-
1
-
-
20844432908
-
Can cell systems biology rescue drug discovery?
-
Butcher E.C. Can cell systems biology rescue drug discovery?. Nat. Rev. Drug Discov. 4 (2005) 461-467
-
(2005)
Nat. Rev. Drug Discov.
, vol.4
, pp. 461-467
-
-
Butcher, E.C.1
-
2
-
-
2042437650
-
Initial sequencing and analysis of the human genome
-
Lander E.S., et al. Initial sequencing and analysis of the human genome. Nature 409 (2001) 860-921
-
(2001)
Nature
, vol.409
, pp. 860-921
-
-
Lander, E.S.1
-
3
-
-
27144530248
-
Towards a proteome-scale map of the human protein-protein interaction network
-
Rual J.F., et al. Towards a proteome-scale map of the human protein-protein interaction network. Nature 437 (2005) 1173-1178
-
(2005)
Nature
, vol.437
, pp. 1173-1178
-
-
Rual, J.F.1
-
4
-
-
25144498379
-
A human protein-protein interaction network: a resource for annotating the proteome
-
Stelzl U., et al. A human protein-protein interaction network: a resource for annotating the proteome. Cell 122 (2005) 957-968
-
(2005)
Cell
, vol.122
, pp. 957-968
-
-
Stelzl, U.1
-
5
-
-
33947219266
-
Large-scale mapping of human protein-protein interactions by mass spectrometry
-
Ewing R.M., et al. Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol. Syst. Biol. 3 (2007) 89
-
(2007)
Mol. Syst. Biol.
, vol.3
, pp. 89
-
-
Ewing, R.M.1
-
6
-
-
33846064113
-
NCBI GEO: mining tens of millions of expression profiles-database and tools update
-
Barrett T., et al. NCBI GEO: mining tens of millions of expression profiles-database and tools update. Nucleic Acids Res. 35 (2007) D760-765
-
(2007)
Nucleic Acids Res.
, vol.35
-
-
Barrett, T.1
-
7
-
-
33846039701
-
ArrayExpress-a public database of microarray experiments and gene expression profiles
-
Parkinson H., et al. ArrayExpress-a public database of microarray experiments and gene expression profiles. Nucleic Acids Res 35 (2007) D747-750
-
(2007)
Nucleic Acids Res
, vol.35
-
-
Parkinson, H.1
-
8
-
-
33847421719
-
Meet the human metabolome
-
Pearson H. Meet the human metabolome. Nature 446 (2007) 8
-
(2007)
Nature
, vol.446
, pp. 8
-
-
Pearson, H.1
-
9
-
-
33846088138
-
HMDB: the Human Metabolome Database
-
Wishart D.S., et al. HMDB: the Human Metabolome Database. Nucleic Acids Res. 35 (2007) D521-526
-
(2007)
Nucleic Acids Res.
, vol.35
-
-
Wishart, D.S.1
-
10
-
-
33746628593
-
Case histories, magic bullets and the state of drug discovery
-
Drews J. Case histories, magic bullets and the state of drug discovery. Nat. Rev. Drug Discov. 5 (2006) 635-640
-
(2006)
Nat. Rev. Drug Discov.
, vol.5
, pp. 635-640
-
-
Drews, J.1
-
11
-
-
29144508395
-
Finding new drug targets in the 21st century
-
Lindsay M.A. Finding new drug targets in the 21st century. Drug Discov. Today 10 (2005) 1683-1687
-
(2005)
Drug Discov. Today
, vol.10
, pp. 1683-1687
-
-
Lindsay, M.A.1
-
12
-
-
31144438390
-
Innovation: Rescuing drug discovery: in vivo systems pathology and systems pharmacology
-
van der Greef J., and McBurney R.N. Innovation: Rescuing drug discovery: in vivo systems pathology and systems pharmacology. Nat. Rev. Drug Discov. 4 (2005) 961-967
-
(2005)
Nat. Rev. Drug Discov.
, vol.4
, pp. 961-967
-
-
van der Greef, J.1
McBurney, R.N.2
-
13
-
-
54249117223
-
Targeting and tinkering with interaction networks
-
Russell R.B., and Aloy P. Targeting and tinkering with interaction networks. Nat. Chem. Biol. 4 (2008) 666-673
-
(2008)
Nat. Chem. Biol.
