The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general french population

Diabetes

Volumn 57, Issue 8, 2008, Pages 2253-2257

  Vaxillaire, Martine ^a,b   Cavalcanti Proença, Christine ^a,b   Dechaume, Aurélie ^a,b   Tichet, Jean ^c   Marre, Michel ^d,e,f   Balkau, Beverley ^d,g   Froguel, Philippe ^a,b,h  

^a INSTITUT PASTEUR DE LILLE   (France)

^b UNIV LILLE   (France)

^c Regional Institute for Health   (France)

^d INSERM   (France)

^e UNIVERSITÉ PARIS DESCARTES   (France)

^f BICHAT HOSPITAL   (France)

^g UNIVERSITÉ PARIS SACLAY   (France)

^h HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOKINASE; GLUCOKINASE REGULATORY PROTEIN; GLUCOSE; INSULIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; GCKR PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ARTICLE; DISEASE PREDISPOSITION; DNA POLYMORPHISM; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HETEROZYGOTE; HUMAN; HYPERGLYCEMIA; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULINEMIA; MAJOR CLINICAL STUDY; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; RISK ASSESSMENT; RISK REDUCTION; TRIACYLGLYCEROL BLOOD LEVEL; ADULT; BLOOD; CAUCASIAN; DIET RESTRICTION; ETHNOLOGY; FEMALE; FRANCE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC PREDISPOSITION; GENETICS; MALE; METABOLISM; MIDDLE AGED; SINGLE NUCLEOTIDE POLYMORPHISM;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADULT; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; EUROPEAN CONTINENTAL ANCESTRY GROUP; FASTING; FEMALE; FRANCE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; HYPERGLYCEMIA; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; TRIGLYCERIDES;

EID: 50949132578     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db07-1807     Document Type: Article

References (19)

1. Matschinsky FM: Glucokinase, glucose homeostasis, and diabetes mellitus. Curr Diab Rep 5:171-176, 2005
2. Van Schaftingen E, Detheux M, Veiga da Cunha: Short-term control of glucokinase activity: role of a regulatory protein. FASEB J 8:414-419,1994
3. Farrelly D, Brown KS, Tieman A, Ren J, Lira SA, Hagan D, Gregg R, Mookhtiar KA, Hariharan N: Mice mutant for glucokinase regulatory protein exhibit decreased liver glucokinase: a sequestration mechanism in metabolic regulation. Proc Natl Acad Sci USA 965:14511-14516, 1999
4. Grimsby J, Coffey JW, Dvorozniak MT, Magram J, Li G, Matschinsky FM, Shiota C, Kaur S, Magnuson MA, Grippo JF: Characterization of glucoki- nase regulatory protein-deficient mice. J Biol Chem 275:7826-7831, 2000
5. Slosberg ED, Desai UJ, Fanelli B, St Denny I, Connelly S, Kaleko M, Boettcher BR, Caplan SL: Treatment of type 2 diabetes by adenoviral-mediated overexpression of the glucokinase regulatory protein. Diabetes 50:1813-1820, 2001
6. Vaxillaire M, Froguel P: Genetic basis of maturity-onset diabetes of the young. Endocrinol Metab Clin North Am 35:371-384, 2006
7. Veiga-da-Cunha M, Delplanque J, Gillain A, Bonthron DT, Boutin P, Van Schaftingen E, Froguel P: Mutations in the glucokinase regulatory protein gene in 2p23 in obese French caucasians. Diabetologia 46:704-711, 2003
8. K0ster B, Fenger M, Poulsen P, Vaag A, Bentzen J: Novel polymorphisms in the GCKR gene and their influence on glucose and insulin levels in a Danish twin population. Diabet Med 22:1677-1682, 2005
9. Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research: Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316:1331-1336, 2007
10. Sparsø T, Andersen G, Nielsen T, Burgdorf KS, Gjesing AP, Nielsen AL, Albrechtsen A, Rasmussen SS, Jørgensen T, Borch-Johnsen K, Sandbæk A, Lauritzen T, Madsbad S, Hansen T, Pedersen O: The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes. Diabetologia 51:70-75, 2008
11. Vaxillaire M, Veslot J, Dina C, Proenca C, Cauchi S, Charpentier G, Tichet J, Fumeron F, Marre M, Meyre D, Balkau B, Froguel P: Impact of common type 2 diabetes risk polymorphisms in the DESIR Prospective Study. Diabetes 57:244-254, 2008
12. Balkau B, Eschwege E, Tichet J, Marre M: Proposed criteria for the diagnosis of diabetes: evidence from a French epidemiological study (D.E.S.I.R.). Diabetes Metab 23:428-434, 1997
13. de la Iglesia N, Mukhtar M, Seoane J, Guinovart JJ, Agius L: The role of the regulatory protein of glucokinase in the glucose sensory mechanism of the hepatocyte. J Biol Chem 275:10597-10603, 2000
14. Coutinho M, Gerstein HC, Wang Y, Yusuf S: The relationship between glucose and incident cardiovascular events: a metaregression analysis of published data from 20 studies of 95,783 individuals followed for 12.4 years. Diabetes Care 22:233-240, 1999
15. Balkau B, Bertrais S, Ducimetiere P, Eschwege E: Is there a glycemic threshold for mortality risk? Diabetes Care 22:696-699, 1999
16. Panzer C, Lauer MS, Brieke A, Blackstone E, Hoogwerf B: Association of fasting plasma glucose with heart rate recovery in healthy adults: a population-based study. Diabetes 51:803-807, 2002
17. Marz W, Nauck M, Hoffmann MM, Nagel D, Boehm BO, Koenig W, Rothenbacher D, Winkelmann BR: G(-30)A polymorphism in the pancreatic promoter of the glucokinase gene associated with angiographic coronary artery disease and type 2 diabetes mellitus. Circulation 109: 2844-2849, 2004
18. Brocklehurst KJ, Davies RA, Agius L: Differences in regulatory properties between human and rat glucokinase regulatory protein. Biochem J 378: 693-697, 2004
19. Desai UJ, Slosberg ED, Boettcher BR, Caplan SL, Fanelli B, Stephan Z, Gunther VJ, Kaleko M, Connelly S: Phenotypic correction of diabetic mice by adenovirus-mediated glucokinase expression. Diabetes 50:2287-2295, 2001