로고    scopus 로고
    • Increased expression of G-protein-coupled receptor kinases 3 and 4 in hyperfunctioning thyroid nodules
    • Voigt C., Holzapfel H.P., Meyer S., and Paschke R. Increased expression of G-protein-coupled receptor kinases 3 and 4 in hyperfunctioning thyroid nodules. J. Endocrinol. 182 (2004) 173-182
    • (2004) J. Endocrinol. , vol.182 , pp. 173-182
    • Voigt, C.1    Holzapfel, H.P.2    Meyer, S.3    Paschke, R.4
  • 58
    • 0031282001 scopus 로고    scopus 로고
    • Identification of a gene (GPR30) with homology to the G-protein-coupled receptor superfamily associated with estrogen receptor expression in breast cancer
    • Carmeci C., Thompson D.A., Ring H.Z., Francke U., and Weigel R.J. Identification of a gene (GPR30) with homology to the G-protein-coupled receptor superfamily associated with estrogen receptor expression in breast cancer. Genomics 45 (1997) 607-617
    • (1997) Genomics , vol.45 , pp. 607-617
    • Carmeci, C.1    Thompson, D.A.2    Ring, H.Z.3    Francke, U.4    Weigel, R.J.5
  • 59
    • 0033780783 scopus 로고    scopus 로고
    • Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF
    • Filardo E.J., Quinn J.A., Bland K.I., and Frackelton Jr. A.R. Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF. Mol. Endocrinol. 14 (2000) 1649-1660
    • (2000) Mol. Endocrinol. , vol.14 , pp. 1649-1660
    • Filardo, E.J.1    Quinn, J.A.2    Bland, K.I.3    Frackelton Jr., A.R.4
  • 61
    • 12344307170 scopus 로고    scopus 로고
    • Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells
    • Thomas P., Pang Y., Filardo E.J., and Dong J. Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. Endocrinology 146 (2005) 624-632
    • (2005) Endocrinology , vol.146 , pp. 624-632
    • Thomas, P.1    Pang, Y.2    Filardo, E.J.3    Dong, J.4
  • 62
    • 0034966945 scopus 로고    scopus 로고
    • Humoral mechanisms in prostate cancer: A role for FSH
    • Porter A.T., F. A.C.R.O., and Ben-Josef E. Humoral mechanisms in prostate cancer: A role for FSH. Urol. Oncol. 6 (2001) 131-138
    • (2001) Urol. Oncol. , vol.6 , pp. 131-138
    • Porter, A.T.1    F., A.C.R.O.2    Ben-Josef, E.3
  • 63
    • 0037162093 scopus 로고    scopus 로고
    • Mitogenic action of LPA in prostate
    • Daaka Y. Mitogenic action of LPA in prostate. Biochim. Biophys. Acta 1582 (2002) 265-269
    • (2002) Biochim. Biophys. Acta , vol.1582 , pp. 265-269
    • Daaka, Y.1
  • 65
    • 0141844538 scopus 로고    scopus 로고
    • Targeting Gbetagamma signaling to inhibit prostate tumor formation and growth
    • Bookout A.L., Finney A.E., Guo R., Peppel K., Koch W.J., and Daaka Y. Targeting Gbetagamma signaling to inhibit prostate tumor formation and growth. J. Biol. Chem. 278 (2003) 37569-37573
    • (2003) J. Biol. Chem. , vol.278 , pp. 37569-37573
    • Bookout, A.L.1    Finney, A.E.2    Guo, R.3    Peppel, K.4    Koch, W.J.5    Daaka, Y.6
  • 67
    • 0037244775 scopus 로고    scopus 로고
    • Lipids as a target for drugs modulating multidrug resistance of cancer cells
    • Hendrich A.B., and Michalak K. Lipids as a target for drugs modulating multidrug resistance of cancer cells. Curr. Drug Targets 4 (2003) 23-30
    • (2003) Curr. Drug Targets , vol.4 , pp. 23-30
    • Hendrich, A.B.1    Michalak, K.2
  • 69
    • 0030831998 scopus 로고    scopus 로고
    • Role of lipid polymorphism in G protein-membrane interactions: nonlamellar-prone phospholipids and peripheral protein binding to membranes
    • Escriba P.V., Ozaita A., Ribas C., Miralles A., Fodor E., Farkas T., and Garcia-Sevilla J.A. Role of lipid polymorphism in G protein-membrane interactions: nonlamellar-prone phospholipids and peripheral protein binding to membranes. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 11375-11380
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 11375-11380
    • Escriba, P.V.1    Ozaita, A.2    Ribas, C.3    Miralles, A.4    Fodor, E.5    Farkas, T.6    Garcia-Sevilla, J.A.7
  • 71
    • 22344441881 scopus 로고    scopus 로고
    • Influence of the membrane lipid structure on signal processing via G protein-coupled receptors
    • Yang Q., Alemany R., Casas J., Kitajka K., Lanier S.M., and Escriba P.V. Influence of the membrane lipid structure on signal processing via G protein-coupled receptors. Mol. Pharmacol. 68 (2005) 210-217
    • (2005) Mol. Pharmacol. , vol.68 , pp. 210-217
    • Yang, Q.1    Alemany, R.2    Casas, J.3    Kitajka, K.4    Lanier, S.M.5    Escriba, P.V.6
  • 72
    • 30644466209 scopus 로고    scopus 로고
    • Membrane-lipid therapy: a new approach in molecular medicine
    • Escriba P.V. Membrane-lipid therapy: a new approach in molecular medicine. Trends Mol. Med. 12 (2006) 34-43
    • (2006) Trends Mol. Med. , vol.12 , pp. 34-43
    • Escriba, P.V.1
  • 73
    • 0027491609 scopus 로고
    • Changes in G protein-mediated signal transduction in aging and Alzheimer's disease
