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Volumn 59, Issue 11, 2010, Pages 2697-2707

Pathogenesis of fasting and postprandial hyperglycemia in type 2 diabetes: Implications for therapy

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON; GLUCOKINASE; GLUCOSE; INSULIN;

EID: 78049259220     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db10-1032     Document Type: Article
Times cited : (276)

References (38)
  • 1
    • 0025966024 scopus 로고
    • Contribution to postprandial hyperglycemia and effect on initial splanchnic glucose clearance of hepatic glucose cycling in glucose-intolerant or NIDDM patients
    • Butler PC, Rizza RA. Contribution to postprandial hyperglycemia and effect on initial splanchnic glucose clearance of hepatic glucose cycling in glucose-intolerant or NIDDM patients. Diabetes 1991;40:73-81
    • (1991) Diabetes , vol.40 , pp. 73-81
    • Butler, P.C.1    Rizza, R.A.2
  • 3
    • 0014951784 scopus 로고
    • Abnormal alpha-cell function in diabetes: Response to carbohydrate and protein ingestion
    • Müller WA, Faloona GR, Aguilar-Parada E, Unger RH. Abnormal alpha-cell function in diabetes: response to carbohydrate and protein ingestion. N Engl J Med 1970;283:109-115
    • (1970) N Engl J Med , vol.283 , pp. 109-115
    • Müller, W.A.1    Faloona, G.R.2    Aguilar-Parada, E.3    Unger, R.H.4
  • 4
    • 0016850888 scopus 로고
    • Abnormal pancreatic glucagon secretion and postprandial hyperglycemia in diabetes mellitus
    • Gerich JE, Lorenzi M, Karam JH, Schneider V, Forsham PH. Abnormal pancreatic glucagon secretion and postprandial hyperglycemia in diabetes mellitus. JAMA 1975;234:159-165
    • (1975) JAMA , vol.234 , pp. 159-165
    • Gerich, J.E.1    Lorenzi, M.2    Karam, J.H.3    Schneider, V.4    Forsham, P.H.5
  • 5
    • 0013990334 scopus 로고
    • Plasma insulin responses to glucose and tolbutamide of normal weight and obese diabetic and nondiabetic subjects
    • Perley M, Kipnis DM. Plasma insulin responses to glucose and tolbutamide of normal weight and obese diabetic and nondiabetic subjects. Diabetes 1966;15:867-874
    • (1966) Diabetes , vol.15 , pp. 867-874
    • Perley, M.1    Kipnis, D.M.2
  • 6
    • 0026110135 scopus 로고
    • Banting lecture 1990: β-cells in type II diabetes mellitus
    • Porte D Jr. Banting lecture 1990: β-cells in type II diabetes mellitus. Diabetes 1991;40:166-180
    • (1991) Diabetes , vol.40 , pp. 166-180
    • Porte Jr., D.1
  • 8
    • 33847682160 scopus 로고    scopus 로고
    • Inappropriate suppression of glucagon during OGTT but not during isoglycaemic i.v. glucose infusion contributes to the reduced incretin effect in type 2 diabetes mellitus
    • DOI 10.1007/s00125-006-0566-z
    • Knop FK, Vilsbøll T, Madsbad S, Holst JJ, Krarup T. Inappropriate suppression of glucagon during OGTT but not during isoglycaemic i.v. glucose infusion contributes to the reduced incretin effect in type 2 diabetes mellitus. Diabetologia 2007;50:797-805 (Pubitemid 46355821)
    • (2007) Diabetologia , vol.50 , Issue.4 , pp. 797-805
    • Knop, F.K.1    Vilsboll, T.2    Madsbad, S.3    Holst, J.J.4    Krarup, T.5
  • 9
    • 0026795010 scopus 로고
    • Carbohydrate metabolism in non-insulin-dependent diabetes mellitus
    • Dinneen S, Gerich J, Rizza R. Carbohydrate metabolism in non-insulin-dependent diabetes mellitus. N Engl J Med 1992;327:707-713
    • (1992) N Engl J Med , vol.327 , pp. 707-713
    • Dinneen, S.1    Gerich, J.2    Rizza, R.3
  • 10
    • 0022467301 scopus 로고
    • Postprandial hyperglycemia in patients with noninsulin-dependent diabetes mellitus: Role of hepatic and extrahepatic tissues
    • Firth RG, Bell PM, Marsh HM, Hansen I, Rizza RA. Postprandial hyperglycemia in patients with noninsulin-dependent diabetes mellitus: role of hepatic and extrahepatic tissues. J Clin Invest 1986;77:1525-1532
