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Volumn 14, Issue 2, 2013, Pages 2388-2409

Parkinson's disease: A complex interplay of mitochondrial DNA alterations and oxidative stress

Author keywords

Base excision repair (BER); C Abl; Mitochondria; Neurodegenerative diseases; Oxidative stress; Oxidized glutathione (GSS ); Parkinson's disease (PD); Reactive nitrogen species (RNS); Reactive oxidative species (ROS); Reduced glutathione (GSH)

Indexed keywords

ABELSON KINASE; ADENOSINE TRIPHOSPHATE; HYDROGEN PEROXIDE; HYDROXYL RADICAL; MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUPEROXIDE;

EID: 84875121203     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms14022388     Document Type: Review
Times cited : (56)

References (134)
  • 2
    • 84860704002 scopus 로고    scopus 로고
    • Oxidative genome damage and its repair: Implications in aging and neurodegenerative diseases
    • Hegde, M.L.; Mantha, A.K.; Hazra, T.K.; Bhakat, K.K.; Mitra, S.; Szczesny, B. Oxidative genome damage and its repair: Implications in aging and neurodegenerative diseases. Mech. Ageing Dev. 2012, 133, 157-168.
    • (2012) Mech. Ageing Dev. , vol.133 , pp. 157-168
    • Hegde, M.L.1    Mantha, A.K.2    Hazra, T.K.3    Bhakat, K.K.4    Mitra, S.5    Szczesny, B.6
  • 3
    • 79953776915 scopus 로고    scopus 로고
    • DNA double-strand break signaling and human disorders
    • Bohgaki, T.; Bohgaki, M.; Hakem, R. DNA double-strand break signaling and human disorders. Genome Integr. 2010, 1, 15.
    • (2010) Genome Integr. , vol.1 , pp. 15
    • Bohgaki, T.1    Bohgaki, M.2    Hakem, R.3
  • 4
    • 84884863139 scopus 로고    scopus 로고
    • Oxidative stress, neurodegeneration, and the balance of protein degradation and protein synthesis
    • doi:10.1016/j.freeradbiomed.2012.09.016
    • Dasuri, K.; Zhang, L.; Keller, J.N. Oxidative stress, neurodegeneration, and the balance of protein degradation and protein synthesis. Free Radic. Biol. Med. 2012, doi:10.1016/j.freeradbiomed.2012.09.016.
    • (2012) Free Radic. Biol. Med.
    • Dasuri, K.1    Zhang, L.2    Keller, J.N.3
  • 5
    • 79961207854 scopus 로고    scopus 로고
    • A review and appraisal of the DNA damage theory of ageing
    • Freitas, A.A.; de Magalhaes, J.P. A review and appraisal of the DNA damage theory of ageing. Mut. Res. 2011, 728, 12-22.
    • (2011) Mut. Res. , vol.728 , pp. 12-22
    • Freitas, A.A.1    de Magalhaes, J.P.2
  • 6
    • 34249068577 scopus 로고    scopus 로고
    • Hallmarks of protein oxidative damage in neurodegenerative diseases: Focus on Alzheimer's disease
    • Polidori, M.C.; Griffiths, H.R.; Mariani, E.; Mecocci, P. Hallmarks of protein oxidative damage in neurodegenerative diseases: Focus on Alzheimer's disease. Amino Acids 2007, 32, 553-559.
    • (2007) Amino Acids , vol.32 , pp. 553-559
    • Polidori, M.C.1    Griffiths, H.R.2    Mariani, E.3    Mecocci, P.4
  • 7
    • 84884879594 scopus 로고    scopus 로고
    • Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease
    • doi:10.1016/j.freeradbiomed.2012.11.014
    • Yan, M.H.; Wang, X.; Zhu, X. Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease. Free Radic. Biol. Med. 2012, doi:10.1016/j.freeradbiomed.2012.11.014.
    • (2012) Free Radic. Biol. Med.
    • Yan, M.H.1    Wang, X.2    Zhu, X.3
  • 8
    • 0028235259 scopus 로고
    • Age-dependent respiratory function decline and DNA deletions in human muscle mitochondria
    • Hsieh, R.H.; Hou, J.H.; Hsu, H.S.; Wei, Y.H. Age-dependent respiratory function decline and DNA deletions in human muscle mitochondria. Biochem. Mol. Biol. Int. 1994, 32, 1009-1022.
    • (1994) Biochem. Mol. Biol. Int. , vol.32 , pp. 1009-1022
    • Hsieh, R.H.1    Hou, J.H.2    Hsu, H.S.3    Wei, Y.H.4
  • 9
    • 0028109380 scopus 로고
    • Correlation between mitochondrial DNA 4977-bp deletion and respiratory chain enzyme activities in aging human skeletal muscles
    • Lezza, A.M.; Boffoli, D.; Scacco, S.; Cantatore, P.; Gadaleta, M.N. Correlation between mitochondrial DNA 4977-bp deletion and respiratory chain enzyme activities in aging human skeletal muscles. Biochem. Biophys. Res. Commun. 1994, 205, 772-779.
    • (1994) Biochem. Biophys. Res. Commun. , vol.205 , pp. 772-779
    • Lezza, A.M.1    Boffoli, D.2    Scacco, S.3    Cantatore, P.4    Gadaleta, M.N.5
  • 10
    • 82555194263 scopus 로고    scopus 로고
    • Mitochondrial mutations: Newly discovered players in neuronal degeneration
    • Lax, N.Z.; Turnbull, D.M.; Reeve, A.K. Mitochondrial mutations: Newly discovered players in neuronal degeneration. Neuroscientist 2011, 17, 645-658.
    • (2011) Neuroscientist , vol.17 , pp. 645-658
    • Lax, N.Z.1    Turnbull, D.M.2    Reeve, A.K.3
  • 11
    • 0028349234 scopus 로고
    • Differential accumulations of 4,977 bp deletion in mitochondrial DNA of various tissues in human ageing
    • Lee, H.C.; Pang, C.Y.; Hsu, H.S.; Wei, Y.H. Differential accumulations of 4,977 bp deletion in mitochondrial DNA of various tissues in human ageing. Biochim. Biophys. Acta 1994, 1226, 37-43.
