Research and development of glucokinase activators for diabetes therapy: Theoretical and practical aspects

Handbook of Experimental Pharmacology

Volumn 203, Issue , 2011, Pages 357-401

  Matschinsky, Franz M ^a   Zelent, Bogumil ^a   Doliba, Nicolai M ^a   Kaestner, Klaus H ^a   Vanderkooi, Jane M ^a   Grimsby, Joseph ^b   Berthel, Steven J ^c   Sarabu, Ramakanth ^c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Hoffman La Roche Department of Metabolic Diseases   (United States)

^c HOFFMANN LA ROCHE INC   (United States)

Author keywords

GK Activators (GKAs); Glucokinase (GK); Glucose Homeostasis; Hyperglycemia; Type 2 Diabetes Mellitus (T2DM )

Indexed keywords

ANTIDIABETIC AGENT; DIPEPTIDYL PEPTIDASE IV INHIBITOR; GLUCAGON LIKE PEPTIDE 1 DERIVATIVE; GLUCOKINASE; GLUCOKINASE ACTIVATOR; GLUCOSE; GLYCOGEN; INSULIN; INSULIN SENSITIZING AGENT; METFORMIN; PIRAGLIATIN; RO 0281675; UNCLASSIFIED DRUG; DRUG RECEPTOR; ENZYME ACTIVATOR;

BLOOD GLUCOSE MONITORING; CATALYSIS; DRUG BINDING; DRUG EFFICACY; DRUG TARGETING; DRUG TOLERABILITY; ENDOCRINE CELL; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE MUTATION; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; HIGH THROUGHPUT SCREENING; HUMAN; HYPERGLYCEMIA; HYPERINSULINISM; HYPOGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; INSULIN SYNTHESIS; LIVER CELL; METABOLIC REGULATION; MONOTHERAPY; NEUROSECRETORY CELL; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; REVIEW; SINGLE DRUG DOSE; STRUCTURE ACTIVITY RELATION; ANIMAL; DIABETES MELLITUS; DRUG EFFECT; HOMEOSTASIS; METABOLISM; ANTIDIABETIC ACTIVITY; ARTICLE; DRUG MECHANISM; DRUG SAFETY; DRUG STRUCTURE; ENZYME DEFECT; GENE TARGETING; GLUCOSE SENSOR; PROTEIN EXPRESSION;

ANIMALS; DIABETES MELLITUS; DIABETES MELLITUS, TYPE 2; ENZYME ACTIVATORS; GLUCOKINASE; HOMEOSTASIS; HUMANS; HYPERINSULINISM; HYPOGLYCEMIC AGENTS; RECEPTORS, DRUG;

EID: 79955605398     PISSN: 01712004     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-642-17214-4_15     Document Type: Review

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