Oxidative stress, DNA damage, and c-Abl signaling: At the crossroad in neurodegenerative diseases?

International Journal of Cell Biology

Volumn , Issue , 2012, Pages

  Gonfloni, Stefania ^a   Maiani, Emiliano ^a   Di Bartolomeo, Claudia ^a   Diederich, Marc ^b   Cesareni, Gianni ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b LABORATOIRE DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE DU CANCER   (Luxembourg)

Author keywords

[No Author keywords available]

Indexed keywords

ABELSON KINASE; AMYLOID BETA PROTEIN; IMATINIB; PEROXIREDOXIN 1; PROTEIN KINASE C DELTA; REACTIVE OXYGEN METABOLITE; TAU PROTEIN; UBIQUITIN PROTEIN LIGASE E3;

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; APOPTOSIS; AUTOPHAGY; CELL SURVIVAL; CEREBELLUM; DEGENERATIVE DISEASE; DISEASE COURSE; DNA DAMAGE; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; ENTORHINAL CORTEX; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME INHIBITION; FEEDBACK SYSTEM; HIPPOCAMPUS; HUMAN; HUNTINGTON CHOREA; METABOLIC REGULATION; MITOCHONDRION; NERVE CELL; NERVE CELL NECROSIS; NEUROFIBRILLARY TANGLE; NEUROTOXICITY; NIEMANN PICK DISEASE; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PURKINJE CELL; REVIEW; SIGNAL TRANSDUCTION;

MUS;

EID: 84863644570     PISSN: 16878876     EISSN: 16878884     Source Type: Journal    
DOI: 10.1155/2012/683097     Document Type: Review

References (60)

