Nutritional modulation of cognitive function and mental health

Journal of Nutritional Biochemistry

Volumn 24, Issue 5, 2013, Pages 725-743

  Parletta, Natalie ^a   Milte, Catherine M ^b   Meyer, Barbara J ^c  

^a UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

^b DEAKIN UNIVERSITY   (Australia)

^c UNIVERSITY OF WOLLONGONG   (Australia)

Author keywords

Antioxidants; Cognition; Folate; Homocysteine; Mediterranean diet; Mental health; Omega 3 fatty acids; Polyphenols; Vitamin B12; Vitamin B6

Indexed keywords

ANTIOXIDANT; CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; OMEGA 3 FATTY ACID; PYRIDOXINE; VITAMIN B GROUP;

BRAIN FUNCTION; COGNITION; MEDITERRANEAN DIET; MENTAL HEALTH; NUTRITION; OXIDATIVE STRESS; REVIEW;

ANIMALS; ANTIOXIDANTS; BRAIN; CHRONIC DISEASE; COGNITION; DIET, MEDITERRANEAN; DISEASE MODELS, ANIMAL; FATTY ACIDS, OMEGA-3; FOLIC ACID; HOMOCYSTEINE; HUMANS; LIFE STYLE; MENTAL HEALTH; NUTRITIONAL PHYSIOLOGICAL PHENOMENA; RISK FACTORS; VITAMIN B COMPLEX;

EID: 84876788934     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2013.01.002     Document Type: Review

References (281)

