Elevated S-adenosylhomocysteine in Alzheimer brain: Influence on methyltransferases and cognitive function

Journal of Neural Transmission

Volumn 111, Issue 4, 2004, Pages 547-567

  Kennedy, B P ^a   Bottiglieri, T ^b   Arning, E ^b   Ziegler, M G ^a   Hansen, L A ^c   Masliah, E ^c  

^a UCSD MEDICAL CENTER   (United States)

^b BAYLOR UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alzheimer; Catechol O methyltransferase; Homocysteine; Phenylethanolamine N methyltransferase; S adenosylhomocysteine

Indexed keywords

CATECHOL METHYLTRANSFERASE; CHOLINE ACETYLTRANSFERASE; METHYLTRANSFERASE; PHENYLETHANOLAMINE N METHYLTRANSFERASE; S ADENOSYLHOMOCYSTEINE; SYNAPTOPHYSIN;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN FUNCTION; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN TISSUE; HYPERHOMOCYSTEINEMIA; INHIBITION KINETICS; MAJOR CLINICAL STUDY; MALE; NEUROFIBRILLARY TANGLE; PREFRONTAL CORTEX; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE;

ADULT; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; BRAIN; COGNITION; FEMALE; HUMANS; HYPERHOMOCYSTEINEMIA; MALE; METHYLTRANSFERASES; MIDDLE AGED; NEUROFIBRILLARY TANGLES; PREFRONTAL CORTEX; S-ADENOSYLHOMOCYSTEINE; TIME FACTORS;

EID: 1842778936     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00702-003-0096-5     Document Type: Article

References (63)

