Dimerization and ligand binding affect the structure network of A 2A adenosine receptor

Biochimica et Biophysica Acta - Biomembranes

Volumn 1808, Issue 5, 2011, Pages 1256-1266

  Fanelli, Francesca ^a   Felline, Angelo ^a  

^a DULBECCO TELETHON INSTITUTE   (Italy)

Author keywords

GPCR dimerization; Intramolecular and intermolecular communication; Molecular Dynamics simulations; Protein Structure Network

Indexed keywords

ADENOSINE A2A RECEPTOR; RHODOPSIN;

AMINO ACID SEQUENCE; ARTICLE; CRYSTALLOGRAPHY; DIMERIZATION; LIGAND BINDING; MOLECULAR DYNAMICS; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN MOTIF; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; DIMERIZATION; HUMANS; LIGANDS; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; RECEPTOR, ADENOSINE A2A; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 79953194763     PISSN: 00052736     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamem.2010.08.006     Document Type: Article

References (52)

1. R.J. Lefkowitz The superfamily of heptahelical receptors Nat. Cell Biol. 2 2000 E133 E136
2. S. Terrillon, and M. Bouvier Roles of G-protein-coupled receptor dimerization EMBO Rep. 5 2004 30 34 (Pubitemid 38228524)
3. V.V. Gurevich, and E.V. Gurevich GPCR monomers and oligomers: it takes all kinds Trends Neurosci. 31 2008 74 81
4. K. Fuxe, M. Canals, M. Torvinen, D. Marcellino, A. Terasmaa, S. Genedani, G. Leo, D. Guidolin, Z. Diaz-Cabiale, A. Rivera, L. Lundstrom, U. Langel, J. Narvaez, S. Tanganelli, C. Lluis, S. Ferre, A. Woods, R. Franco, and L.F. Agnati Intramembrane receptor-receptor interactions: a novel principle in molecular medicine J. Neural Transm. 114 2007 49 75 (Pubitemid 46018675)
5. M. Canals, J. Burgueno, D. Marcellino, N. Cabello, E.I. Canela, J. Mallol, L. Agnati, S. Ferre, M. Bouvier, K. Fuxe, F. Ciruela, C. Lluis, and R. Franco Homodimerization of adenosine A2A receptors: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer J. Neurochem. 88 2004 726 734 (Pubitemid 38140216)
6. T.H. Bayburt, A.J. Leitz, G. Xie, D.D. Oprian, and S.G. Sligar Transducin activation by nanoscale lipid bilayers containing one and two rhodopsins J. Biol. Chem. 282 2007 14875 14881 (Pubitemid 47093370)
7. O.P. Ernst, V. Gramse, M. Kolbe, K.P. Hofmann, and M. Heck Monomeric G protein-coupled receptor rhodopsin in solution activates its G protein transducin at the diffusion limit Proc. Natl Acad. Sci. USA 104 2007 10859 10864 (Pubitemid 47175191)
8. M.R. Whorton, M.P. Bokoch, S.G. Rasmussen, B. Huang, R.N. Zare, B. Kobilka, and R.K. Sunahara A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein Proc. Natl Acad. Sci. USA 104 2007 7682 7687 (Pubitemid 47185966)
9. J.F. White, J. Grodnitzky, J.M. Louis, L.B. Trinh, J. Shiloach, J. Gutierrez, J.K. Northup, and R. Grisshammer Dimerization of the class A G protein-coupled neurotensin receptor NTS1 alters G protein interaction Proc. Natl Acad. Sci. USA 104 2007 12199 12204 (Pubitemid 47189413)
10. J.J. Fung, X. Deupi, L. Pardo, X.J. Yao, G.A. Velez-Ruiz, B.T. Devree, R.K. Sunahara, and B.K. Kobilka Ligand-regulated oligomerization of beta(2)-adrenoceptors in a model lipid bilayer EMBO J. 28 2009 3315 3328
11. W. Guo, E. Urizar, M. Kralikova, J.C. Mobarec, L. Shi, M. Filizola, and J.A. Javitch Dopamine D2 receptors form higher order oligomers at physiological expression levels EMBO J. 27 2008 2293 2304
12. G. Milligan G-protein-coupled receptor heterodimers: pharmacology, function and relevance to drug discovery Drug Discov. Today 11 2006 541 549
13. B.A. Jordan, and L.A. Devi G-protein-coupled receptor heterodimerization modulates receptor function Nature 399 1999 697 700 (Pubitemid 29289066)
14. S.C. Prinster, C. Hague, and R.A. Hall Heterodimerization of g protein-coupled receptors: specificity and functional significance Pharmacol. Rev. 57 2005 289 298 (Pubitemid 41196951)