, vol.4
, pp. 666-673
-
-
Russell, R.B.1
Aloy, P.2
-
14
-
-
58149305794
-
An empirical framework for binary interactome mapping
-
Venkatesan K., et al. An empirical framework for binary interactome mapping. Nat. Methods 6 (2009) 83-90
-
(2009)
Nat. Methods
, vol.6
, pp. 83-90
-
-
Venkatesan, K.1
-
15
-
-
39149143293
-
A systems biology approach to prediction of oncogenes and molecular perturbation targets in B-cell lymphomas
-
Mani K.M., et al. A systems biology approach to prediction of oncogenes and molecular perturbation targets in B-cell lymphomas. Mol. Syst. Biol. 4 (2008) 169
-
(2008)
Mol. Syst. Biol.
, vol.4
, pp. 169
-
-
Mani, K.M.1
-
16
-
-
35349024501
-
Network modeling links breast cancer susceptibility and centrosome dysfunction
-
Pujana M.A., et al. Network modeling links breast cancer susceptibility and centrosome dysfunction. Nat. Genet. 39 (2007) 1338-1349
-
(2007)
Nat. Genet.
, vol.39
, pp. 1338-1349
-
-
Pujana, M.A.1
-
17
-
-
70349882120
-
Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses
-
Amit I., et al. Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses. Science 326 (2009) 257-263
-
(2009)
Science
, vol.326
, pp. 257-263
-
-
Amit, I.1
-
18
-
-
35348891430
-
Network-based classification of breast cancer metastasis
-
Chuang H.Y., et al. Network-based classification of breast cancer metastasis. Mol. Syst. Biol. 3 (2007) 140
-
(2007)
Mol. Syst. Biol.
, vol.3
, pp. 140
-
-
Chuang, H.Y.1
-
19
-
-
40749105508
-
Variations in DNA elucidate molecular networks that cause disease
-
Chen Y., et al. Variations in DNA elucidate molecular networks that cause disease. Nature 452 (2008) 429-435
-
(2008)
Nature
, vol.452
, pp. 429-435
-
-
Chen, Y.1
-
20
-
-
33746927955
-
International alliances for quantitative modeling in systems biology
-
Kitano H. International alliances for quantitative modeling in systems biology. Mol. Syst. Biol. 1 (2005) 0007
-
(2005)
Mol. Syst. Biol.
, vol.1
, pp. 0007
-
-
Kitano, H.1
-
21
-
-
33645870422
-
Production of the antimalarial drug precursor artemisinic acid in engineered yeast
-
Ro D.K., et al. Production of the antimalarial drug precursor artemisinic acid in engineered yeast. Nature 440 (2006) 940-943
-
(2006)
Nature
, vol.440
, pp. 940-943
-
-
Ro, D.K.1
-
22
-
-
37349099750
-
A predictive model for transcriptional control of physiology in a free living cell
-
Bonneau R., et al. A predictive model for transcriptional control of physiology in a free living cell. Cell 131 (2007) 1354-1365
-
(2007)
Cell
, vol.131
, pp. 1354-1365
-
-
Bonneau, R.1
-
23
-
-
33846080260
-
A systems biology analysis of the Drosophila phagosome
-
Stuart L.M., et al. A systems biology analysis of the Drosophila phagosome. Nature 445 (2007) 95-101
-
(2007)
Nature
, vol.445
, pp. 95-101
-
-
Stuart, L.M.1
-
24
-
-
55249125245
-
Pharmaceutical futures: a fiendish puzzle
-
Abbott A. Pharmaceutical futures: a fiendish puzzle. Nature 455 (2008) 1164-1167
-
(2008)
Nature
, vol.455
, pp. 1164-1167
-
-
Abbott, A.1
-
26
-
-
0033168957
-
Monogenic traits are not simple: lessons from phenylketonuria
-
Scriver C.R., and Waters P.J. Monogenic traits are not simple: lessons from phenylketonuria. Trends Genet. 15 (1999) 267-272
-
(1999)
Trends Genet.
