메뉴 건너뛰기




Volumn 302, Issue 1, 2012, Pages

Glucokinase activation repairs defective bioenergetics of islets of Langerhans isolated from type 2 diabetics

Author keywords

Glucokinase activators; Insulin secretion; Pancreatic islets; Type 2 diabetes

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM ION; EXENDIN 4; GLUCOKINASE; INSULIN;

EID: 83455197122     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00218.2011     Document Type: Article
Times cited : (78)

References (78)
  • 1
    • 49649099805 scopus 로고    scopus 로고
    • Glucokinase and molecular aspects of liver glycogen metabolism
    • Agius L. Glucokinase and molecular aspects of liver glycogen metabolism. Biochem J 414: 1-18, 2008.
    • (2008) Biochem J , vol.414 , pp. 1-18
    • Agius, L.1
  • 2
    • 67349176115 scopus 로고    scopus 로고
    • Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes
    • Ahren B. Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes. Nat Rev Drug Discov 8: 369-385, 2009.
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 369-385
    • Ahren, B.1
  • 4
    • 0021741559 scopus 로고
    • Glucose induces closure of single potassium channels in isolated rat pancreatic beta-cells
    • Ashcroft FM, Harrison DE, Ashcroft SJ. Glucose induces closure of single potassium channels in isolated rat pancreatic beta-cells. Nature 312: 446-448, 1984.
    • (1984) Nature , vol.312 , pp. 446-448
    • Ashcroft, F.M.1    Harrison, D.E.2    Ashcroft, S.J.3
  • 5
    • 0022847855 scopus 로고
    • A potassium channel modulated by glucose metabolism in rat pancreatic beta-cells
    • Ashcroft FM, Harrison DE, Ashcroft SJ. A potassium channel modulated by glucose metabolism in rat pancreatic beta-cells. Adv Exp Med Biol 211: 53-62, 1986.
    • (1986) Adv Exp Med Biol , vol.211 , pp. 53-62
    • Ashcroft, F.M.1    Harrison, D.E.2    Ashcroft, S.J.3
  • 8
    • 0033009463 scopus 로고    scopus 로고
    • Effects of fatty acids and ketone bodies on basal insulin secretion in type 2 diabetes
    • Boden G, Chen X. Effects of fatty acids and ketone bodies on basal insulin secretion in type 2 diabetes. Diabetes 48: 577-583, 1999.
    • (1999) Diabetes , vol.48 , pp. 577-583
    • Boden, G.1    Chen, X.2
  • 9
    • 78049512890 scopus 로고    scopus 로고
    • Piragliatin (RO4389620), a novel glucokinase activator, lowers plasma glucose both in the postabsorptive state and after a glucose challenge in patients with type 2 diabetes mellitus: A mechanistic study
    • Bonadonna RC, Heise T, Arbet-Engels C, Kapitza C, Avogaro A, Grimsby J, Zhi J, Grippo JF, Balena R. Piragliatin (RO4389620), a novel glucokinase activator, lowers plasma glucose both in the postabsorptive state and after a glucose challenge in patients with type 2 diabetes mellitus: a mechanistic study. J Clin Endocrinol Metab 95: 5028-5036, 2010.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 5028-5036
    • Bonadonna, R.C.1    Heise, T.2    Arbet-Engels, C.3    Kapitza, C.4    Avogaro, A.5    Grimsby, J.6    Zhi, J.7    Grippo, J.F.8    Balena, R.9
  • 11
    • 33947149143 scopus 로고    scopus 로고
    • Beta-cell preservation with thiazolidinediones
    • Campbell IW, Mariz S. Beta-cell preservation with thiazolidinediones. Diabetes Res Clin Pract 76: 163-176, 2007.
    • (2007) Diabetes Res Clin Pract , vol.76 , pp. 163-176
    • Campbell, I.W.1    Mariz, S.2
  • 19
    • 77956819081 scopus 로고    scopus 로고
    • Palmitic acid acutely inhibits acetylcholine- but not GLP-1-stimulated insulin secretion in mouse pancreatic islets
    • Doliba NM, Qin W, Vinogradov SA, Wilson DF, Matschinsky FM. Palmitic acid acutely inhibits acetylcholine- but not GLP-1-stimulated insulin secretion in mouse pancreatic islets. Am J Physiol Endocrinol Metab 299: E475-E485, 2010.
