Towards drugs targeting multiple proteins in a systems biology approach

Current Topics in Medicinal Chemistry

Volumn 7, Issue 10, 2007, Pages 943-951

  Keskin, O ^a   Gursoy, A ^a   Ma, Buyong ^b   Nussinov, Ruth ^b,c,d  

^a KOÇ UNIVERSITY   (Turkey)

^b SAIC FREDERICK INC   (United States)

^c TEL AVIV UNIVERSITY   (Israel)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Allosteric site; Drug design; FK1012; G protein coupled receptors; Hot regions

Indexed keywords

BREFELDIN A; CAMPTOTHECIN; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; G PROTEIN COUPLED RECEPTOR; RNA DIRECTED DNA POLYMERASE; TACROLIMUS; TRASTUZUMAB;

BINDING SITE; BREAST CANCER; CELL FUNCTION; CELL GROWTH; DRUG BINDING; DRUG DESIGN; DRUG RESEARCH; DRUG TARGETING; HUMAN; MOLECULAR BIOLOGY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TARGETING; REVIEW;

ANIMALS; BINDING SITES; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; MOLECULAR MIMICRY; PEPTIDE LIBRARY; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; PROTEINS; SYSTEMS BIOLOGY;

EID: 34447288741     PISSN: 15680266     EISSN: None     Source Type: Journal    
DOI: 10.2174/156802607780906690     Document Type: Review

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