GKAs for diabetes therapy: Why no clinically useful drug after two decades of trying?

Trends in Pharmacological Sciences

Volumn 34, Issue 2, 2013, Pages 90-99

  Matschinsky, Franz M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMG 151; ARRY 403; ENZYME ACTIVATOR; GLUCOKINASE; GLUCOKINASE ACTIVATOR; GLUCOSE; GLUCOSE 6 PHOSPHATASE; GLUCOSE 6 PHOSPHATE; INSULIN GLARGINE; METFORMIN; MK 0941; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PIRAGLIATIN; PROTEIN BAD; PYRUVATE KINASE; RO 5305552; UNCLASSIFIED DRUG;

ANTIDIABETIC ACTIVITY; BINDING AFFINITY; CHEMOPROPHYLAXIS; DIABETES MELLITUS; DRUG EFFICACY; DRUG MEGADOSE; DRUG PROTEIN BINDING; DRUG RESPONSE; DRUG SAFETY; DRUG TARGETING; DRUG TOLERABILITY; DRUG WITHDRAWAL; ENZYME ACTIVATION; GLUCOSE METABOLISM; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; HYPOGLYCEMIA; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REVIEW;

ANIMALS; DIABETES MELLITUS, TYPE 2; DRUG DISCOVERY; ENZYME ACTIVATORS; GLUCOKINASE; HUMANS; HYPOGLYCEMIC AGENTS; MICE; MODELS, MOLECULAR; RATS;

EID: 84873412741     PISSN: 01656147     EISSN: 18733735     Source Type: Journal    
DOI: 10.1016/j.tips.2012.11.007     Document Type: Review

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