    • Joseph J.A., Cutler R., and Roth G.S. Changes in G protein-mediated signal transduction in aging and Alzheimer's disease. Ann. N. Y. Acad. Sci. 695 (1993) 42-45
    • (1993) Ann. N. Y. Acad. Sci. , vol.695 , pp. 42-45
    • Joseph, J.A.1    Cutler, R.2    Roth, G.S.3
  • 74
    • 0025831123 scopus 로고
    • Regionally specific age-dependent decline in alpha 2-adrenoceptors: an autoradiographic study in human brain
    • Pascual J., del Arco C., Gonzalez A.M., Diaz A., del Olmo E., and Pazos A. Regionally specific age-dependent decline in alpha 2-adrenoceptors: an autoradiographic study in human brain. Neurosci. Lett. 133 (1991) 279-283
    • (1991) Neurosci. Lett. , vol.133 , pp. 279-283
    • Pascual, J.1    del Arco, C.2    Gonzalez, A.M.3    Diaz, A.4    del Olmo, E.5    Pazos, A.6
  • 75
    • 0028236453 scopus 로고
    • Density of alpha-2A adrenoceptors and Gi proteins in the human brain: ratio of high-affinity agonist sites to antagonist sites and effect of age
    • Sastre M., and Garcia-Sevilla J.A. Density of alpha-2A adrenoceptors and Gi proteins in the human brain: ratio of high-affinity agonist sites to antagonist sites and effect of age. J. Pharmacol. Exp. Ther. 269 (1994) 1062-1072
    • (1994) J. Pharmacol. Exp. Ther. , vol.269 , pp. 1062-1072
    • Sastre, M.1    Garcia-Sevilla, J.A.2
  • 76
    • 0035917312 scopus 로고    scopus 로고
    • Relationships between beta- and alpha2-adrenoceptors and G coupling proteins in the human brain: effects of age and suicide
    • Sastre M., Guimon J., and Garcia-Sevilla J.A. Relationships between beta- and alpha2-adrenoceptors and G coupling proteins in the human brain: effects of age and suicide. Brain Res. 898 (2001) 242-255
    • (2001) Brain Res. , vol.898 , pp. 242-255
    • Sastre, M.1    Guimon, J.2    Garcia-Sevilla, J.A.3
  • 77
    • 1442348869 scopus 로고    scopus 로고
    • Influence of age, postmortem delay and freezing storage period on cannabinoid receptor density and functionality in human brain
    • Mato S., and Pazos A. Influence of age, postmortem delay and freezing storage period on cannabinoid receptor density and functionality in human brain. Neuropharmacology 46 (2004) 716-726
    • (2004) Neuropharmacology , vol.46 , pp. 716-726
    • Mato, S.1    Pazos, A.2
  • 79
    • 0018725469 scopus 로고
    • A quantitative study of the pigmented neurons in the nuclei locus coeruleus and subcoeruleus in man as related to aging
    • Vijayashankar N., and Brody H. A quantitative study of the pigmented neurons in the nuclei locus coeruleus and subcoeruleus in man as related to aging. J. Neuropathol. Exp. Neurol. 38 (1979) 490-497
    • (1979) J. Neuropathol. Exp. Neurol. , vol.38 , pp. 490-497
    • Vijayashankar, N.1    Brody, H.2
  • 81
    • 0023656556 scopus 로고
    • Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium
    • Jones D.T., and Reed R.R. Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium. J. Biol. Chem. 262 (1987) 14241-14249
    • (1987) J. Biol. Chem. , vol.262 , pp. 14241-14249
    • Jones, D.T.1    Reed, R.R.2
  • 82
    • 0024746268 scopus 로고
    • Gi2 mediates alpha 2-adrenergic inhibition of adenylyl cyclase in platelet membranes: in situ identification with G alpha C-terminal antibodies
    • Simonds W.F., Goldsmith P.K., Codina J., Unson C.G., and Spiegel A.M. Gi2 mediates alpha 2-adrenergic inhibition of adenylyl cyclase in platelet membranes: in situ identification with G alpha C-terminal antibodies. Proc. Natl. Acad. Sci. U. S. A. 86 (1989) 7809-7813
    • (1989) Proc. Natl. Acad. Sci. U. S. A. , vol.86 , pp. 7809-7813
    • Simonds, W.F.1    Goldsmith, P.K.2    Codina, J.3    Unson, C.G.4    Spiegel, A.M.5
  • 83
    • 0025216532 scopus 로고
    • Selective binding of ligands to beta 1, beta 2 or chimeric beta 1/beta 2-adrenergic receptors involves multiple subsites
    • Marullo S., Emorine L.J., Strosberg A.D., and Delavier-Klutchko C. Selective binding of ligands to beta 1, beta 2 or chimeric beta 1/beta 2-adrenergic receptors involves multiple subsites. EMBO J. 9 (1990) 1471-1476
    • (1990) EMBO J. , vol.9 , pp. 1471-1476
    • Marullo, S.1    Emorine, L.J.2    Strosberg, A.D.3    Delavier-Klutchko, C.4
  • 85
    • 0028088929 scopus 로고
    • Adenylyl cyclase activity and G-protein subunit levels in postmortem frontal cortex of suicide victims
    • Cowburn R.F., Marcusson J.O., Eriksson A., Wiehager B., and O'Neill C. Adenylyl cyclase activity and G-protein subunit levels in postmortem frontal cortex of suicide victims. Brain Res. 633 (1994) 297-304
    • (1994) Brain Res. , vol.633 , pp. 297-304
    • Cowburn, R.F.1    Marcusson, J.O.2    Eriksson, A.3    Wiehager, B.4    O'Neill, C.5
  • 87
    • 0028343627 scopus 로고
    • Impaired phosphoinositide hydrolysis in Alzheimer's disease brain
    • Jope R.S., Song L., Li X., and Powers R. Impaired phosphoinositide hydrolysis in Alzheimer's disease brain. Neurobiol. Aging 15 (1994) 221-226
    • (1994) Neurobiol. Aging , vol.15 , pp. 221-226