1. Abalan F, Zittoun J, Boutami C, Dugrais G, Manciet G, Decamps A, Antoniol B (1996) Variations des folates plasmatiques, intraerythrocytaires et intrarachidiens, dans la demence senile de type Alzheimer. Encepahle 22: 430-434
2. Alford MF, Masliah E, Hansen L, Terry RD (1994) A simple dot-immunobinding assay for the quantification of activity in human brain. J Histochem Cytochem 42: 283-287
3. Ardawi MS, Rouzi AA, Qari MH, Dahlawi FM, Al-Raddadi RM (2002) Influence of age, sex, folate and vitamin B12 status on plasma homocysteine in Saudis. Saudi Med J 23: 959-968
4. Bailey LB, Duhaney RL, Maneval DR, Kauwell GP, Quinlivan EP, Davis SR, Caudras A, Hutson AD, Gregory JF III (2002) Vitamin B-12 status is inversely associated with plasma homocysteine in young women with C677T and/or A1298C methylenetetrahydorfolate reductase polymorphisms. J Nutr 132: 1872-1878
5. Borchardt RT, Wu YS (1975) Potential inhibitors of S-adenosymethionine- dependent methyltransferases. 3. Modifications of the sugar portion of S-adenosylhomocysteine. J Med Chem 18: 300-304
6. Bottiglieri T (1990) Isocratic HPLC analysis of S-adenosylmethionine and S-adenosylhomocysteine in animal tissues: the effect of exposure to nitrous oxide. Biomed Chromatogr 4: 239-241
7. Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82: 239-259
8. Burke WJ, Chung HD, Nakra BRS, Grossberg GT, Joh TH (1987) Phenylethanolamine N-methyltransferase is decreased in Alzheimer's disease brains. Ann Neurol 22: 278-280
9. Burke WJ, Chung HD, Marshall GL, Gillespie KN, Joh TH (1990) Evidence for decreased transport of PNMT protein in advanced Alzheimer's disease. J Am Geriatr Soc 38: 1275-1282
10. Caudill MA, Wang JC, Melnyk S, Pogribny IP, Jernigan S, Collins MD, Swendseid ME, Cogger EA, James SJ (2001) Intracellular S-adenosylhomocysteine concentrations predict global DNA hypomethylation in tissues of methyl-deficient cystathione beta-synthase heterozygous mice. J Nutr 131: 2811-2818
11. Clarke R, Smith D, Jobst KA, Fefsum H, Sutton L, Ueland PM (1998) Folate, vitamin B12 and serum homocysteine levels in confirmed Alzheimer disease. Arch Neurol 55: 1449-1455
12. Crelin R, Bottiglieri T, Reynolds EH (1993) Folates and psychiatric disorders. Drugs 45: 623-626
13. Deguchi T, Barchas J (1971) Inhibition of transmethylations of biogenic amines by S-adeno-sylmethione: enhancement of transmethylation by adenosylhomocysteinase. J Biol Chem 246: 3175-3181
14. Eloranta TO (1977) Tissue distribution of S-adenosylmethionine and S-adenosylhomocysteine in the rat. Biochem J 166: 521-529
15. Eto K, Asada T, Arima K, Makifuchi T, Kimura H (2002) Brain hydrogen sulfide is severely decreased in Alzheimer's disease. Biochem Biophys Res Commun 293(5): 1485-1488
16. Fernandes MAS, Proenca MT, Nogueira AJA, Grazina MMM, Oliveira LMV, Fernandes AIP, Santiago B, Santana I, Oliveira CR (1999) Influence of apolipoprotein E genotype on blood redox status of Alzheimer's disease patients. Int J Mol Med 4: 179-186
17. Finkelstein JD (1967) Methionine metabolism in mammals: effects of age, diet, and hormones on three enzymes of the pathway in rat tissues. Arch Biochem Biophys 122: 583-590
18. Fonnum F (1969) Radiochemical microassays for the determination of choline acetyl transferase and acetyl cholinesterase activities. J Biochem 115: 465-472
19. Fuller RW, Perry KW, Hemrick-Leucke SK (1984) Tropolone antagonism of the L-dopa-induced elevation of S-adenosylhomocysteine: S-adenosylmethionine ratio but not depletion of adrenaline in the rat hypothalamus. J Pharm Pharmacol 36: 419-420
20. Fykse EM, Takei K, Walch-Solimena C, Geppert M, Jahn R, De Camilli P, Sudhof TC (1993) Relative properties and localizations of synaptic vesicle protein isoforms: the case of the synaptophysins. J Neurosci 13: 4997-5007
21. Goggins M, Scott JM, Weir DG (1999) Methylation of cortical brain proteins from patients with HIV infection. Acta Neurol Scand 100: 326-331