    • (1986) J Clin Invest , vol.77 , pp. 1525-1532
    • Firth, R.G.1    Bell, P.M.2    Marsh, H.M.3    Hansen, I.4    Rizza, R.A.5
  • 11
    • 0016363937 scopus 로고
    • Interaction of insulin and glucose in the control of hepatic glucose balance
    • Bergman RN, Bucolo RJ. Interaction of insulin and glucose in the control of hepatic glucose balance. Am J Physiol 1974;227:1314-1322
    • (1974) Am J Physiol , vol.227 , pp. 1314-1322
    • Bergman, R.N.1    Bucolo, R.J.2
  • 12
    • 0017871767 scopus 로고
    • Relationship between the plasma glucose level and glucose uptake in the conscious dog
    • Cherrington AD, Williams PE, Harris MS. Relationship between the plasma glucose level and glucose uptake in the conscious dog. Metabolism 1978;27:787-791
    • (1978) Metabolism , vol.27 , pp. 787-791
    • Cherrington, A.D.1    Williams, P.E.2    Harris, M.S.3
  • 14
    • 0020684724 scopus 로고
    • Regulation of splanchnic and peripheral glucose uptake by insulin and hyperglycemia in man
    • DeFronzo RA, Ferrannini E, Hendler R, Felig P, Wahren J. Regulation of splanchnic and peripheral glucose uptake by insulin and hyperglycemia in man. Diabetes 1983;32:35-45 (Pubitemid 13203694)
    • (1983) Diabetes , vol.32 , Issue.1 , pp. 35-45
    • DeFronzo, R.A.1    Ferrannini, E.2    Hendler, R.3
  • 15
    • 3242790931 scopus 로고    scopus 로고
    • Insulin dose-response curves for stimulation of splanchnic glucose uptake and suppression of endogenous glucose production differ in nondiabetic humans and are abnormal in people with type 2 diabetes
    • DOI 10.2337/diabetes.53.8.2042
    • Basu R, Basu A, Johnson CM, Schwenk WF, Rizza RA. Insulin dose-response curves for stimulation of splanchnic glucose uptake and suppression of endogenous glucose production differ in nondiabetic humans and are abnormal in people with type 2 diabetes. Diabetes 2004;53:2042-2050 (Pubitemid 38970753)
    • (2004) Diabetes , vol.53 , Issue.8 , pp. 2042-2050
    • Basu, R.1    Basu, A.2    Johnson, C.M.3    Schwenk, W.F.4    Rizza, R.A.5
  • 16
    • 0033985724 scopus 로고    scopus 로고
    • Effects of type 2 diabetes on the ability of insulin and glucose to regulate splanchnic and muscle glucose metabolism: Evidence for a defect in hepatic glucokinase activity
    • Basu A, Basu R, Shah P, Vella A, Johnson CM, Nair KS, Jensen MD, Schwenk WF, Rizza RA. Effects of type 2 diabetes on the ability of insulin and glucose to regulate splanchnic and muscle glucose metabolism: evidence for a defect in hepatic glucokinase activity. Diabetes 2000;49:272-283
    • (2000) Diabetes , vol.49 , pp. 272-283
    • Basu, A.1    Basu, R.2    Shah, P.3    Vella, A.4    Johnson, C.M.5    Nair, K.S.6    Jensen, M.D.7    Schwenk, W.F.8    Rizza, R.A.9
  • 18
    • 0028015892 scopus 로고
    • Glucokinase: Structural analysis of a protein involved in susceptibility to diabetes
    • Pilkis SJ, Weber IT, Harrison RW, Bell GI. Glucokinase: structural analysis of a protein involved in susceptibility to diabetes. J BiolChem 1994;269:21925-21928
    • (1994) J BiolChem , vol.269 , pp. 21925-21928
    • Pilkis, S.J.1    Weber, I.T.2    Harrison, R.W.3    Bell, G.I.4
  • 19
    • 0033527659 scopus 로고    scopus 로고
    • Glucokinase overexpression restores glucose utilization and storage in cultured hepatocytes from male zucker diabetic fatty rats
    • Seoane J, Barberà A, Télémaque-Potts S, Newgard CB, Guinovart JJ. Glucokinase overexpression restores glucose utilization and storage in cultured hepatocytes from male Zucker diabetic fatty rats. J Biol Chem 1999;274:31833-31838 (Pubitemid 129503768)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.45 , pp. 31833-31838