15. S.R. George, B.F. O'Dowd, and S.P. Lee G-protein-coupled receptor oligomerization and its potential for drug discovery Nat. Rev. Drug Discov. 1 2002 808 820 (Pubitemid 37361564)
16. A. Soriano, R. Ventura, A. Molero, R. Hoen, V. Casado, A. Cortes, F. Fanelli, F. Albericio, C. Lluis, R. Franco, and M. Royo Adenosine A2A receptor-antagonist/dopamine D2 receptor-agonist bivalent ligands as pharmacological tools to detect A2A-D2 receptor heteromers J. Med. Chem. 52 2009 5590 5602
17. V.V. Gurevich, and E.V. Gurevich How and why do GPCRs dimerize? Trends Pharmacol. Sci. 29 2008 234 240
18. G. Milligan A day in the life of a G protein-coupled receptor: the contribution to function of G protein-coupled receptor dimerization Br. J. Pharmacol. 153 Suppl 1 2008 S216 S229
19. L.M. Simpson, B. Taddese, I.D. Wall, and C.A. Reynolds Bioinformatics and molecular modelling approaches to GPCR oligomerization Curr. Opin. Pharmacol. 10 2010 30 37
20. Y. Liang, D. Fotiadis, S. Filipek, D.A. Saperstein, K. Palczewski, and A. Engel Organization of the G protein-coupled receptors rhodopsin and opsin in native membranes J. Biol. Chem. 278 2003 21655 21662 (Pubitemid 36792566)
21. D.T. Lodowski, D. Salom, I. Le Trong, D.C. Teller, J.A. Ballesteros, K. Palczewski, and R.E. Stenkamp Crystal packing analysis of Rhodopsin crystals J. Struct. Biol. 158 2007 455 462 (Pubitemid 46764573)
22. V. Cherezov, D.M. Rosenbaum, M.A. Hanson, S.G. Rasmussen, F.S. Thian, T.S. Kobilka, H.J. Choi, P. Kuhn, W.I. Weis, B.K. Kobilka, and R.C. Stevens High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor Science 318 2007 1258 1265 New York, N.Y (Pubitemid 350172884)
23. W. Guo, M. Filizola, H. Weinstein, and J.A. Javitch Crosstalk in G protein-coupled receptors: changes at the transmembrane homodimer interface determine activation Proc. Natl Acad. Sci. USA 102 2005 17495 17500 (Pubitemid 41740894)
24. W. Guo, L. Shi, and J.A. Javitch The fourth transmembrane segment forms the interface of the dopamine D2 receptor homodimer J. Biol. Chem. 278 2003 4385 4388 (Pubitemid 36800928)
25. F. Mancia, Z. Assur, A.G. Herman, R. Siegel, and W.A. Hendrickson Ligand sensitivity in dimeric associations of the serotonin 5HT2c receptor EMBO Rep. 9 2008 363 369
26. J.H. Park, P. Scheerer, K.P. Hofmann, H.W. Choe, and O.P. Ernst Crystal structure of the ligand-free G-protein-coupled receptor opsin Nature 454 2008 183 187 (Pubitemid 351969893)
27. D. Casciari, M. Seeber, and F. Fanelli Quaternary structure predictions of transmembrane proteins starting from the monomer: a docking-based approach BMC Bioinform. 7 2006 340
28. M. Canals, D. Marcellino, F. Fanelli, F. Ciruela, P. De Benedetti, S.R. Goldberg, K. Neve, K. Fuxe, L.F. Agnati, A.S. Woods, S. Ferre, C. Lluis, M. Bouvier, and R. Franco Adenosine A2A-dopamine D2 receptor-receptor heteromerization: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer J. Biol. Chem. 278 2003 46741 46749 (Pubitemid 37452253)
29. F. Fanelli Dimerization of the lutropin receptor: insights from computational modeling Mol. Cell. Endocrinol. 260-262 2007 59 64 (Pubitemid 44792332)
30. D. Casciari, D. Dell'Orco, and F. Fanelli Homodimerization of neurotensin 1 receptor involves helices 1, 2, and 4: insights from quaternary structure predictions and dimerization free energy estimations J. Chem. Inf. Model. 48 2008 1669 1678
31. M. Vendruscolo, N.V. Dokholyan, E. Paci, and M. Karplus Small-world view of the amino acids that play a key role in protein folding Phys. Rev. E. Stat. Nonlin. Soft Matter Phys. 65 2002 061910
32. G. Amitai, A. Shemesh, E. Sitbon, M. Shklar, D. Netanely, I. Venger, and S. Pietrokovski Network analysis of protein structures identifies functional residues J. Mol. Biol. 344 2004 1135 1146 (Pubitemid 39491254)
