Role of alpha-synuclein protein levels in mitochondrial morphology and cell survival in cell lines

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Zhu, Min ^a,b   Li, Wenwei ^a,b   Lu, Chuanzhen ^b  

^a FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; 1 METHYL 4 PHENYLPYRIDINIUM; DOPAMINE;

ARTICLE; CELL LINE; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; GENE SILENCING; MITOCHONDRION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; ANIMAL; CELL STRAIN; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; HELA CELL; HUMAN; METABOLISM; PROTEIN TRANSPORT; RAT;

1-METHYL-4-PHENYLPYRIDINIUM; ALPHA-SYNUCLEIN; ANIMALS; CELL SURVIVAL; DOPAMINE; GENE EXPRESSION REGULATION; HELA CELLS; HUMANS; MITOCHONDRIA; PC12 CELLS; PROTEIN TRANSPORT; RATS;

EID: 84860471851     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0036377     Document Type: Article

References (49)

1. Maroteaux L, Campanelli JT, Scheller RH, (1988) Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal. J Neurosci 8: 2804-2815.
2. Andringa G, Du F, Chase TN, Bennett MC, (2003) Mapping of rat brain using the Synuclein-1 monoclonal antibody reveals somatodendritic expression of alpha-synuclein in populations of neurons homologous to those vulnerable to Lewy body formation in human synucleopathies. J Neuropathol Exp Neurol 62: 1060-1075.
3. Nussbaum RL, Polymeropoulos MH, (1997) Genetics of Parkinson's disease. Hum Mol Genet 6: 1687-1691.
4. Spillantini MG, Schmidt ML, Lee VM, Trojanowski JQ, Jakes R, et al. (1997) Alpha-synuclein in Lewy bodies. Nature 388: 839-840.
5. Iwai A, (2000) Properties of NACP/alpha-synuclein and its role in Alzheimer's disease. Biochim Biophys Acta 1502: 95-109.
6. Fung KM, Rorke LB, Giasson B, Lee VM, Trojanowski JQ, (2003) Expression of alpha-, beta-, and gamma-synuclein in glial tumors and medulloblastomas. Acta Neuropathol 106: 167-175.
7. Bruening W, Giasson BI, Klein-Szanto AJ, Lee VM, Trojanowski JQ, et al. (2000) Synucleins are expressed in the majority of breast and ovarian carcinomas and in preneoplastic lesions of the ovary. Cancer 88: 2154-2163.
8. von Bohlen und Halbach O, Schober A, Krieglstein K, (2004) Genes, proteins, and neurotoxins involved in Parkinson's disease. Prog Neurobiol 73: 151-177.
9. Heikkila RE, Manzino L, Cabbat FS, Duvoisin RC, (1984) Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors. Nature 311: 467-469.
10. Javitch JA, D'Amato RJ, Strittmatter SM, Snyder SH, (1985) Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. Proc Natl Acad Sci U S A 82: 2173-2177.
11. Vila M, Vukosavic S, Jackson-Lewis V, Neystat M, Jakowec M, et al. (2000) Alpha-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP. J Neurochem 74: 721-729.
12. Dauer W, Kholodilov N, Vila M, Trillat AC, Goodchild R, et al. (2002) Resistance of alpha-synuclein null mice to the parkinsonian neurotoxin MPTP. Proc Natl Acad Sci U S A 99: 14524-14529.
13. Song DD, Shults CW, Sisk A, Rockenstein E, Masliah E, (2004) Enhanced substantia nigra mitochondrial pathology in human alpha-synuclein transgenic mice after treatment with MPTP. Exp Neurol 186: 158-172.
14. Martin LJ, Pan Y, Price AC, Sterling W, Copeland NG, et al. (2006) Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death. J Neurosci 26: 41-50.
15. Stichel CC, Zhu XR, Bader V, Linnartz B, Schmidt S, et al. (2007) Mono- and double-mutant mouse models of Parkinson's disease display severe mitochondrial damage. Hum Mol Genet 16: 2377-2393.
16. Buttner S, Bitto A, Ring J, Augsten M, Zabrocki P, et al. (2008) Functional mitochondria are required for alpha-synuclein toxicity in aging yeast. J Biol Chem 283: 7554-7560.
17. Li WW, Yang R, Guo JC, Ren HM, Zha XL, et al. (2007) Localization of alpha-synuclein to mitochondria within midbrain of mice. Neuroreport 18: 1543-1546.
18. Devi L, Raghavendran V, Prabhu BM, Avadhani NG, Anandatheerthavarada HK, (2008) Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain. J Biol Chem 283: 9089-9100.
19. Parihar MS, Parihar A, Fujita M, Hashimoto M, Ghafourifar P, (2008) Mitochondrial association of alpha-synuclein causes oxidative stress. Cell Mol Life Sci 65: 1272-1284.
20. Kamp F, Exner N, Lutz AK, Wender N, Hegermann J, et al. (2010) Inhibition of mitochondrial fusion by alpha-synuclein is rescued by PINK1, Parkin and DJ-1. EMBO J 29: 3571-3589.
21. Nakamura K, Nemani VM, Azarbal F, Skibinski G, Levy JM, et al. (2011) Direct membrane association drives mitochondrial fission by the Parkinson Disease-associated protein {alpha}-synuclein. J Biol Chem 286 (23): 20710-20726.
