The mitochondrial production of reactive oxygen species: Mechanisms and implications in human pathology

IUBMB Life

Volumn 52, Issue 3-5, 2001, Pages 159-164

  Lenaz, G ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Coenzyme p; Complex I; Complex III; Mitochondria; Reactive oxygen species

Indexed keywords

DIHYDROOROTATE DEHYDROGENASE; GLYCEROL 3 PHOSPHATE DEHYDROGENASE; MITOCHONDRIAL ENZYME; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE (UBIQUINONE); SUPEROXIDE; UBIQUINOL CYTOCHROME C REDUCTASE;

ELECTRON TRANSPORT; ENZYME DEFECT; HUMAN; MITOCHONDRIAL MEMBRANE; OXIDATION REDUCTION STATE; RESPIRATORY CHAIN; REVIEW; SIGNAL TRANSDUCTION;

EID: 0036139856     PISSN: 15216543     EISSN: None     Source Type: Journal    
DOI: 10.1080/15216540152845957     Document Type: Review

References (46)

1. The cellular production of hydrogen peroxide
2. Mitochondrial disease in superoxide dismutase 2 mutant mice
3. Mitochondrial oxidative stress in mice lacking the glutathione peroxidase-1 gene
4. Hydroxyl radical generation during mitochondrial electron transfer and the formation of 8-hydroxydesoxyguanosine in mitochondrial DNA
5. Mitochondrial respiratory chain-dependent generation of superoxide anion and its release into the intermembrane space
6. Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria
7. Substrate and site specificity of hydrogen peroxide generation in mouse mitochondria
8. 2 formation: Relationship with energy conservation
9. 1 complex
10. 1 site of the mitochondrial respiratory chain
11. Role of mitochondria in oxidative stress and aging
12. Conditions allowing redox-cycling ubisemiquinone in mitochondria to establish a direct redox couple with molecular oxygen
13. Antioxidant-derived prooxidant formation from ubiquinol
14. Superoxides from mitochondrial Complex III: The role of manganese superoxide dismutase
15. The site of production of superoxide radical in mitochondrial Complex I is not a bound ubisemquinone but presumably iron-sulfur cluster N2
16. NADH and NADPH-dependent formation of superoxide anions by bovine heart submitochondrial particles and NADH-ubiquinone reductase preparation
17. Production of superoxide radicals and hydrogen peroxide by NADHubiquinone reductase and ubiquinol-cytochrome c reductase from beef heart mitochondria
18. Redox cycling of anthracyclines by cardiac mitochondria. I. Anthracycline radical formation by NADH dehydrogenase
19. The interaction of Q analogs, particularly hydroxydecyl benzoquinone (idebenone), with the respiratory complexes of heart mitochondria
20. Mitochondrial oxygen radical generation and leak: Sites of production in states 4 and 3, organ specificity, and relation to aging and longevity
21. Localization of the site of oxygen radical generation inside the complex I of heart and nonsynaptic brain mammalian mitochondria
22. The contribution of mitochondrial respiratory complexes to the production of reactive oxygen species
23. Inhibitors of NADH-ubiquinone reductase: An overview
24. Iron-sulfur clusters/semiquinones in Complex I
25. Modelling the effects of age-related mtDNA mutation accumulation: Complex I deficiency, superoxide and cell death
26. A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes
27. Generation of superoxide anion by succinate cytochrome c reductase from bovine heart mitochondria
28. Extramitochondrial release of hydrogen peroxide from insect and mouse liver mitochondria using the respiratory inhibitors phosphine, myxothiazol, and antimycin and spectral analysis of inhibited cytochromes
29. Specific properties of Coenzyme Q function in brown adipose tissue cells
30. Superoxide production and electron transport in mitochondrial oxidation of dihydroorotic acid
31. Malarial dihydroorotate dehydrogenase mediates superoxide radical production
32. Are mitochondria a permanent source of reactive oxygen species?
33. High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria
34. Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants
35. Uncoupling to survive? The role of mitochondrial inefficiency in ageing
36. Mutations in mitochondrial cytochrome c oxidase genes segregate with late onset Alzheimer disease
37. Mitochondrial energy metabolism is regulated via nuclear-coded subunits of cytochrome c oxidase
38. Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species
39. Superoxide in apoptosis. Mitochondrial generation triggered by cytochrome c loss
40. Arachidonic acid interaction with the mitochondrial electron transport chain promotes reactive oxygen species generation
41. Arachidonic acid causes cell death through the mitochondrial permeability transition
42. Titrating the effects of mitochondrial Complex I impairment in the cell physiology
43. Mitochondrial Complex I deficiency leads to increased production of superoxide radicals and induction of superoxide dismutase
44. mtDNA mutations confer cellular sensitivity to oxidant stress that is partly rescued by calcium depletion and cyclosporin A
45. Origin and functional consequences of the Complex I defect in Parkinson's disease
46. A rapid bioessay for chemicals that induce pro-oxidant states