Enzyme inhibition by allosteric capture of an inactive conformation

Journal of Molecular Biology

Volumn 411, Issue 5, 2011, Pages 999-1016

  Lee, Gregory M ^a   Shahian, Tina ^a   Baharuddin, Aida ^a   Gable, Jonathan E ^a   Craik, Charles S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

monomer trap; NMR spectroscopy; protein protein interactions; small molecule inhibitor; X ray crystallography

Indexed keywords

ENZYME; KAPOSI SARCOMA ASSOCIATED HERPESVIRUS PROTEASE; KAPOSI SARCOMA ASSOCIATED HERPESVIRUS PROTEASE INHIBITOR; MONOMER; PROTEINASE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CIRCULAR DICHROISM; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG INHIBITION; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME INHIBITION; HERPES SIMPLEX VIRUS; HUMAN CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 8; HYDROPHOBICITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; X RAY CRYSTALLOGRAPHY;

HERPESVIRIDAE; HUMAN HERPESVIRUS 5; HUMAN HERPESVIRUS 8;

EID: 80051666040     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2011.06.032     Document Type: Article

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