Trapping moving targets with small molecules

Science

Volumn 324, Issue 5924, 2009, Pages 213-215

  Lee, Gregory M ^a   Craik, Charles S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DASATINIB; IMATINIB; NILOTINIB; RNA DIRECTED DNA POLYMERASE;

DRUG; DRUG DEVELOPMENT; NUCLEAR MAGNETIC RESONANCE; PROTEIN;

ALLOSTERISM; DRUG DESIGN; LIGAND BINDING; MACROMOLECULE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN INTERACTION; REVIEW;

ALLOSTERIC REGULATION; ALLOSTERIC SITE; APOPROTEINS; CATALYTIC DOMAIN; CREB-BINDING PROTEIN; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DRUG DESIGN; DRUG DISCOVERY; ENZYME INHIBITORS; LIGANDS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PIPERAZINES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEIN-TYROSINE KINASES; PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; PYRIMIDINES; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES; THERMODYNAMICS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 64849113665     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1169378     Document Type: Review

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41. This research was supported in part by grants from the NIH (grant 1R01A1067423) and the HIV Accessory and Regulatory Complex Center (grant P50 GM082250). G.M.L. is a recipient of the 2007-2008 UCSF-Gladstone Institute for Virology & Immunology/Center for AIDS Research Clinical Science Pilot Award (grant P30-AI027763). We also thank K. Dill, J. Gross, D. Hostetter, and T. Shahian for discussion and proofreading of this manuscript.