33. R. Chen, and Z. Weng A novel shape complementarity scoring function for protein-protein docking Proteins 51 2003 397 408 (Pubitemid 36528825)
34. V.P. Jaakola, M.T. Griffith, M.A. Hanson, V. Cherezov, E.Y. Chien, J.R. Lane, A.P. Ijzerman, and R.C. Stevens The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist Science 322 2008 1211 1217 New York, N.Y
35. W. Im, M. Feig, and C.L. Brooks III An implicit membrane generalized born theory for the study of structure, stability, and interactions of membrane proteins Biophys. J. 85 2003 2900 2918 (Pubitemid 37345782)
36. A.D.J. MacKerell, D. Bashford, M. Bellott, R.L.J. Dunbrack, J.D. Evanseck, M.J. Field, S. Fischer, J. Gao, H. Guo, S. Ha, D. Joseph-McCarthy, L. Kuchnir, K. Kuczera, F.T.K. Lau, C. Mattos, S. Michnick, T. Ngo, T.D. Nguyen, B. Prodhom, W.E.I. Reiher, B. Roux, M. Schlenkrich, J.C. Smith, R. Stote, J. Straub, M. Watanabe, J. Wiòrkiewicz-Kuczera, D. Yin, and M. Karplus All-atom empirical potential for molecular modeling and dynamics studies of proteins J. Phys. Chem. B 102 1998 3586 3616 (Pubitemid 128576688)
37. A. Fiser, R.K. Do, and A. Sali Modeling of loops in protein structures Protein Sci. 9 2000 1753 1773
38. M. Seeber, M. Cecchini, F. Rao, G. Settanni, and A. Caflisch Wordom: a program for efficient analysis of molecular dynamics simulations Bioinformatics 23 2007 2625 2627 (Pubitemid 350048368)
39. S. Vishveshwara, K.V. Brinda, and N. Kannan Protein structure: insights from graph theory J. Theor. Comput. Chem. 1 2002 187 211
40. S. Vishveshwara, A. Ghosh, and P. Hansia Intra and inter-molecular communications through protein structure network Curr. Protein Pept. Sci. 10 2009 146 160
41. N. Kannan, and S. Vishveshwara Identification of side-chain clusters in protein structures by a graph spectral method J. Mol. Biol. 292 1999 441 464 (Pubitemid 29435778)
42. O.F. Lange, and H. Grubmuller Generalized correlation for biomolecular dynamics Proteins: Struct., Funct., Bioinf. 62 2006 1053 1061 (Pubitemid 43364168)
43. T. Mirzadegan, G. Benko, S. Filipek, and K. Palczewski Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin Biochemistry 42 2003 2759 2767 (Pubitemid 36331518)
44. J.A. Ballesteros, and H. Weinstein Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein-coupled receptors Methods Neurosci. 25 1995 366 428
45. F. Fanelli, and M. Seeber Structural insights into retinitis pigmentosa from unfolding simulations of rhodopsin mutants FASEB J. 24 9 2010 1 14
46. S.G. Rasmussen, H.J. Choi, D.M. Rosenbaum, T.S. Kobilka, F.S. Thian, P.C. Edwards, M. Burghammer, V.R. Ratnala, R. Sanishvili, R.F. Fischetti, G.F. Schertler, W.I. Weis, and B.K. Kobilka Crystal structure of the human beta2 adrenergic G-protein-coupled receptor Nature 450 2007 383 387 (Pubitemid 350126755)
47. T. Warne, M.J. Serrano-Vega, J.G. Baker, R. Moukhametzianov, P.C. Edwards, R. Henderson, A.G. Leslie, C.G. Tate, and G.F. Schertler Structure of a beta1-adrenergic G-protein-coupled receptor Nature 454 2008 486 491
48. V.P. Jaakola, M.T. Griffith, M.A. Hanson, V. Cherezov, E.Y. Chien, J.R. Lane, A.P. Ijzerman, and R.C. Stevens The 2.6 Angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist Science 322 5905 2008 1211 1217
49. K. Palczewski G protein-coupled receptor rhodopsin Annu. Rev. Biochem. 75 2006 743 767 (Pubitemid 44118051)
50. P. Scheerer, J.H. Park, P.W. Hildebrand, Y.J. Kim, N. Krauss, H.W. Choe, K.P. Hofmann, and O.P. Ernst Crystal structure of opsin in its G-protein-interacting conformation Nature 455 2008 497 502
51. F. Fanelli, and D. Dell'Orco Rhodopsin activation follows pre-coupling with transducin: inferences from computational analysis Biochemistry 44 2005 14695 14700 (Pubitemid 41612248)
52. F. Fanelli, and P.G. De Benedetti Computational modeling approaches to structure-function analysis of G protein-coupled receptors Chem. Rev. 105 2005 3297 3351 (Pubitemid 41430812)