    • (1994) Biochim. Biophys. Acta , vol.1226 , pp. 37-43
    • Lee, H.C.1    Pang, C.Y.2    Hsu, H.S.3    Wei, Y.H.4
  • 12
    • 84859516931 scopus 로고    scopus 로고
    • Oxidative stress in developmental brain disorders
    • Hayashi, M.; Miyata, R.; Tanuma, N. Oxidative stress in developmental brain disorders. Adv. Exp. Med. Biol. 2012, 724, 278-290.
    • (2012) Adv. Exp. Med. Biol. , vol.724 , pp. 278-290
    • Hayashi, M.1    Miyata, R.2    Tanuma, N.3
  • 13
    • 2342429093 scopus 로고    scopus 로고
    • Oxidative stress in mild cognitive impairment and Alzheimer disease: A continuum
    • Mecocci, P. Oxidative stress in mild cognitive impairment and Alzheimer disease: A continuum. J. Alzheimer's Dis. 2004, 6, 159-163.
    • (2004) J. Alzheimer's Dis. , vol.6 , pp. 159-163
    • Mecocci, P.1
  • 15
    • 78649498783 scopus 로고    scopus 로고
    • DNA damage stress response in germ cells: Role of c-Abl and clinical implications
    • Gonfloni, S. DNA damage stress response in germ cells: Role of c-Abl and clinical implications. Oncogene 2010, 29, 6193-6202.
    • (2010) Oncogene , vol.29 , pp. 6193-6202
    • Gonfloni, S.1
  • 16
    • 77956920417 scopus 로고    scopus 로고
    • ABL tyrosine kinases: Evolution of function, regulation, and specificity
    • re6
    • Colicelli, J. ABL tyrosine kinases: Evolution of function, regulation, and specificity. Sci. Signal. 2010, 3, re6.
    • (2010) Sci. Signal. , vol.3
    • Colicelli, J.1
  • 17
    • 19644387170 scopus 로고    scopus 로고
    • Role of c-Abl in the DNA damage stress response
    • Shaul, Y.; Ben-Yehoyada, M. Role of c-Abl in the DNA damage stress response. Cell Res. 2005, 15, 33-35.
    • (2005) Cell Res. , vol.15 , pp. 33-35
    • Shaul, Y.1    Ben-Yehoyada, M.2
  • 18
    • 84863644570 scopus 로고    scopus 로고
    • Oxidative stress, DNA damage, and c-Abl signaling: At the crossroad in neurodegenerative diseases?
    • Gonfloni, S.; Maiani, E.; Di Bartolomeo, C.; Diederich, M.; Cesareni, G. Oxidative stress, DNA damage, and c-Abl signaling: At the crossroad in neurodegenerative diseases? Int. J. Cell Biol. 2012, 2012, 683097.
    • (2012) Int. J. Cell Biol. , vol.2012 , pp. 683097
    • Gonfloni, S.1    Maiani, E.2    Di Bartolomeo, C.3    Diederich, M.4    Cesareni, G.5
  • 19
    • 79959660090 scopus 로고    scopus 로고
    • Neuronal c-Abl overexpression leads to neuronal loss and neuroinflammation in the mouse forebrain
    • Schlatterer, S.D.; Tremblay, M.A.; Acker, C.M.; Davies, P. Neuronal c-Abl overexpression leads to neuronal loss and neuroinflammation in the mouse forebrain. J. Alzheimer's Dis. 2011, 25, 119-133.
    • (2011) J. Alzheimer's Dis. , vol.25 , pp. 119-133
    • Schlatterer, S.D.1    Tremblay, M.A.2    Acker, C.M.3    Davies, P.4
  • 20
    • 80054863696 scopus 로고    scopus 로고
    • Parkinson's disease and cancer: Two wars, one front
    • Devine, M.J.; Plun-Favreau, H.; Wood, N.W. Parkinson's disease and cancer: Two wars, one front. Nat. Rev. Cancer 2011, 11, 812-823.
    • (2011) Nat. Rev. Cancer , vol.11 , pp. 812-823
    • Devine, M.J.1    Plun-Favreau, H.2    Wood, N.W.3
  • 21
    • 0033152195 scopus 로고    scopus 로고
    • Endogenous apurinic/apyrimidinic sites in genomic DNA of mammalian tissues
    • Nakamura, J.; Swenberg, J.A. Endogenous apurinic/apyrimidinic sites in genomic DNA of mammalian tissues. Cancer Res.1999, 59, 2522-2526.
    • (1999) Cancer Res. , vol.59 , pp. 2522-2526
    • Nakamura, J.1    Swenberg, J.A.2
  • 23
    • 84862792679 scopus 로고    scopus 로고
    • DNA base excision repair: A mechanism of trinucleotide repeat expansion
    • Liu, Y.; Wilson, S.H. DNA base excision repair: A mechanism of trinucleotide repeat expansion. Trends Biochem. Sci. 2012, 37, 162-172.
    • (2012) Trends Biochem. Sci. , vol.37 , pp. 162-172
    • Liu, Y.1    Wilson, S.H.2
  • 24
    • 48249095920 scopus 로고    scopus 로고
    • Single-strand break repair and genetic disease
    • Caldecott, K.W. Single-strand break repair and genetic disease. Nat. Rev. Genet. 2008, 9, 619-631.
    • (2008) Nat. Rev. Genet. , vol.9 , pp. 619-631
    • Caldecott, K.W.1
  • 25
    • 32844458451 scopus 로고    scopus 로고
    • Mechanisms of eukaryotic DNA double strand break repair
    • Cahill, D.; Connor, B.; Carney, J.P. Mechanisms of eukaryotic DNA double strand break repair. Front. Biosci. 2006, 11, 1958-1976.
    • (2006) Front. Biosci. , vol.11 , pp. 1958-1976
    • Cahill, D.1    Connor, B.2    Carney, J.P.3
  • 27
    • 84867478618 scopus 로고    scopus 로고
    • New insights into the roles of ATM and DNA-PKcs in the cellular response to oxidative stress
    • Chen, B.P.; Li, M.; Asaithamby, A. New insights into the roles of ATM and DNA-PKcs in the cellular response to oxidative stress. Cancer Lett. 2012, 327, 103-110.
    • (2012) Cancer Lett. , vol.327 , pp. 103-110
    • Chen, B.P.1    Li, M.2    Asaithamby, A.3
  • 29
  • 30
    • 28444474288 scopus 로고    scopus 로고
    • DNA double strand break repair in brain: Reduced NHEJ activity in aging rat neurons
    • Vyjayanti, V.N.; Rao, K.S. DNA double strand break repair in brain: Reduced NHEJ activity in aging rat neurons. Neurosci. Lett. 2006, 393, 18-22.