    • Jope, R.S.1    Song, L.2    Li, X.3    Powers, R.4
  • 90
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: genes, proteins, and therapy
    • Selkoe D.J. Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 81 (2001) 741-766
    • (2001) Physiol. Rev. , vol.81 , pp. 741-766
    • Selkoe, D.J.1
  • 91
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics
    • Hardy J., and Selkoe D.J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297 (2002) 353-356
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 92
    • 7044238416 scopus 로고    scopus 로고
    • Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs
    • Forman M.S., Trojanowski J.Q., and Lee V.M. Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs. Nat. Med. 10 (2004) 1055-1063
    • (2004) Nat. Med. , vol.10 , pp. 1055-1063
    • Forman, M.S.1    Trojanowski, J.Q.2    Lee, V.M.3
  • 93
    • 17044439021 scopus 로고    scopus 로고
    • Alzheimer's disease: Abeta, tau and synaptic dysfunction
    • LaFerla F.M., and Oddo S. Alzheimer's disease: Abeta, tau and synaptic dysfunction. Trends Mol. Med. 11 (2005) 170-176
    • (2005) Trends Mol. Med. , vol.11 , pp. 170-176
    • LaFerla, F.M.1    Oddo, S.2
  • 94
    • 33644853531 scopus 로고    scopus 로고
    • Metabolism of amyloid beta peptide and pathogenesis of Alzheimer's disease. Towards presymptomatic diagnosis, prevention and therapy
    • Saido T.C., and Iwata N. Metabolism of amyloid beta peptide and pathogenesis of Alzheimer's disease. Towards presymptomatic diagnosis, prevention and therapy. Neurosci. Res. 54 (2006) 235-253
    • (2006) Neurosci. Res. , vol.54 , pp. 235-253
    • Saido, T.C.1    Iwata, N.2
  • 95
    • 33646383889 scopus 로고    scopus 로고
    • Down-regulation of endogenous amyloid precursor protein processing due to cellular aging
    • Kern A., Roempp B., Prager K., Walter J., and Behl C. Down-regulation of endogenous amyloid precursor protein processing due to cellular aging. J. Biol. Chem. 281 (2006) 2405-2413
    • (2006) J. Biol. Chem. , vol.281 , pp. 2405-2413
    • Kern, A.1    Roempp, B.2    Prager, K.3    Walter, J.4    Behl, C.5
  • 97
    • 0029061685 scopus 로고
    • Neutral endopeptidase can hydrolyze beta-amyloid(1-40) but shows no effect on beta-amyloid precursor protein metabolism
    • Howell S., Nalbantoglu J., and Crine P. Neutral endopeptidase can hydrolyze beta-amyloid(1-40) but shows no effect on beta-amyloid precursor protein metabolism. Peptides 16 (1995) 647-652
    • (1995) Peptides , vol.16 , pp. 647-652
    • Howell, S.1    Nalbantoglu, J.2    Crine, P.3
  • 98
    • 0037010286 scopus 로고    scopus 로고
    • Region-specific reduction of A beta-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging
    • Iwata N., Takaki Y., Fukami S., Tsubuki S., and Saido T.C. Region-specific reduction of A beta-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging. J. Neurosci. Res. 70 (2002) 493-500
    • (2002) J. Neurosci. Res. , vol.70 , pp. 493-500
    • Iwata, N.1    Takaki, Y.2    Fukami, S.3    Tsubuki, S.4    Saido, T.C.5
  • 99
    • 0035846826 scopus 로고    scopus 로고
    • Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of beta-amyloid peptide
    • Yasojima K., Akiyama H., McGeer E.G., and McGeer P.L. Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of beta-amyloid peptide. Neurosci. Lett. 297 (2001) 97-100
    • (2001) Neurosci. Lett. , vol.297 , pp. 97-100
    • Yasojima, K.1    Akiyama, H.2    McGeer, E.G.3    McGeer, P.L.4
  • 100
    • 0035900189 scopus 로고    scopus 로고
    • Relationship between beta amyloid peptide generating molecules and neprilysin in Alzheimer disease and normal brain
    • Yasojima K., McGeer E.G., and McGeer P.L. Relationship between beta amyloid peptide generating molecules and neprilysin in Alzheimer disease and normal brain. Brain Res. 919 (2001) 115-121
    • (2001) Brain Res. , vol.919 , pp. 115-121
    • Yasojima, K.1    McGeer, E.G.2    McGeer, P.L.3
  • 101
  • 102
    • 27344441173 scopus 로고    scopus 로고
    • Metabolism of amyloid-beta peptide and Alzheimer's disease
    • Iwata N., Higuchi M., and Saido T.C. Metabolism of amyloid-beta peptide and Alzheimer's disease. Pharmacol. Ther. 108 (2005) 129-148
    • (2005) Pharmacol. Ther. , vol.108 , pp. 129-148
    • Iwata, N.1    Higuchi, M.2    Saido, T.C.3
  • 104
    • 0027132379 scopus 로고
    • Diminished muscarinic receptor-stimulated [3H]-PIP2 hydrolysis in Alzheimer's disease
    • Ferrari-DiLeo G., and Flynn D.D. Diminished muscarinic receptor-stimulated [3H]-PIP2 hydrolysis in Alzheimer's disease. Life Sci. 53 (1993) PL439-PL444
    • (1993) Life Sci. , vol.53
    • Ferrari-DiLeo, G.1    Flynn, D.D.2
  • 106
  • 107
    • 0035845705 scopus 로고    scopus 로고
    • Psychosis of Alzheimer's disease is associated with elevated muscarinic M2 binding in the cortex
    • Lai M.K., Lai O.F., Keene J., Esiri M.M., Francis P.T., Hope T., and Chen C.P. Psychosis of Alzheimer's disease is associated with elevated muscarinic M2 binding in the cortex. Neurology 57 (2001) 805-811