, vol.15
, pp. 267-272
-
-
Scriver, C.R.1
Waters, P.J.2
-
27
-
-
0033799531
-
Modifier genes convert "simple" Mendelian disorders to complex traits
-
Dipple K.M., and McCabe E.R. Modifier genes convert "simple" Mendelian disorders to complex traits. Mol. Genet. Metab. 71 (2000) 43-50
-
(2000)
Mol. Genet. Metab.
, vol.71
, pp. 43-50
-
-
Dipple, K.M.1
McCabe, E.R.2
-
28
-
-
52149123619
-
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
-
Jones S., et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 321 (2008) 1801-1806
-
(2008)
Science
, vol.321
, pp. 1801-1806
-
-
Jones, S.1
-
29
-
-
52949127312
-
An integrated genomic analysis of human glioblastoma multiforme
-
Parsons D.W., et al. An integrated genomic analysis of human glioblastoma multiforme. Science 321 (2008) 1807-1812
-
(2008)
Science
, vol.321
, pp. 1807-1812
-
-
Parsons, D.W.1
-
30
-
-
54549108740
-
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
-
Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455 (2008) 1061-1068
-
(2008)
Nature
, vol.455
, pp. 1061-1068
-
-
Cancer Genome Atlas Research Network1
-
31
-
-
55349109688
-
Pathways to cancer therapy
-
Jones D. Pathways to cancer therapy. Nat. Rev. Drug Discov. 7 (2008) 875-876
-
(2008)
Nat. Rev. Drug Discov.
, vol.7
, pp. 875-876
-
-
Jones, D.1
-
32
-
-
41149137043
-
Towards a molecular characterisation of pathological pathways
-
Pache R.A., et al. Towards a molecular characterisation of pathological pathways. FEBS Lett. 582 (2008) 1259-1265
-
(2008)
FEBS Lett.
, vol.582
, pp. 1259-1265
-
-
Pache, R.A.1
-
33
-
-
7644238181
-
Biological robustness
-
Kitano H. Biological robustness. Nat. Rev. Genet 5 (2004) 826-837
-
(2004)
Nat. Rev. Genet
, vol.5
, pp. 826-837
-
-
Kitano, H.1
-
34
-
-
67349276056
-
A network medicine approach to human disease
-
Zanzoni A., et al. A network medicine approach to human disease. FEBS Lett. 583 (2009) 1759-1765
-
(2009)
FEBS Lett.
, vol.583
, pp. 1759-1765
-
-
Zanzoni, A.1
-
35
-
-
49249103327
-
Cellular imaging predictions of clinical drug-induced liver injury
-
Xu J.J., et al. Cellular imaging predictions of clinical drug-induced liver injury. Toxicol. Sci. 105 (2008) 97-105
-
(2008)
Toxicol. Sci.
, vol.105
, pp. 97-105
-
-
Xu, J.J.1
-
36
-
-
59349083179
-
Mechanisms of drug combinations: interaction and network perspectives
-
Jia J., et al. Mechanisms of drug combinations: interaction and network perspectives. Nat. Rev. Drug Discov. 8 (2009) 111-128
-
(2009)
Nat. Rev. Drug Discov.
, vol.8
, pp. 111-128
-
-
Jia, J.1
-
37
-
-
34147220392
-
Mediators of vascular remodelling co-opted for sequential steps in lung metastasis
-
Gupta G.P., et al. Mediators of vascular remodelling co-opted for sequential steps in lung metastasis. Nature 446 (2007) 765-770
-
(2007)
Nature
, vol.446
, pp. 765-770
-
-
Gupta, G.P.1
-
38
-
-
33845381862
-
Tumor inhibitory effect of gefitinib (ZD1839, Iressa) and taxane combination therapy in EGFR-overexpressing breast cancer cell lines (MCF7/ADR, MDA-MB-231)
-
Takabatake D., et al. Tumor inhibitory effect of gefitinib (ZD1839, Iressa) and taxane combination therapy in EGFR-overexpressing breast cancer cell lines (MCF7/ADR, MDA-MB-231). Int. J. Cancer 120 (2007) 181-188
-
(2007)
Int. J. Cancer
, vol.120
, pp. 181-188
-
-
Takabatake, D.1
-
39
-
-
0018828666
-
Combined antibacterial activity of amoxicillin with clavulanic acid against ampicillin-resistant strains
-
Matsuura M., et al. Combined antibacterial activity of amoxicillin with clavulanic acid against ampicillin-resistant strains. Antimicrob. Agents Chemother. 17 (1980) 908-911
-
(1980)
Antimicrob. Agents Chemother.