1. Kessler R.C., Angermeyer M., Anthony J.C., Graaf R.D., Demyttenaere K., Gasquet I., et al. Lifetime prevalence and age-of-onset distributions of mental disorders in the World Health Organisation's World Mental Health Survey Initiative. World Psychiatry 2007, 6(3):168-176.
2. Ferri C.P., Prince M., Brayne C., Brodaty H., Fratiglioni L., Ganguli M., et al. Global prevalence of dementia: a Delphi consensus study. Lancet 2005, 366:2112-2117.
3. Trichopoulou A., Costacou T., Bamia C., Trichopoulou D. Adherence to a Mediterranean diet and survival in a Greek population. N Eng J Med 2003, 348(26):2599-2608.
4. Sofi F., Cesari F., Abbate R., et al. Adherence to Mediterranean diet and health status: a meta-analysis. BMJ 2008, 337:a1344.
5. Schröder H. Protective mechanisms of the Mediterranean diet in obesity and type 2 diabetes. J Nutr Biochem 2007, 18:149-160.
6. Serra-Majem L., Roman B., Estruch R. Scientific evidence of interventions using the Mediterranean diet: a systematic review. Nutr Rev 2006, 64(2):S27-S47.
7. Razquin C., Martinez J.A., Martinez-Gonzalez M.A., Mitjavila M.T., Estruch R., Marti A. A 3 year follow-up of a Mediterranean diet rich in virgin olive oil is associated with high plasma antioxidant capacity and reduced body weight gain. Eur J Clin Nutr 2009, 63:1387-1393.
8. Salas-Salvado J., Garcia-Arellano A., Estruch R., Marquez-Sandoval F., Corella D., Fiol M., et al. Components of the Mediterranean-type food pattern and serum inflammatory markers among patients at high risk for cardiovascular disease. Eur J Clin Nutr 2007, 62:651-659.
9. Salas-Salvado J., Bulló M., Babio N., Martínez-González M.A., Ibarrola-Jurado N., et al. Reduction in the incidence of type 2 diabetes with the Mediterranean diet: results of the PREDIMED-Reus nutrition intervention randomized trial. Diabetes Care 2011, 34(1):14-19.
10. Nordmann A.J., Suter-Zimmermann K., Bucher H.C., Shai I., Tuttle K.R., Estruch R., et al. Meta-analysis comparing Mediterranean to low-fat diets for modification of cardiovascular risk factors. Am J Med 2011, 124:841-851.
11. Bourre J.-M. Effects of nutrients (in food) on the structure and function of the nervous system: Update on dietary requirements for brain, part 1: micronutrients. J Nutr Health Aging 2006, 10(5):377-385.
12. Bourre J.-M. Effects of nutrients (in food) on the structure and function of the nervous system: update on dietary requirements for brain. Part 2: macronutrients. J Nutr Health Aging 2006, 10(5):386-399.
13. Sathyanarayana Rao T., Asha M., Ramesh B., Jagannatha Rao K. Understanding nutrition, depression and mental illnesses. Indian J Psychiatry 2008, 50(2):77-82.
14. Nutritional neuroscience. Nutrition, brain, and behaviour 2005, Taylor & Francis Group, Boca Raton. H.R. Lieberman, R.B. Kanarek, C. Prasad (Eds.).
15. Forsyth A.K., Deane F.P., Williams P. Dietitians and exercise physiologists in primary care: lifestyle interventions for patients with depressoin and/or anxiety. J Allied Health 2009, 38(2):63E-68E.
16. Forsyth A.K., Williams P.G., Deane F.P. Nutrition status of primary care patients with depression and anxiety. Aust J Prim Health 2011, 18(2):172-176.
17. Freeman M.P. Nutrition and psychiatry. Am J Psychiatry 2010, 167(3):244-247.
18. Martinsen E.W. Anxiety/depression: lifestyle medicine approaches. Am J Lifestyle Med 2007, 1:159-166.
19. Joseph J., Cole G., Head E., Ingram D. Nutrition, brain aging, and neurodegeneration. J Neurosci 2009, 29(41):12795-12801.
20. Jacka F.N., Mykletun A., Berk M. Moving towards a population health approach to the primary prevention of common mental disorders. BMC Med 2012, 10:149.
21. Sanchez-Villegas A., Martinez-Gonzalez M.A. Diet, a new target to prevent depression?. BMC Med 2013, 11:3. 10.1186/1741-7015-11-3.
22. Munoz M.-A., Fito M., Marrugat J., Covas M.-I., Schroder H. Adherence to the Mediterranean diet is associated with better mental and physical health. Br J Nutr 2009, 101:1821-1827. on behalf of the REGICOR and HERMES investigators.
23. Sanchez-Villegas A., Henriquez P., Bes-Rastrollo M., Doreste J. Mediterranean diet and depression. Pub Health Nutr 2006, 9(8A):1104-1109.
24. Jacka F.N., Mykletun A., Berk M., Bjelland I., Tell G.S. The association between habitual diet quality and the common mental disorders in community-dwelling adults: The Hordaland Health Study. Psychosom Med 2011, 73(6):483-490.
25. Jacka F.N., Pasco J.A., Mykletun A., Williams L.J., Nicholson G.C., Kotowicz M.A., et al. Diet quality in bipolar disorder in a population-based sample of women. J Affect Disord 2011, 129:332-337.
26. Jacka F.N., Pasco J.A., Mykletun A., Williams L.J., Hodge A.M., Linette O'Reilly S., et al. Association of western and traditional diets with depression and anxiety in women. Am J Psychiatry 2010, 167(3):305-311.
27. Oddy W.H., Robinson M., Ambrosini G.L., O'Sullivan T.A., de Klerk N.H., Beilin L.J., et al. The association between dietary patterns and mental health in early adolescence. Prev Med 2009, 49(1):39-44.
28. Panza F., Solfrizzi V., Colacicco A.M., D'Introno A., Capurso C., Torres F., et al. Mediterranean diet and cognitive decline. Pub Health Nutr 2004, 7(7):959-963.
29. Scarmeas N., Stern Y., Tang M.-X., Mayeux R., Luchsinger J.A. Mediterranean diet and risk for Alzheimer's disease. Ann Neurol 2006, 59(6):912-921.
30. Scarmeas N., Stern Y., Mayeux R., Manly J.J., Schupf N., Luchsinger J.A. Mediterranean diet and mild cognitive impairment. Arch Neurol 2009, 66(2):216-225.
31. Gu Y., Nieves J.W., Stern Y., Luchsinger J.A., Scarmeas N. Food combination and Alzheimer disease risk: a protective diet. Arch Neurol 2010, 67(6):699-706.
32. Rogers P.J. A healthy body, a healthy mind: long-term impact of diet on mood and cognitive function. Proc Nutr Soc 2001, 60:135-143.
33. Eilander A., Gera T., Sachdev H.S., Transler C., Van der Knapp H.C.M., Kok F.J., et al. Multiple micronutrient supplementation for improving cognitive performance in children: systematic review of randomised controlled trials. Am J Clin Nutr 2010, 91:115-130.
34. Schoenthaler S.J., Bier I.D. Vitamin-mineral intake and intelligence: a macrolevel analysis of randomised controlled trials. J Altern Complement Med 1999, 5(2):125-134.
35. Schoenthaler S.J., Amos S., Doraz W., Kelly M.-A., Muedeking G., Wakefield J. The effect of randomized vitamin-mineral supplementation on violent and non-violent antisocial behavior among incarcerated juveniles. J Nutr Environ Med 1997, 7:343-352.
36. Gesch B., Hammond S.M., Hampson S.E., Eves A., Crowder M.J. Influence of supplementary vitamins, minerals and essential fatty acids on the antisocial behaviour of young adult prisoners. Br J Psychiatry 2002, 181:22-28.
37. Zaalberg A., Nijman H., Bulten E., Stroosma L., van der Staak C. Effects of nutritional supplements on aggression, rule-breaking, and psychopathology among young adult prisoners. Aggress Behav 2010, 36:117-126.
38. Bodnar L.M., Wisner K.L. Nutrition and depression: implications for improving mental health among childbearing-aged women. Biol Psychiatry 2005, 58(9):679-685.
39. Zimmerman M.B. Iodine deficiency in pregnancy and the effects of maternal iodine supplementation on the offspring: a review. Am J Clin Nutr 2009, 89(2):668S-672S.