    • (2001) Neurology , vol.57 , pp. 805-811
    • Lai, M.K.1    Lai, O.F.2    Keene, J.3    Esiri, M.M.4    Francis, P.T.5    Hope, T.6    Chen, C.P.7
  • 108
    • 0025969654 scopus 로고
    • Loss of high-affinity agonist binding to M1 muscarinic receptors in Alzheimer's disease: implications for the failure of cholinergic replacement therapies
    • Flynn D.D., Weinstein D.A., and Mash D.C. Loss of high-affinity agonist binding to M1 muscarinic receptors in Alzheimer's disease: implications for the failure of cholinergic replacement therapies. Ann. Neurol. 29 (1991) 256-262
    • (1991) Ann. Neurol. , vol.29 , pp. 256-262
    • Flynn, D.D.1    Weinstein, D.A.2    Mash, D.C.3
  • 110
    • 0033302310 scopus 로고    scopus 로고
    • Cholinergic muscarinic receptor signaling by the phosphoinositide signal transduction system in Alzheimer's disease
    • Jope R.S. Cholinergic muscarinic receptor signaling by the phosphoinositide signal transduction system in Alzheimer's disease. J. Alzheimers Dis. 1 (1999) 231-247
    • (1999) J. Alzheimers Dis. , vol.1 , pp. 231-247
    • Jope, R.S.1
  • 111
    • 33746210128 scopus 로고    scopus 로고
    • Impaired coupling of muscarinic M(1) receptors to G-proteins in the neocortex is associated with severity of dementia in Alzheimer's disease
    • Tsang S.W., Lai M.K., Kirvell S., Francis P.T., Esiri M.M., Hope T., Chen C.P., and Wong P.T. Impaired coupling of muscarinic M(1) receptors to G-proteins in the neocortex is associated with severity of dementia in Alzheimer's disease. Neurobiol. Aging 27 (2006) 1216-1223
    • (2006) Neurobiol. Aging , vol.27 , pp. 1216-1223
    • Tsang, S.W.1    Lai, M.K.2    Kirvell, S.3    Francis, P.T.4    Esiri, M.M.5    Hope, T.6    Chen, C.P.7    Wong, P.T.8
  • 112
    • 0026090446 scopus 로고
    • Reduced basal and stimulated (isoprenaline, Gpp(NH)p, forskolin) adenylate cyclase activity in Alzheimer's disease correlated with histopathological changes
    • Ohm T.G., Bohl J., and Lemmer B. Reduced basal and stimulated (isoprenaline, Gpp(NH)p, forskolin) adenylate cyclase activity in Alzheimer's disease correlated with histopathological changes. Brain Res. 540 (1991) 229-236
    • (1991) Brain Res. , vol.540 , pp. 229-236
    • Ohm, T.G.1    Bohl, J.2    Lemmer, B.3
  • 113
    • 0026550678 scopus 로고
    • Adenylyl cyclase activity in postmortem human brain: evidence of altered G protein mediation in Alzheimer's disease
    • Cowburn R.F., O'Neill C., Ravid R., Alafuzoff I., Winblad B., and Fowler C.J. Adenylyl cyclase activity in postmortem human brain: evidence of altered G protein mediation in Alzheimer's disease. J. Neurochem. 58 (1992) 1409-1419
    • (1992) J. Neurochem. , vol.58 , pp. 1409-1419
    • Cowburn, R.F.1    O'Neill, C.2    Ravid, R.3    Alafuzoff, I.4    Winblad, B.5    Fowler, C.J.6
  • 114
    • 0026612032 scopus 로고
    • Preservation of Gi-protein inhibited adenylyl cyclase activity in the brains of patients with Alzheimer's disease
    • Cowburn R.F., O'Neill C., Ravid R., Winblad B., and Fowler C.J. Preservation of Gi-protein inhibited adenylyl cyclase activity in the brains of patients with Alzheimer's disease. Neurosci. Lett. 141 (1992) 16-20
    • (1992) Neurosci. Lett. , vol.141 , pp. 16-20
    • Cowburn, R.F.1    O'Neill, C.2    Ravid, R.3    Winblad, B.4    Fowler, C.J.5
  • 115
    • 0028224211 scopus 로고
    • Adenylyl cyclase activity in Alzheimer's disease brain: stimulatory and inhibitory signal transduction pathways are differently affected
    • Schnecko A., Witte K., Bohl J., Ohm T., and Lemmer B. Adenylyl cyclase activity in Alzheimer's disease brain: stimulatory and inhibitory signal transduction pathways are differently affected. Brain Res. 644 (1994) 291-296
    • (1994) Brain Res. , vol.644 , pp. 291-296
    • Schnecko, A.1    Witte, K.2    Bohl, J.3    Ohm, T.4    Lemmer, B.5
  • 116
    • 1542313774 scopus 로고    scopus 로고
    • Impairment of G(salpha) function in human brain cortex of Alzheimer's disease: comparison with normal aging
    • Hashimoto E., Ozawa H., Saito T., Gsell W., Takahata N., Riederer P., and Frolich L. Impairment of G(salpha) function in human brain cortex of Alzheimer's disease: comparison with normal aging. J. Neural Transm. 111 (2004) 311-322
    • (2004) J. Neural Transm. , vol.111 , pp. 311-322
    • Hashimoto, E.1    Ozawa, H.2    Saito, T.3    Gsell, W.4    Takahata, N.5    Riederer, P.6    Frolich, L.7
  • 117
    • 0027280874 scopus 로고
    • Disrupted beta 1-adrenoceptor-G protein coupling in the temporal cortex of patients with Alzheimer's disease
    • Cowburn R.F., Vestling M., Fowler C.J., Ravid R., Winblad B., and O'Neill C. Disrupted beta 1-adrenoceptor-G protein coupling in the temporal cortex of patients with Alzheimer's disease. Neurosci. Lett. 155 (1993) 163-166
    • (1993) Neurosci. Lett. , vol.155 , pp. 163-166