    • Seoane, J.1    Barbera, A.2    Telemaque-Potts, S.3    Newgard, C.B.4    Guinovart, J.J.5
  • 22
    • 0021691098 scopus 로고
    • Relationships between insulin secretion, insulin action, and fasting plasma glucose concentration in nondiabetic and noninsulin-dependent diabetic subjects
    • Bogardus C, Lillioja S, Howard BV, Reaven G, Mott D. Relationships between insulin secretion, insulin action, and fasting plasma glucose concentration in nondiabetic and noninsulin-dependent diabetic subjects. J Clin Invest 1984;74:1238-1246 (Pubitemid 15206819)
    • (1984) Journal of Clinical Investigation , vol.74 , Issue.4 , pp. 1238-1246
    • Bogardus, C.1    Lillioja, S.2    Howard, B.V.3
  • 23
    • 0035082482 scopus 로고    scopus 로고
    • Effects of free fatty acids on gluconeogenesis and autoregulation of glucose production in type 2 diabetes
    • Boden G, Chen X, Capulong E, Mozzoli M. Effects of free fatty acids on gluconeogenesis and autoregulation of glucose production in type 2 diabetes. Diabetes 2001;50:810-816
    • (2001) Diabetes , vol.50 , pp. 810-816
    • Boden, G.1    Chen, X.2    Capulong, E.3    Mozzoli, M.4
  • 25
    • 0026488079 scopus 로고
    • Increased rate of gluconeogenesis in type II diabetes mellitus: A 13C nuclear magnetic resonance study
    • Magnusson I, Rothman DL, Katz LD, Shulman RG, Shulman GI. Increased rate of gluconeogenesis in type II diabetes mellitus: a 13C nuclear magnetic resonance study. J Clin Invest 1992;90:1323-1327
    • (1992) J Clin Invest , vol.90 , pp. 1323-1327
    • Magnusson, I.1    Rothman, D.L.2    Katz, L.D.3    Shulman, R.G.4    Shulman, G.I.5
  • 26
    • 0034889906 scopus 로고    scopus 로고
    • Production and metabolic clearance of glucose under basal conditions in type II (non-insulin-dependent) diabetes mellitus
    • Radziuk J, Pye S. Production and metabolic clearance of glucose under basal conditions in type II (non-insulin-dependent) diabetes mellitus. Diabetologia 2001;44:983-991
    • (2001) Diabetologia , vol.44 , pp. 983-991
    • Radziuk, J.1    Pye, S.2
  • 27
    • 0023832956 scopus 로고
    • Quantification of the relative impairment in actions of insulin on hepatic glucose production and peripheral glucose uptake in non-insulin- dependent diabetes mellitus
    • Campbell PJ, Mandarino LJ, Gerich JE. Quantification of the relative impairment in actions of insulin on hepatic glucose production and peripheral glucose uptake in non-insulin-dependent diabetes mellitus. Metabolism 1988;37:15-21
    • (1988) Metabolism , vol.37 , pp. 15-21
    • Campbell, P.J.1    Mandarino, L.J.2    Gerich, J.E.3
  • 28
    • 3042701667 scopus 로고    scopus 로고
    • Both fasting glucose production and disappearance are abnormal in people with "mild" and "severe" type 2 diabetes
    • Basu R, Schwenk WF, Rizza RA. Both fasting glucose production and disappearance are abnormal in people with "mild" and "severe" type 2 diabetes. Am J Physiol Endocrinol Metab 2004;287:E55-E62
    • (2004) Am J Physiol Endocrinol Metab , vol.287
    • Basu, R.1    Schwenk, W.F.2    Rizza, R.A.3
  • 29
    • 34249674023 scopus 로고    scopus 로고
    • Contribution of hepatic and extrahepatic insulin resistance to the pathogenesis of impaired fasting glucose: Role of increased rates of gluconeogenesis
    • Bock G, Chittilapilly E, Basu R, Toffolo G, Cobelli C, Chandramouli V, Landau BR, Rizza RA. Contribution of hepatic and extrahepatic insulin resistance to the pathogenesis of impaired fasting glucose: role of increased rates of gluconeogenesis. Diabetes 2007;56:1703-1711
    • (2007) Diabetes , vol.56 , pp. 1703-1711
    • Bock, G.1    Chittilapilly, E.2    Basu, R.3    Toffolo, G.4    Cobelli, C.5    Chandramouli, V.6    Landau, B.R.7    Rizza, R.A.8