22. Gogos JA, Morgan M, Luine V, Santha M, Ogawa S, Pfaff D, Karayiorgou M (1998) Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior. Proc Natl Acad Sci USA 95(17): 9991-9996
23. Grieve A, Butcher SP, Griffiths R (1992) Synaptosomal plasma membrane transport of excitatory sulphur amino acid transmitter candidates: kinetic characterization and analysis of carrier specificity. J Neurosci Res 32: 60-68
24. Guan ZZ, Wang YN, Hu PS, Liu JL (1999) Activity of phosphatidylethanolamine-N-methyl-transferase in brain affected by Alzheimer's disease. Neurochem Int 34: 41-47
25. Hansen L, Masliah E, Quijada-Fawcett S, Rexin D (1991) Entorhinal neurofibrillary tangles in Alzheimer disease with Lewy bodies. Neurosci Lett 129: 269-272
26. Hansen L, De Teresa R, Davies P, Terry R (1998) Neocortical morphometry, lesion counts, and choline acetyltransferase levels in the age spectrum of Alzheimer's disease. Neurology 38: 48-54
27. Hensley K, Carney JM, Mattson MP, Aksenova M, Harris M, Wu JF, Floyd RA, Butterfield DA (1994) A model for β-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease. Proc Natl Acad Sci USA 91: 3270-3274
28. Hoffman DR, Cornatzer WE, Duerre JA (1979) Relationship between tissue levels of S-adenosylmethionine, S-adenosylhomocysteine, and transmethylation reactions. Can J Biochem 57: 56-65
29. Hong J, Shu-Leong H, Tao X, Lap-Ping Y (1998) Distribution of catechol O-methyltransferase in human central nervous system. Neuroreport 9(12): 2861-2864
30. James SJ, Melnyk S, Pogribna M, Pogribny JP, Caudill MA (2002) Elevation in S-adenosylhomocysteine and DNA hypomethylation: potential epigenetic mechanism for homocysteine-related pathology. J Nutr 132: 2361S-2366S
31. Joosten E, Lesaffre E, Riezler R, Ghekiere V, Dereymaeker L, Pelemans W, Dejaeger E (1997) Is metabolic evidence for vitamin B-12 and folate deficiency more frequent in elderly patients with Alzheimer's disease? J Gerontol A Biol Sci Med Sci 52: M76-M79
32. Karhunen T, Tilgmann C, Ulmanen I, Panula P (1995) Catechol-O- methyltransferase (COMT) in rat brain: immunoelectron microscopic study with an antiserum against rat recombinant COMT protein. Neurosci Lett 187: 57-60
33. Kerins DM, Koury MJ, Capdevila A, Sarvadaman R, Wagner C (2001) Plasma S-adenosylhomocysteine is a more sensitive indicator of cardiovascular disease than plasma homocysteine. Am J Clin Nutr 74: 723-729
34. Lee H-S, Schulz AR, Fuller RW (1978) Product inhibition studies and the reactions sequence of rabbit adrenal norepinephrine N-methyltransferase isozymes. Arch Biochem Biophys 185: 239-250
35. Lewis DA, Melchitzky DS, Sesack SR, Whitehead RE, Sungyoung AUH, Sampson A (2001) Dopamine transporter immunoreactivity in monkey cerebral cortex. J Comp Neurol 432: 119-136
36. Lussier-Cacan S, Xhignesse M, Piolot A, Selhub J, Davignin J, Genest J Jr (1996) Plasma total homocysteine in healthy subjects: sex-specific relation with biological traits. Am J Clin Nutr 64: 587-593
37. Mann MB, Wu S, Rostamkhani M, Tourtellotte W, MacMurray J, Comings DE (2001) Phenylethanolamine N-methyltransferase (PNMT) gene and early-onset Alzheimer disease. Am J Med Genet (Neuropsychiat Genet) 105: 312-316
38. McCaddon A, Davies G, Hudason P, Tandy S, Cattell H (1998) Total serum homocysteine in senile dementia of Alzheimer type. Int J Geriatr Psychol 13: 235-239
39. Miller JW, Shukitt-Hale B, Villalobos-Molina R, Nadeau MR, Selhub J, Joseph JA (1997) Effect of L-Dopa and the catechol-O-methyltransferase inhibitor Ro 41-0960 on sulfur amino acid metabolites in rats. Clin Neuropharmacol 20: 55-66
40. Mirra S, Gearing M, McKeel DJ, Crain B, Hughes J, Van Belle G, Heyman A (1994) Interlaboratory comparison of neuropathology assessments in Alzheimer's disease: a study of the consortium to establish a registry for Alzheimer's disease (CERAD). J Neuropathol Exp Neurol 53: 303-315
41. Morrison LD, Smith DD, Kish SJ (1996) Brain S-adenosylmethionine levels are severely depressed in Alzheimer's disease. J Neurochem 67: 1328-1331