    • (2006) Neurosci. Lett. , vol.393 , pp. 18-22
    • Vyjayanti, V.N.1    Rao, K.S.2
  • 31
    • 46149093913 scopus 로고    scopus 로고
    • Tissue-specific accelerated aging in nucleotide excision repair deficiency. Mechanisms of ageing and development
    • Niedernhofer, L.J. Tissue-specific accelerated aging in nucleotide excision repair deficiency. Mechanisms of ageing and development. Mech. Ageing Dev. 2008, 129, 408-415.
    • (2008) Mech. Ageing Dev. , vol.129 , pp. 408-415
    • Niedernhofer, L.J.1
  • 32
    • 38049178545 scopus 로고    scopus 로고
    • Transcription-coupled nucleotide excision repair in mammalian cells: Molecular mechanisms and biological effects
    • Fousteri, M.; Mullenders, L.H. Transcription-coupled nucleotide excision repair in mammalian cells: Molecular mechanisms and biological effects. Cell Res. 2008, 18, 73-84.
    • (2008) Cell Res. , vol.18 , pp. 73-84
    • Fousteri, M.1    Mullenders, L.H.2
  • 33
    • 38049164275 scopus 로고    scopus 로고
    • Eukaryotic nucleotide excision repair: From understanding mechanisms to influencing biology
    • Shuck, S.C.; Short, E.A.; Turchi, J.J. Eukaryotic nucleotide excision repair: From understanding mechanisms to influencing biology. Cell Res. 2008, 18, 64-72.
    • (2008) Cell Res. , vol.18 , pp. 64-72
    • Shuck, S.C.1    Short, E.A.2    Turchi, J.J.3
  • 34
    • 33845518305 scopus 로고    scopus 로고
    • DNA repair in neurons: So if they don't divide what's to repair?
    • Fishel, M.L.; Vasko, M.R.; Kelley, M.R. DNA repair in neurons: So if they don't divide what's to repair? Mut. Res. 2007, 614, 24-36.
    • (2007) Mut. Res. , vol.614 , pp. 24-36
    • Fishel, M.L.1    Vasko, M.R.2    Kelley, M.R.3
  • 35
  • 36
    • 33646187811 scopus 로고    scopus 로고
    • The multifaceted mismatch-repair system
    • Jiricny, J. The multifaceted mismatch-repair system. Nat. Rev. Mol. Cell Biol. 2006, 7, 335-346.
    • (2006) Nat. Rev. Mol. Cell Biol. , vol.7 , pp. 335-346
    • Jiricny, J.1
  • 38
    • 55449088400 scopus 로고    scopus 로고
    • Recruitment of mismatch repair proteins to the site of DNA damage in human cells
    • Hong, Z.; Jiang, J.; Hashiguchi, K.; Hoshi, M.; Lan, L.; Yasui, A. Recruitment of mismatch repair proteins to the site of DNA damage in human cells. J. Cell Sci. 2008, 121, 3146-3154.
    • (2008) J. Cell Sci. , vol.121 , pp. 3146-3154
    • Hong, Z.1    Jiang, J.2    Hashiguchi, K.3    Hoshi, M.4    Lan, L.5    Yasui, A.6
  • 39
    • 84870183760 scopus 로고    scopus 로고
    • DNA mismatch repair system: Repercussions in cellular homeostasis and relationship with aging
    • Conde-Perezprina, J.C.; Leon-Galvan, M.A.; Konigsberg, M. DNA mismatch repair system: Repercussions in cellular homeostasis and relationship with aging. Oxid. Med. Cell. Longevity 2012, 2012, 728430.
    • (2012) Oxid. Med. Cell. Longevity , vol.2012 , pp. 728430
    • Conde-Perezprina, J.C.1    Leon-Galvan, M.A.2    Konigsberg, M.3
  • 41
    • 0036139856 scopus 로고    scopus 로고
    • The mitochondrial production of reactive oxygen species: Mechanisms and implications in human pathology
    • Lenaz, G. The mitochondrial production of reactive oxygen species: Mechanisms and implications in human pathology. IUBMB Life 2001, 52, 159-164.
    • (2001) IUBMB Life , vol.52 , pp. 159-164
    • Lenaz, G.1
  • 44
    • 84867582500 scopus 로고    scopus 로고
    • Mitochondrial disturbances, excitotoxicity, neuroinflammation and kynurenines: Novel therapeutic strategies for neurodegenerative disorders
    • Zadori, D.; Klivenyi, P.; Szalardy, L.; Fulop, F.; Toldi, J.; Vecsei, L. Mitochondrial disturbances, excitotoxicity, neuroinflammation and kynurenines: Novel therapeutic strategies for neurodegenerative disorders. J. Neurol. Sci. 2012, 322, 187-191.
    • (2012) J. Neurol. Sci. , vol.322 , pp. 187-191
    • Zadori, D.1    Klivenyi, P.2    Szalardy, L.3    Fulop, F.4    Toldi, J.5    Vecsei, L.6
  • 45
    • 79955574688 scopus 로고    scopus 로고
    • Learning from oncocytic tumors: Why choose inefficient mitochondria?
    • Gasparre, G.; Romeo, G.; Rugolo, M.; Porcelli, A.M. Learning from oncocytic tumors: Why choose inefficient mitochondria? Biochim. Biophys. Acta 2011, 1807, 633-642.
    • (2011) Biochim. Biophys. Acta , vol.1807 , pp. 633-642
    • Gasparre, G.1    Romeo, G.2    Rugolo, M.3    Porcelli, A.M.4
  • 46
    • 84875103469 scopus 로고    scopus 로고
    • High level of oxidized nucleosides in thyroid mitochondrial DNA; damaging effects of Fenton reaction substrates
    • Karbownik-Lewi Ska, M.G.; St Pniak, J.; Lewi Ski, A. High level of oxidized nucleosides in thyroid mitochondrial DNA; damaging effects of Fenton reaction substrates. Thyroid Res. 2012, 5, 24.
    • (2012) Thyroid Res. , vol.5 , pp. 24
    • Karbownik-Lewi Ska, M.G.1    St Pniak, J.2    Lewi Ski, A.3
  • 47
    • 77953507107 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations in disease and aging
    • Wallace, D.C. Mitochondrial DNA mutations in disease and aging. Environ. Mol. Mutagen. 2010, 51, 440-450.