, vol.17
, pp. 908-911
-
-
Matsuura, M.1
-
40
-
-
1442275740
-
Combination antifungal therapy
-
Johnson M.D., et al. Combination antifungal therapy. Antimicrob. Agents Chemother. 48 (2004) 693-715
-
(2004)
Antimicrob. Agents Chemother.
, vol.48
, pp. 693-715
-
-
Johnson, M.D.1
-
41
-
-
33845762340
-
Multi-target therapeutics: when the whole is greater than the sum of the parts
-
Zimmermann G.R., et al. Multi-target therapeutics: when the whole is greater than the sum of the parts. Drug Discov. Today 12 (2007) 34-42
-
(2007)
Drug Discov. Today
, vol.12
, pp. 34-42
-
-
Zimmermann, G.R.1
-
42
-
-
67650488269
-
Synergistic drug combinations tend to improve therapeutically relevant selectivity
-
Lehar J., et al. Synergistic drug combinations tend to improve therapeutically relevant selectivity. Nat. Biotechnol. 27 (2009) 659-666
-
(2009)
Nat. Biotechnol.
, vol.27
, pp. 659-666
-
-
Lehar, J.1
-
43
-
-
54249155522
-
Network pharmacology: the next paradigm in drug discovery
-
Hopkins A.L. Network pharmacology: the next paradigm in drug discovery. Nat. Chem. Biol. 4 (2008) 682-690
-
(2008)
Nat. Chem. Biol.
, vol.4
, pp. 682-690
-
-
Hopkins, A.L.1
-
44
-
-
47349124275
-
What does systems biology mean for drug development?
-
Schrattenholz A., and Soskić V. What does systems biology mean for drug development?. Curr. Med. Chem. 15 (2008) 1520-1528
-
(2008)
Curr. Med. Chem.
, vol.15
, pp. 1520-1528
-
-
Schrattenholz, A.1
Soskić, V.2
-
45
-
-
70350103708
-
Class effects of tyrosine kinase inhibitors in the treatment of chronic myeloid leukemia
-
Giles F.J., et al. Class effects of tyrosine kinase inhibitors in the treatment of chronic myeloid leukemia. Leukemia (2009)
-
(2009)
Leukemia
-
-
Giles, F.J.1
-
46
-
-
35148838537
-
Drug-target network
-
Yildirim M.A., et al. Drug-target network. Nat. Biotechnol. 25 (2007) 1119-1126
-
(2007)
Nat. Biotechnol.
, vol.25
, pp. 1119-1126
-
-
Yildirim, M.A.1
-
47
-
-
33746156959
-
Global mapping of pharmacological space
-
Paolini G.V., et al. Global mapping of pharmacological space. Nat. Biotechnol. 24 (2006) 805-815
-
(2006)
Nat. Biotechnol.
, vol.24
, pp. 805-815
-
-
Paolini, G.V.1
-
49
-
-
42349096647
-
A global view of drug-therapy interactions
-
Nacher J.C., and Schwartz J.-M. A global view of drug-therapy interactions. BMC Pharmacol. 8 (2008) 5
-
(2008)
BMC Pharmacol.
, vol.8
, pp. 5
-
-
Nacher, J.C.1
Schwartz, J.-M.2
-
50
-
-
4644271084
-
Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia
-
Roth B.L., et al. Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia. Nat. Rev. Drug Discov. 3 (2004) 353-359
-
(2004)
Nat. Rev. Drug Discov.