40. Qian M., Wang D., Watkins W., Gebski V., Yan Y.Q., Li M., et al. The effects of iodine on intelligence in children: a meta-analysis of studies conducted in China. Asia Pac J Clin Nutr 2005, 14(1):32-42.
41. van den Briel T., West C.E., Bleichrodt N., van de Vijver F.J.R., Ategbo E.A., Hautvast J.G. Improved iodine status is associated with improved mental performance of schoolchildren in Benin. Am J Clin Nutr 2000, 72:1179-1185.
42. Launer L.J., Kalmijn S. Anti-oxidants and cognitive function: a review of clinical and epidemiologic studies. J Neural Transm Suppl 1998, 53:1-8.
43. Esposito E., Rotilio D., Di Matteo V., Di Giulio C., Cacchio M., Algeri S. A review of specific dietary antioxidants and the effects on biochemical mechanisms related to neurodegenerative processes. Neurobiol Aging 2002, 23:719-735.
44. Mulero J., Zafrilla P., Martinez-Cacha A. Oxidative stress, frailty and cognitive decline. J Nutr Health Aging 2011, 15(9):756-760.
45. Coppen A., Bolander-Gouaille C. Treatment of depression: time to consider folic acid and vitamin B12. J Psychopharmacol 2005, 19(1):59-65.
46. Smith D., Refsum H. Vitamin B-12 and cognition in the elderly. Am J Clin Nutr 2009, 89(Suppl.):707S-711S.
47. Malouf R., Grimley Evans J. Folic acid with or without vitamin B12 for the prevention and treatment of healthy elderly and demented people. Cochrane Database Syst Rev 2008, 8(4):CD004514.
48. Sinn N., Milte C., Howe P.R.C. Oiling the brain: A review of randomised controlled trials of omega-3 fatty acids in psychopathology across the lifespan. Nutrients 2010, 2(2):128-170.
49. Lakhan S.E., Vieira K.F. Nutritional therapies for mental disorders. Nutr J 2008, 7(2). 10.1186/1475-2891-7-2.
50. Sinn N. Nutritional and dietary influences on attention deficit hyperactivity disorder. Nutr Rev 2008, 66(10):558-568.
51. Young S.N. Clinical nutrition 3: the fuzzy boundary between nutrition and psychopharmacology. CMAJ 2002, 166(2):205-209.
52. Dauncey M.J. New insights into nutrition and cognitive neuroscience. Proc Nutr Soc 2009, 68:408-415.
53. Dauncey M.J. Recent advances in nutrition, genes and brain health. Proc Nutr Soc 2012, 71:581-591.
54. Gomez-Pinilla F. The influences of diet and exercise on mental health through hormesis. Ageing Res Rev 2008, 7:49-62.
55. Fang Y.-Z., Yang S., Wu G. Free radicals, antioxidants, and nutrition. Nutrition 2002, 18(10):872-879.
56. Rao P.S., Kalva S., Yerramilli A., Mamidi S. Free radicals and tissue damage: role of antioxidants. Free Radic Antioxid 2011, 1(4):2-7.
57. Massaad C.A. Neuronal and vascular oxidative stress in Alzheimer's disease. Curr Neuropharmacol 2011, 9(4):662-673.
58. Halliwell B. Oxidative stress and neurodegeneration: where are we now?. J Neurochem 2006, 97(6):1634-1658.
59. Gandhi S., Abramov A.Y. Mechanism of oxidative stress in neurodegeneration. Oxidative Med Cell Longevity 2012, 2012(Article ID 428010):11.
60. Scapagnini G., Davinelli S., Drago F., De Lorenzo A., Oriani G. Antioxidants as antidepressants: fact or fiction?. CNS Drugs 2012, 26(6):477-490.
61. Ng F., Berk M., Dean O., Bush A.I. Oxidative stress in psychiatric disorders: evidence base and therapeutic implications. Int J Neuropsychopharmacol 2008, 21:1-26. [Epub ahead of print].
62. Pandya C., Howell K., Pillai A. Antioxidants as potential therapeutics for neuropsychiatric disorders. Prog Neuro-Psychopharmacol Biol Psychiatry 2012, 10.1016/j.pnpbp.2012.10.017.
63. Sies H. Oxidative stress: oxidants and antioxidants. Exp Physiol 1997, 82:291-295.
64. Su Z.Y., Shu L., Khor T.O., Lee J.H., Fuentes F., Kong A.N. A perspective on dietary phytochemicals and cancer chemoprevention: oxidative stress, Nrf2, and epigenomics. Top Curr Chem 2012, 329:133-162.
65. Machlin L.J., Bendich A. Free radical tissue damage: protective role of antioxidant nutrients. FASEB J 1987, 1(6):441-445.
66. Sies H., Stahl W., Sundquist A.R. Antioxidant functions of vitamins: vitamins E and C, beta-carotene, and other carotenoids. Ann N Y Acad Sci 1992, 669:7-20.
67. Wray W.D., Nishiyama S.K., Harris R.A., Zhao J., McDaniel J., Fjeldstad A.S., et al. Acute reversal of endothelial dysfunction in the elderly after antioxidant consumption. Hypertension 2012, 59:818-824.
68. Wu A., Ying Z., Gomez-Pinilla F. Dietary omega-3 fatty acids normalise BDNF levels, reduce oxidative damage, and counteract learning disability after traumatic brain injury in rats. J Neurotrauma 2004, 21(10):1457-1467.
69. Wen S., Zhang T., Tan T. Utilization of amino acids to enhance glutathione production in Saccharomyces cerevisiae. Enzyme Microb Technol 2004, 35(6-7):501-507.
70. Miller H.E., Rigelhof F., Marquart L., Prakash A., Kanter M. Antioxidant content of whole grain breakfast cereals, fruits and vegetables. J Am Coll Nutr 2000, 19(3):312S-319S.
71. Yang J., Liu R.H., Halim L. Antioxidant and antiproliferate activities of common edible nut seeds. LWT- Food Sci Technol 2009, 42(1):1-8.
72. Basli A., Soulet S., Chaher N., Merillon J.-M., Chibane M., Monti J.-P., et al. Wine polyphenols: potential agents in neuroprotection. Oxidative Med Cell Longevity 2012, 2012(Article ID 805762):14.
73. Nijveldt R.J., van Nood E., van Hoorn D.E., Boelens P.G., van Norren K., van Leeuwen P.A. Flavonoids: a review of probable mechanisms of action and applications. Am J Clin Nutr 2001, 74(4):418-425.
74. Visioli F., Poli A., Gall C. Antioxidant and other biological activities of phenols from olives and olive oil. Med Res Rev 2002, 22(1):65-75.
75. Lai P.K., Roy J. Antimicrobial and chemopreventive properties of herbs and spices. Curr Med Chem 2004, 11(11):1451-1460.
76. Middleton E., Kandaswami C., Theoharides T.C. Effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease and cancer. Pharmacol Rev 2000, 52:673-751.
77. Hwang S.L., Shih P.H., Yen G.C. Neuroprotective effects of citrus flavonoids. J Agric Food Chem 2012, 60(4):877-885.
78. Mahal H.S., Mukherjee T. Scavenging of reactive oxygen radicals by resveratrol: antioxidant effect. Res Chem Intermed 2006, 32(1):59-71.
79. Manach C., Scalbert A., Morand C., Rémésy C., Jiménez L. Polyphenols: food sources and bioavailability. Am J Clin Nutr 2004, 79:727-747.
80. Natella F., Nardini M., Di Felice M., Scaccini C. Benzoic and cinnamic acid derivatives as antioxidants: structure-activity relation. J Agric Food Chem 1999, 47(4):1453-1459.
81. Arts I.C.W., Hollman P.C.H. Polyphenols and disease risk in epidemiologic studies. Am J Clin Nutr 2005, 81(3):317S-325S.
82. Liu R.H. Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals. Am J Clin Nutr 2003, 78(Suppl.):517S-520S.
83. George T.W., Paterson E., Waroonphan S., Gordon M.H., Lovegrove J.A. Effects of chronic consumption of fruit and vegetable puree-based drinks on vasodilation, plasma oxidative stability and antioxidant status. J Hum Nutr Diet 2012, 25:477-487.
84. Mastaloudis A., Wood S.M. Age-related changes in cellular protection, purification, and inflammation-related gene expression: role of dietary phytonutrients. Ann N Y Acad Sci 2012, 1249(1):112-120.