    • Cowburn, R.F.1    Vestling, M.2    Fowler, C.J.3    Ravid, R.4    Winblad, B.5    O'Neill, C.6
  • 118
    • 0027244664 scopus 로고
    • Altered beta-adrenergic receptor-stimulated cAMP formation in cultured skin fibroblasts from Alzheimer donors
    • Huang H.M., and Gibson G.E. Altered beta-adrenergic receptor-stimulated cAMP formation in cultured skin fibroblasts from Alzheimer donors. J. Biol. Chem. 268 (1993) 14616-14621
    • (1993) J. Biol. Chem. , vol.268 , pp. 14616-14621
    • Huang, H.M.1    Gibson, G.E.2
  • 119
    • 0033550704 scopus 로고    scopus 로고
    • 3H]cAMP binding to cytosolic and particulate protein kinase A in post-mortem brain staged for Alzheimer's disease neurofibrillary changes and amyloid deposits
    • 3H]cAMP binding to cytosolic and particulate protein kinase A in post-mortem brain staged for Alzheimer's disease neurofibrillary changes and amyloid deposits. Brain Res. 818 (1999) 383-396
    • (1999) Brain Res. , vol.818 , pp. 383-396
    • Bonkale, W.L.1    Cowburn, R.F.2    Ohm, T.G.3    Bogdanovic, N.4    Fastbom, J.5
  • 120
    • 0031773487 scopus 로고    scopus 로고
    • Fatty acid composition of human brain phospholipids during normal development
    • Martinez M., and Mougan I. Fatty acid composition of human brain phospholipids during normal development. J. Neurochem. 71 (1998) 2528-2533
    • (1998) J. Neurochem. , vol.71 , pp. 2528-2533
    • Martinez, M.1    Mougan, I.2
  • 121
    • 0035883185 scopus 로고    scopus 로고
    • The relationship between age and the fatty acid composition of cerebral cortex and erythrocytes in human subjects
    • Carver J.D., Benford V.J., Han B., and Cantor A.B. The relationship between age and the fatty acid composition of cerebral cortex and erythrocytes in human subjects. Brain Res. Bull. 56 (2001) 79-85
    • (2001) Brain Res. Bull. , vol.56 , pp. 79-85
    • Carver, J.D.1    Benford, V.J.2    Han, B.3    Cantor, A.B.4
  • 122
    • 0022784561 scopus 로고
    • n-3 fatty acids in the brain and retina: evidence for their essentiality
    • Neuringer M., and Connor W.E. n-3 fatty acids in the brain and retina: evidence for their essentiality. Nutr. Rev. 44 (1986) 285-294
    • (1986) Nutr. Rev. , vol.44 , pp. 285-294
    • Neuringer, M.1    Connor, W.E.2
  • 123
    • 0022445141 scopus 로고
    • Biochemical and functional effects of prenatal and postnatal omega 3 fatty acid deficiency on retina and brain in rhesus monkeys
    • Neuringer M., Connor W.E., Lin D.S., Barstad L., and Luck S. Biochemical and functional effects of prenatal and postnatal omega 3 fatty acid deficiency on retina and brain in rhesus monkeys. Proc. Natl. Acad. Sci. U. S. A. 83 (1986) 4021-4025
    • (1986) Proc. Natl. Acad. Sci. U. S. A. , vol.83 , pp. 4021-4025
    • Neuringer, M.1    Connor, W.E.2    Lin, D.S.3    Barstad, L.4    Luck, S.5
  • 124
    • 0031032264 scopus 로고    scopus 로고
    • Arachidonic acid offsets the effects on mouse brain and behavior of a diet with a low (n-6):(n-3) ratio and very high levels of docosahexaenoic acid
    • Wainwright P.E., Xing H.C., Mutsaers L., McCutcheon D., and Kyle D. Arachidonic acid offsets the effects on mouse brain and behavior of a diet with a low (n-6):(n-3) ratio and very high levels of docosahexaenoic acid. J. Nutr. 127 (1997) 184-193
    • (1997) J. Nutr. , vol.127 , pp. 184-193
    • Wainwright, P.E.1    Xing, H.C.2    Mutsaers, L.3    McCutcheon, D.4    Kyle, D.5
  • 125
    • 0034237584 scopus 로고    scopus 로고
    • Essential fatty acids and the brain: possible health implications
    • Youdim K.A., Martin A., and Joseph J.A. Essential fatty acids and the brain: possible health implications. Int. J. Dev. Neurosci. 18 (2000) 383-399
    • (2000) Int. J. Dev. Neurosci. , vol.18 , pp. 383-399
    • Youdim, K.A.1    Martin, A.2    Joseph, J.A.3
  • 128
    • 0034500422 scopus 로고    scopus 로고
    • Fatty acid analysis of blood plasma of patients with Alzheimer's disease, other types of dementia, and cognitive impairment
    • Conquer J.A., Tierney M.C., Zecevic J., Bettger W.J., and Fisher R.H. Fatty acid analysis of blood plasma of patients with Alzheimer's disease, other types of dementia, and cognitive impairment. Lipids 35 (2000) 1305-1312
    • (2000) Lipids , vol.35 , pp. 1305-1312
    • Conquer, J.A.1    Tierney, M.C.2    Zecevic, J.3    Bettger, W.J.4    Fisher, R.H.5
  • 129
    • 0031745753 scopus 로고    scopus 로고
    • Membrane instability, plasmalogen content, and Alzheimer's Disease
    • Ginsberg L., Xuereb J.H., and Gershfeld N.L. Membrane instability, plasmalogen content, and Alzheimer's Disease. J. Neurochem. 70 (1998) 2533-2538
    • (1998) J. Neurochem. , vol.70 , pp. 2533-2538
    • Ginsberg, L.1    Xuereb, J.H.2    Gershfeld, N.L.3
  • 130
  • 133
    • 0028916836 scopus 로고
    • Membrane alterations as causes of impaired signal transduction in Alzheimer's disease and aging