42. Natori Y (1963) Studies on ethionine. VI. Sex-dependent behavior of methionine and ethionine in rats. J Biol Chem 238: 2075-2080
43. Oscarsson J, Gardmo C, Eden S, Mode A (2001) Pulsatile growth hormone secretion decreases S-adenosylmethionine synthetase in rat liver. Am J Physiol 280: E280-E286
44. Pan F, Lee SC, Chang GG, Chin SF (1968) Gonadal hormones in the regulation of methionine adenosyltransferase levels in rat liver. Proc Soc Exp Biol Med 129: 161-165
45. Postiglione A, Milan G, Ruocco A, Gallotta G, Guiotto G, Di Minno G (2001) Plasma folate, vitamin B(12), and total homocysteine and homozygosity for the C677T mutation of the 5,10-methylene tetrahydrofolate reductase gene in patients with Alzheimer's dementia. A case control study. Gerontology 47: 324-329
46. Rivett AJ, Roth JA (1982) Kinetic studies on the O-methylation of dopamine by human brain membrane-bound catechol O-methyltransferase. Biochemistry 21: 1740-1742
47. Rivett AJ, Francis A, Roth JA (1983) Distinct cellular localization of membrane-bound and soluble forms of catechol-O-methyltransferase in brain. J Neurochem 40: 215-219
48. Sassi S, Cosmi B, Palareti G, Legnani C, Grossi G, Musolesi S, Coccheri S (2002) Influence of age, sex, and vitamin status on fasting and post-methionine load plasma homocysteine levels. Haematologica 87: 957-964
49. Scott JM (1992) Folate-vitamin interrelationships in the central nervous system. Proc Nutr Soc 51: 219-224
50. Selley ML, Close DR, Stern SE (2002) The effect of increased concentrations of homocysteine on the concentration of (E)-4-hydroxy-2-nonenal in the plasma and cerebrospinal fluid of patients with Alzheimer's disease. Neurobiol Aging 23: 383-388
51. Sesack SR, Hawrylak VA, Matus C, Guido MA, Levey AI (1998) Dopamine axon varicosities in the prelimbic division of the rat prefrontal cortex exhibit sparse immunoreactivity for the dopamine transporter. J Neurosci 18: 2697-2708
52. Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, D'Agostino RB, Wilson PW, Wolf PA (2002) Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med 346(7): 476-483
53. Shea TB, Lyons-Weiler J, Rogers E (2002) Homocysteine, folate deprivation and Alzheimer neuropathology. J Alzheimer Dis 4(4): 261-267
54. Vafai SB, Stock JB (2002) Protein phosphatase 2A methyation: a link between elevated plasma homocysteine and Alzheimers disease. FEBS Lett 518: 1-4
55. Venn BJ, Mann JI, Williams SM, Riddell LJ, Chisholm A, Harper MJ, Aitken W (2002) Dietary counseling to increase natural folate intake: a randomized, placebo-controlled trial in free-living subjects to assess effects on serum folate and plasma total homocysteine. Am J Clin Nutr 76: 758-765
56. ras methylation in vascular endothelial cells be homocysteine but not cysteine. J Biol Chem 272: 25380-25385
57. Wong DL, Yamasaki L, Ciaranello RD (1987) Characterization of the isozymes of bovine adrenal medullary phenylethanolamine N-methyltransferase. Brain Res 410: 32-44
58. Yassin MS, Cheng H, Ekblom J, Oreland L (1998) Inhibitors of catecholamine metabolizing enzymes cause changes in S-adenosylmethionine and S-adenosylhomocysteine in the rat brain. Neurochem Int 32: 53-59
59. Yi P, Melnyk S, Pogribna M, Pogribny IP, Hine RJ, James SJ (2000) Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation. J Biol Chem 275: 29318-29323
60. Zhu BT (2002) On the mechanism of homocysteine pathophysiology and pathogenesis: a unifying hypothesis. Histol Histopatol 17: 1283-1291
61. Zhu BT, Patel UK, Cai MX, Conney AH (2000) O-methylation of tea polyphenols catalyzed by human placental cytosolic catechol-O-methyltransferase. Drug Metab Disp 28: 1024-1030
62. Ziegler MG, Kennedy B, Elayan HE (1982) A sensitive radioenzymatic assay for epinephrine forming enzymes. Life Sci 43: 2117-2122
63. Zurcher G, Da Prada M (1982) Rapid and sensitive single-step radiochemical assay for catechol-O-methyltransferase. J Neurochem 38: 191-195