, vol.3
, pp. 353-359
-
-
Roth, B.L.1
-
51
-
-
57749099247
-
Memoquin: a multi-target-directed ligand as an innovative therapeutic opportunity for Alzheimer's disease
-
Bolognesi M.L., et al. Memoquin: a multi-target-directed ligand as an innovative therapeutic opportunity for Alzheimer's disease. Neurotherapeutics 6 (2009) 152-162
-
(2009)
Neurotherapeutics
, vol.6
, pp. 152-162
-
-
Bolognesi, M.L.1
-
52
-
-
54249162351
-
Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases
-
Apsel B., et al. Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat. Chem. Biol. 4 (2008) 691-699
-
(2008)
Nat. Chem. Biol.
, vol.4
, pp. 691-699
-
-
Apsel, B.1
-
53
-
-
50149111428
-
Targeting QseC signaling and virulence for antibiotic development
-
Rasko D.A., et al. Targeting QseC signaling and virulence for antibiotic development. Science 321 (2008) 1078-1080
-
(2008)
Science
, vol.321
, pp. 1078-1080
-
-
Rasko, D.A.1
-
54
-
-
0035251638
-
Design and application of diabodies, triabodies and tetrabodies for cancer targeting
-
Todorovska A., et al. Design and application of diabodies, triabodies and tetrabodies for cancer targeting. J. Immunol. Methods 248 (2001) 47-66
-
(2001)
J. Immunol. Methods
, vol.248
, pp. 47-66
-
-
Todorovska, A.1
-
55
-
-
33847377573
-
A robustness-based approach to systems-oriented drug design
-
Kitano H. A robustness-based approach to systems-oriented drug design. Nat. Rev. Drug Discov. 6 (2007) 202-210
-
(2007)
Nat. Rev. Drug Discov.
, vol.6
, pp. 202-210
-
-
Kitano, H.1
-
56
-
-
77956061007
-
Phase II study of sunitinib malate in head and neck squamous cell carcinoma
-
Aug, 4. Ahead of print
-
Choong N.W., et al. Phase II study of sunitinib malate in head and neck squamous cell carcinoma. Invest. New Drugs (2009) Aug, 4. Ahead of print
-
(2009)
Invest. New Drugs
-
-
Choong, N.W.1
-
57
-
-
34347388459
-
Nonlinear blending: a useful general concept for the assessment of combination drug synergy
-
Peterson J.J., and Novick S.J. Nonlinear blending: a useful general concept for the assessment of combination drug synergy. J. Recept. Signal Transduct. Res. 27 (2007) 125-146
-
(2007)
J. Recept. Signal Transduct. Res.
, vol.27
, pp. 125-146
-
-
Peterson, J.J.1
Novick, S.J.2
-
58
-
-
53649095010
-
A network solution
-
Henney A., and Superti-Furga G. A network solution. Nature 455 (2008) 730-731
-
(2008)
Nature
, vol.455
, pp. 730-731
-
-
Henney, A.1
Superti-Furga, G.2
-
59
-
-
40749128970
-
Flexible informatics for linking experimental data to mathematical models via DataRail
-
Saez-Rodriguez J., et al. Flexible informatics for linking experimental data to mathematical models via DataRail. Bioinformatics 24 (2008) 840-847
-
(2008)
Bioinformatics
, vol.24
, pp. 840-847
-
-
Saez-Rodriguez, J.1
-
60
-
-
14844289540
-
Illuminating drug discovery with biological pathways
-
Apic G., et al. Illuminating drug discovery with biological pathways. FEBS Lett. 579 (2005) 1872-1877
-
(2005)
FEBS Lett.
, vol.579
, pp. 1872-1877
-
-
Apic, G.1
-
61
-
-
67149130229
-
Drug discovery. Repurposing with a difference
-
Boguski M.S., et al. Drug discovery. Repurposing with a difference. Science 324 (2009) 1394-1395
-
(2009)
Science
, vol.324
, pp. 1394-1395
-
-
Boguski, M.S.1
-
62
-
-
0031925579
-
Reactions and interactions of some commonly used systemic drugs in dermatology
-
Cleach L.L., et al. Reactions and interactions of some commonly used systemic drugs in dermatology. Dermatol. Clin. 16 (1998) 421-429
-
(1998)
Dermatol. Clin.