    • (2010) Environ. Mol. Mutagen. , vol.51 , pp. 440-450
    • Wallace, D.C.1
  • 48
    • 84880325519 scopus 로고    scopus 로고
    • Chronic progressive external ophthalmoplegia coexistent with motor neuron disease in a patient with a novel large-scale mitochondrial DNA deletion
    • doi:10.1016/j.clineuro.2012.11.011
    • Zhao, D.; Wang, Z.; Hong, D.; Zhang, W.; Yuan, Y. Chronic progressive external ophthalmoplegia coexistent with motor neuron disease in a patient with a novel large-scale mitochondrial DNA deletion. Clin. Neurol. Neurosurg. 2012, doi:10.1016/j.clineuro.2012.11.011.
    • (2012) Clin. Neurol. Neurosurg.
    • Zhao, D.1    Wang, Z.2    Hong, D.3    Zhang, W.4    Yuan, Y.5
  • 49
    • 84871750408 scopus 로고    scopus 로고
    • Mitochondrial targeting of recombinant RNAs modulates the level of a heteroplasmic mutation in human mitochondrial DNA associated with Kearns Sayre Syndrome
    • Comte, C.; Tonin, Y.; Heckel-Mager, A.M.; Boucheham, A.; Smirnov, A.; Aure, K.; Lornbes, A.; Martin, R.P.; Entelis, N.; Tarassov, I. Mitochondrial targeting of recombinant RNAs modulates the level of a heteroplasmic mutation in human mitochondrial DNA associated with Kearns Sayre Syndrome. Nucleic Acids Res. 2013, 41, 418-433.
    • (2013) Nucleic Acids Res. , vol.41 , pp. 418-433
    • Comte, C.1    Tonin, Y.2    Heckel-Mager, A.M.3    Boucheham, A.4    Smirnov, A.5    Aure, K.6    Lornbes, A.7    Martin, R.P.8    Entelis, N.9    Tarassov, I.10
  • 51
    • 84876501833 scopus 로고    scopus 로고
    • Neuroimaging characteristics in mitochondrial encephalopathies associated with the m.3243A>G MTTL1 mutation
    • doi:10.1007/s00415-012-6763-4
    • Tschampa, H.J.; Urbach, H.; Greschus, S.; Kunz, W.S.; Kornblum, C. Neuroimaging characteristics in mitochondrial encephalopathies associated with the m.3243A>G MTTL1 mutation. J. Neurol. 2012, doi:10.1007/s00415-012-6763-4.
    • (2012) J. Neurol.
    • Tschampa, H.J.1    Urbach, H.2    Greschus, S.3    Kunz, W.S.4    Kornblum, C.5
  • 53
    • 0025666322 scopus 로고
    • A mutation in the tRNA(Leu)(UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies
    • Goto, Y.; Nonaka, I.; Horai, S. A mutation in the tRNA(Leu)(UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies. Nature 1990, 348, 651-653.
    • (1990) Nature , vol.348 , pp. 651-653
    • Goto, Y.1    Nonaka, I.2    Horai, S.3
  • 54
    • 0025368281 scopus 로고
    • Myoclonic epilepsy and ragged-red fiber disease (MERRF) is associated with a mitochondrial DNA tRNA(Lys) mutation
    • Shoffner, J.M.; Lott, M.T.; Lezza, A.M.; Seibel, P.; Ballinger, S.W.; Wallace, D.C. Myoclonic epilepsy and ragged-red fiber disease (MERRF) is associated with a mitochondrial DNA tRNA(Lys) mutation. Cell 1990, 61, 931-937.
    • (1990) Cell , vol.61 , pp. 931-937
    • Shoffner, J.M.1    Lott, M.T.2    Lezza, A.M.3    Seibel, P.4    Ballinger, S.W.5    Wallace, D.C.6
  • 55
    • 84876815263 scopus 로고    scopus 로고
    • Late-onset Leigh syndrome with myoclonic epilepsy with ragged-red fibers
    • doi:10.1016/j.braindev.2012.08.006
    • Monden, Y.; Mori, M.; Kuwajima, M.; Goto, T.; Yamagata, T.; Momoi, M.Y. Late-onset Leigh syndrome with myoclonic epilepsy with ragged-red fibers. Brain Dev. 2012, doi:10.1016/j.braindev.2012.08.006.
    • (2012) Brain Dev.
    • Monden, Y.1    Mori, M.2    Kuwajima, M.3    Goto, T.4    Yamagata, T.5    Momoi, M.Y.6
  • 56
    • 0033972463 scopus 로고    scopus 로고
    • Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals
    • Barja, G.; Herrero, A. Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals. FASEB J. 2000, 14, 312-318.
    • (2000) FASEB J. , vol.14 , pp. 312-318
    • Barja, G.1    Herrero, A.2
  • 58
    • 0036790385 scopus 로고    scopus 로고
    • Oxidative stress, mitochondrial DNA mutation, and impairment of antioxidant enzymes in aging
    • Wei, Y.H.; Lee, H.C. Oxidative stress, mitochondrial DNA mutation, and impairment of antioxidant enzymes in aging. Exp. Biol. Med. (Maywood) 2002, 227, 671-682.
    • (2002) Exp. Biol. Med. (Maywood) , vol.227 , pp. 671-682
    • Wei, Y.H.1    Lee, H.C.2
  • 59
    • 33750347347 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
    • Lin, M.T.; Beal, M.F. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 2006, 443, 787-795.
    • (2006) Nature , vol.443 , pp. 787-795
    • Lin, M.T.1    Beal, M.F.2
  • 60
    • 0033624419 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease
    • Albers, D.S.; Beal, M.F. Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease. J. Neural Transm. Suppl. 2000, 59, 133-154.
    • (2000) J. Neural Transm. Suppl. , vol.59 , pp. 133-154
    • Albers, D.S.1    Beal, M.F.2
  • 61
    • 0000847978 scopus 로고    scopus 로고
    • Gene-expression profile of the ageing brain in mice
    • Lee, C.K.; Weindruch, R.; Prolla, T.A. Gene-expression profile of the ageing brain in mice. Nat. Genet. 2000, 25, 294-297.
