Interfacial inhibition of macromolecular interactions: Nature's paradigm for drug discovery

Trends in Pharmacological Sciences

Volumn 26, Issue 3, 2005, Pages 138-145

  Pommier, Yves ^a   Cherfils, Jacqueline ^b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b LABORATOIRE D ENZYMOLOGIE ET BIOCHIMIE STRUCTURALES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA AMANITIN; APHIDICOLIN; BREFELDIN A; CAMPTOTHECIN; CIPROFLOXACIN; COLCHICINE; CYCLOSPORIN; DNA; DNA TOPOISOMERASE INHIBITOR; DOXORUBICIN; ECTEINASCIDIN; EPOTHILONE A; FORSKOLIN; FUSICOCCIN; FUSIDIC ACID; IMMUNOPHILIN; IRINOTECAN; MOCIMYCIN; NALIDIXIC ACID; PACLITAXEL; PROTEIN; PROTEIN INHIBITOR; QUINOLONE DERIVATIVE; RAPAMYCIN; RAZOXANE; TACROLIMUS; THIOSTREPTON; TOPOTECAN; TUBULIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

CELL ACTIVITY; DRUG BINDING; DRUG HALF LIFE; DRUG MECHANISM; DRUG STRUCTURE; ENERGY; HUMAN; KINETICS; MACROMOLECULE; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN TARGETING; REVIEW; SIDE EFFECT;

EID: 14644420930     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tips.2005.01.008     Document Type: Review

References (60)

