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Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 3, 2008, Pages 901-906

Allosteric effects in the marginally stable von Hippel-Lindau tumor suppressor protein and allostery-based rescue mutant design

(2) Liu, Jin a Nussinov, Ruth a,b

a SAIC FREDERICK INC (United States)

b TEL AVIV UNIVERSITY (Israel)

Author keywords

Allosteric site prediction; Drug design; E3 ubiquitin ligase; HIF; Molecular dynamics simulations

Indexed keywords

ELONGIN C; HYPOXIA INDUCIBLE FACTOR 1; MUTANT PROTEIN; VON HIPPEL LINDAU PROTEIN;

ALLOSTERISM; ALPHA CHAIN; ARTICLE; BETA CHAIN; BINDING AFFINITY; BINDING SITE; ENTHALPY; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STABILITY; SIMULATION; WILD TYPE; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; GENETICS; METABOLISM; MUTATION; PROTEIN ENGINEERING; PROTEIN QUATERNARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

ALLOSTERIC REGULATION; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; MODELS, MOLECULAR; MUTATION; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN STRUCTURE, QUATERNARY; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 38949190032 PISSN: 00278424 EISSN: 10916490 Source Type: Journal
DOI: 10.1073/pnas.0707401105 Document Type: Article

Times cited : (76)

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