, vol.16
, pp. 421-429
-
-
Cleach, L.L.1
-
63
-
-
0033253519
-
Finasteride in the treatment of benign prostatic hypertrophy: an update. New indications for finasteride therapy
-
Ekman P. Finasteride in the treatment of benign prostatic hypertrophy: an update. New indications for finasteride therapy. Scand. J. Urol. Nephrol. Suppl. 203 (1999) 15-20
-
(1999)
Scand. J. Urol. Nephrol. Suppl.
, vol.203
, pp. 15-20
-
-
Ekman, P.1
-
64
-
-
33644668387
-
Finding new tricks for old drugs: an efficient route for public-sector drug discovery
-
O'Connor K.A., and Roth B.L. Finding new tricks for old drugs: an efficient route for public-sector drug discovery. Nat. Rev. Drug Discov. 4 (2005) 1005-1014
-
(2005)
Nat. Rev. Drug Discov.
, vol.4
, pp. 1005-1014
-
-
O'Connor, K.A.1
Roth, B.L.2
-
65
-
-
37049002657
-
The novel combination of chlorpromazine and pentamidine exerts synergistic antiproliferative effects through dual mitotic action
-
Lee M.S., et al. The novel combination of chlorpromazine and pentamidine exerts synergistic antiproliferative effects through dual mitotic action. Cancer Res. 67 (2007) 11359-11367
-
(2007)
Cancer Res.
, vol.67
, pp. 11359-11367
-
-
Lee, M.S.1
-
66
-
-
46349091971
-
The social network of a cell: recent advances in interactome mapping
-
Charbonnier S., et al. The social network of a cell: recent advances in interactome mapping. Biotechnol. Annu. Rev. 14 (2008) 1-28
-
(2008)
Biotechnol. Annu. Rev.
, vol.14
, pp. 1-28
-
-
Charbonnier, S.1
-
67
-
-
54249089813
-
Combination chemical genetics
-
Lehar J., et al. Combination chemical genetics. Nat. Chem. Biol. 4 (2008) 674-681
-
(2008)
Nat. Chem. Biol.
, vol.4
, pp. 674-681
-
-
Lehar, J.1
-
68
-
-
48249137780
-
Unraveling protein networks with power graph analysis
-
Royer L., et al. Unraveling protein networks with power graph analysis. PLoS Comput. Biol. 4 (2008) e1000108
-
(2008)
PLoS Comput. Biol.
, vol.4
-
-
Royer, L.1
-
69
-
-
66249092826
-
Information flow analysis of interactome networks
-
Missiuro P.V., et al. Information flow analysis of interactome networks. PLoS Comput. Biol. 5 (2009) e1000350
-
(2009)
PLoS Comput. Biol.
, vol.5
-
-
Missiuro, P.V.1
-
70
-
-
0842288337
-
Inferring cellular networks using probabilistic graphical models
-
Friedman N. Inferring cellular networks using probabilistic graphical models. Science 303 (2004) 799-805
-
(2004)
Science
, vol.303
, pp. 799-805
-
-
Friedman, N.1
-
71
-
-
17644427718
-
Causal protein-signaling networks derived from multiparameter single-cell data
-
Sachs K., et al. Causal protein-signaling networks derived from multiparameter single-cell data. Science 308 (2005) 523-529
-
(2005)
Science
, vol.308
, pp. 523-529
-
-
Sachs, K.1
-
72
-
-
0142052944
-
A Bayesian networks approach for predicting protein-protein interactions from genomic data
-
Jansen R., et al. A Bayesian networks approach for predicting protein-protein interactions from genomic data. Science 302 (2003) 449-453
-
(2003)
Science
, vol.302
, pp. 449-453
-
-
Jansen, R.1
-
73
-
-
56849119061
-
Annotating proteins with generalized functional linkages
-
Llewellyn R., and Eisenberg D.S. Annotating proteins with generalized functional linkages. Proc. Natl. Acad. Sci. U S A 105 (2008) 17700-17705
-
(2008)
Proc. Natl. Acad. Sci. U S A
, vol.105
, pp. 17700-17705
-
-
Llewellyn, R.1
Eisenberg, D.S.2
-
74
-
-
32644431906
-
Relationships between probabilistic Boolean networks and dynamic Bayesian networks as models of gene regulatory networks
-
Lahdesmaki H., et al. Relationships between probabilistic Boolean networks and dynamic Bayesian networks as models of gene regulatory networks. Signal Processing 86 (2006) 814-834
-
(2006)
Signal Processing
, vol.86
, pp. 814-834
-
-
Lahdesmaki, H.1
-
75
-
-
22844450110
-
Systematic interpretation of genetic interactions using protein networks
-
Kelley R., and Ideker T. Systematic interpretation of genetic interactions using protein networks. Nat. Biotechnol. 23 (2005) 561-566
-
(2005)
Nat. Biotechnol.