1. F. McCormick Small-molecule inhibitors of cell signaling Curr. Opin. Biotechnol. 11 2000 593 597
2. A.A. Bogan, and K.S. Thorn Anatomy of hot spots in protein interfaces J. Mol. Biol. 280 1998 1 9
3. M.R. Arkin, and J.A. Wells Small-molecule inhibitors of protein-protein interactions: progressing towards the dream Nat. Rev. Drug Discov. 3 2004 301 317
4. B.L. Staker The mechanism of topoisomerase I poisoning by a camptothecin analog Proc. Natl. Acad. Sci. U. S. A. 99 2002 15387 15392
5. J.E. Chrencik Mechanisms of camptothecin resistance by human topoisomerase I mutations J. Mol. Biol. 339 2004 773 784
6. Staker, B.L. et al. Structure of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex. J. Med. Chem. (in press)
7. S. Robineau Binding site of brefeldin A at the interface between the small G protein ADP-ribosylation factor 1 (ARF1) and the nucleotide-exchange factor Sec7 domain Proc. Natl. Acad. Sci. U. S. A. 97 2000 9913 9918
8. L. Renault Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor Nature 426 2003 525 530
9. G. Capranico Local sequence requirements for DNA cleavage by mammalian topoisomerase II in the presence of doxorubicin Nucleic Acids Res. 18 1990 6611 6619
10. C. Jaxel Effect of local DNA sequence on topoisomerase I cleavage in the presence or absence of camptothecin J. Biol. Chem. 266 1991 20418 20423
11. M.E. Wall, and M.C. Wani Camptothecin and taxol: discovery to clinic-thirteenth Bruce F. Cain Memorial Award lecture Cancer Res. 55 1995 753 760
12. Y.H. Hsiang Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I J. Biol. Chem. 260 1985 14873 14878
13. M-A. Bjornsti Expression of human DNA topoisomerase I in yeast cells lacking yeast DNA topoisomerase I: restoration of sensitivity of the cells to the antitumor drug camptothecin Cancer Res. 49 1989 6318 6323
14. Y. Pommier Topoisomerase I inhibitors: selectivity and cellular resistance Drug Resist. Updat. 2 1999 307 318
15. C. Jaxel Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and a relation to antitumor activity Cancer Res. 49 1989 1465 1469
16. J.C. Wang Cellular roles of DNA topoisomerases: a molecular perspective Nat. Rev. Mol. Cell Biol. 3 2002 430 440
17. J.J. Champoux DNA Topoisomerases: structure, function, and mechanism Annu. Rev. Biochem. 70 2001 369 413
18. Y. Pommier Interaction of an alkylating camptothecin derivative with a DNA base at topoisomerase I-DNA cleavage sites Proc. Natl. Acad. Sci. U. S. A. 92 1995 8861 8865
19. V.L. Singleton Decumbin, a new compound from a species of Penicillium Nature 181 1958 1072 1073
20. K.G. Tietjen, and U. Matern Induction and suppression of phytoalexin biosynthesis in cultured cells of safflower, Carthamus tinctorius L., by metabolites of Alternaria carthami Chowdhury Arch. Biochem. Biophys. 229 1984 136 144
21. G. Tamura Antiviral activity of brefeldin A and verrucarin A J. Antibiot. (Tokyo) 21 1968 160 161
22. J.W. Zhu Elucidation of strict structural requirements of brefeldin A as an inducer of differentiation and apoptosis Bioorg. Med. Chem. 8 2000 455 463
23. Y. Misumi Novel blockade by brefeldin A of intracellular transport of secretory proteins in cultured rat hepatocytes J. Biol. Chem. 261 1986 11398 11403
24. J.B. Helms, and J.E. Rothman Inhibition by brefeldin A of a Golgi membrane enzyme that catalyses exchange of guanine nucleotide bound to ARF Nature 360 1992 352 354
25. J.G. Donaldson Brefeldin A inhibits Golgi membrane-catalysed exchange of guanine nucleotide onto ARF protein Nature 360 1992 350 352
26. C.L. Jackson, and J.E. Casanova Turning on ARF: the Sec7 family of guanine-nucleotide-exchange factors Trends Cell Biol. 10 2000 60 67
27. A. Peyroche Brefeldin A acts to stabilize an abortive ARF-GDP-Sec7 domain protein complex: involvement of specific residues of the Sec7 domain Mol. Cell 3 1999 275 285
28. P. Chardin, and F. McCormick Brefeldin A: the advantage of being uncompetitive Cell 97 1999 153 155
29. J. Cherfils, and P. Chardin GEFs: structural basis for their activation of small GTP-binding proteins Trends Biochem. Sci. 24 1999 306 311
30. E. Mossessova Crystal structure of ARF1*Sec7 complexed with Brefeldin A and its implications for the guanine nucleotide exchange mechanism Mol. Cell 12 2003 1403 1411
31. J. Goldberg Structural basis for activation of ARF GTPase: mechanisms of guanine nucleotide exchange and GTP-myristoyl switching Cell 95 1998 237 248
32. J.C. Amor Structure of the human ADP-ribosylation factor 1 complexed with GDP Nature 372 1994 704 708
33. M. Sata Structural basis for the inhibitory effect of brefeldin A on guanine nucleotide-exchange proteins for ADP-ribosylation factors Proc. Natl. Acad. Sci. U. S. A. 96 1999 2752 2757
34. F. Baumgartner A point mutation in an unusual Sec7 domain is linked to brefeldin A resistance in a Plasmodium falciparum line generated by drug selection Mol. Microbiol. 41 2001 1151 1158
35. Y. Pommier Repair of and checkpoint response to topoisomerase I-mediated DNA damage Mutat. Res. 532 2003 173 203
36. N. Sciaky Golgi tubule traffic and the effects of brefeldin A visualized in living cells J. Cell Biol. 139 1997 1137 1155
37. J.J. Tesmer Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS Science 278 1997 1907 1916
38. J.H. Hurley Structure, mechanism, and regulation of mammalian adenylyl cyclase J. Biol. Chem. 274 1999 7599 7602
39. R.B. Ravelli Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain Nature 428 2004 198 202
40. J.P. Snyder The binding conformation of Taxol in beta-tubulin: a model based on electron crystallographic density Proc. Natl. Acad. Sci. U. S. A. 98 2001 5312 5316
41. J.H. Nettles The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography Science 305 2004 866 869
42. D.A. Bushnell Structural basis of transcription: alpha-amanitin-RNA polymerase II cocrystal at 2.8 A resolution Proc. Natl. Acad. Sci. U. S. A. 99 2002 1218 1222
43. R.K. Agrawal, and J. Frank Structural studies of the translational apparatus Curr. Opin. Struct. Biol. 9 1999 215 221
44. M. Laurberg Structure of a mutant EF-G reveals domain III and possibly the fusidic acid binding site J. Mol. Biol. 303 2000 593 603
45. Bowen, W.S. et al. Interaction of thiostrepton and elongation factor-G with the ribosomal protein L11-binding domain. J. Biol. Chem. (in press)
46. Y. Takebayashi Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair Nat. Med. 7 2001 961 966
47. P. Pourquier Topoisomerase I and II activity assays R. Brown U. Böger-Brown Methods in Molecular Medicine: Cytototoxic Drug Resistance Mechanisms Vol. 28 1999 Human Press 95 110
48. L. Jin, and S.C. Harrison Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin Proc. Natl. Acad. Sci. U. S. A. 99 2002 13522 13526
49. Q. Huai Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes Proc. Natl. Acad. Sci. U. S. A. 99 2002 12037 12042
50. M. Wurtele Structural view of a fungal toxin acting on a 14-3-3 regulatory complex EMBO J. 22 2003 987 994
51. C.R. Kissinger Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex Nature 378 1995 641 644
52. J.P. Griffith X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex Cell 82 1995 507 522
53. J. Choi Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP Science 273 1996 239 242
54. J. Roca Antitumor bisdioxopiperazines inhibit yeast DNA topoisomerase II by trapping the enzyme in the form of a closed protein clamp Proc. Natl. Acad. Sci. U. S. A. 91 1994 1781 1785
55. S. Classen Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187 Proc. Natl. Acad. Sci. U. S. A. 100 2003 10629 10634
56. J.G. Heddle The interaction of drugs with DNA gyrase: a model for the molecular basis of quinolone action Nucleosides Nucleotides Nucleic Acids 19 2000 1249 1264
57. D. Strumberg Importance of the fourth alpha-helix within the CAP homology domain of type II topoisomerase for DNA cleavage site recognition and quinolone action Antimicrob. Agents Chemother. 46 2002 2735 2746
58. J.A. Huberman New views of the biochemistry of eucaryotic DNA replication revealed by aphidicolin, an unusual inhibitor of DNA polymerase alpha Cell 23 1981 647 648
59. D.J. Hazuda Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells Science 287 2000 646 650
60. C. Marchand Metal-dependent inhibition of HIV-1 integrase by {beta}-diketo acids and resistance of the soluble double-mutant (F185K/C280S) Mol. Pharmacol. 64 2003 600 609