Effects of a glucokinase activator on hepatic intermediary metabolism: Study with 13C-isotopomer-based metabolomics

Biochemical Journal

Volumn 444, Issue 3, 2012, Pages 537-551

  Nissim, Itzhak ^a,b   Horyn, Oksana ^a   Nissim, Ilana ^a   Daikhin, Yevgeny ^a   Wehrli, Suzanne L ^a   Yudkoff, Marc ^a,b   Matschinsky, Franz M ^b  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Gluconeogenesis; Glycogenesis; Glycolysis; N acetyl glutamate (NAG); Tricarboxylic acid (TCA) cycle; Ureagenesis

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALANINE; ANTIDIABETIC AGENT; ASPARTIC ACID; CARBON 13; CITRIC ACID; ENZYME ACTIVATOR; GLUCOKINASE; GLUCOKINASE ACTIVATOR; GLUCOSE; GLUTAMIC ACID; GLUTAMINE; GLYCINE; GLYCOGEN; LACTIC ACID; N ACETYLGLUTAMIC ACID; PIRAGLIATIN; SERINE; TRICARBOXYLIC ACID; UNCLASSIFIED DRUG; UREA;

AMINO ACID SYNTHESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOENERGY; CARBON NUCLEAR MAGNETIC RESONANCE; CELL ISOLATION; CITRIC ACID CYCLE; CONTROLLED STUDY; FATTY LIVER; GLUCONEOGENESIS; GLYCOGEN SYNTHESIS; GLYCOLYSIS; ISOTOPE LABELING; LACTIC ACIDOSIS; LIVER CELL; LIVER METABOLISM; LIVER PERFUSION; MALE; MASS SPECTROMETRY; METABOLOMICS; NONHUMAN; PRIORITY JOURNAL; RAT; RISK BENEFIT ANALYSIS; UREA CYCLE;

ANIMALS; BENZENEACETAMIDES; ENZYME ACTIVATION; GLUCOKINASE; HEPATOCYTES; LIVER; MALE; METABOLOMICS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84862215515     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20120163     Document Type: Article

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