    • (2000) Nat. Genet. , vol.25 , pp. 294-297
    • Lee, C.K.1    Weindruch, R.2    Prolla, T.A.3
  • 62
    • 84870721304 scopus 로고    scopus 로고
    • Comparison of mitochondrial mutation spectra in ageing human colonic epithelium and disease: Absence of evidence for purifying selection in somatic mitochondrial DNA point mutations
    • Greaves, L.C.; Elson, J.L.; Nooteboom, M.; Grady, J.P.; Taylor, G.A.; Taylor, R.W.; Mathers, J.C.; Kirkwood, T.B.; Turnbull, D.M. Comparison of mitochondrial mutation spectra in ageing human colonic epithelium and disease: Absence of evidence for purifying selection in somatic mitochondrial DNA point mutations. PLoS Genet. 2012, 8, e1003082.
    • (2012) PLoS Genet. , vol.8
    • Greaves, L.C.1    Elson, J.L.2    Nooteboom, M.3    Grady, J.P.4    Taylor, G.A.5    Taylor, R.W.6    Mathers, J.C.7    Kirkwood, T.B.8    Turnbull, D.M.9
  • 63
    • 77957938682 scopus 로고    scopus 로고
    • Somatic mutations of mitochondrial DNA in aging and cancer progression
    • Lee, H.C.; Chang, C.M.; Chi, C.W. Somatic mutations of mitochondrial DNA in aging and cancer progression. Ageing Res. Rev. 2010, 9, S47-S58.
    • (2010) Ageing Res. Rev. , vol.9
    • Lee, H.C.1    Chang, C.M.2    Chi, C.W.3
  • 64
    • 84871005673 scopus 로고    scopus 로고
    • The pathways of mitophagy for quality control and clearance of mitochondria
    • Ashrafi, G.; Schwarz, T.L. The pathways of mitophagy for quality control and clearance of mitochondria. Cell Death Differ. 2012, 20, 31-42.
    • (2012) Cell Death Differ. , vol.20 , pp. 31-42
    • Ashrafi, G.1    Schwarz, T.L.2
  • 65
    • 84865544952 scopus 로고    scopus 로고
    • Mitochondrial fission, fusion, and stress
    • Youle, R.J.; van der Bliek, A.M. Mitochondrial fission, fusion, and stress. Science 2012, 337, 1062-1065.
    • (2012) Science , vol.337 , pp. 1062-1065
    • Youle, R.J.1    van der Bliek, A.M.2
  • 67
    • 84866247628 scopus 로고    scopus 로고
    • DNA damage and base excision repair in mitochondria and their role in aging
    • Gredilla, R. DNA damage and base excision repair in mitochondria and their role in aging. J. Aging Res. 2010, 2011, 257093.
    • (2010) J. Aging Res. , vol.2011 , pp. 257093
    • Gredilla, R.1
  • 69
    • 33847666362 scopus 로고    scopus 로고
    • Intracellular trafficking and regulation of mammalian AP-endonuclease 1 (APE1), an essential DNA repair protein
    • Mitra, S.; Izumi, T.; Boldogh, I.; Bhakat, K.K.; Chattopadhyay, R.; Szczesny, B. Intracellular trafficking and regulation of mammalian AP-endonuclease 1 (APE1), an essential DNA repair protein. DNA Repair 2007, 6, 461-469.
    • (2007) DNA Repair , vol.6 , pp. 461-469
    • Mitra, S.1    Izumi, T.2    Boldogh, I.3    Bhakat, K.K.4    Chattopadhyay, R.5    Szczesny, B.6
  • 70
    • 84859598872 scopus 로고    scopus 로고
    • Biology of mitochondria in neurodegenerative diseases
    • Martin, L.J. Biology of mitochondria in neurodegenerative diseases. Prog. Mol. Biol. Transl. Sci. 2012, 107, 355-415.
    • (2012) Prog. Mol. Biol. Transl. Sci. , vol.107 , pp. 355-415
    • Martin, L.J.1
  • 71
    • 16844369889 scopus 로고    scopus 로고
    • Nuclear and mitochondrial DNA repair: Similar pathways?
    • Larsen, N.B.; Rasmussen, M.; Rasmussen, L.J. Nuclear and mitochondrial DNA repair: Similar pathways? Mitochondrion 2005, 5, 89-108.
    • (2005) Mitochondrion , vol.5 , pp. 89-108
    • Larsen, N.B.1    Rasmussen, M.2    Rasmussen, L.J.3
  • 72
    • 77953348161 scopus 로고    scopus 로고
    • Mitochondrial DNA repair and association with aging-An update
    • Gredilla, R.; Bohr, V.A.; Stevnsner, T. Mitochondrial DNA repair and association with aging-An update. Exp. Gerontol. 2010, 45, 478-488.
    • (2010) Exp. Gerontol. , vol.45 , pp. 478-488
    • Gredilla, R.1    Bohr, V.A.2    Stevnsner, T.3
  • 73
    • 84455177137 scopus 로고    scopus 로고
    • Mitochondrial dysfunction during brain aging: Role of oxidative stress and modulation by antioxidant supplementation
    • Chakrabarti, S.; Munshi, S.; Banerjee, K.; Thakurta, I.G.; Sinha, M.; Bagh, M.B. Mitochondrial dysfunction during brain aging: Role of oxidative stress and modulation by antioxidant supplementation. Aging Dis. 2011, 2, 242-256.
    • (2011) Aging Dis. , vol.2 , pp. 242-256
    • Chakrabarti, S.1    Munshi, S.2    Banerjee, K.3    Thakurta, I.G.4    Sinha, M.5    Bagh, M.B.6
  • 76
    • 30044434360 scopus 로고    scopus 로고
    • The mitochondrial theory of aging and its relationship to reactive oxygen species damage and somatic mtDNA mutations
    • Loeb, L.A.; Wallace, D.C.; Martin, G.M. The mitochondrial theory of aging and its relationship to reactive oxygen species damage and somatic mtDNA mutations. Proc. Natl. Acad. Sci. USA 2005, 102, 18769-18770.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 18769-18770
    • Loeb, L.A.1    Wallace, D.C.2    Martin, G.M.3
  • 77
    • 57649178442 scopus 로고    scopus 로고
    • Oxidative stress and energy crises in neuronal dysfunction
    • Nicholls, D.G. Oxidative stress and energy crises in neuronal dysfunction. Ann. N. Y. Acad. Sci. 2008, 1147, 53-60.