85. Carmona-Ramirez I., Santamaria A., Tobon-Velasco J., Orozco-Ibarra M., Gonzalez-Herrera I.G., Pedraza-Chavern J., et al. Curcumin restores Nrf2 levels and prevents quinolinic acid-induced neurotoxicity. J Nutr Biochem 2013, 24(1):14-24.
86. Vauzour D. Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects. Oxidative Med Cell Longevity 2012, 2012. Article ID 914273, 16 pages.
87. Halliwell B., Rafter J., Jenner A. Health promotion by flavonoids, tocopherols, tocotrienols, and other phenols: direct or indirect effects?. Am J Clin Nutr 2005, 81(1):2685-2765.
88. Jenner A.M., Rafter J., Halliwell B. Human fecal content of phenolics: the extent of colonic exposure to aromatic compounds. Free Radic Biol Med 2005, 38(6):763-772.
89. Collins S.M., Bercik P. The relationship between intestinal microbiota and the central nervous system in normal gastrointestinal function and disease. Gastroenterology 2009, 136(6):2003-2014.
90. Milaneschi Y., Bandinelli S., Penninx B.W., Corsi A.M., Lauretani F., Vazzana R., et al. The relationship between plasma carotenoids and depressive symptoms in older persons. World J Biol Psychiatry 2012, 13:588-598.
91. Engelhart M.J., Geerlings M.I., Ruitenberg A., van Swieten J.C., Hofman A., Witteman J.C.M., et al. Dietary intake of antioxidants and risk of Alzheimer disease. JAMA 2002, 287(24):3223-3229.
92. Bouayed J. Polyphenols: a potential new strategy for the prevention and treatment of anxiety and depression. Curr Nutr Food Sci 2010, 6(1):13-18.
93. Brody S. High-dose ascorbic acid increases intercourse frequency and improves mood: a randomized controlled clinical trial. Biol Psychiatry 2002, 52(4):371-374.
94. Lamport D.J., Dye L., Wightman J.D., Lawton C.L. The effects of flavonoid and other polyphenol consumption on cognitive performance: a systematic research review of human experimental and epidemiological studies. Nutr Aging 2012, 1(1):5-25.
95. Trebatická J., Kopasová S., Hradečná Z., Cinovsky K., Škodáček I., Šuba J., et al. Treatment of ADHD with French maritime pine bark extract, Pycnogenol®. Eur Child Adolesc Psychiatry 2006, 15(6):329-335.
96. Dvořáková M., Sivoňová M., Trebatická J., Škodáček I., Waczuliková I., Muchová J., et al. The effect of polyphenolic extract from pine bark, Pycnogenol®, on the level of glutathione in children suffering from attention deficit hyperactivity disorder (ADHD). Redox Rep 2006, 11(4):163-172.
97. Tenenbaum S., Paull J.C., Sparrow E.P., Dodd D.K., Green L. An experimental comparison of Pycnogenol and methylphenidate in adults with Attention-Deficit/Hyperactivity Disorder (ADHD). J Atten Disord 2002, 6:49-60.
98. Arvindakshan M., Ghate M., Ranjekar P., Evans D.R., Mahadik S.P. Supplementation with a combination of w-3 fatty acids and antioxidants (vitamins E and C) improves the outcome of schizophrenia. Schizophr Res 2003, 62:195-204.
99. Sinclair A.J., Begg D., Mathai M., Weisinger R.S. Omega 3 fatty acids and the brain: review of studies in depression. Asia Pac J Clin Nutr 2007, 16(Suppl. 1):391-397.
100. Sinclair A.J., Crawford M.A. The accumulation of arachidonate and docosahexaenoate in the developing rat brain. J Neurochem 1972, 19:1753-1758.
101. Haag M. Essential fatty acids and the brain. Can J Psychiatry 2003, 48(3):195-203.
102. Lauritzen L., Hansen H.S., Jørgensen M.H., Michaelsen K.F. The essentiality of long chain n-3 fatty acids in relation to development and function of the brain and retina. Prog Lipid Res 2001, 40:1-94.
103. Freeman M.P., Hibbeln J.R., Wisner K.L., Davis J.M., Mischoulon D., Peet M., et al. Omega-3 fatty acids: evidence base for treatment and future research in psychiatry. J Clin Psychiatry 2006, 67:1954-1967.
104. Brenna T.J. Efficiency of conversion of [alpha]-linolenic acid to long chain n-3 fatty acids in man. Curr Opin Clin Nutr Metab Care 2002, 5(2):127-132.
105. 13C]α-linolenic acid to longer-chain fatty acids and partitioning towards β-oxidation in older men. Br J Nutr 2003, 90:311-321.
106. Burdge G. α-Linolenic acid metabolism in men and women: nutritional and biological implications. Curr Opin Clin Nutr Metab Care 2004, 7:137-144.
107. Le H.D., Meisel J.A., de Meijer V.E., Gura K.M., Puder M. The essentiality of arachidonic acid and docosahexaenoic acid. Prostaglandins Leukot Essent Fatty Acids 2009, 81:165-170.
108. Saldanha L.G., Salem N.J., Brenna T.J. Workshop on DHA as a required nutrient: overview. Prostaglandins Leukot Essent Fatty Acids 2009, 81:233-236.
109. Meyer B.J., Kolanu N. Australian children are not consuming enough long-chain omega-3 polyunsaturated fatty acids for optimal health. Nutrition 2011, 27:1136-1140.
110. Meyer B.J., Mann N.J., Lewis J.L., Milligan G.C., Sinclair A.J., Howe P.R.C. Dietary intakes and food sources of omega-6 and omega-3 polyunsaturated fatty acids. Lipids 2003, 38:391-398.
111. Simopoulos A.P. Omega-3 fatty acids in wild plants, nuts and seeds. Asia Pac J Clin Nutr 2002, 11(S6):S163-S173.
112. Simopoulos A.P. The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomed Pharmacother 2002, 56(8):365-379.
113. Sioen I.A., Pynaert I., Matthys C., De Backer G., Van Camp J., De Henauw S. Dietary intakes and food sources of fatty acids for Belgian women, focused on n-6 and n-3 polyunsaturated fatty acids. Lipids 2006, 41:415-422.
114. Blasbalg T.L., Hibbeln J.R., Ramsden C.E., Majchrzak S.F., Rawlings R.R. Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century. Am J Clin Nutr 2011, 93(5):950-962.
115. Hibbeln J.R., Nieminen L.R.G., Blasbalg T.L., Riggs J.A., Lands W.E.M. Healthy intakes of n-3 and n-6 fatty acids: estimations considering worldwide diversity. Am J Clin Nutr 2006, 83(6):S1483-S1493.
116. Wainwright P.E. Dietary essential fatty acids and brain function: a developmental perspective on mechanisms. Proc Nutr Soc 2002, 61:61-69.
117. O'Brien J.S., Sampson E.L. Lipid composition of the normal human brain: gray matter, white matter, and myelin. J Lipid Res 1965, 6:537-544.
118. Hicks A.M., DeLong C.J., Thomas M.J., Samuel M., Cui Z. Unique molecular signatures of glycerophospholipid species in different rat tissues analyzed by tandem mass spectrometry. Biochim Biophys Acta (BBA) - Mol Cell Biol. Lipids 2006, 1761(9):1022-1029.
119. Kennedy E.M., Weiss S.B. The function of cytidine coenzymes in the biosynthesis of phospholipides. J Biol Chem 1956, 222:193-214.
120. Galletti P., De Rosa M., Cotticelli M.G., Morana A., Vaccaro R., Zappia V. Biochemical rationale for the use of CDPcholine in traumatic brain injury: pharmocokinetics of the orally administered drug. J Neurol Sci 1991, 103(Supplement):19-25.
121. Cansev M., Wurtman R.J. Chronic administration of docosahexaenoic acid or eicosapentaenoic acid, but not arachidonic acid, alone or in combination with uridine, increases brain phosphatide and synaptic protein levels in gerbils. Neuroscience 2007, 148(2):421-431.
122. Hogans A.F., Guroff G., Udenfriend S. Studies on the origin of pyrimidines for biosynthesis of neural RNA in the rat. J Neurochem 1971, 18(9):1699-1710.
123. Redzic Z.B., Biringer J., Barnes K., Baldwin S.A., Al-Sarraf H., Nicola P.A., et al. Polarized distribution of nucleoside transporters in rat brain endothelial and choroid plexus epithelial cells. J Neurochem 2005, 94:1420-1426.