1. Murphy M. P., How mitochondria produce reactive oxygen species Biochemical Journal 2009 417 1 1 13
2. Fraga C. G., Shigenaga M. K., Park J. W., Degan P., Ames B. N., Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine Proceedings of the National Academy of Sciences of the United States of America 1990 87 12 4533 4537
3. Niki E., Lipid peroxidation: physiological levels and dual biological effects Free Radical Biology and Medicine 2009 47 5 469 484
4. Ugarte N., Petropoulos I., Friguet B., Oxidized mitochondrial protein degradation and repair in aging and oxidative stress Antioxidants and Redox Signaling 2010 13 4 539 549
5. Flohé L., Toppo S., Cozza G., Ursini F., A comparison of thiol peroxidase mechanisms Antioxidants and Redox Signaling 2011 15 3 763 780
6. Yu B. P., Cellular defenses against damage from reactive oxygen species Physiological Reviews 1994 74 1 139 162 (Pubitemid 24045676)
7. Vurusaner B., Poli G., Basaga H., Tumor suppressor genes and ROS: complex networks of interactions Free Radical Biology and Medicine 2012 52 7 18
8. Martindale J. L., Holbrook N. J., Cellular response to oxidative stress: signaling for suicide and survival Journal of Cellular Physiology 2002 192 1 1 15 (Pubitemid 34587382)
9. Ditch S., Paull T. T., The ATM protein kinase and cellular redox signaling: beyond the DNA damage response Trends in Biochemical Sciences 2012 37 15 22
10. Chen B. P., Li M., Asaithamby A., New insights into the roles of ATM and DNA-PKcs in the cellular response to oxidative stress. Cancer Letters. In press
11. Maiani E., Diederich M., Gonfloni S., DNA damage response: the emerging role of c-Abl as a regulatory switch? Biochemical Pharmacology 2011 82 1269 1276
12. Imam S. Z., Indig F. E., Cheng W. H., Saxena S. P., Stevnsner T., Kufe D., Bohr V. A., Cockayne syndrome protein B interacts with and is phosphorylated by c-Abl tyrosine kinase Nucleic Acids Research 2007 35 15 4941 4951 (Pubitemid 47394181)
13. D'Autréaux B., Toledano M. B., ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis Nature Reviews Molecular Cell Biology 2007 8 10 813 824 (Pubitemid 47462134)
14. Sun X., Wu F., Datta R., Kharbanda S., Kufe D., Interaction between protein kinase C and the c-Abl tyrosine kinase in the cellular response to oxidative stress The Journal of Biological Chemistry 2000 275 11 7470 7473 (Pubitemid 30159641)
15. Cao C., Ren X., Kharbanda S., Koleske A., Prasad K. V. S., Kufe D., The ARG tyrosine kinase interacts with Siva-1 in the apoptotic response to oxidative stress The Journal of Biological Chemistry 2001 276 15 11465 11468
16. Cao C., Leng Y., Liu X., Yi Y., Li P., Kufe D., Catalase is regulated by ubiquitination and proteosomal degradation. Role of the c-Abl and Arg tyrosine kinases Biochemistry 2003 42 35 10348 10353 (Pubitemid 37071434)
17. Li B., Wang X., Rasheed N., Hu Y., Boast S., Ishii T., Nakayama K., Nakayama K. I., Golf S. P., Distinct roles of c-Abl and Atm in oxidative stress response are mediated by protein kinase C Genes and Development 2004 18 15 1824 1837 (Pubitemid 39025093)
18. Wen S. T., Van Etten R. A., The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity Genes and Development 1997 11 19 2456 2467 (Pubitemid 27438828)
19. Cao C., Leng Y., Huang W., Liu X., Kufe D., Glutathione peroxidase 1 is regulated by the c-Abl and Arg tyrosine kinases The Journal of Biological Chemistry 2003 278 41 39609 39614 (Pubitemid 37248520)
20. Leonberg A. K., Chai Y. C., The functional role of cysteine residues for c-Abl kinase activity Molecular and Cellular Biochemistry 2007 304 1-2 207 212 (Pubitemid 47456867)
21. Schlatterer S. D., Tremblay M. A., Acker C. M., Davies P., Neuronal c-Abl overexpression leads to neuronal loss and neuroinflammation in the mouse forebrain Journal of Alzheimer's Disease 2011 25 1 119 133
22. Yoshida K., Yamaguchi T., Natsume T., Kufe D., Miki Y., JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage Nature Cell Biology 2005 7 3 278 285 (Pubitemid 40331129)
23. Jing Z., Caltagarone J., Bowser R., Altered subcellular distribution of c-Abl in alzheimer's disease Journal of Alzheimer's Disease 2009 17 2 409 422
24. Tremblay M. A., Acker C. M., Davies P., Tau phosphorylated at tyrosine 394 is found in Alzheimer's disease tangles and can be a product of the abl-related kinase, Arg Journal of Alzheimer's Disease 2010 19 2 721 733