    • (2008) Ann. N. Y. Acad. Sci. , vol.1147 , pp. 53-60
    • Nicholls, D.G.1
  • 78
    • 13444271923 scopus 로고    scopus 로고
    • Mitochondrial biogenesis and mitochondrial DNA maintenance of mammalian cells under oxidative stress
    • Lee, H.C.; Wei, Y.H. Mitochondrial biogenesis and mitochondrial DNA maintenance of mammalian cells under oxidative stress. Int. J. Biochem. Cell Biol. 2005, 37, 822-834.
    • (2005) Int. J. Biochem. Cell Biol. , vol.37 , pp. 822-834
    • Lee, H.C.1    Wei, Y.H.2
  • 79
    • 42049114034 scopus 로고    scopus 로고
    • Transcriptional paradigms in mammalian mitochondrial biogenesis and function
    • Scarpulla, R.C. Transcriptional paradigms in mammalian mitochondrial biogenesis and function. Physiol. Rev. 2008, 88, 611-638.
    • (2008) Physiol. Rev. , vol.88 , pp. 611-638
    • Scarpulla, R.C.1
  • 80
    • 78650913154 scopus 로고    scopus 로고
    • Impaired redox signaling and antioxidant gene expression in endothelial cells in diabetes: A role for mitochondria and the nuclear factor-E2-related factor 2-Kelch-like ECH-associated protein 1 defense pathway
    • Cheng, X.; Siow, R.C.; Mann, G.E. Impaired redox signaling and antioxidant gene expression in endothelial cells in diabetes: A role for mitochondria and the nuclear factor-E2-related factor 2-Kelch-like ECH-associated protein 1 defense pathway. Antioxid. Redox Signal. 2011, 14, 469-487.
    • (2011) Antioxid. Redox Signal. , vol.14 , pp. 469-487
    • Cheng, X.1    Siow, R.C.2    Mann, G.E.3
  • 81
    • 33847050801 scopus 로고    scopus 로고
    • Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway
    • Kensler, T.W.; Wakabayashi, N.; Biswal, S. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Ann. Rev. Pharmacol. Toxicol. 2007, 47, 89-116.
    • (2007) Ann. Rev. Pharmacol. Toxicol. , vol.47 , pp. 89-116
    • Kensler, T.W.1    Wakabayashi, N.2    Biswal, S.3
  • 83
    • 0019980317 scopus 로고
    • Transforming gene of a human leukaemia cell is unrelated to the expressed tumour virus related gene of the cell
    • Ozanne, B.; Wheeler, T.; Zack, J.; Smith, G.; Dale, B. Transforming gene of a human leukaemia cell is unrelated to the expressed tumour virus related gene of the cell. Nature 1982, 299, 744-747.
    • (1982) Nature , vol.299 , pp. 744-747
    • Ozanne, B.1    Wheeler, T.2    Zack, J.3    Smith, G.4    Dale, B.5
  • 84
    • 80054714014 scopus 로고    scopus 로고
    • DNA damage response: The emerging role of c-Abl as a regulatory switch?
    • 1269-1266
    • Maiani, E.; Diederich, M.; Gonfloni, S. DNA damage response: The emerging role of c-Abl as a regulatory switch? Biochem. Pharmacol. 2011, 82, 1269-1266.
    • (2011) Biochem. Pharmacol. , vol.82
    • Maiani, E.1    Diederich, M.2    Gonfloni, S.3
  • 85
    • 78650403081 scopus 로고    scopus 로고
    • Reimagining Alzheimer's disease-An age-based hypothesis
    • Herrup, K. Reimagining Alzheimer's disease-An age-based hypothesis. J. Neurosci. 2010, 30, 16755-16762.
    • (2010) J. Neurosci. , vol.30 , pp. 16755-16762
    • Herrup, K.1
  • 86
    • 67849130954 scopus 로고    scopus 로고
    • Altered subcellular distribution of c-Abl in Alzheimer's disease
    • Jing, Z.; Caltagarone, J.; Bowser, R. Altered subcellular distribution of c-Abl in Alzheimer's disease. J. Alzheimer's Dis. 2009, 17, 409-422.
    • (2009) J. Alzheimer's Dis , vol.17 , pp. 409-422
    • Jing, Z.1    Caltagarone, J.2    Bowser, R.3
  • 88
    • 50849116386 scopus 로고    scopus 로고
    • STI571 prevents apoptosis, tau phosphorylation and behavioural impairments induced by Alzheimer's beta-amyloid deposits
    • Cancino, G.I.; Toledo, E.M.; Leal, N.R.; Hernandez, D.E.; Yévenes, L.F.; Inestrosa, N.C.; Alvarez, A.R. STI571 prevents apoptosis, tau phosphorylation and behavioural impairments induced by Alzheimer's beta-amyloid deposits. Brain 2008, 131, 2425-2442.
    • (2008) Brain , vol.131 , pp. 2425-2442
    • Cancino, G.I.1    Toledo, E.M.2    Leal, N.R.3    Hernandez, D.E.4    Yévenes, L.F.5    Inestrosa, N.C.6    Alvarez, A.R.7
  • 92
    • 0031418498 scopus 로고    scopus 로고
    • Neurodegenerative disorders in humans: The role of glutathione in oxidative stress-mediated neuronal death
    • Bains, J.S.; Shaw, C.A. Neurodegenerative disorders in humans: The role of glutathione in oxidative stress-mediated neuronal death. Brain Res. Brain Res. Rev. 1997, 25, 335-358.
    • (1997) Brain Res. Brain Res. Rev. , vol.25 , pp. 335-358
    • Bains, J.S.1    Shaw, C.A.2
  • 93
    • 79954575965 scopus 로고    scopus 로고
    • Glutathione depletion and overproduction both initiate degeneration of nigral dopaminergic neurons
    • Garrido, M.; Tereshchenko, Y.; Zhevtsova, Z.; Taschenberger, G.; Bahr, M.; Kugler, S. Glutathione depletion and overproduction both initiate degeneration of nigral dopaminergic neurons. Acta Neuropathol. 2011, 121, 475-485.
