Investigation of functionally liver selective glucokinase activators for the treatment of type 2 diabetes

Journal of Medicinal Chemistry

Volumn 52, Issue 19, 2009, Pages 6142-6152

  Bebernitz, Gregory R ^a   Beaulieu, Valerie ^a   Dale, Bethany A ^a   Deacon, Richard ^a   Duttaroy, Alokesh ^a   Gao, Jiaping ^a   Grondine, Melissa S ^a   Gupta, Ramesh C ^b   Kakmak, Mesut ^a   Kavana, Michael ^a   Kirman, Louise C ^a   Liang, Jinsheng ^a   Maniara, Wieslawa M ^a   Munshi, Siralee ^b   Nadkarni, Sunil S ^b   Schuster, Herbert F ^a   Stams, Travis ^a   St Denny, Irene ^a   Taslimi, Paul M ^a   Vash, Brian ^a   Caplan, Shari L ^a   more..

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^b Torrent Research Centre   (India)

Author keywords

[No Author keywords available]

Indexed keywords

3 CYCLOPENTYL N (5 METHOXY THIAZOLO[5,4 B]PYRIDIN 2 YL) 2 [4 (4 METHYLPIPERAZINE 1 SULFONYL)PHENYL] PROPIONAMIDE; ANTIDIABETIC AGENT; GLUCOKINASE; GLUCOSE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; GLUCOKINASE; GLUCOSE TOLERANCE TEST; HYPOGLYCEMIC AGENTS; LIVER; MICE; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 70349641037     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900839k     Document Type: Article

References (31)

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