124. Cansev M. Uridine and cytidine in the brain: their transport and utilization. Brain Res Rev 2006, 52(2):389-397.
125. Richardson U.I., Wurtman R.J. Polyunsaturated fatty acids stimulate phosphatidylcholine synthesis in PC12 cells. Biochim Biophys Acta (BBA) - Mol Cell Biol. Lipids 2007, 1771(4):558-563.
126. Mathews C.K., van Holde K.E., Ahern K.G. Biochemistry 2000, Benjamin Cummings, San Francisco.
127. O'Brien J.S., Sampson E.L. Fatty acid and fatty aldehyde composition of the major brain lipids in normal human gray matter, white matter, and myelin. J Lipid Res 1965, 6:544-551.
128. Schaefer E.J., Bongard V., Beiser A.S., Lamon-Fava S., Robins S.J., Au R., et al. Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study. Arch Neurol 2006, 63(11):1545-1550.
129. Swierk M., Williams P.G., Wilcox J., Russell K.G., Meyer B.J. Validation of an Australian electronic food frequency questionnaire to measure polyunsaturated fatty acid intake. Nutrition 2011, 27:641-646.
130. Castellano C.-A., Chouinard-Watkins R., Brenna T.J., Meyer B.J., Cunnane S.C. Does aging change docosahexaenoic acid homeostasis? Implications for the challenge to cognitive health in the elderly. OCL 2011, 18(4):175-180.
131. Sakamoto T., Cansev M., Wurtman R.J. Oral supplementation with docosahexaenoic acid and uridine-5'-monophosphate increases dendritic spine density in adult gerbil hippocampus. Brain Res 2007, 1182:50-59.
132. Marszalek J.R., Kitidis C., Dararutana A., Lodish H.F. Acyl-CoA synthetase 2 overexpression enhances fatty acid internalization and neurite outgrowth. J Biol Chem 2004, 279:23882-23891.
133. Marszalek J.R., Kitidis C., DiRusso C.C., Lodish H.F. Long-chain acyl CoA sythetase 6 preferentially promotes DHA metabolism. J Biol Chem 2005, 280:10817-10826.
134. Wurtman R.J., Ulus I.H., Cansev M., Watkins C.J., Wang L., Marzloff G. Synaptic proteins and phospholipids are increased in gerbil brain by administering uridine plus docosahexaenoic acid orally. Brain Res 2006, 1088(1):83-92.
135. Futerman A.H., Banker G.A. The economics of neurite outgrowth: the addition of new membrane to growing axons. Trends Neurosci 1996, 19:144-149.
136. Sofroniew M.V., Howe C.L., Mobley W.C. Nerve growth factor signaling, neuroprotection, and neural repair. Ann Rev Neurosci 2001, 24:1217-1281.
137. Hornfelt M., Ekstrom P.A., Edstrom A. Involvement of axonal phospholipase A2 activity in the outgrowth of adult mouse sensory axons in vitro. Neuroscience 1999, 91:1539-1547.
138. Darios F., Davletov B. Omega-3 and omega-6 fatty acids stimulate cell membrane expansion by acting on syntaxin 3. Nature 2006, 440:813-817.
139. Rizo J., Sudhof T.C. SNAREs and Munc18 in synaptic vesicle fusion. Nat Rev Neurosci 2002, 3:641-653.
140. Ungar D., Hughson F.M. SNARE protein structure and function. Ann Rev Cell Dev Biol 2003, 19(1):493-517.
141. Kothapalli K.S.D., Anthony J.C., Pan B.S., Hsieh A.T., Nathanielsz P.W., Brenna T.J. Differential cerebral cortex transcriptomes of baboon neonates consuming moderate and high docosahexaenoic acid formulas. PLoS One 2007, 2:e370.
142. Lands W.E.M., Inoue M., Sugiura Y., Okuyama H. Selective incorporation of polyunsaturated fatty acids into phosphatidylcholine by rat liver microsomes. J Biol Chem 1982, 257:14968-14972.
143. Pawlosky R.J., Hibbeln J.R., Novotny J.A., Salem N.J. Physiological compartmental analysis of a-linolenic acid metabolism in adult humans. J Lipid Res 2001, 42:1257-1265.
144. Zhou L., Vessby B., Nilsson A. Quantitative role of plasma free fatty acids in the supply of arachidonic acid to extrahepatic tissues in rats. J Nutr 2002, 132:2626-2631.
145. Kawakita E., Hashimoto M., Shido O. Docosahexaenoic acid promotes neurogenesis in vitro and in vivo. Neuroscience 2006, 139(3):991-997.
146. Leach J.L., Baxter J.H., Molitor B.E., Ramstack M.B., Masor M.L. Total potentially available nucleosides of human milk by stage of lactation. Am J Clin Nutr 1995, 61(6):1224-1230.
147. Thorell L., Sjöberg L., Hernell O. Nucleotides in human milk: sources and metabolism by the newborn infant. Pediatr Res 1996, 40:845-852.
148. Nealon J.R., Blanksby S.J., Mitchell T.W., Else P.L. Systematic differences in membrane acyl composition associated with varying body mass in mammals occur in all phospholipid classes: an analysis of kidney and brain. J Exp Biol 2008, 211:3195-3204.
149. Schroeder F., Sweet W.D. The role of membrane lipid and structure asymmetry on transport systems. Advances in Biotechnology of Membrane Ion Transport 1988, 183-195. Elsevier, New York. P.L. Jorgensen, R. Verna (Eds.).
150. Alves I.D., Salgado G.F., Salamon Z., Brown M.F., Tollin G., Hruby V.J. Phosphatidylethanolamine enhances rhodopsin photoactivation and transducin binding in a solid supported lipid bilayer as determined using plasmon-waveguide resonance spectroscopy. Biophys J 2005, 88(1):198-210.
151. Niu S.L., Mitchell D.C., Litman B.J. Optimization of receptor-G protein coupling by bilayer lipid composition II: formation of metarhodopsin II-transducin complex. J Biol Chem 2001, 276:42807-42811.
152. Innis S.A., Friesen R.W. Essential n-3 fatty acids in pregnant women and early visual acuity maturation in term infants. Am J Clin Nutr 2008, 87:548-557.
153. Anderson G.H. Diet, neurotransmitters and brain function. Br Med Bull 1981, 37(1):95-100.
154. Heinrichs S.C. Dietary ω-3 fatty acid supplementation for optimizing neuronal structure and function. Mol Nutr Food Res 2010, 54:447-456.
155. Chalon S. Omega-3 fatty acids and monoamine neurotransmission. Prostaglandins Leukot Essent Fatty Acids 2006, 75:259-269.
156. Meyer B.J., Lane A.E., Mann N.J. Comparison of seal oil to tuna oil on plasma lipid levels and blood pressure in hypertriglyceridaemic subjects. Lipids 2009, 44:827-835.
157. Nettleton J.A. Omega-3 fatty acids and health 1995, Chapman & Hall, New York.
158. Dyerberg J., Bang H.O., Stoffersen E., Moncada S., Vane J.R. Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis?. Lancet 1978, 312(8081):117-119.
159. Simopoulos A.P. Essential fatty acids in health and chronic disease. Am J Clin Nutr 1999, 70(Suppl.):560S-569S.
160. Calder P.C. Immunomodulation by omega-3 fatty acids. Prostaglandins Leukot Essent Fatty Acids 2007, 77(5-6):327-335.
161. Ajmone-Cat M.A., Salvatori M.L., De Simone R., Mancini M., Biagioni S., Bernardo A., et al. Docosahexaenoic acid modulates inflammatory and antineurogenic functions of activated microglial cells. J Neurosci Res 2012, 90(3):575-587.
162. Sokoloff L. Metabolism of ketone bodies by the brain. Ann Rev Med 1973, 24:271-280.
163. da Silva A.X., Lavialle F., Gendrot G., Guesnet P., Alessandri J.-M., Lavialle M. Glucose transport and utilization are altered in the brain of rats deficient in n-3 polyunsaturated fatty acids. J Neurochem 2002, 81:1328-1337.
164. Pifferi F., Roux F., Langelier B., Alessandri J.-M., Vancassel S., Jouin M., et al. (n-3) polyunsaturated fatty acid deficiency reduces the expression of both isoforms of the brain glucose transporter GLUT1 in rats. J Nutr 2005, 135:2241-2246.
165. Brenna T.J., Diau G.-Y. The influence of dietary docosahexaenoic acid and arachidonic acid on central nervous system polyunsaturated fatty acid composition. Prostaglandins Leukot Essent Fatty Acids 2007, 77(5-6):247-250.