, vol.23
, pp. 561-566
-
-
Kelley, R.1
Ideker, T.2
-
76
-
-
45149106353
-
Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks
-
Zhu J., et al. Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks. Nat. Genet. 40 (2008) 854-861
-
(2008)
Nat. Genet.
, vol.40
, pp. 854-861
-
-
Zhu, J.1
-
77
-
-
67049098922
-
Hypergraphs and cellular networks
-
Klamt S., et al. Hypergraphs and cellular networks. PLoS Comput. Biol. 5 (2009) e1000385
-
(2009)
PLoS Comput. Biol.
, vol.5
-
-
Klamt, S.1
-
78
-
-
0742305866
-
Network biology: understanding the cell's functional organization
-
Barabasi A.L., and Oltvai Z.N. Network biology: understanding the cell's functional organization. Nat. Rev. Genet. 5 (2004) 101-113
-
(2004)
Nat. Rev. Genet.
, vol.5
, pp. 101-113
-
-
Barabasi, A.L.1
Oltvai, Z.N.2
-
79
-
-
0033518234
-
From molecular to modular cell biology
-
Hartwell L.H., et al. From molecular to modular cell biology. Nature 402 (1999) C47-52
-
(1999)
Nature
, vol.402
-
-
Hartwell, L.H.1
-
80
-
-
0037199968
-
Hierarchical organization of modularity in metabolic networks
-
Ravasz E., et al. Hierarchical organization of modularity in metabolic networks. Science 297 (2002) 1551-1555
-
(2002)
Science
, vol.297
, pp. 1551-1555
-
-
Ravasz, E.1
-
81
-
-
33644555054
-
Proteome survey reveals modularity of the yeast cell machinery
-
Gavin A.C., et al. Proteome survey reveals modularity of the yeast cell machinery. Nature 440 (2006) 631-636
-
(2006)
Nature
, vol.440
, pp. 631-636
-
-
Gavin, A.C.1
-
82
-
-
0036578795
-
Network motifs in the transcriptional regulation network of Escherichia coli
-
Shen-Orr S.S., et al. Network motifs in the transcriptional regulation network of Escherichia coli. Nat. Genet. 31 (2002) 64-68
-
(2002)
Nat. Genet.
, vol.31
, pp. 64-68
-
-
Shen-Orr, S.S.1
-
83
-
-
0037174670
-
Network motifs: simple building blocks of complex networks
-
Milo R., et al. Network motifs: simple building blocks of complex networks. Science 298 (2002) 824-827
-
(2002)
Science
, vol.298
, pp. 824-827
-
-
Milo, R.1
-
84
-
-
3442886313
-
PathBLAST: a tool for alignment of protein interaction networks
-
Kelley B.P., et al. PathBLAST: a tool for alignment of protein interaction networks. Nucleic Acids Res. 32 (2004) W83-88
-
(2004)
Nucleic Acids Res.
