Comparison of Mitochondrial Mutation Spectra in Ageing Human Colonic Epithelium and Disease: Absence of Evidence for Purifying Selection in Somatic Mitochondrial DNA Point Mutations

PLoS Genetics

Volumn 8, Issue 11, 2012, Pages

  Greaves, Laura C ^a   Elson, Joanna L ^a   Nooteboom, Marco ^a   Grady, John P ^a   Taylor, Geoffrey A ^a   Taylor, Robert W ^a   Mathers, John C ^a   Kirkwood, Thomas B L ^a   Turnbull, Doug M ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA;

AGED; AGING; ARTICLE; CELL EXPANSION; COLON DISEASE; COLON MUCOSA; COMPARATIVE STUDY; CONTROLLED STUDY; DNA SEQUENCE; FRAMESHIFT MUTATION; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOME ANALYSIS; HUMAN; HUMAN TISSUE; MUTATIONAL ANALYSIS; PATHOGENICITY; POINT MUTATION; POPULATION GENETICS; SOMATIC CELL;

AGING; COLON; DNA, MITOCHONDRIAL; EPITHELIUM; GERM-LINE MUTATION; HUMANS; MITOCHONDRIA; MUTATION; POINT MUTATION; SELECTION, GENETIC;

EID: 84870721304     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1003082     Document Type: Article

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