166. Jacobs B., Chugani H.T., Chen A.S., Phelps M.E., Pollack D.B., Raleigh M.J. Developmental changes in brain metabolism in sedated rhesus macaques and vervet monkeys revealed by positron emission tomography. Cereb Cortex 1995, 5:222-233.
167. Sinn N., Howe P.R.C. Mental health benefits of omega-3 fatty acids may be mediated by improvements in cerebral vascular function. Biosci Hypotheses 2008, 1(2):103-108.
168. Jackson P.A., Reay J.L., Scholey A.B., Kennedy D.O. DHA-rich oil modulates the cerebral haemodynamic response to cognitive tasks in healthy young adults: a near IR spectroscopy pilot study. Br J Nutr 2012, 107:1093-1098.
169. Troller J.N., Smith E., Baune B.T., Kochan N.A., Campbell L., Samaras K., et al. Systemic inflammation is associated with MCI and its subtypes: the Sydney Memory and Aging Study. Dement Geriatr Cogn Disord 2010, 30(6):569-578.
170. Agrawal R., Gomez-Pinilla F. 'Metabolic syndrome' in the brain: deficiency in omega-3 fatty acid exacerbates dysfunctions in insulin receptor signalling and cognition. J Physiol 2012, 590(10):2485-2499.
171. Kim H.-Y., Bigelow J., Kevala J.H. Substrate preference in phosphatidylserine biosynthesis for docosahexaenoic acid containing species. Biochemistry 2004, 43(4):1030-1036.
172. Kim H.-Y. Novel metabolism of docosahexaenoic acid in neural cells. J Biol Chem 2007, 282:18661-18665.
173. Akbar M., Calderon F., Wen Z., Kim H.-Y. Docosahexaenoic acid: a positive modulator of Akt signaling in neuronal survival. Proc Natl Acad Sci 2005, 102(31):10858-10863.
174. Kim H.-Y., Akbar M., Lau A., Edsall L. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3): role of phosphatidylserine in antiapoptotic effect. J Biol Chem 2000, 275:35215-35223.
175. Wen Z., Kim H.-Y. Inhibition of phosphatidylserine biosynthesis in developing rat brain by maternal exposure to ethanol. J Neurosci Res 2007, 85(7):1568-1578.
176. Hong S., Gonert K., Devchand P.R., Moussignac R.L., Serhan C.N. Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. J Biol Chem 2003, 278:14677-14687.
177. Kim H.-Y., Akbar M., Lau A. Effects of docosapentaenoic acid on neuronal apoptosis. Lipids 2003, 38(4):453-457.
178. Montuschi P., Barnes P.J., Roberts L.J. Isoprostanes: markers and mediators of oxidative stress. FASEB J 2004, 18(15):1791-1800.
179. Montine T.J., Neely M.D., Quinn J.F., Beal M.F., Markesbery W.R., Roberts L.J.I., et al. Lipid peroxidation in aging brain and Alzheimer's disease. Free Radic Biol Med 2002, 33:620-626.
180. Praticò D., Clark C.M., Liun F., Lee V.Y., Trojanowski J.Q. Increase of brain oxidative stress in mild cognitive impairment: a possible predictor of Alzheimer disease. Arch Neurol 2002, 59:972-976.
181. Musiek E.S., Brooks J.D., Joo M., Brunoldi E., Porta A., Zanoni G., et al. Electrophilic cyclopentenone neuroprostanes are anti-inflammatory mediators formed from the peroxidation of the ω-3 polyunsaturated fatty acid docosahexaenoic acid. J Biol Chem 2008, 283(29):19927-19935.
182. Ledesma M.D., Martin M.G., Dotti C.G. Lipid changes in the aged brain: effect on synaptic function and neuronal survival. Prog Lipid Res 2012, 51(1):23-35.
183. Rouser G., Yamamoto A. Curvilinear regression course of human brain lipid composition changes with age. Lipids 1968, 3:284-287.
184. Aprikyan G.V., Gekchyan K.G. Release of neurotransmitter amino acids from rat brain synaptosomes and its regulation in aging. Gerontology 1988, 34:35-40.
185. Fordyce D.E., Wehner J.M. Effects of aging on spatial learning and hippocampal protein kinase C in mice. Neurobiol Aging 1993, 14:309-317.
186. Morrison J.H., Hof P.R. Life and death of neurons in the aging brain. Science 1997, 278(5337):412-419.
187. McEwen B.S. Physiology and neurobiology of stress and adaptation: central role of the brain. Physiol Rev 2007, 87:873-904.
188. Lentz B.R., Carpenter T.J., Alford D.R. Spontaneous fusion of phosphatidylcholine small unilamellar vesicles in the fluid phase. Biochemistry 1987, 26:5389-5397.
189. Piomelli D., Astarita G., Rapaka R. A neuroscientist's guide to lipidomics. Nat Rev Neurosci 2007, 8:743-754.
190. Barnes C.A. Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. J Comp Physiol Psychol 1979, 93:74-104.
191. Rosenzweig E.S., Barnes C.A. Impact of aging on hippocampal function: plasticity, network dynamics, and cognition. Prog Neurobiol 2003, 69:143-179.
192. Barnes C.A., McNaughton B.L. Physiological compensation for loss of afferent synapses in rat hippocampal granule cells during senescence. J Physiol 1980, 309:473-485.
193. Kelly A., Maguire C., Lynch M.A. Deficits in nerve growth factor release and tyrosine receptor kinase phosphorylation are associated with age-related impairment in long-term potentiation in the dentate gyrus. Neuroscience 2000, 95:359-365.
194. Bliss T.V.P. LTP and spatial learning. J Physiol Paris 1996, 90(5-6):335.
195. McGahon B.M., Martin D.S., Horrobin D.F., Lynch M.A. Age-related changes in synaptic function: analysis of the effect of dietary supplementation with omega-3 fatty acids. Neuroscience 1999, 94:305-314.
196. Magnusson K.R. Aging of glutamate receptors: correlations between binding and spatial memory performance in mice. Mech Ageing Dev 1998, 104:227-248.
197. Foster T.C., Kumar A. Calcium dysregulation in the aging brain. Neuroscientist 2002, 8(4):297-301.
198. Passafaro M., Nakagawa T., Sala C., Sheng M. Induction of dendritic spines by an extracellular domain of AMPA receptor subunit GluR2. Nature 2003, 424(6949):677-681.
199. Dyall S.C., Michael G.J., Whelpton R., Scott A.G., Michael-Titus A.T. Dietary enrichment with omega-3 polyunsaturated fatty acids reverses age-related decreases in the GluR2 and NR2B glutamate receptor subunits in rat forebrain. Neurobiol Aging 2007, 28(3):424-439.
200. Palacios-Pelaez R., Lukiw W.J., Bazan N.G. Omega-3 essential fatty acids modulate initiation and progression of neurodegenerative disease. Mol Neurobiol 2010, 41(2-3):367-374.
201. Hashimoto M., Hossain S., Shimada T., Sugioka K., Yamasaki H., Fujii Y., et al. Docosahexaenoic acid provides protection from impairment of learning ability in Alzheimer's disease model rats. J Neurochem 2002, 81(5):1084-1091.
202. McCann J.C., Ames B.N. Is docosahexaenoic acid, an n-3 long-chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioral tests in humans and animals. Am J Clin Nutr 2005, 82(2):281-295.
203. Sinn N., Milte C.M., Street S.J., Buckley J.D., Coates A.M., Petkov J., et al. Effects of omega-3 fatty acids, EPA v. DHA, on depressive symptoms, quality of life, memory and executive function in older adults with mild cognitive impairment: A 6-month randomised controlled trial. Br J Nutr 2012, 107(11):1682-1693.
204. Takeuchi T., Iwanaga M., Harada E. Possible regulatory mechanism of DHA-induced anti-stress reaction in rats. Brain Res 2003, 964:136-143.
205. Delarue J., Matzinger O., Binnert C., Schneiter P., Chioléro R., Tappy L. Fish oil prevents the adrenal activation elicited by mental stress in healthy men. Diabetes Metab 2003, 29(3):289-295.
206. Nitsch R.M., Blusztajn J.K., Pittas A.G., Slack B.E., Growdon J.H., Wurtman R.J. Evidence for a membrane defect in Alzheimer disease brain. Proc Natl Acad Sci 1992, 89(5):1671-1675.