  • 32
    • 67650254269 scopus 로고    scopus 로고
    • Additional evidence that transaldolase exchange, isotope discrimination during the triose-isomerase reaction, or both occur in humans: Effects of type 2 diabetes
    • Basu R, Chandramouli V, Schumann W, Basu A, Landau BR, Rizza RA. Additional evidence that transaldolase exchange, isotope discrimination during the triose-isomerase reaction, or both occur in humans: effects of type 2 diabetes. Diabetes 2009;58:1539-1543
    • (2009) Diabetes , vol.58 , pp. 1539-1543
    • Basu, R.1    Chandramouli, V.2    Schumann, W.3    Basu, A.4    Landau, B.R.5    Rizza, R.A.6
  • 34
    • 0029935830 scopus 로고    scopus 로고
    • Effects of a change in the pattern of insulin delivery on carbohydrate tolerance in diabetic and nondiabetic humans in the presence of differing degrees of insulin resistance
    • Basu A, Alzaid A, Dinneen S, Caumo A, Cobelli C, Rizza RA. Effects of a change in the pattern of insulin delivery on carbohydrate tolerance in diabetic and nondiabetic humans in the presence of differing degrees of insulin resistance. J Clin Invest 1996;97:2351-2361 (Pubitemid 26165724)
    • (1996) Journal of Clinical Investigation , vol.97 , Issue.10 , pp. 2351-2361
    • Basu, A.1    Alzaid, A.2    Dinneen, S.3    Caumo, A.4    Cobelli, C.5    Rizza, R.A.6
  • 35
    • 0016744760 scopus 로고
    • Normalization of fasting hyperglucagonemia and excessive glucagon responses to intravenous arginine in human diabetes mellitus by prolonged infusion of insulin
    • Gerich JE, Tsalikian E, Lorenzi M, Schneider V, Bohannon NV, Gustafson G, Karam JH. Normalization of fasting hyperglucagonemia and excessive glucagon responses to intravenous arginine in human diabetes mellitus by prolonged infusion of insulin. J Clin Endocrinol Metab 1975;41:1178-1180
    • (1975) J Clin Endocrinol Metab , vol.41 , pp. 1178-1180
    • Gerich, J.E.1    Tsalikian, E.2    Lorenzi, M.3    Schneider, V.4    Bohannon, N.V.5    Gustafson, G.6    Karam, J.H.7
  • 36
    • 0032877316 scopus 로고    scopus 로고
    • Impact of lack of suppression of glucagon on glucose tolerance in humans
    • Shah P, Basu A, Basu R, Rizza R. Impact of lack of suppression of glucagon on glucose tolerance in humans. Am J Physiol Endocrinol Metab 1999;277:E283-E290
    • (1999) Am J Physiol Endocrinol Metab , vol.277
    • Shah, P.1    Basu, A.2    Basu, R.3    Rizza, R.4
  • 37
    • 21344463062 scopus 로고    scopus 로고
    • Obesity and type 2 diabetes impair insulin-induced suppression of glycogenolysis as well as gluconeogenesis
    • DOI 10.2337/diabetes.54.7.1942
    • Basu R, Chandramouli V, Dicke B, Landau B, Rizza R. Obesity and type 2 diabetes impair insulin-induced suppression of glycogenolysis as well as gluconeogenesis. Diabetes 2005;54:1942-1948 (Pubitemid 40911255)
    • (2005) Diabetes , vol.54 , Issue.7 , pp. 1942-1948
    • Basu, R.1    Chandramouli, V.2    Dicke, B.3    Landau, B.4    Rizza, R.5
  • 38
    • 0034992273 scopus 로고    scopus 로고
    • Type 2 diabetes impairs splanchnic uptake of glucose but does not alter intestinal glucose absorption during enteral glucose feeding: Additional evidence for a defect in hepatic glucokinase activity
    • Basu A, Basu R, Shah P, Vella A, Johnson CM, Jensen M, Nair KS, Schwenk WF, Rizza RA. Type 2 diabetes impairs splanchnic uptake of glucose but does not alter intestinal glucose absorption during enteral glucose feeding: additional evidence for a defect in hepatic glucokinase activity. Diabetes 2001;50:1351-1362
    • (2001) Diabetes , vol.50 , pp. 1351-1362
    • Basu, A.1    Basu, R.2    Shah, P.3    Vella, A.4    Johnson, C.M.5    Jensen, M.6    Nair, K.S.7    Schwenk, W.F.8    Rizza, R.A.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.