22. Weinreb PH, Zhen W, Poon AW, Conway KA, Lansbury PT Jr, (1996) NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded. Biochemistry 35: 13709-13715.
23. Uversky VN, Li J, Fink AL, (2001) Evidence for a partially folded intermediate in alpha-synuclein fibril formation. J Biol Chem 276: 10737-10744.
24. Uversky VN, (2003) A protein-chameleon: conformational plasticity of alpha-synuclein, a disordered protein involved in neurodegenerative disorders. J Biomol Struct Dyn 21: 211-234.
25. Eisenberg I, Novershtern N, Itzhaki Z, Becker-Cohen M, Sadeh M, et al. (2008) Mitochondrial processes are impaired in hereditary inclusion body myopathy. Hum Mol Genet 17: 3663-3674.
26. Koopman WJ, Verkaart S, Visch HJ, van der Westhuizen FH, Murphy MP, et al. (2005) Inhibition of complex I of the electron transport chain causes O2-.-mediated mitochondrial outgrowth. Am J Physiol Cell Physiol 288 (6): C1440-1450.
27. Mortiboys H, Thomas KJ, Koopman WJ, Klaffke S, Abou-Sleiman P, et al. (2008) Mitochondrial function and morphology are impaired in parkin-mutant fibroblasts. Ann Neurol 64: 555-565.
28. Wang X, Su B, Liu W, He X, Gao Y, et al. (2011) DLP1-dependent mitochondrial fragmentation mediates 1-methyl-4-phenylpyridinium toxicity in neurons: implications for Parkinson's disease. Aging Cell 10 (5): 807-823.
29. Bereiter-Hahn J, Voth M, (1994) Dynamics of mitochondria in living cells: shape changes, dislocations, fusion, and fission of mitochondria. Microsc Res Tech 27: 198-219.
30. Detmer SA, Chan DC, (2007) Complementation between mouse Mfn1 and Mfn2 protects mitochondrial fusion defects caused by CMT2A disease mutations. J Cell Biol 176: 405-414.
31. Cho DH, Nakamura T, Lipton SA, (2010) Mitochondrial dynamics in cell death and neurodegeneration. Cell Mol Life Sci 67: 3435-3447.
32. Chen H, Chan DC, (2009) Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases. Hum Mol Genet 18: R169-176.
33. Cho DH, Nakamura T, Lipton SA, (2010) Mitochondrial dynamics in cell death and neurodegeneration. Cell Mol Life Sci 67: 3435-3447.
34. Knott AB, Perkins G, Schwarzenbacher R, Bossy-Wetzel E, (2008) Mitochondrial fragmentation in neurodegeneration. Nat Rev Neurosci 9: 505-518.
35. Yang Y, Ouyang Y, Yang L, Beal MF, McQuibban A, et al. (2008) Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery. Proc Natl Acad Sci U S A 105: 7070-7075.
36. Cookson MR, (2009) alpha-Synuclein and neuronal cell death. Mol Neurodegener 4: 9.
37. Chen H, Chan DC, (2004) Mitochondrial dynamics in mammals. Curr Top Dev Biol 59: 119-144.
38. Chang DT, Reynolds IJ, (2006) Differences in mitochondrial movement and morphology in young and mature primary cortical neurons in culture. Neuroscience 141: 727-736.
39. Ishihara N, Nomura M, Jofuku A, Kato H, Suzuki SO, et al. (2009) Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice. Nat Cell Biol 11: 958-966.
40. Raghavan R, Kruijff L, Sterrenburg MD, Rogers BB, Hladik CL, et al. (2004) Alpha-synuclein expression in the developing human brain. Pediatr Dev Pathol 7: 506-516.
41. Ltic S, Perovic M, Mladenovic A, Raicevic N, Ruzdijic S, et al. (2004) Alpha-synuclein is expressed in different tissues during human fetal development. J Mol Neurosci 22: 199-204.
42. Abeliovich A, Schmitz Y, Farinas I, Choi-Lundberg D, Ho WH, et al. (2000) Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron 25: 239-252.
43. Steidl JV, Gomez-Isla T, Mariash A, Ashe KH, Boland LM, (2003) Altered short-term hippocampal synaptic plasticity in mutant alpha-synuclein transgenic mice. Neuroreport 14: 219-223.
44. Cabin DE, Shimazu K, Murphy D, Cole NB, Gottschalk W, et al. (2002) Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein. J Neurosci 22: 8797-8807.
45. Wirdefeldt K, Gatz M, Schalling M, Pedersen NL, (2004) No evidence for heritability of Parkinson disease in Swedish twins. Neurology 63: 305-311.
46. Piccini P, Burn DJ, Ceravolo R, Maraganore D, Brooks DJ, (1999) The role of inheritance in sporadic Parkinson's disease: evidence from a longitudinal study of dopaminergic function in twins. Ann Neurol 45: 577-582.
47. Tanner CM, Ottman R, Goldman SM, Ellenberg J, Chan P, et al. (1999) Parkinson disease in twins: an etiologic study. JAMA 281: 341-346.
48. Kingsbury AE, Daniel SE, Sangha H, Eisen S, Lees AJ, et al. (2004) Alteration in alpha-synuclein mRNA expression in Parkinson's disease. Mov Disord 19: 162-170.
49. Du H, Guo L, Fang F, Chen D, Sosunov AA, et al. (2008) Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease. Nat Med 14: 1097-1105.