    • (2010) Am J Physiol Endocrinol Metab , vol.299
    • Doliba, N.M.1    Qin, W.2    Vinogradov, S.A.3    Wilson, D.F.4    Matschinsky, F.M.5
  • 20
    • 0037312854 scopus 로고    scopus 로고
    • Differential effects of glucose and glyburide on energetics and Na levels of betaHC9 cells: Nuclear magnetic resonance spectroscopy and respirometry studies
    • Doliba NM, Vatamaniuk MZ, Buettger CW, Qin W, Collins HW, Wehrli SL, Carr RD, Matschinsky FM. Differential effects of glucose and glyburide on energetics and Na levels of betaHC9 cells: nuclear magnetic resonance spectroscopy and respirometry studies. Diabetes 52: 394-402, 2003.
    • (2003) Diabetes , vol.52 , pp. 394-402
    • Doliba, N.M.1    Vatamaniuk, M.Z.2    Buettger, C.W.3    Qin, W.4    Collins, H.W.5    Wehrli, S.L.6    Carr, R.D.7    Matschinsky, F.M.8
  • 21
    • 50049086521 scopus 로고    scopus 로고
    • The emerging genetic architecture of type 2 diabetes
    • Doria A, Patti ME, Kahn CR. The emerging genetic architecture of type 2 diabetes. Cell Metab 8: 186-200, 2008.
    • (2008) Cell Metab , vol.8 , pp. 186-200
    • Doria, A.1    Patti, M.E.2    Kahn, C.R.3
  • 22
    • 0032806183 scopus 로고    scopus 로고
    • Glucose regulation of glutaminolysis and its role in insulin secretion
    • Gao ZY, Li G, Najafi H, Wolf BA, Matschinsky FM. Glucose regulation of glutaminolysis and its role in insulin secretion. Diabetes 48: 1535-1542, 1999.
    • (1999) Diabetes , vol.48 , pp. 1535-1542
    • Gao, Z.Y.1    Li, G.2    Najafi, H.3    Wolf, B.A.4    Matschinsky, F.M.5
  • 23
    • 0026333684 scopus 로고
    • The role of ATP and free ADP in metabolic coupling during fuel-stimulated insulin release from islet beta-cells in the isolated perfused rat pancreas
    • Ghosh A, Ronner P, Cheong E, Khalid P, Matschinsky FM. The role of ATP and free ADP in metabolic coupling during fuel-stimulated insulin release from islet beta-cells in the isolated perfused rat pancreas. J Biol Chem 266: 22887-22892, 1991.
    • (1991) J Biol Chem , vol.266 , pp. 22887-22892
    • Ghosh, A.1    Ronner, P.2    Cheong, E.3    Khalid, P.4    Matschinsky, F.M.5
  • 24
    • 54049100425 scopus 로고    scopus 로고
    • Islet oxygen consumption and insulin secretion tightly coupled to calcium derived from L-type calcium channels but not from the endoplasmic reticulum
    • Gilbert M, Jung SR, Reed BJ, Sweet IR. Islet oxygen consumption and insulin secretion tightly coupled to calcium derived from L-type calcium channels but not from the endoplasmic reticulum. J Biol Chem 283: 24334-24342, 2008.
    • (2008) J Biol Chem , vol.283 , pp. 24334-24342
    • Gilbert, M.1    Jung, S.R.2    Reed, B.J.3    Sweet, I.R.4
  • 25
  • 26
    • 59149101384 scopus 로고    scopus 로고
    • Glucokinase activators for the potential treatment of type 2 diabetes
    • Grimsby J, Berthel SJ, Sarabu R. Glucokinase activators for the potential treatment of type 2 diabetes. Curr Top Med Chem 8: 1524-1532, 2008.
    • (2008) Curr Top Med Chem , vol.8 , pp. 1524-1532
    • Grimsby, J.1    Berthel, S.J.2    Sarabu, R.3
  • 28
    • 0033760442 scopus 로고    scopus 로고
    • Triggering and amplifying pathways of regulation of insulin secretion by glucose
    • Henquin JC. Triggering and amplifying pathways of regulation of insulin secretion by glucose. Diabetes 49: 1751-1760, 2000.
    • (2000) Diabetes , vol.49 , pp. 1751-1760
    • Henquin, J.C.1
  • 29
    • 33845541249 scopus 로고    scopus 로고
    • Nutrient control of insulin secretion in isolated normal human islets
    • Henquin JC, Dufrane D, Nenquin M. Nutrient control of insulin secretion in isolated normal human islets. Diabetes 55: 3470-3477, 2006.
    • (2006) Diabetes , vol.55 , pp. 3470-3477
    • Henquin, J.C.1    Dufrane, D.2    Nenquin, M.3
  • 31
    • 0037283601 scopus 로고    scopus 로고
    • The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes
    • Kahn SE. The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. Diabetologia 46: 3-19, 2003.