    • Roth G.S., Joseph J.A., and Mason R.P. Membrane alterations as causes of impaired signal transduction in Alzheimer's disease and aging. Trends Neurosci. 18 (1995) 203-206
    • (1995) Trends Neurosci. , vol.18 , pp. 203-206
    • Roth, G.S.1    Joseph, J.A.2    Mason, R.P.3
  • 135
    • 0037452724 scopus 로고    scopus 로고
    • Short-term administration of omega 3 fatty acids from fish oil results in increased transthyretin transcription in old rat hippocampus
    • Puskas L.G., Kitajka K., Nyakas C., Barcelo-Coblijn G., and Farkas T. Short-term administration of omega 3 fatty acids from fish oil results in increased transthyretin transcription in old rat hippocampus. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 1580-1585
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 1580-1585
    • Puskas, L.G.1    Kitajka, K.2    Nyakas, C.3    Barcelo-Coblijn, G.4    Farkas, T.5
  • 136
    • 1942532069 scopus 로고    scopus 로고
    • High carbohydrate diets and Alzheimer's disease
    • Henderson S.T. High carbohydrate diets and Alzheimer's disease. Med. Hypotheses 62 (2004) 689-700
    • (2004) Med. Hypotheses , vol.62 , pp. 689-700
    • Henderson, S.T.1
  • 138
    • 0033301784 scopus 로고    scopus 로고
    • Dietary links to Alzheimer's disease: 1999 update
    • Grant W.B. Dietary links to Alzheimer's disease: 1999 update. J. Alzheimer's Dis. 1 (1999) 197-201
    • (1999) J. Alzheimer's Dis. , vol.1 , pp. 197-201
    • Grant, W.B.1
  • 139
    • 0033301717 scopus 로고    scopus 로고
    • Diet and oxidative stress: a novel synthesis of epidemiological data on Alzheimer's disease
    • Smith M.A., Petot G.J., and Perry G. Diet and oxidative stress: a novel synthesis of epidemiological data on Alzheimer's disease. J. Alzheimer's Dis. 1 (1999) 203-206
    • (1999) J. Alzheimer's Dis. , vol.1 , pp. 203-206
    • Smith, M.A.1    Petot, G.J.2    Perry, G.3
  • 140
    • 0038579615 scopus 로고    scopus 로고
    • Dietary lipids in the aetiology of Alzheimer's disease: implications for therapy
    • Cooper J.L. Dietary lipids in the aetiology of Alzheimer's disease: implications for therapy. Drugs Aging 20 (2003) 399-418
    • (2003) Drugs Aging , vol.20 , pp. 399-418
    • Cooper, J.L.1
  • 142
    • 0035693924 scopus 로고    scopus 로고
    • Inflammation, autotoxicity and Alzheimer disease
    • McGeer P.L., and McGeer E.G. Inflammation, autotoxicity and Alzheimer disease. Neurobiol. Aging 22 (2001) 799-809
    • (2001) Neurobiol. Aging , vol.22 , pp. 799-809
    • McGeer, P.L.1    McGeer, E.G.2
  • 146
    • 0141611923 scopus 로고    scopus 로고
    • Age-related changes in vascular adrenergic signaling: clinical and mechanistic implications
    • Schutzer W.E., and Mader S.L. Age-related changes in vascular adrenergic signaling: clinical and mechanistic implications. Ageing Res. Rev. 2 (2003) 169-190
    • (2003) Ageing Res. Rev. , vol.2 , pp. 169-190
    • Schutzer, W.E.1    Mader, S.L.2
  • 147
    • 0027417262 scopus 로고
    • Cardiovascular regulatory mechanisms in advanced age
    • Lakatta E.G. Cardiovascular regulatory mechanisms in advanced age. Physiol. Rev. 73 (1993) 413-467
    • (1993) Physiol. Rev. , vol.73 , pp. 413-467
    • Lakatta, E.G.1
  • 148
    • 0027136046 scopus 로고
    • Physiology of cardiovascular aging
    • Folkow B., and Svanborg A. Physiology of cardiovascular aging. Physiol. Rev. 73 (1993) 725-764
    • (1993) Physiol. Rev. , vol.73 , pp. 725-764
    • Folkow, B.1    Svanborg, A.2
  • 150
    • 0034325276 scopus 로고    scopus 로고
    • Human ageing and the sympathoadrenal system
    • Seals D.R., and Esler M.D. Human ageing and the sympathoadrenal system. J. Physiol. 528 (2000) 407-417
    • (2000) J. Physiol. , vol.528 , pp. 407-417
    • Seals, D.R.1    Esler, M.D.2
  • 151
    • 4644286385 scopus 로고    scopus 로고
    • Autonomic receptor systems in the failing and aging human heart: similarities and differences
    • Brodde O.E., and Leineweber K. Autonomic receptor systems in the failing and aging human heart: similarities and differences. Eur. J. Pharmacol. 500 (2004) 167-176
    • (2004) Eur. J. Pharmacol. , vol.500 , pp. 167-176
    • Brodde, O.E.1    Leineweber, K.2
  • 152
    • 0025330663 scopus 로고
    • Cardiovascular responses in ageing: a review
    • Docherty J.R. Cardiovascular responses in ageing: a review. Pharmacol. Rev. 42 (1990) 103-125
    • (1990) Pharmacol. Rev. , vol.42 , pp. 103-125
    • Docherty, J.R.1
  • 153
    • 0031426844 scopus 로고    scopus 로고
    • Alterations in beta-adrenoceptor mechanisms in the aging heart, relationship with heart failure
    • Ferrara N., Davia K., Abete P., Rengo F., and Harding S.E. Alterations in beta-adrenoceptor mechanisms in the aging heart, relationship with heart failure. Aging 9 (1997) 391-403
    • (1997) Aging , vol.9 , pp. 391-403
    • Ferrara, N.1    Davia, K.2    Abete, P.3    Rengo, F.4    Harding, S.E.5
  • 157
    • 0032544793 scopus 로고    scopus 로고