    • (2011) Acta Neuropathol. , vol.121 , pp. 475-485
    • Garrido, M.1    Tereshchenko, Y.2    Zhevtsova, Z.3    Taschenberger, G.4    Bahr, M.5    Kugler, S.6
  • 94
    • 0037097270 scopus 로고    scopus 로고
    • Elevation of brain glutathione by gamma-glutamylcysteine ethyl ester protects against peroxynitrite-induced oxidative stress
    • Drake, J.; Kanski, J.; Varadarajan, S.; Tsoras, M.; Butterfield, D.A. Elevation of brain glutathione by gamma-glutamylcysteine ethyl ester protects against peroxynitrite-induced oxidative stress. J. Neurosci. Res. 2002, 68, 776-784.
    • (2002) J. Neurosci. Res. , vol.68 , pp. 776-784
    • Drake, J.1    Kanski, J.2    Varadarajan, S.3    Tsoras, M.4    Butterfield, D.A.5
  • 96
    • 0028263070 scopus 로고
    • Structure and function of glutathione S-transferases
    • Wilce, M.C.; Parker, M.W. Structure and function of glutathione S-transferases. Biochim. Biophys. Acta 1994, 1205, 1-18.
    • (1994) Biochim. Biophys. Acta , vol.1205 , pp. 1-18
    • Wilce, M.C.1    Parker, M.W.2
  • 99
    • 84867316285 scopus 로고    scopus 로고
    • GST P1, a novel downstream regulator of LRRK2, G2019S-induced neuronal cell death
    • Chen, J.; Liou, A.; Zhang, L.; Weng, Z.; Gao, Y.; Cao, G.; Zigmond, M.J.; Chen, J. GST P1, a novel downstream regulator of LRRK2, G2019S-induced neuronal cell death. Front. Biosci. 2012, 4, 2365-2377.
    • (2012) Front. Biosci. , vol.4 , pp. 2365-2377
    • Chen, J.1    Liou, A.2    Zhang, L.3    Weng, Z.4    Gao, Y.5    Cao, G.6    Zigmond, M.J.7    Chen, J.8
  • 100
    • 41149163183 scopus 로고    scopus 로고
    • Parkinson's disease: Clinical features and diagnosis
    • Jankovic, J. Parkinson's disease: Clinical features and diagnosis. J. Neurol. Neurosurg. Psychiatry 2008, 79, 368-376.
    • (2008) J. Neurol. Neurosurg. Psychiatry , vol.79 , pp. 368-376
    • Jankovic, J.1
  • 101
    • 57649155208 scopus 로고    scopus 로고
    • Oxidative stress in Parkinson's disease: A mechanism of pathogenic and therapeutic significance
    • Zhou, C.; Huang, Y.; Przedborski, S. Oxidative stress in Parkinson's disease: A mechanism of pathogenic and therapeutic significance. Ann. N. Y. Acad. Sci. 2008, 1147, 93-104.
    • (2008) Ann. N. Y. Acad. Sci. , vol.1147 , pp. 93-104
    • Zhou, C.1    Huang, Y.2    Przedborski, S.3
  • 102
    • 49349106093 scopus 로고    scopus 로고
    • Redox imbalance in Parkinson's disease
    • Chinta, S.J.; Andersen, J.K. Redox imbalance in Parkinson's disease. Biochim. Biophys. Acta 2008, 1780, 1362-1367.
    • (2008) Biochim. Biophys. Acta , vol.1780 , pp. 1362-1367
    • Chinta, S.J.1    Andersen, J.K.2
  • 103
    • 0026034279 scopus 로고
    • Iron and aluminum increase in the substantia nigra of patients with Parkinson's disease: An X-ray microanalysis
    • Hirsch, E.C.; Brandel, J.P.; Galle, P.; Javoy-Agid, F.; Agid, Y. Iron and aluminum increase in the substantia nigra of patients with Parkinson's disease: An X-ray microanalysis. J. Neurochem. 1991, 56, 446-451.
    • (1991) J. Neurochem. , vol.56 , pp. 446-451
    • Hirsch, E.C.1    Brandel, J.P.2    Galle, P.3    Javoy-Agid, F.4    Agid, Y.5
  • 104
    • 0034776095 scopus 로고    scopus 로고
    • Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: Implications for Lewy-body formation in Parkinson disease
    • Chung, K.K.; Zhang, Y.; Lim, K.L.; Tanaka, Y.; Huang, H.; Gao, J.; Ross, C.A.; Dawson, V.L.; Dawson, T.M. Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: Implications for Lewy-body formation in Parkinson disease. Nat. Med. 2001, 7, 1144-1150.
    • (2001) Nat. Med. , vol.7 , pp. 1144-1150
    • Chung, K.K.1    Zhang, Y.2    Lim, K.L.3    Tanaka, Y.4    Huang, H.5    Gao, J.6    Ross, C.A.7    Dawson, V.L.8    Dawson, T.M.9
  • 105
  • 108
    • 0038206578 scopus 로고    scopus 로고
    • Gene microarrays in hippocampal aging: Statistical profiling identifies novel processes correlated with cognitive impairment
    • Blalock, E.M.; Chen, K.C.; Sharrow, K.; Herman, J.P.; Porter, N.M.; Foster, T.C.; Landfield, P.W. Gene microarrays in hippocampal aging: Statistical profiling identifies novel processes correlated with cognitive impairment. J. Neurosci. 2003, 23, 3807-3819.
    • (2003) J. Neurosci , vol.23 , pp. 3807-3819
    • Blalock, E.M.1    Chen, K.C.2    Sharrow, K.3    Herman, J.P.4    Porter, N.M.5    Foster, T.C.6    Landfield, P.W.7
  • 109
  • 111
    • 0035170381 scopus 로고    scopus 로고
    • Pathophysiology of bradykinesia in Parkinson's disease
    • Berardelli, A.; Rothwell, J.C.; Thompson, P.D.; Hallett, M. Pathophysiology of bradykinesia in Parkinson's disease. Brain 2001, 124, 2131-2146.
    • (2001) Brain , vol.124 , pp. 2131-2146
    • Berardelli, A.1    Rothwell, J.C.2    Thompson, P.D.3    Hallett, M.4
  • 114
    • 84860471851 scopus 로고    scopus 로고
    • Role of alpha-synuclein protein levels in mitochondrial morphology and cell survival in cell lines
    • Zhu, M.; Li, W.; Lu, C. Role of alpha-synuclein protein levels in mitochondrial morphology and cell survival in cell lines. PLoS One 2012, 7, e36377.