, vol.32
-
-
Kelley, B.P.1
-
85
-
-
39149087720
-
NetworkBLAST: comparative analysis of protein networks
-
Kalaev M., et al. NetworkBLAST: comparative analysis of protein networks. Bioinformatics 24 (2008) 594-596
-
(2008)
Bioinformatics
, vol.24
, pp. 594-596
-
-
Kalaev, M.1
-
86
-
-
51349087811
-
Global alignment of multiple protein interaction networks with application to functional orthology detection
-
Singh R., et al. Global alignment of multiple protein interaction networks with application to functional orthology detection. Proc. Natl. Acad. Sci. U S A 105 (2008) 12763-12768
-
(2008)
Proc. Natl. Acad. Sci. U S A
, vol.105
, pp. 12763-12768
-
-
Singh, R.1
-
87
-
-
27744568481
-
The Plasmodium protein network diverges from those of other eukaryotes
-
Suthram S., et al. The Plasmodium protein network diverges from those of other eukaryotes. Nature 438 (2005) 108-112
-
(2005)
Nature
, vol.438
, pp. 108-112
-
-
Suthram, S.1
-
88
-
-
60349092402
-
Mapping complex disease traits with global gene expression
-
Cookson W., et al. Mapping complex disease traits with global gene expression. Nat. Rev. Genet. 10 (2009) 184-194
-
(2009)
Nat. Rev. Genet.
, vol.10
, pp. 184-194
-
-
Cookson, W.1
-
89
-
-
67349208911
-
Bioinformatics analysis of mass spectrometry-based proteomics data sets
-
Kumar C., and Mann M. Bioinformatics analysis of mass spectrometry-based proteomics data sets. FEBS Lett. 583 (2009) 1703-1712
-
(2009)
FEBS Lett.
, vol.583
, pp. 1703-1712
-
-
Kumar, C.1
Mann, M.2
-
90
-
-
68949206409
-
Applying mass spectrometry-based proteomics to genetics, genomics and network biology
-
Gstaiger M., and Aebersold R. Applying mass spectrometry-based proteomics to genetics, genomics and network biology. Nat. Rev. Genet. 10 (2009) 617-627
-
(2009)
Nat. Rev. Genet.
, vol.10
, pp. 617-627
-
-
Gstaiger, M.1
Aebersold, R.2
-
91
-
-
33746742909
-
Looking towards label-free biomolecular interaction analysis in a high-throughput format: a review of new surface plasmon resonance technologies
-
Boozer C., et al. Looking towards label-free biomolecular interaction analysis in a high-throughput format: a review of new surface plasmon resonance technologies. Curr. Opin. Biotechnol. 17 (2006) 400-405
-
(2006)
Curr. Opin. Biotechnol.
, vol.17
, pp. 400-405
-
-
Boozer, C.1
-
92
-
-
34547790172
-
Development of surface plasmon resonance mass spectrometry array platform
-
Nedelkov D. Development of surface plasmon resonance mass spectrometry array platform. Anal. Chem. 79 (2007) 5987-5990
-
(2007)
Anal. Chem.
, vol.79
, pp. 5987-5990
-
-
Nedelkov, D.1
-
93
-
-
67649392701
-
Determination of in vivo dissociation constant, KD, of Cdc42-effector complexes in live mammalian cells using single wavelength fluorescence cross-correlation spectroscopy
-
Sudhaharan T., et al. Determination of in vivo dissociation constant, KD, of Cdc42-effector complexes in live mammalian cells using single wavelength fluorescence cross-correlation spectroscopy. J. Biol. Chem. 284 (2009) 13602-13609
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 13602-13609
-
-
Sudhaharan, T.1
-
94
-
-
58849147890
-
The influence of catalysis on mad2 activation dynamics
-
Simonetta M., et al. The influence of catalysis on mad2 activation dynamics. PLoS Biol. 7 (2009) e10
-
(2009)
PLoS Biol.
, vol.7
-
-
Simonetta, M.1
-
95
-
-
33750078971
-
NMR structural and kinetic characterization of a homeodomain diffusing and hopping on nonspecific DNA
-
Iwahara J., et al. NMR structural and kinetic characterization of a homeodomain diffusing and hopping on nonspecific DNA. Proc. Natl. Acad. Sci. U S A 103 (2006) 15062-15067
-
(2006)
Proc. Natl. Acad. Sci. U S A
, vol.103
, pp. 15062-15067
-
-
Iwahara, J.1
-
96
-
-
33846928691
-
Quantitative dynamics and binding studies of the 20S proteasome by NMR
-
Sprangers R., and Kay L.E. Quantitative dynamics and binding studies of the 20S proteasome by NMR. Nature 445 (2007) 618-622
-
(2007)
Nature
, vol.445
, pp. 618-622
-
-
Sprangers, R.1
Kay, L.E.2
|