    • (2003) Diabetologia , vol.46 , pp. 3-19
    • Kahn, S.E.1
  • 33
    • 67349228410 scopus 로고    scopus 로고
    • The beta cell lesion in type 2 diabetes: There has to be a primary functional abnormality
    • Kahn SE, Zraika S, Utzschneider KM, Hull RL. The beta cell lesion in type 2 diabetes: there has to be a primary functional abnormality. Diabetologia 52: 1003-1012, 2009.
    • (2009) Diabetologia , vol.52 , pp. 1003-1012
    • Kahn, S.E.1    Zraika, S.2    Utzschneider, K.M.3    Hull, R.L.4
  • 34
    • 0035886966 scopus 로고    scopus 로고
    • cAMP-regulated guanine nucleotide exchange factor II (Epac2) mediates Ca2+-induced Ca2+ release in INS-1 pancreatic beta-cells
    • Kang G, Chepurny OG, Holz GG. cAMP-regulated guanine nucleotide exchange factor II (Epac2) mediates Ca2+-induced Ca2+ release in INS-1 pancreatic beta-cells. J Physiol 536: 375-385, 2001.
    • (2001) J Physiol , vol.536 , pp. 375-385
    • Kang, G.1    Chepurny, O.G.2    Holz, G.G.3
  • 35
    • 0026801953 scopus 로고
    • Glucocorticoid increases glucose cycling and inhibits insulin release in pancreatic islets of ob/ob mice
    • Khan A, Ostenson CG, Berggren PO, Efendic S. Glucocorticoid increases glucose cycling and inhibits insulin release in pancreatic islets of ob/ob mice. Am J Physiol Endocrinol Metab 263: E663-E666, 1992.
    • (1992) Am J Physiol Endocrinol Metab , vol.263
    • Khan, A.1    Ostenson, C.G.2    Berggren, P.O.3    Efendic, S.4
  • 36
    • 67651154419 scopus 로고    scopus 로고
    • Pioglitazone acutely reduces insulin secretion and causes metabolic deceleration of the pancreatic beta-cell at submaximal glucose concentrations
    • Lamontagne J, Pepin E, Peyot ML, Joly E, Ruderman NB, Poitout V, Madiraju SR, Nolan CJ, Prentki M. Pioglitazone acutely reduces insulin secretion and causes metabolic deceleration of the pancreatic beta-cell at submaximal glucose concentrations. Endocrinology 150: 3465-3474, 2009.
    • (2009) Endocrinology , vol.150 , pp. 3465-3474
    • Lamontagne, J.1    Pepin, E.2    Peyot, M.L.3    Joly, E.4    Ruderman, N.B.5    Poitout, V.6    Madiraju, S.R.7    Nolan, C.J.8    Prentki, M.9
  • 42
    • 47749151440 scopus 로고    scopus 로고
    • Elimination of KATP channels in mouse islets results in elevated [U-13C]glucose metabolism, glutaminolysis, and pyruvate cycling but a decreased gammaaminobutyric acid shunt
    • Li C, Nissim I, Chen P, Buettger C, Najafi H, Daikhin Y, Nissim I, Collins HW, Yudkoff M, Stanley CA, Matschinsky FM. Elimination of KATP channels in mouse islets results in elevated [U-13C]glucose metabolism, glutaminolysis, and pyruvate cycling but a decreased gammaaminobutyric acid shunt. J Biol Chem 283: 17238-17249, 2008.
    • (2008) J Biol Chem , vol.283 , pp. 17238-17249
    • Li, C.1    Nissim, I.2    Chen, P.3    Buettger, C.4    Najafi, H.5    Daikhin, Y.6    Nissim, I.7    Collins, H.W.8    Yudkoff, M.9    Stanley, C.A.10    Matschinsky, F.M.11
  • 46
    • 77449154126 scopus 로고    scopus 로고
    • Molecular and metabolic evidence for mitochondrial defects associated with beta-cell dysfunction in a mouse model of type 2 diabetes
    • Lu H, Koshkin V, Allister EM, Gyulkhandanyan AV, Wheeler MB. Molecular and metabolic evidence for mitochondrial defects associated with beta-cell dysfunction in a mouse model of type 2 diabetes. Diabetes 59: 448-459, 2010.