207. Söderberg M., Edlund C., Kristensson K., Dallner G. Fatty acid composition of brain phospholipids in aging and in Alzheimer's Disease. Lipids 1991, 26(1):421-425.
208. Jacobsen J.S., Wu C.-C., Redwine J.M., Comery T.A., Arias R., Bowlby M., et al. Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease. Proc Natl Acad Sci 2006, 103(13):5161-5166.
209. Mann J., Truswell A.S. Essentials of human nutrition 2012, Oxford University Press, New York. 4th ed.
210. World Health Organisation Vitamin and mineral requirements in human nutrition: report of a joint FAO/WHO expert consultation 2004, WHO, Geneva.
211. Bottiglieri T. Homocysteine and folate metabolism in depression. Prog Neuro-Psychopharmacol Biol Psychiatry 2005, 29:1103-1112.
212. Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA 2002, 288(16):2015-2022. Homocysteine Studies Collaboration.
213. Refsum H., Ueland P.M., Nygård O., Vollset M.D. Homocysteine and cardiovascular disease. Medicine 1998, 49:31-62.
214. Cantoni G.L. The role of S-adenosylhomocysteine in the biological utilization of S-adenosylmethionine. Prog Clin Biol Res 1985, 198:47-65.
215. Lima C.P., Davis S.R., Mackey A.D., Scheer J.B., Williamson J., Gregory J.F. Vitamin B-6 deficiency suppresses the hepatic transsulfuration pathway but increases glutathione concentration in rats fed AIN-76A or AIN-93G diets. J Nutr 2006, 136(8):2141-2147.
216. Sunden S.L., Renduchintala M.S., Park E.I., Miklasz S.D., Garrow T.A. Betaine-homocysteine methyltransferase expression in porcine and human tissues and chromosomal localization of the human gene. Arch Biochem Biophys 1997, 345(1):171-174.
217. Grieve A., Butcher S.P., Griffiths R. Synaptosomal plasma membrane transport of excitatory sulphur amino acid transmitter candidates: kinetic characterisation and analysis of carrier specificity. J Neurosci Res 1992, 32(1):60-68.
218. Refsum H., Smith A.D., Ueland P.M., Nexo E., Clarke R., McPartlin J., et al. Facts and recommendations about total homocysteine determinations: an expert opinion. Clin Chem 2004, 50(1):3-32.
219. Meijer A., Conradi H.J., Bos E.H., Thombs B.D., van Melle J.P., de Jonge P. Prognostic association of depression following myocardial infarction with mortality and cardiovascular events: a meta-analysis of 25 years of research. Gen Hosp Psychiatry 2011, 33(3):203-216.
220. Meng L., Dongmei C., Yang Y., Yang Z., Rutai H. Depression increases the risk of hypertension incidence: a meta-analysis of prospective cohort studies. J Hypertens 2012, 30(5):842-851.
221. Beary M., Hodgson R., Wildgust H.J. A critical review of major mortality risk factors for all-cause mortality in first-episode schizophrenia: clinical and research implications. J Psychopharmacol 2012, 26(5 Suppl):52-61.
222. O'Donnell M., Teo K., Gao P., Anderson C., Sleight P., Dans A., et al. Cognitive impairment and risk of cardiovascular events and mortality. Eur Heart J 2012, 33(14):1777-1786.
223. Hogervorst E., Ribeiro H.M., Molyneux A., Budge M., Smith A.D. Plasma homocysteine levels, cerebrovascular risk factors, and cerebral white matter changes (leukoaraiosis) in patients with Alzheimer disease. Arch Neurol 2002, 59(5):787-793.
224. Matsui T., Arai H., Yuzuriha T., Yao H., Miura M., Hashimoto S., et al. Elevated plasma homocysteine levels and risk of silent brain infarction in elderly people. Stroke 2001, 32(5):1116-1119.
225. Fassbender K., Mielke O., Bertsch T., Nafe B., Froeschen S., Hennerici M. Homocysteine in cerebral macroangiography and microangiopathy. Lancet 1999, 353(9164):1586-1587.
226. Troen A.M., Shea-Budgell M., Shukitt-Hale B., Smith D.E., Selhub J., Rosenberg I.H. B-vitamin deficiency causes hyperhomocysteinemia and vascular cognitive impairment in mice. Proc Natl Acad Sci 2008, 105(34):12474-12479.
227. Lominadze D., Roberts A.M., Tyagi N., Moshal K.S., Tyagi S.C. Homocysteine causes cerebrovascular leakage in mice. Am J Physiol Heart Circ Physiol 2006, 290(3):H1206-H1213.
228. Kamath A.F., Chauhan A.K., Kisucka J., Dole V.S., Loscalzo J., Handy D.E., et al. Elevated levels of homocysteine compromise blood-brain barrier integrity in mice. Blood 2006, 107(2):591-593.
229. Kennedy B.P., Bottiglieri T., Arning E., Ziegler M.G., Hansen L.A., Masliah E. Elevated S-adenosylhomocysteine in Alzheimer brain: influence on methyltransferases and cognitive function. J Neural Transm 2004, 111:547-567.
230. Botez M.I., Young S.N., Bachevalier J., Gauthier S. Folate deficiency and decreased brain 5-hydroxytryptamine synthesis in man and rat. Nature 1979, 278:182-183.
231. Botez M.I., Young S.N. Effects of anticonvulsant treatment and low levels of folate and thiamine on amine metabolites in cerebrospinal fluid. Brain 1991, 114(Pt 1A):333-348.
232. Bottiglieri T. Folate deficiency, biopterin and monoamine metabolism in depression. Psychol Med 1992, 22(4):871-876.
233. Hartvig P., Lindner K.J., Bjurling P., Langstrom B., Tedroff J. Pyridoxine effect on synthesis rate of serotonin in the monkey brain measured with positron emission tomography. J Neural Transm 1995, 102(2):91-97.
234. Bottiglieri T., Laundy M., Crellin R., Toone B.K., Carney M.W.P., Reynolds E.H. Homocysteine, folate, methylation, and monoamine metabolism in depression. J Neurol Neurosurg Psychiatry 2000, 69:228-232.
235. Kruman I., Culmsee C., Chan S.L., Kruman Y., Guo Z., Penix L., et al. Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity. J Neurosci 2000, 20(18):6920-6926.
236. Lipton S.A., Kim W.-K., Choi Y.-B., Kumar S., D'Emilia D.M., Rayudu P.V., et al. Neurotoxicity associated with dual actions of homocysteine at the N-methyl-d-aspartate receptor. Proc Natl Acad Sci 1997, 94(11):5923-5928.
237. Mattson M.P., Shea T.B. Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. Trends Neurosci 2003, 26(3):137-146.
238. Kruman I., Kumaravel T.S., Lohani A., Pedersen W.A., Cutler R.G., Kruman Y., et al. Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease. J Neurosci 2002, 22(5):1752-1762.
239. Bharath S., Hsu M., Kaur D., Rajagopalan S., Andersen J.K. Glutathione, iron and Parkinson's disease. Biochem Pharmacol 2002, 64(5-6):1037-1048.
240. Venkateshappa C., Harish G., Mahadevan A., Bharath M.M.S., Shankar S.K. Elevated oxidative stress and decreased antioxidant function in the human hippocampus and frontal cortex with increasing age: implications for neurodegeneration in Alzheimer's disease. Neurochem Res 2012, 37(8):1601-1614.
241. Gaete J.M., Bogousslavsky J. Post-stroke depression. Expert Rev Neurother 2008, 8(1):75-92.
242. Reeves R.R., Panguluri R.L. Neuropsychiatric complications of traumatic brain injury. J Psychosoc Nurs Ment Health Serv 2011, 49(3):42-50.
243. Tiemeier H. Biological risk factors for late life depression. Eur J Epidemiol 2003, 18(8):745-750.
244. Boldyrev A.A., Johnson P. Homocysteine and its derivatives as possible modulators of neuronal and non-neuronal cell glutamate receptors in Alzheimer's disease. J Alzheimers Dis 2007, 11(2):219-228.
245. Ho P.I., Ashline D., Dhitavat S., Ortiz D., Collins S.C., Shea T.B., et al. Folate deprivation induces neurodegeneration: roles of oxidative stress and increased homocysteine. Neurobiol Dis 2003, 14(1):32-42.
