The active conformation of human glucokinase is not altered by allosteric activators

Acta Crystallographica Section D: Biological Crystallography

Volumn 67, Issue 11, 2011, Pages 929-935

  Petit, Pierre ^a   Antoine, Mathias ^b   Ferry, Gilles ^b   Boutin, Jean A ^b   Lagarde, Amandine ^a   Gluais, Laure ^a   Vincentelli, Renaud ^a   Vuillard, Laurent ^a  

^a Centre National de la Recherche Scientifique   (France)

^b INSTITUT DE RECHERCHES SERVIER   (France)

Author keywords

allosteric modulators; ATP analogues; glucokinase; glucose

Indexed keywords

ADENOSINE TRIPHOSPHATE; ADENYLYLIMIDODIPHOSPHATE; ANTIDIABETIC AGENT; DRUG DERIVATIVE; GLUCOKINASE; GLUCOSE; INSULIN;

ALLOSTERISM; ARTICLE; CHEMISTRY; CRYSTALLIZATION; DRUG EFFECT; ENZYME ACTIVATION; HUMAN; METABOLISM; PANCREAS ISLET BETA CELL; PATHOLOGY; PERSISTENT HYPERINSULINEMIC HYPOGLYCEMIA OF INFANCY; PROTEIN BINDING; PROTEIN CONFORMATION; SECRETION; X RAY CRYSTALLOGRAPHY;

ADENOSINE TRIPHOSPHATE; ADENYLYL IMIDODIPHOSPHATE; ALLOSTERIC REGULATION; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; GLUCOKINASE; GLUCOSE; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN-SECRETING CELLS; PERSISTENT HYPERINSULINEMIA HYPOGLYCEMIA OF INFANCY; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 80955139676     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S0907444911036729     Document Type: Article

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