    • (2010) Diabetes , vol.59 , pp. 448-459
    • Lu, H.1    Koshkin, V.2    Allister, E.M.3    Gyulkhandanyan, A.V.4    Wheeler, M.B.5
  • 50
    • 0001675217 scopus 로고
    • The hypoglycemic action of ketones. II. Evidence for a stimulatory feedback of ketones on the pancreatic beta cells
    • Madison LL, Mebane D, Unger RH, Lochner A. The hypoglycemic action of ketones. II. Evidence for a stimulatory feedback of ketones on the pancreatic beta cells. J Clin Invest 43: 408-415, 1964.
    • (1964) J Clin Invest , vol.43 , pp. 408-415
    • Madison, L.L.1    Mebane, D.2    Unger, R.H.3    Lochner, A.4
  • 51
    • 67349139275 scopus 로고    scopus 로고
    • Assessing the potential of glucokinase activators in diabetes therapy
    • Matschinsky FM. Assessing the potential of glucokinase activators in diabetes therapy. Nat Rev Drug Discov 8: 399-416, 2009.
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 399-416
    • Matschinsky, F.M.1
  • 52
    • 0030067124 scopus 로고    scopus 로고
    • Banting Lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm
    • Matschinsky FM. Banting Lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm. Diabetes 45: 223-241, 1996.
    • (1996) Diabetes , vol.45 , pp. 223-241
    • Matschinsky, F.M.1
  • 55
    • 0031972156 scopus 로고    scopus 로고
    • UKPDS 26: Sulphonylurea failure in non-insulin-dependent diabetic patients over six years. UK Prospective Diabetes Study (UKPDS) Group
    • Matthews DR, Cull CA, Stratton IM, Holman RR, Turner RC. UKPDS 26: Sulphonylurea failure in non-insulin-dependent diabetic patients over six years. UK Prospective Diabetes Study (UKPDS) Group. Diabet Med 15: 297-303, 1998.
    • (1998) Diabet Med , vol.15 , pp. 297-303
    • Matthews, D.R.1    Cull, C.A.2    Stratton, I.M.3    Holman, R.R.4    Turner, R.C.5
  • 56
    • 0036325596 scopus 로고    scopus 로고
    • Genetic approaches to the molecular understanding of type 2 diabetes
    • McCarthy MI, Froguel P. Genetic approaches to the molecular understanding of type 2 diabetes. Am J Physiol Endocrinol Metab 283: E217-E225, 2002.
    • (2002) Am J Physiol Endocrinol Metab , vol.283
    • McCarthy, M.I.1    Froguel, P.2
  • 59
    • 57749185452 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in pancreatic beta-cells in Type 2 diabetes
    • Mulder H, Ling C. Mitochondrial dysfunction in pancreatic beta-cells in Type 2 diabetes. Mol Cell Endocrinol 297: 34-40, 2009.
    • (2009) Mol Cell Endocrinol , vol.297 , pp. 34-40
    • Mulder, H.1    Ling, C.2
  • 60
    • 0001089824 scopus 로고    scopus 로고
    • Substrate control of insulin release
    • CA: Oxford Univ. Press
    • Newgard CB, Matschinsky FM. Substrate control of insulin release. In: Handbook of Physiology, edited by Jefferson L. Oxford, CA: Oxford Univ. Press, 2001, p. 125-151.
    • (2001) Handbook of Physiology , pp. 125-151
    • Newgard, C.B.1    Matschinsky, F.M.2
  • 63
    • 0032884829 scopus 로고    scopus 로고
    • Metabolic impact of glucokinase overexpression in liver: Lowering of blood glucose in fed rats is accompanied by hyperlipidemia
    • O'Doherty RM, Lehman DL, Telemaque-Potts S, Newgard CB. Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia. Diabetes 48: 2022-2027, 1999.
    • (1999) Diabetes , vol.48 , pp. 2022-2027
    • O'Doherty, R.M.1    Lehman, D.L.2    Telemaque-Potts, S.3    Newgard, C.B.4
  • 66
    • 67349270566 scopus 로고    scopus 로고
    • Translating TCF7L2: From gene to function
    • Pearson ER. Translating TCF7L2: from gene to function. Diabetologia 52: 1227-1230, 2009.
    • (2009) Diabetologia , vol.52 , pp. 1227-1230
    • Pearson, E.R.1
  • 67
    • 0023525741 scopus 로고
    • Ca2, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion
    • Prentki M, Matschinsky FM. Ca2, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion. Physiol Rev 67: 1185-1248, 1987.
    • (1987) Physiol Res , vol.67 , pp. 1185-1248
    • Prentki, M.1    Matschinsky, F.M.2
  • 68
    • 0024160877 scopus 로고
    • Banting lecture 1988. Role of insulin resistance in human disease
    • Reaven GM. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 37: 1595-1607, 1988.