    • (2012) PLoS One , vol.7
    • Zhu, M.1    Li, W.2    Lu, C.3
  • 116
    • 0036014117 scopus 로고    scopus 로고
    • Mutant and wild-type alpha-synuclein interact with mitochondrial cytochrome C oxidase
    • Elkon, H.; Don, J.; Melamed, E.; Ziv, I.; Shirvan, A.; Offen, D. Mutant and wild-type alpha-synuclein interact with mitochondrial cytochrome C oxidase. J. Mol. Neurosci. 2002, 18, 229-238.
    • (2002) J. Mol. Neurosci. , vol.18 , pp. 229-238
    • Elkon, H.1    Don, J.2    Melamed, E.3    Ziv, I.4    Shirvan, A.5    Offen, D.6
  • 117
    • 0034007822 scopus 로고    scopus 로고
    • Pathoanatomy of Parkinson's disease
    • Braak, H.; Braak, E. Pathoanatomy of Parkinson's disease. J. Neurol. 2000, 247, II3-II10.
    • (2000) J. Neurol. , vol.247
    • Braak, H.1    Braak, E.2
  • 118
    • 84872195238 scopus 로고    scopus 로고
    • Mitochondria drive autophagy pathology via microtubule disassembly: A new hypothesis for Parkinson disease
    • Arduino, D.M.; Esteves, A.R.; Cardoso, S.M. Mitochondria drive autophagy pathology via microtubule disassembly: A new hypothesis for Parkinson disease. Autophagy 2012, 9, 112-114.
    • (2012) Autophagy , vol.9 , pp. 112-114
    • Arduino, D.M.1    Esteves, A.R.2    Cardoso, S.M.3
  • 119
    • 84872345893 scopus 로고    scopus 로고
    • Existing and emerging mitochondrial-targeting therapies for altering Parkinson's disease severity and progression
    • doi:10.1016/j.pharmthera.2012.08.010
    • Pienaar, I.S.; Chinnery, P.F. Existing and emerging mitochondrial-targeting therapies for altering Parkinson's disease severity and progression. Pharmacol. Ther. 2012, doi:10.1016/j.pharmthera.2012.08.010.
    • (2012) Pharmacol. Ther.
    • Pienaar, I.S.1    Chinnery, P.F.2
  • 121
    • 34547127902 scopus 로고    scopus 로고
    • PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1
    • Pridgeon, J.W.; Olzmann, J.A.; Chin, L.S.; Li, L. PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1. PLoS Biol. 2007, 5, e172.
    • (2007) PLoS Biol. , vol.5
    • Pridgeon, J.W.1    Olzmann, J.A.2    Chin, L.S.3    Li, L.4
  • 125
  • 127
    • 0032957883 scopus 로고    scopus 로고
    • Immunohistochemical and subcellular localization of Parkin protein: Absence of protein in autosomal recessive juvenile parkinsonism patients
    • Shimura, H.; Hattori, N.; Kubo, S.; Yoshikawa, M.; Kitada, T.; Matsumine, H.; Asakawa, S.; Minoshima, S.; Yamamura, Y.; Shimizu, N.; et al. Immunohistochemical and subcellular localization of Parkin protein: Absence of protein in autosomal recessive juvenile parkinsonism patients. Ann. Neurol. 1999, 45, 668-672.
    • (1999) Ann. Neurol. , vol.45 , pp. 668-672
    • Shimura, H.1    Hattori, N.2    Kubo, S.3    Yoshikawa, M.4    Kitada, T.5    Matsumine, H.6    Asakawa, S.7    Minoshima, S.8    Yamamura, Y.9    Shimizu, N.10
  • 129
    • 0031687793 scopus 로고    scopus 로고
    • Understanding cell death in Parkinson's disease
    • Jenner, P.; Olanow, C.W. Understanding cell death in Parkinson's disease. Ann. Neurol. 1998, 44, S72-S84.
    • (1998) Ann. Neurol. , vol.44
    • Jenner, P.1    Olanow, C.W.2
  • 130
    • 82555174637 scopus 로고    scopus 로고
    • Striatal dysfunctions associated with mitochondrial DNA damage in dopaminergic neurons in a mouse model of Parkinson's disease
    • Pickrell, A.M.; Pinto, M.; Hida, A.; Moraes, C.T. Striatal dysfunctions associated with mitochondrial DNA damage in dopaminergic neurons in a mouse model of Parkinson's disease. J. Neurosci. 2011, 31, 17649-17658.
    • (2011) J. Neurosci , vol.31 , pp. 17649-17658
    • Pickrell, A.M.1    Pinto, M.2    Hida, A.3    Moraes, C.T.4
  • 131
    • 84874809600 scopus 로고    scopus 로고
    • P73 and age-related diseases: Is there any link with Parkinson Disease?
    • Available online: (accessed on 5 December 2012)
    • Grespi, F.; Melino, G. P73 and age-related diseases: Is there any link with Parkinson Disease? Aging 2012, Available online: http://www.impactaging.com/papers/v4/n12/full/100515.html (accessed on 5 December 2012).
    • (2012) Aging
    • Grespi, F.1    Melino, G.2
  • 133
    • 79959960788 scopus 로고    scopus 로고
    • The c-Abl-MST1 signaling pathway mediates oxidative stress-induced neuronal cell death
    • Xiao, L.; Chen, D.; Hu, P.; Wu, J.; Liu, W.; Zhao, Y.; Cao, M.; Fang, Y.; Bi, W.; Zheng, Z.; et al. The c-Abl-MST1 signaling pathway mediates oxidative stress-induced neuronal cell death. J. Neurosci 2011, 31, 9611-9619.
    • (2011) J. Neurosci , vol.31 , pp. 9611-9619
    • Xiao, L.1    Chen, D.2    Hu, P.3    Wu, J.4    Liu, W.5    Zhao, Y.6    Cao, M.7    Fang, Y.8    Bi, W.9    Zheng, Z.10
  • 134
    • 0033825627 scopus 로고    scopus 로고
    • Oxidative stress and genetics in the pathogenesis of Parkinson's disease
    • Zhang, Y.; Dawson, V.L.; Dawson, T.M. Oxidative stress and genetics in the pathogenesis of Parkinson's disease. Neurobiol. Dis. 2000, 7, 240-250.
    • (2000) Neurobiol. Dis. , vol.7 , pp. 240-250
    • Zhang, Y.1    Dawson, V.L.2    Dawson, T.M.3


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