Mitochondrial DNA toxicity in forebrain neurons causes apoptosis, neurodegeneration, and impaired behavior

Molecular and Cellular Biology

Volumn 30, Issue 6, 2010, Pages 1357-1367

  Lauritzen, Knut H ^a   Moldestad, Olve ^b   Eide, Lars ^a   Carlsen, Harald ^b   Nesse, Gaute ^a   Storm, Johan F ^b   Mansuy, Isabelle M ^c   Bergersen, Linda H ^b   Klungland, Arne ^a,b  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

^c University of Zurich Brain Research Institute   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; PROTEIN MUTUNG 1; THYMINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; APOPTOSIS; APYRIMIDINIC SITE; ARTICLE; BEHAVIOR DISORDER; CELL DEATH; COGNITION; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; FOREBRAIN; GENE DELETION; GENE MUTATION; MOUSE; NERVE CELL; NERVE DEGENERATION; NONHUMAN; PREMATURE AGING; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ANXIETY; APOPTOSIS; ATROPHY; BEHAVIOR, ANIMAL; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CELL LINE; COGNITION; DENDRITIC SPINES; DNA, MITOCHONDRIAL; HUMANS; LOCOMOTION; MICE; MICE, TRANSGENIC; MITOCHONDRIA; MODELS, ANIMAL; MUTANT PROTEINS; NERVE DEGENERATION; NEURONS; PROSENCEPHALON; PYRAMIDAL CELLS; SYNAPSES; URACIL-DNA GLYCOSIDASE;

MUS;

EID: 77749330821     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.01149-09     Document Type: Article

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