    • (1988) Diabetes , vol.37 , pp. 1595-1607
    • Reaven, G.M.1
  • 69
    • 57649210496 scopus 로고    scopus 로고
    • Genetic dissection of type 2 diabetes
    • Ridderstrale M, Groop L. Genetic dissection of type 2 diabetes. Mol Cell Endocrinol 297: 10-17, 2009.
    • (2009) Mol Cell Endocrinol , vol.297 , pp. 10-17
    • Ridderstrale, M.1    Groop, L.2
  • 70
    • 34547410534 scopus 로고    scopus 로고
    • Loss of glycemic control in patients with type 2 diabetes mellitus who were receiving initial metformin, sulfonylurea, or thiazolidinedione monotherapy
    • Riedel AA, Heien H, Wogen J, Plauschinat CA. Loss of glycemic control in patients with type 2 diabetes mellitus who were receiving initial metformin, sulfonylurea, or thiazolidinedione monotherapy. Pharmacotherapy 27: 1102-1110, 2007.
    • (2007) Pharmacotherapy , vol.27 , pp. 1102-1110
    • Riedel, A.A.1    Heien, H.2    Wogen, J.3    Plauschinat, C.A.4
  • 73
    • 12344264661 scopus 로고    scopus 로고
    • Insulin resistance syndrome, pre-diabetes, and the prevention of type 2 diabetes mellitus
    • 7-6
    • Smith DO, LeRoith D. Insulin resistance syndrome, pre-diabetes, and the prevention of type 2 diabetes mellitus. Clin Cornerstone 6: 7-6, 2004.
    • (2004) Clin Cornerstone , vol.6
    • Smith, D.O.1    Leroith, D.2
  • 74
    • 34249051680 scopus 로고    scopus 로고
    • Immunohistochemical evidence for the presence of glucokinase in the gonadotropes and thyrotropes of the anterior pituitary gland of rat and monkey
    • Sorenson RL, Stout LE, Brelje TC, Jetton TL, Matschinsky FM. Immunohistochemical evidence for the presence of glucokinase in the gonadotropes and thyrotropes of the anterior pituitary gland of rat and monkey. J Histochem Cytochem 55: 555-566, 2007.
    • (2007) J Histochem Cytochem , vol.55 , pp. 555-566
    • Sorenson, R.L.1    Stout, L.E.2    Brelje, T.C.3    Jetton, T.L.4    Matschinsky, F.M.5
  • 76
    • 53549098812 scopus 로고    scopus 로고
    • Crucial role of insulin receptor substrate-2 in compensatory beta-cell hyperplasia in response to high fat diet-induced insulin resistance
    • Takamoto I, Terauchi Y, Kubota N, Ohsugi M, Ueki K, Kadowaki T. Crucial role of insulin receptor substrate-2 in compensatory beta-cell hyperplasia in response to high fat diet-induced insulin resistance. Diabetes Obes Metab 10, Suppl 4: 147-156, 2008.
    • (2008) Diabetes Obes Metab , vol.10 , Issue.SUPPL. 4 , pp. 147-156
    • Takamoto, I.1    Terauchi, Y.2    Kubota, N.3    Ohsugi, M.4    Ueki, K.5    Kadowaki, T.6
  • 77
    • 34250665869 scopus 로고    scopus 로고
    • Troglitazone acutely activates AMP-activated protein kinase and inhibits insulin secretion from beta cells
    • Wang X, Zhou L, Shao L, Qian L, Fu X, Li G, Luo T, Gu Y, Li F, Li J, Zheng S, Luo M. Troglitazone acutely activates AMP-activated protein kinase and inhibits insulin secretion from beta cells. Life Sci 81: 160-165, 2007.
    • (2007) Life Sci , vol.81 , pp. 160-165
    • Wang, X.1    Zhou, L.2    Shao, L.3    Qian, L.4    Fu, X.5    Li, G.6    Luo, T.7    Gu, Y.8    Li, F.9    Li, J.10    Zheng, S.11    Luo, M.12
  • 78
    • 0018398492 scopus 로고
    • Metabolism and insulinreleasing capabilities of glucosamine and N-acetylglucosamine in isolated rat islets
    • Zawalich WS, Dye ES, Matschinsky FM. Metabolism and insulinreleasing capabilities of glucosamine and N-acetylglucosamine in isolated rat islets. Biochem J 180: 145-152, 1979.
    • (1979) Biochem J , vol.180 , pp. 145-152
    • Zawalich, W.S.1    Dye, E.S.2    Matschinsky, F.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.