246. Matte C., Mackedanz V., Stefanello F.M., Scherer E.B.S., Andreazza A.C., Zanotto C., et al. Chronic hyperhomocysteinemia alters antioxidant defenses and increases DNA damage in brain and blood of rats: protective effect of folic acid. Neurochem Int 2009, 54(1):7-13.
247. Zhang F., Slungaard A., Vercellotti G.M., Iadecola C. Superoxide-dependent cerebrovascular effects of homocysteine. Am J Physiol Regul Integr Comp Physiol 1998, 274(6 Pt 2):R1704-R1711.
248. James S.J., Cutler P., Melnyk S., Jernigan S., Janak L., Gaylor D.W., et al. Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. Am J Clin Nutr 2004, 80(6):1611-1617.
249. Isobe C., Murata T., Sato C., Terayama Y. Increase of total homocysteine concentration in cerebrospinal fluid in patients with Alzheimer's disease and Parkinson's disease. Life Sci 2005, 77(15):1836-1843.
250. Vitvitsky V., Thomas M., Ghorpade A., Gendelman H.E., Banerjee R. A functional transsulfuration pathway in the brain links to glutathione homeostasis. J Biol Chem 2006, 281(47):35785-35793.
251. Oltean S., Banerjee R. Nutritional modulation of gene expression and homocysteine utilization by vitamin B12. J Biol Chem 2003, 278(23):20778-20784.
252. Kato T., Iwamoto K., Kakiuchi C., Kuratomi G., Okazaki Y. Genetic or epigenetic difference causing discordance between monozygotic twins as a clue to molecular basis of mental disorders. Mol Psychiatry 2005, 10:622-630.
253. Muskiet F.A., Kemperman R.F. Folate and long-chain polyunsaturated fatty acids in psychiatric disease. J Nutr Biochem 2006, 17(11):717-727.
254. Bohacek J., Gapp K., Saab B.J., Mansuy I.M. Transgenerational epigenetic effects on brain functions. Biol Psychiatry 2013, 73:313-320.
255. Susser E., Neugebauer R., Hoek H.W., Brown A.S., Lin S., Labovitz D., et al. Schizophrenia after prenatal famine. Further evidence [see comments]. Arch Gen Psychiatry 1996, 53(1):25-31.
256. Brown A.S., van Os J., Driessens C., Hoek H.W., Susser E. Further evidence of relation between prenatal famine and major affective disorder. Am J Psychiatry 2000, 157(2):190-195.
257. Franzek E.J., Sprangers N., Janssens A., Van Duijn C.M., Van De Wetering B.J.M. Prenatal exposure to the 1944-45 Dutch 'hunger winter' and addiction later in life. Addiction 2008, 103(3):433-438.
258. Rakic P. Defects of neuronal migration and the pathogenesis of cortical malformations. Prog Brain Res 1988, 73:15-37.
259. Akbarian S., Bunney W.E., Potkin S.G., Wigal S.B., Hagman J.O., Sandman C.A., et al. Altered distribution of nicotinamide-adenine dinucleotide phosphate-diaphorase cells in frontal lobe of schizophrenics implies disturbances of cortical development. Arch Gen Psychiatry 1993, 50(3):169-177.
260. Beckman H., Jakob H. Prenatal disturbances of nerve cell migration in the entorhinal region: a common vulnerability factor in functional psychoses?. J Neural Transm 1991, 84(1-2):155-164.
261. Jakob H., Beckman H. Prenatal developmental disturbances in the limbic allocortex in schizophrenics. J Neural Transm 1986, 65(3-4):303-326.
262. Dong E., Agis-Balboa R.C., Simonini M.V., Grayson D.R., Costa E., Guidotti A. Reelin and glutamic acid decarboxylase67 promoter remodeling in an epigenetic methionine-induced mouse model of schizophrenia. Proc Natl Acad Sci 2005, 102(35):12578-12583.
263. Tremolizzo L., Carboni G., Ruzicka W.B., Mitchell C.P., Sugaya I., Tueting P., et al. An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability. Proc Natl Acad Sci 2002, 99(26):17095-17100.
264. Abdolmaleky H.M., Cheng K., Russo A., Smith C.L., Faraone S.V., Wilcox M., et al. Hypermethylation of the reelin (RELN) promoter in the brain of schizophrenic patients: a preliminary report. Am J Med Genet B Neuropsychiatr Genet 2005, 134B(1):60-66.
265. Torrey E.F., Barci B.M., Webster M.J., Bartko J.J., Meador-Woodruff J.H., Knable M.B. Neurochemical markers for schizophrenia, bipolar disorder, and major depression in postmortem brains. Biol Psychiatry 2005, 57(3):252-260.
266. Fatemi S.H., Snow A.V., Stary J.M., Araghi-Niknam M., Reutiman T.J., Lee S., et al. Reelin signaling is impaired in autism. Biol Psychiatry 2005, 57(7):777-787.
267. Iwamoto K., Bundo M., Yamada K., Takao H., Iwayama-Shigeno Y., Yoshikawa T., et al. DNA methylation status of SOX10 correlates with its downregulation and oligodendrocyte dysfunction in schizophrenia. J Neurosci 2005, 25(22):5376-5381.
268. Smith A.D. The worldwide challenge of the dementias: a role for B vitamins and homocysteine?. Food Nutr Bull 2008, 29(2 Suppl):S143-S172.
269. Van de Rest O., Van Hooijdonk L.W.A., Doets E., Schiepers O.J.G., Eilander A., De Groot C.P. B vitamins and n-3 fatty acids for brain development and function: review of human studies. Ann Nutr Metab 2012, 60(4):272-292.
270. De Jager C.A., Oulhaj A., Jacoby R., Refsum H., Smith A.D. Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial. Int J Geriatr Psychiatry 2012, 27(6):592-600.
271. Smith A.D., Smith S.M., de Jager C.A., Whitbread P., Johnston C., Agacinski G., et al. Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial. PLoS ONE 2010, 5(9):e12244. 10.1371/journal.pone.0012244.
272. Gariballa S., Forster S. Effects of dietary supplements on depressive symptoms in older patients: a randomised double-blind placebo-controlled trial. Clin Nutr 2007, 26(5):545-551.
273. Gariballa S. Testing homocysteine-induced neurotransmitter deficiency, and depression of mood hypothesis in clinical practice. Age Ageing 2011, 40(6):702.
274. Gabryelewicz T., Styczynska M., Luczywek E., Barczak A., Pfeffer A., Androsiuk W., et al. The rate of conversion of mild cognitive impairment to dementia: predictive role of depression. Int J Geriatr Psychiatry 2007, 22(6):563-567.
275. Modrego P., Ferrández J. Depression in patients with mild cognitive impairment increases the risk of developing dementia of Alzheimer type. Arch Neurol 2004, 61:1290-1293.
276. Watanabe H., Ishida S., Konno Y., Matsumoto M., Nomachi S., Masaki K., et al. Impact of dietary folate intake on depressive symptoms in young women of reproductive age. J Midwifery Womens Health 2012, 57(1):43-48.
277. Beydoun M.A., Shroff M.R., Beydoun H.A., Zonderman A.B. Serum folate, vitamin B-12, and homocysteine and their association with depressive symptoms among U.S. adults. Psychosom Med 2010, 72(9):862-873.
278. Herbison C.E., Hickling S., Allen K.L., O'Sullivan T.A., Robinson M., Bremner A.P., et al. Low intake of B-vitamins is associated with poor adolescent mental health and behaviour. Prev Med 2012, 55:634-638.
279. Sandstead H.H., Penland J.G., Alcock N.W., Dayal H.H., Chen X.C., Li J.S., et al. Effects of repletion with zinc and other micronutrients on neuropsychologic performance and growth of Chinese children. Am J Clin Nutr 1998, 68(Suppl.):470S-475S.
280. Rucklidge J., Kaplan B.J. Broad spectrum micronutrients for the treatment of psychiatric symptoms: a systematic review. Expert Rev Neurother 2013, 13(1):49-63.
281. Jacques P.F., Tucker K.L. Are dietary patterns useful for understanding the role of diet in chronic disease?. Am J Clin Nutr 2001, 73(1):1-2.