25. Derkinderen P., Scales T. M. E., Hanger D. P., Leung K. Y., Byers H. L., Ward M. A., Lenz C., Price C., Bird I. N., Perera T., Kellie S., Williamson R., Noble W., Van Etten R. A., Leroy K., Brion J. P., Reynolds C. H., Anderton B. H., Tyrosine 394 is phosphorylated in Alzheimer's paired helical filament tau and in fetal tau with c-Abl as the candidate tyrosine kinase Journal of Neuroscience 2005 25 28 6584 6593 (Pubitemid 40995290)
26. Alvarez A. R., Sandoval P. C., Leal N. R., Castro P. U., Kosik K. S., Activation of the neuronal c-Abl tyrosine kinase by amyloid- -peptide and reactive oxygen species Neurobiology of Disease 2004 17 2 326 336 (Pubitemid 39345788)
27. Cancino G. I., Toledo E. M., Leal N. R., Hernandez D. E., Yévenes L. F., Inestrosa N. C., Alvarez A. R., STI571 prevents apoptosis, tau phosphorylation and behavioural impairments induced by Alzheimer's -amyloid deposits Brain 2008 131 9 2425 2442
28. Klein A., Maldonado C., Vargas L. M., Gonzalez M., Robledo F., Perez de Arce K., Muoz F. J., Hetz C., Alvarez A. R., Zanlungo S., Oxidative stress activates the c-Abl/p73 proapoptotic pathway in Niemann-Pick type C neurons Neurobiology of Disease 2011 41 1 209 218
29. Alvarez A. R., Klein A., Castro J., Cancino G. I., Amigo J., Mosqueira M., Vargas L. M., Yévenes L. F., Bronfman F. C., Zanlungo S., Imatinib therapy blocks cerebellar apoptosis and improves neurological symptoms in a mouse model of Niemann-Pick type C disease The FASEB Journal 2008 22 10 3617 3627
30. Jia D. Y., Du Z. H., Liu S. M., Liu H. J., Wang F. W., Ling E. A., Liu K., Hao A. J., c-Abl is involved in high glucose-induced apoptosis in embryonic E12.5 cortical neural progenitor cells from the mouse brain Journal of Neurochemistry 2008 106 4 1720 1730
31. Lee J. H., Jeong M. W., Kim W., Yoon H. C., Kim K. T., Cooperative roles of c-Abl and Cdk5 in regulation of p53 in response to oxidative stress The Journal of Biological Chemistry 2008 283 28 19826 19835
32. Liu S., Yuan Q., Zhao S., Wang J., Guo Y., Wang F., Zhang Y., Liu Q., Zhang S., Ling E. A., Hao A., High glucose induces apoptosis in embryonic neural progenitor cells by a pathway involving protein PKC Cellular Signalling 2011 23 8 1366 1374
33. Lee H. P., Pancholi N., Esposito L., Previll L. A., Wang X., Zhu X., Early induction of oxidative stress in mouse model of Alzheimer disease with reduced mitochondrial superoxide dismutase activity PLoS One 2012 7
34. Alam Z. I., Jenner A., Daniel S. E., Lees A. J., Cairns N., Marsden C. D., Jenner P., Halliwell B., Oxidative DNA damage in the Parkinsonian brain: an apparent selective increase in 8-hydroxyguanine levels in substantia nigra Journal of Neurochemistry 1997 69 3 1196 1203 (Pubitemid 27364841)
35. Ko H. S., Lee Y., Shin J. H., Karuppagounder S. S., Gadad B. S., Koleske A. J., Pletnikova O., Troncoso J. C., Dawson V. L., Dawson T. M., Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function Proceedings of the National Academy of Sciences of the United States of America 2010 107 38 16691 16696
36. Imam S. Z., Zhou Q., Yamamoto A., Valente A. J., Ali S. F., Bains M., Roberts J. L., Kahle P. J., Clark R. A., Li S., Novel regulation of Parkin function through c-Abl-mediated tyrosine phosphorylation: Implications for Parkinson's disease Journal of Neuroscience 2011 31 1 157 163
37. Kanthasamy A. G., Kitazawa M., Kaul S., Yang Y., Lahiri D. K., Anantharam V., Kanthasamy A., Proteolytic activation of proapoptotic kinase PKC is regulated by overexpression of Bcl-2: implications for oxidative stress and environmental factors in Parkinson's disease Annals of the New York Academy of Sciences 2003 1010 683 686 (Pubitemid 38265066)
38. Kaul S., Kanthasamy A., Kitazawa M., Anantharam V., Kanthasamy A. G., Caspase-3 dependent proteolytic activation of protein kinase C mediates and regulates 1-methyl-4-phenylpyridinium (MPP+)-induced apoptotic cell death in dopaminergic cells: relevance to oxidative stress in dopaminergic degeneration European Journal of Neuroscience 2003 18 6 1387 1401 (Pubitemid 37215094)
39. Brodie C., Blumberg P. M., Regulation of cell apoptosis by protein kinase c Apoptosis 2003 8 1 19 27 (Pubitemid 36133134)
40. Lu W., Lee H. K., Xiang C., Finniss S., Brodie C., The phosphorylation of tyrosine 332 is necessary for the caspase 3-dependent cleavage of PKC and the regulation of cell apoptosis Cellular Signalling 2007 19 10 2165 2173 (Pubitemid 47353819)
41. El Jamali A., Valente A. J., Clark R. A., Regulation of phagocyte NADPH oxidase by hydrogen peroxide through a Ca 2+ /c-Abl signaling pathway Free Radical Biology and Medicine 2010 48 6 798 810
