Allo-network drugs: Extension of the allosteric drug concept to protein- protein interaction and signaling networks

Current Topics in Medicinal Chemistry

Volumn 13, Issue 1, 2013, Pages 64-77

  Szilágyi, András ^a,b   Nussinov, Ruth ^c,d   Csermely, Péter ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b INSTITUTE OF ENZYMOLOGY   (Hungary)

^c SAIC FREDERICK INC   (United States)

^d TEL AVIV UNIVERSITY   (Israel)

Author keywords

Allo network drugs; Allosteric drugs; Interactome; Protein structure networks; Protein protein interaction networks; Signaling networks

Indexed keywords

B RAF KINASE; EGLIN C; MICRORNA; MITOGEN ACTIVATED PROTEIN KINASE KINASE; RAPAMYCIN;

ALLOSTERISM; ARTICLE; CELL COMMUNICATION; DEGENERATIVE DISEASE; DIABETES MELLITUS; DRUG DESIGN; HUMAN; INTRACELLULAR SIGNALING; MOLECULAR DYNAMICS; NEOPLASM; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM;

ALLOSTERIC REGULATION; ALLOSTERIC SITE; DRUG DISCOVERY; DRUGS, INVESTIGATIONAL; EUKARYOTIC CELLS; HUMANS; LIGANDS; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN INTERACTION MAPPING; PROTEINS; SIGNAL TRANSDUCTION; THERMODYNAMICS;

EID: 84876709135     PISSN: 15680266     EISSN: 18734294     Source Type: Journal    
DOI: 10.2174/1568026611313010007     Document Type: Article

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