Mitochondrial targeting of recombinant RNAs modulates the level of a heteroplasmic mutation in human mitochondrial DNA associated with Kearns Sayre Syndrome

Nucleic Acids Research

Volumn 41, Issue 1, 2013, Pages 418-433

  Comte, Caroline ^a   Tonin, Yann ^a   Heckel Mager, Anne Marie ^a   Boucheham, Abdeldjalil ^a   Smirnov, Alexandre ^a,c   Auré, Karine ^b,d   Lombès, Anne ^b   Martin, Robert P ^a   Entelis, Nina ^a   Tarassov, Ivan ^a  

^a Université de Strasbourg   (France)

^b INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE   (France)

^c UNIVERSITY OF WÜRZBURG   (Germany)

^d HÔPITAL AMBROISE PARÉ   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CREATINE KINASE; CYTOCHROME C OXIDASE; LACTIC ACID; MITOCHONDRIAL DNA; OLIGORIBONUCLEOTIDE; RECOMBINANT RNA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); RNA 5S; TRANSFER RNA; UBIQUINOL CYTOCHROME C REDUCTASE;

ADOLESCENT; ANIMAL CELL; ARTICLE; CASE REPORT; CEREBROSPINAL FLUID LEVEL; CLINICAL FEATURE; CONTROLLED STUDY; DNA REPLICATION; DNA SEQUENCE; GENE DELETION; GENE MUTATION; GENE TARGETING; GENETIC ASSOCIATION; HETEROPLASMY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYBRID CELL; KEARNS SAYRE SYNDROME; LACTATE BLOOD LEVEL; LIVER MITOCHONDRION; MALE; NEUROIMAGING; NONHUMAN; NONVIRAL GENE THERAPY; PRIORITY JOURNAL; RNA STABILITY; RNA TRANSPORT; RNA VECTOR; SOUTHERN BLOTTING; STABLE EXPRESSION;

ADOLESCENT; DNA REPLICATION; DNA, MITOCHONDRIAL; GENETIC VECTORS; HUMANS; KEARNS-SAYRE SYNDROME; MALE; MITOCHONDRIA; MUTATION; OLIGORIBONUCLEOTIDES; RNA TRANSPORT; TRANSFECTION;

EID: 84871750408     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gks965     Document Type: Article

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