42. Xiao L., Chen D., Hu P., Wu J., Liu W., Zhao Y., Cao M., Fang Y., Bi W., Zheng Z., Ren J., Ji G., Wang Y., Yuan Z., The c-Abl-MST1 signaling pathway mediates oxidative stress-induced neuronal cell death Journal of Neuroscience 2011 31 26 9611 9619
43. Banerjee K., Sinha M., Pham C. L. L., Jana S., Chanda D., Cappai R., Chakrabarti S., -Synuclein induced membrane depolarization and loss of phosphorylation capacity of isolated rat brain mitochondria: implications in Parkinson's disease FEBS Letters 2010 584 8 1571 1576
44. Wong E., Cuervo A. M., Autophagy gone awry in neurodegenerative diseases Nature Neuroscience 2010 13 7 805 811
45. Song I. U., Kim Y. D., Cho H. J., Chung S. W., Chung Y. A., An FP-CIT PET comparison of the differences in dopaminergic neuronal loss between idiopathic Parkinson disease with dementia and without dementia. Alzheimer Disease and Associated Disorders. In press
46. Yogalingam G., Pendergast A. M., Abl kinases regulate autophagy by promoting the trafficking and function of lysosomal components The Journal of Biological Chemistry 2008 283 51 35941 35953
47. Ertmer A., Huber V., Gilch S., Yoshimori T., Erfle V., Duyster J., Elssser H. P., Schzl H. M., The anticancer drug imatinib induces cellular autophagy Leukemia 2007 21 5 936 942 (Pubitemid 46672069)
48. Nihira K., Taira N., Miki Y., Yoshida K., TTK/Mps1 controls nuclear targeting of c-Abl by 14-3-3-coupled phosphorylation in response to oxidative stress Oncogene 2008 27 58 7285 7295
49. Ito Y., Pandey P., Mishra N., Kumar S., Narula N., Kharbanda S., Saxena S., Kufe D., Targeting of the c-Abl tyrosine kinase to mitochondria in endoplasmic reticulum stress-induced apoptosis Molecular and Cellular Biology 2001 21 18 6233 6242 (Pubitemid 34263523)
50. Kumar S., Bharti A., Mishra N. C., Raina D., Kharbanda S., Saxena S., Kufe D., Targeting of the c-Abl tyrosine kinase to mitochondria in the necrotic cell death response to oxidative stress The Journal of Biological Chemistry 2001 276 20 17281 17285
51. Kumar S., Mishra N., Raina D., Saxena S., Kufe D., Abrogation of the cell death response to oxidative stress by the c-Abl tyrosine kinase inhibitor STI571 Molecular Pharmacology 2003 63 2 276 282 (Pubitemid 36158362)
52. Lasfer M., Davenne L., Vadrot N., Alexia C., Sadji-Ouatas Z., Bringuier A. F., Feldmann G., Pessayre D., Reyl-Desmars F., Protein kinase PKC delta and c-Abl are required for mitochondrial apoptosis induction by genotoxic stress in the absence of p53, p73 and Fas receptor FEBS Letters 2006 580 11 2547 2552
53. Gioeli D., The dynamics of the cell signaling network; implications for targeted therapies Targeted Therapies Mechanisms of Resistance 2011 Clifton, NJ, USA Humana 33 53
54. Adrin F. J., Ding Q., Sim T., Velentza A., Sloan C., Liu Y., Zhang G., Hur W., Ding S., Manley P., Mestan J., Fabbro D., Gray N. S., Allosteric inhibitors of Bcr-abl-dependent cell proliferation Nature Chemical Biology 2006 2 2 95 102
55. Zhang J., Adrin F. J., Jahnke W., Cowan-Jacob S. W., Li A. G., Iacob R. E., Sim T., Powers J., Dierks C., Sun F., Guo G. R., Ding Q., Okram B., Choi Y., Wojciechowski A., Deng X., Liu G., Fendrich G., Strauss A., Vajpai N., Grzesiek S., Tuntland T., Liu Y., Bursulaya B., Azam M., Manley P. W., Engen J. R., Daley G. Q., Warmuth M., Gray N. S., Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors Nature 2010 463 7280 501 506
56. Iacob R. E., Zhang J., Gray N. S., Engen J. R., Allosteric interactions between the myristate- and ATP-site of the Abl kinase PLoS ONE 2011 6 1
57. Preyer M., Vigneri P., Wang J. Y. J., Interplay between kinase domain autophosphorylation and F-actin binding domain in regulating imatinib sensitivity and nuclear import of BCR-ABL PLoS ONE 2011 6 2
58. Choi Y., Seeliger M. A., Panjarian S. B., Kim H., Deng X., Sim T., Couch B., Koleske A. J., Smithgall T. E., Gray N. S., N-myristoylated c-Abl tyrosine kinase localizes to the endoplasmic reticulum upon binding to an allosteric inhibitor The Journal of Biological Chemistry 2009 284 42 29005 29014
59. Balogun E., Hoque M., Gong P., Killeen E., Green C. J., Foresti R., Alam J., Motterlini R., Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element Biochemical Journal 2003 371 3 887 895 (Pubitemid 36578887)
60. Lloyd-Evans E., Morgan A. J., He X., Smith D. A., Elliot-Smith E., Sillence D. J., Churchill G. C., Schuchman E. H., Galione A., Platt F. M., Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium Nature Medicine 2008 14 11 1247 1255