    • Age-dependent decrease in the negative inotropic effect of carbachol on isolated human right atrium
    • Giessler C., Wangemann T., Zerkowski H.R., and Brodde O.E. Age-dependent decrease in the negative inotropic effect of carbachol on isolated human right atrium. Eur. J. Pharmacol. 357 (1998) 199-202
    • (1998) Eur. J. Pharmacol. , vol.357 , pp. 199-202
    • Giessler, C.1    Wangemann, T.2    Zerkowski, H.R.3    Brodde, O.E.4
  • 159
    • 0034072691 scopus 로고    scopus 로고
    • G protein-dependent signalling and ageing
    • Roka F., Freissmuth M., and Nanoff C. G protein-dependent signalling and ageing. Exp. Gerontol. 35 (2000) 133-143
    • (2000) Exp. Gerontol. , vol.35 , pp. 133-143
    • Roka, F.1    Freissmuth, M.2    Nanoff, C.3
  • 160
    • 0033922139 scopus 로고    scopus 로고
    • Vascular beta-adrenoceptor function in hypertension and in ageing
    • Werstiuk E.S., and Lee R.M. Vascular beta-adrenoceptor function in hypertension and in ageing. Can. J. Physiol. Pharmacol. 78 (2000) 433-452
    • (2000) Can. J. Physiol. Pharmacol. , vol.78 , pp. 433-452
    • Werstiuk, E.S.1    Lee, R.M.2
  • 161
    • 1242294512 scopus 로고    scopus 로고
    • Modulation of Ca2+sensitivity by cyclic nucleotides in smooth muscle from protein kinase G-deficient mice
    • Bonnevier J., Fassler R., Somlyo A.P., Somlyo A.V., and Arner A. Modulation of Ca2+sensitivity by cyclic nucleotides in smooth muscle from protein kinase G-deficient mice. J. Biol. Chem. 279 (2004) 5146-5151
    • (2004) J. Biol. Chem. , vol.279 , pp. 5146-5151
    • Bonnevier, J.1    Fassler, R.2    Somlyo, A.P.3    Somlyo, A.V.4    Arner, A.5
  • 162
    • 0033804613 scopus 로고    scopus 로고
    • Vascular beta-adrenergic receptor adenylyl cyclase system in maturation and aging
    • Gaballa M.A., Eckhart A.D., Koch W.J., and Goldman S. Vascular beta-adrenergic receptor adenylyl cyclase system in maturation and aging. J. Mol. Cell Cardiol. 32 (2000) 1745-1755
    • (2000) J. Mol. Cell Cardiol. , vol.32 , pp. 1745-1755
    • Gaballa, M.A.1    Eckhart, A.D.2    Koch, W.J.3    Goldman, S.4
  • 164
    • 0028986867 scopus 로고
    • Beta-adrenoceptor-G alpha S coupling decreases with age in rat aorta
    • Gurdal H., Friedman E., and Johnson M.D. Beta-adrenoceptor-G alpha S coupling decreases with age in rat aorta. Mol. Pharmacol. 47 (1995) 772-778
    • (1995) Mol. Pharmacol. , vol.47 , pp. 772-778
    • Gurdal, H.1    Friedman, E.2    Johnson, M.D.3
  • 169
    • 0032908439 scopus 로고    scopus 로고
    • Antiphospholipid antibodies permeabilize and depolarize brain synaptoneurosomes
    • Chapman J., Cohen-Armon M., Shoenfeld Y., and Korczyn A.D. Antiphospholipid antibodies permeabilize and depolarize brain synaptoneurosomes. Lupus 8 (1999) 127-133
    • (1999) Lupus , vol.8 , pp. 127-133
    • Chapman, J.1    Cohen-Armon, M.2    Shoenfeld, Y.3    Korczyn, A.D.4
  • 171
    • 0023605873 scopus 로고
    • Abnormalities of erythrocyte membrane fatty acid composition in human essential hypertension
    • Ollerenshaw J.D., Heagerty A.M., Bing R.F., and Swales J.D. Abnormalities of erythrocyte membrane fatty acid composition in human essential hypertension. J. Hum. Hypertens. 1 (1987) 9-12
    • (1987) J. Hum. Hypertens. , vol.1 , pp. 9-12
    • Ollerenshaw, J.D.1    Heagerty, A.M.2    Bing, R.F.3    Swales, J.D.4
  • 175
    • 0027991543 scopus 로고
    • Polyunsaturated and monounsaturated fatty acids in the diet to prevent coronary heart disease via cholesterol reduction
    • Heyden S. Polyunsaturated and monounsaturated fatty acids in the diet to prevent coronary heart disease via cholesterol reduction. Ann. Nutr. Metab. 38 (1994) 117-122
    • (1994) Ann. Nutr. Metab. , vol.38 , pp. 117-122
    • Heyden, S.1
  • 176
    • 0030471905 scopus 로고    scopus 로고
    • Plasma lipids, erythrocyte membrane lipids and blood pressure of hypertensive women after ingestion of dietary oleic acid from two different sources
    • Ruiz-Gutierrez V., Muriana F.J., Guerrero A., Cert A.M., and Villar J. Plasma lipids, erythrocyte membrane lipids and blood pressure of hypertensive women after ingestion of dietary oleic acid from two different sources. J. Hypertens. 14 (1996) 1483-1490
    • (1996) J. Hypertens. , vol.14 , pp. 1483-1490
    • Ruiz-Gutierrez, V.1    Muriana, F.J.2    Guerrero, A.3    Cert, A.M.4    Villar, J.5
  • 177
    • 0029165975 scopus 로고
    • Transbilayer movement of erythrocyte membrane cholesterol in human essential hypertension
    • Muriana F.J., Montilla C., Villar J., and Ruiz-Gutierrez V. Transbilayer movement of erythrocyte membrane cholesterol in human essential hypertension. J. Hypertens. 13 (1995) 619-623
    • (1995) J. Hypertens. , vol.13 , pp. 619-623
    • Muriana, F.J.1    Montilla, C.2    Villar, J.3    Ruiz-Gutierrez, V.4
  • 178
    • 0029910679 scopus 로고    scopus 로고
    • Validity of studies on distribution and transbilayer movement of erythrocyte membrane cholesterol
