The mitochondrial theory of aging and its relationship to reactive oxygen species damage and somatic mtDNA mutations

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 52, 2005, Pages 18769-18770

  Loeb, Lawrence A ^a   Wallace, Douglas C ^b   Martin, George M ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALANINE; ASPARTIC ACID; CATALASE; DNA DIRECTED DNA POLYMERASE GAMMA; EXONUCLEASE; HYDROCARBON; MESSENGER RNA; MITOCHONDRIAL DNA; MITOCHONDRIAL PROTEIN; OXYGEN; REACTIVE OXYGEN METABOLITE;

AGE; AGING; AMINO ACID SUBSTITUTION; DNA DAMAGE; DNA REPLICATION; DNA SYNTHESIS; ENZYME ACTIVITY; GENE DELETION; HUMAN; LIFESPAN; MITOCHONDRIAL DNA DISORDER; MUTATION RATE; NONHUMAN; NOTE; NUCLEIC ACID BASE SUBSTITUTION; OXYGEN CONSUMPTION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RESPIRATORY CHAIN; SOMATIC MUTATION;

ADENOSINE TRIPHOSPHATE; AGING; ANIMALS; APOPTOSIS; BACTERIA; CELL AGING; DNA DAMAGE; DNA, MITOCHONDRIAL; DNA-DIRECTED DNA POLYMERASE; FREE RADICALS; HUMANS; MICE; MITOCHONDRIA; MODELS, BIOLOGICAL; MUTATION; PHENOTYPE; REACTIVE OXYGEN SPECIES;

EID: 30044434360     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0509776102     Document Type: Note

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