Control of beta cell function and proliferation in mice stimulated by small-molecule glucokinase activator under various conditions

Diabetologia

Volumn 55, Issue 6, 2012, Pages 1745-1754

  Nakamura, A ^a   Togashi, Y ^a   Orime, K ^a   Sato, K ^a   Shirakawa, J ^a   Ohsugi, M ^b   Kubota, N ^b   Kadowaki, T ^b   Terauchi, Y ^a  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Beta cell proliferation; Glucokinase activator; IRS2; Oxidative stress

Indexed keywords

ENZYME ACTIVATOR; EXENDIN 4; GLUCOKINASE ACTIVATOR; GLUCOSE; INSULIN RECEPTOR SUBSTRATE 2; MESSENGER RNA; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG; GLUCOKINASE; INSULIN RECEPTOR SUBSTRATE; IRS2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ISOLATION; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; GENE; GENE EXPRESSION; GLUCOSE METABOLISM; IN VIVO STUDY; INSULIN RECEPTOR SUBSTRATE 2 GENE; INSULIN RELEASE; KNOCKOUT MOUSE; LIPID DIET; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; TRANSCRIPTION FACTOR PDX 1 GENE; WILD TYPE; ANIMAL; CYTOLOGY; DRUG EFFECT; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; MOUSE MUTANT; PANCREAS ISLET; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL PROLIFERATION; ENZYME ACTIVATORS; GLUCOKINASE; IMMUNOHISTOCHEMISTRY; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MICE; MICE, KNOCKOUT; OXIDATIVE STRESS;

EID: 84865444416     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2521-5     Document Type: Article

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