    • Muriana F.J., Alonso A., Villar J., and Ruiz-Gutierrez V. Validity of studies on distribution and transbilayer movement of erythrocyte membrane cholesterol. J. Hypertens. 14 (1996) 1379-1380
    • (1996) J. Hypertens. , vol.14 , pp. 1379-1380
    • Muriana, F.J.1    Alonso, A.2    Villar, J.3    Ruiz-Gutierrez, V.4
  • 179
    • 0030772089 scopus 로고    scopus 로고
    • Intake of olive oil can modulate the transbilayer movement of human erythrocyte membrane cholesterol
    • Muriana F.J., Villar J., and Ruiz-Gutierrez V. Intake of olive oil can modulate the transbilayer movement of human erythrocyte membrane cholesterol. Cell Mol. Life Sci. 53 (1997) 496-500
    • (1997) Cell Mol. Life Sci. , vol.53 , pp. 496-500
    • Muriana, F.J.1    Villar, J.2    Ruiz-Gutierrez, V.3
  • 180
    • 0032829846 scopus 로고    scopus 로고
    • Incorporation of dietary triacylglycerols from olive oil and high-oleic sunflower oil into VLDL triacylglycerols of hypertensive patients
    • Ruiz-Gutierrez V., Perona J.S., Pacheco Y.M., Muriana F.J., and Villar J. Incorporation of dietary triacylglycerols from olive oil and high-oleic sunflower oil into VLDL triacylglycerols of hypertensive patients. Eur. J. Clin. Nutr. 53 (1999) 687-693
    • (1999) Eur. J. Clin. Nutr. , vol.53 , pp. 687-693
    • Ruiz-Gutierrez, V.1    Perona, J.S.2    Pacheco, Y.M.3    Muriana, F.J.4    Villar, J.5
  • 181
    • 0038759711 scopus 로고    scopus 로고
    • Plasma lipid modifications in elderly people after administration of two virgin olive oils of the same variety (Olea europaea var. hojiblanca) with different triacylglycerol composition
    • Perona J.S., Canizares J., Montero E., Sanchez-Dominguez J.M., and Ruiz-Gutierrez V. Plasma lipid modifications in elderly people after administration of two virgin olive oils of the same variety (Olea europaea var. hojiblanca) with different triacylglycerol composition. Br. J. Nutr. 89 (2003) 819-826
    • (2003) Br. J. Nutr. , vol.89 , pp. 819-826
    • Perona, J.S.1    Canizares, J.2    Montero, E.3    Sanchez-Dominguez, J.M.4    Ruiz-Gutierrez, V.5
  • 182
    • 0020692020 scopus 로고
    • Alteration of synaptic membrane cholesterol/phospholipid ratio using a lipid transfer protein. Effect on gamma-aminobutyric acid uptake
    • North P., and Fleischer S. Alteration of synaptic membrane cholesterol/phospholipid ratio using a lipid transfer protein. Effect on gamma-aminobutyric acid uptake. J. Biol. Chem. 258 (1983) 1242-1253
    • (1983) J. Biol. Chem. , vol.258 , pp. 1242-1253
    • North, P.1    Fleischer, S.2
  • 183
    • 0034618743 scopus 로고    scopus 로고
    • Nitric oxide improves membrane fluidity of erythrocytes in essential hypertension: An electron paramagnetic resonance investigation
    • Tsuda K., Kimura K., Nishio I., and Masuyama Y. Nitric oxide improves membrane fluidity of erythrocytes in essential hypertension: An electron paramagnetic resonance investigation. Biochem. Biophys. Res. Commun. 275 (2000) 946-954
    • (2000) Biochem. Biophys. Res. Commun. , vol.275 , pp. 946-954
    • Tsuda, K.1    Kimura, K.2    Nishio, I.3    Masuyama, Y.4
  • 184
    • 0021347893 scopus 로고
    • Age-related modification of dopaminergic and beta-Adrenergic receptor system: restoration to normal activity by modifying membrane fluidity with S-adenosylmethionine
    • Cimino M., Vantini G., Algeri S., Curatola G., Pezzoli C., and Stramentinoli G. Age-related modification of dopaminergic and beta-Adrenergic receptor system: restoration to normal activity by modifying membrane fluidity with S-adenosylmethionine. Life Sci. 34 (1984) 2029-2039
    • (1984) Life Sci. , vol.34 , pp. 2029-2039
    • Cimino, M.1    Vantini, G.2    Algeri, S.3    Curatola, G.4    Pezzoli, C.5    Stramentinoli, G.6
  • 185
    • 0141706805 scopus 로고    scopus 로고
    • Effects of unsaturated fatty acids and triacylglycerols on phosphatidylethanolamine membrane structure
    • Prades J., Funari S.S., Escriba P.V., and Barcelo F. Effects of unsaturated fatty acids and triacylglycerols on phosphatidylethanolamine membrane structure. J. Lipid Res. 44 (2003) 1720-1727
    • (2003) J. Lipid Res. , vol.44 , pp. 1720-1727
    • Prades, J.1    Funari, S.S.2    Escriba, P.V.3    Barcelo, F.4
  • 186
    • 33747140793 scopus 로고    scopus 로고
    • Antihypertensive action of 2-hydroxyoleic acid in SHR mediated by enhancement of the protein kinase A pathway and downregulation of Rho-kinase
    • Alemany R., Vogler O., Teres S., Egea C., Baamonde C., Barcelo F., Delgado C., Jakobs K.H., and Escriba P.V. Antihypertensive action of 2-hydroxyoleic acid in SHR mediated by enhancement of the protein kinase A pathway and downregulation of Rho-kinase. J. Lipid Res. 47 (2006) 1762-1770
    • (2006) J. Lipid Res. , vol.47 , pp. 1762-1770
    • Alemany, R.1    Vogler, O.2    Teres, S.3    Egea, C.4    Baamonde, C.5    Barcelo, F.6    Delgado, C.7    Jakobs, K.H.8    Escriba, P.V.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.